Abstract:
:To determine the possible effect of hypergravity to modify the signal transduction of ionizing radiation, we analyzed the accumulation of p53 and the expression of p53-dependent genes, Waf-1 and Bax, using the western blot analysis. Hypergravity (20 x g) induced the accumulation of p53 in the human glioblastoma cell line A172 after 3 h of incubation. Low-dose (0.5 Gy) irradiation to the cells accumulated p53 1.5 h after irradiation, and induced Waf-1 and Bax. Under the condition of hypergravity (20 x g), the peak of p53 accumulation was shifted from 1.5 h to 3 h after irradiation, and the inductions of Waf-1 and Bax were suppressed entirely. These results indicate that hypergravity modifies the signal transduction of ionizing radiation through p53 in the cells.
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Okaichi K,Usui A,Ohnishi T,Okumura Ydoi
10.1269/jrr.43.s261keywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
S261-4eissn
0449-3060issn
1349-9157journal_volume
43 Supplpub_type
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