Abstract:
:The aim of the study was to evaluate inter-fractional dosimetric variations for high-dose rate breast brachytherapy using a strut-adjusted volume implant (SAVI). For the nine patients included, dosimetric constraints for treatment were as follows: for the planning target volume for evaluation (PTV_Eval), the volume receiving 90, 150 and 200% of the prescribed dose (V90%,150%,200%) should be >90%, ≤50 cm3 and ≤20 cm3, respectively; the dose covering 1 cm3 (D1cc) of the organs at risk should be ≤110% of the prescribed dose; and the air volume should be ≤10% of PTV_Eval. Differences in V90%,150%,200%, D1cc and air volume ($\Delta V$ and $\Delta D$) as inter-fractional dosimetric variations and SAVI displacements were measured with pretreatment and planning computed tomography (CT) images. Inter-fractional dosimetric variations were analyzed for correlations with the SAVI displacements. The patients were divided into two groups based on the distance of the SAVI from the surface skin to assess the relationship between the insertion position of the SAVI and dosimetric parameters. The median ΔV90%,150%,200% for the PTV_Eval in all patients was -0.3%, 0.2 cm3 and 0.2 cm3, respectively. The median (range) ΔD1cc for the chest wall and surface skin was -0.8% (-18.9 to 9.4%) and 0.3% (-7.6 to 5.3%), respectively. SAVI displacement did not correlate with inter-fractional dosimetric variations. In conclusion, the dose constraints were satisfied in most cases. However, there were inter-fractional dosimetric changes due to SAVI displacement.
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Iijima K,Okamoto H,Takahashi K,Aikawa A,Wakita A,Nakamura S,Nishioka S,Harada K,Notake R,Sugawara A,Yoshimura R,Kunieda E,Itami Jdoi
10.1093/jrr/rrz061subject
Has Abstractpub_date
2020-01-23 00:00:00pages
123-133issue
1eissn
0449-3060issn
1349-9157pii
5607846journal_volume
61pub_type
杂志文章abstract::The aim of this study was to evaluate the effectiveness and tolerability of definitive chemo-radiation or radiotherapy alone in patients with esophageal cancer. We retrospectively analyzed the medical records of n = 238 patients with squamous cell carcinoma or adenocarcinoma of the esophagus treated with definitive ra...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv022
更新日期:2015-07-01 00:00:00
abstract::This study determined whether dynamic F-18 FDG PET imaging could differentiate benign from malignant solitary pulmonary nodules (SPNs). Histopathologically confirmed SPNs (10-35 mm), 24 malignant and 10 benign, from 34 patients were studied through both dynamic and static F-18 FDG PET imaging of all patients. Volumes ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.11089
更新日期:2012-01-01 00:00:00
abstract::The estimation of the dose and the irradiated fraction of the body is important information in the primary medical response in case of a radiological accident. The PCC-R assay has been developed for high-dose estimations, but little attention has been given to its applicability for partial-body irradiations. In the pr...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt032
更新日期:2013-09-01 00:00:00
abstract::Although salvage external-beam radiation therapy (EBRT) is an attractive treatment option for pelvic lymph nodal recurrence (PeNR) in patients with prostate cancer (PCa), limited data are available regarding its long-term efficacy. This study examined the long-term clinical outcomes of patients who underwent salvage p...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa044
更新日期:2020-07-06 00:00:00
abstract::To determine the possible effect of hypergravity to modify the signal transduction of ionizing radiation, we analyzed the accumulation of p53 and the expression of p53-dependent genes, Waf-1 and Bax, using the western blot analysis. Hypergravity (20 x g) induced the accumulation of p53 in the human glioblastoma cell l...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.43.s261
更新日期:2002-12-01 00:00:00
abstract::The purpose of this study was to compare single-arc (SA) and double-arc (DA) treatment plans, which are planning techniques often used in prostate cancer volumetric modulated arc therapy (VMAT), in the presence of intrafractional deformation (ID) to determine which technique is superior in terms of target dose coverag...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa123
更新日期:2020-12-21 00:00:00
abstract::The biokinetics of radon in the body has previously been studied with the assumption that its absorption through the skin is negligibly small. This assumption would be acceptable except in specific situations, such as bathing in a radon hot spring where the radon concentration in thermal water is far higher than that ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw024
更新日期:2016-07-01 00:00:00
abstract::The present paper reports and discusses the results concerning both the inter- and intrafraction accuracy achievable combining the immobilization system employed in patients with head-and-neck, brain and skull base tumors with image guidance at our particle therapy center. Moreover, we investigated the influence of in...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt038
更新日期:2013-07-01 00:00:00
abstract::Pericardial effusion is an important late toxicity after concurrent chemoradiotherapy (CCRT) for locally advanced esophageal cancer. We investigated the clinical and dosimetric factors that were related to pericardial effusion among patients with thoracic esophageal cancer who were treated with definitive CCRT using t...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rry029
更新日期:2018-05-01 00:00:00
abstract::The purpose of this study was to assess the toxicity and efficacy of multimodal approaches, including three-dimensional conformal re-irradiation, for patients with recurrent or persistent esophageal cancer after radiotherapy. Thirty-one patients with esophageal cancer treated with three-dimensional conformal re-irradi...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.11066
更新日期:2011-01-01 00:00:00
abstract::The International Space Environment Service (ISES) is an international organization for space weather forecasts and belongs to the International Union of Radio Science (URSI). There are eleven ISES forecast centers in the world, and Communications Research Laboratory (CRL) runs the Japanese one. We make forecasts on t...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.43.s53
更新日期:2002-12-01 00:00:00
abstract::To determine the patterns of gene expression responsible for the radiosensitivity of glioblastoma cells, we analyzed transcriptional changes after ionizing radiation in different cell lines. After completing clonogenic survival assays, we selected two glioblastoma cell lines with different radiosensitivities. Subseque...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.45.53
更新日期:2004-03-01 00:00:00
abstract::Millimeter waves are used in various fields, and the risks of this wavelength range for human health must be carefully evaluated. In this study, we investigated the effects of millimeter waves on genotoxicity and heat shock protein expression in human corneal epithelial (HCE-T) and human lens epithelial (SRA01/04) cel...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrz017
更新日期:2019-07-01 00:00:00
abstract::X-ray induced formation of micronuclei is generally thought to result from DNA double-strand breaks (DSBs). However, DNA DSBs inhibit the cell cycle progression that is required for micronucleus formation. In order to reconcile this apparent discrepancy, we investigated whether DNA DSBs induced during the G1 phase cou...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.11147
更新日期:2012-01-01 00:00:00
abstract::Since December 2009, after breast-conserving surgery for Stage 0-I cancer of the left breast, 21 women with relatively pendulous breasts underwent computed tomography prone and supine simulations. The adjuvant radiotherapy was 50 Gy in 25 fractions to the left breast alone. Four plans--conventional wedged tangents and...
journal_title:Journal of radiation research
pub_type: 临床试验,杂志文章
doi:10.1093/jrr/rrt019
更新日期:2013-09-01 00:00:00
abstract::When DNA is damaged by exposure to a small amount of radiation, it is repaired efficiently by innate mechanisms. However, if cellular damage is more extensive, DNA repair cannot be adequately completed. To clarify the role of the p53 gene in apoptotic tissue repair, the incidence of in-vivo radiation-induced somatic m...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.43.s209
更新日期:2002-12-01 00:00:00
abstract::Radiation therapy (RT) has become particularly important recently for treatment of liver tumors, but there are few experimental investigations pertaining to radiation-induced liver injuries over long-term follow-up periods. Thus, the present study examined pathological liver features over a 10-month period using an in...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru005
更新日期:2014-07-01 00:00:00
abstract::To investigate the importance of gender and aging on the individual radiosensitivity of lineage-committed myeloid hematopoietic stem/progenitor cells (HSPCs) detected in mononuclear cells (MNCs) of steady-state human peripheral blood (PB), the clonogenic survival of HPCs, including colony-forming unit-granulocyte macr...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.10142
更新日期:2011-01-01 00:00:00
abstract::The Radiation Effects Research Foundation (RERF) continues to conduct a follow-up study initiated some years ago of cancer mortality and incidence among the survivors of the atomic bombing of Hiroshima and Nagasaki exposed in utero. Although only 18 incident cases of cancer were identified in the years 1950-1984 (of w...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1269/jrr.32.supplement_231
更新日期:1991-03-01 00:00:00
abstract::The purpose of this study is to survey the current patterns of practice, and barriers to implementation, of 3D image-guided brachytherapy (3D-IGBT) for cervical cancer in Japan. A 30-item questionnaire was sent to 171 Japanese facilities where high-dose-rate brachytherapy devices were available in 2012. In total, 135 ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv047
更新日期:2015-11-01 00:00:00
abstract::The purpose of this study was to evaluate interfractional changes of the minimum dose delivered to 90% of the high-risk clinical target volume (HR-CTV D90) and D2cc of the bladder and rectum during brachytherapy for uterine cervical cancer patients. A total of 52 patients received external beam radiotherapy and high-d...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt073
更新日期:2013-11-01 00:00:00
abstract::To gain an insight into the relationship between UVB-carcinogenesis and natural killer activity, we examined ultraviolet light-induced carcinogenesis in mice with high natural killer, activity (KSN) and mice with natural killer deficiency (KSN-bg). We exposed mice six times a week to three levels of daily ultraviolet ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.39.119
更新日期:1998-06-01 00:00:00
abstract::Low doses (2.5-15 cGy) of X-irradiation two months prior to a second exposure to a sublethal dose enhanced the survival rate in mice. Optimal and significant increase was observed with 5-10 cGy. Endogenous spleen colony counts (endo-CFUs) after 7 Gy increased by a factor of about 1.7 in mice pre-irradiated with 5-10 c...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.31.256
更新日期:1990-09-01 00:00:00
abstract::A number of agents are now available for use in protecting against ionizing radiation. These radiation-protective agents, however, have many adverse effects. Efforts have been made to develop new radiation-protective agents for medical application. Here, we investigated whether a compound, polyethylenimine (PEI), whic...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs098
更新日期:2013-03-01 00:00:00
abstract::The purpose of the study was to quantify local setup errors and evaluate the planning target volume (PTV) margins for sub-regions in cone-beam computed tomography (CBCT)-guided post-mastectomy radiation therapy (PMRT). The local setup errors of 20 patients undergoing CBCT-guided PMRT were analysed retrospectively. Ima...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa007
更新日期:2020-05-22 00:00:00
abstract::An overview is given of the dose-response relationship for stable chromosome aberrations (i.e., translocations and inversions) in the peripheral blood lymphocytes of A-bomb survivors in Hiroshima. Special emphasis is placed on (i) the overdispersion of survivor cases with either unexpectedly high or low aberration fre...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1269/jrr.33.supplement_206
更新日期:1992-03-01 00:00:00
abstract::The multifraction regimens commonly used in conventional clinical radiotherapy are largely based on radiobiological experiments. However, no experimental reports on skin reactions focusing on inter-strain differences have displayed clinical relevance to the fractionated dose schedule. In this study, mice of inbred str...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.45.515
更新日期:2004-12-01 00:00:00
abstract::To understand the biological response of normal cells to fractionated carbon beam irradiation, the effects of potentially lethal damage repair (PLDR) and sublethal damage repair (SLDR) were both taken into account in a linear-quadratic (LQ) model. The model was verified by the results of a fractionated cell survival e...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt012
更新日期:2013-09-01 00:00:00
abstract::Immediately after X-irradiation, monocytic cells can express the gene for interleukin (IL)-1beta, which enhances inflammation and contributes to radioprotection in mice. In order to analyze the mechanism(s) for the immediate-early induction of IL-1beta after X-irradiation at 20 Gy in cultured murine macrophages, we ex...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.44.117
更新日期:2003-06-01 00:00:00
abstract::The purpose of this study was to analyze the patterns of care and outcomes of patients with FIGO Stage I/II cervical cancer who underwent definitive radiotherapy (RT) at multiple Japanese institutions. The Japanese Radiation Oncology Study Group (JROSG) performed a questionnaire-based survey of their cervical cancer p...
journal_title:Journal of radiation research
pub_type: 杂志文章,多中心研究
doi:10.1093/jrr/rrv036
更新日期:2015-09-01 00:00:00