Modeling the biological response of normal human cells, including repair processes, to fractionated carbon beam irradiation.

abstract：:The 239Pu distribution in the 12.5-day-old rat conceptus was compared between in vivo and in vitro experimental systems to establish a possible mechanism of cross-placental transfer of this radionuclide. In the in vivo study, plutonium citrate solution was injected intravenously to pregnant Wistar rats. In the in vitr...

journal_title：Journal of radiation research

authors： Takahashi S,Sato H,Kubota Y,Inaba J

更新日期：1992-12-01 00:00:00

abstract：:Perirectal hyaluronate gel injection (HGI) appears to be a promising technique for healthy tissue dose sparing in pelvic radiotherapy. In this analysis, we report our initial experience of HGI in gynecologic brachytherapy, focusing on its safety and effectiveness for dose reduction to the rectum. Between July 2013 and...

journal_title：Journal of radiation research

authors： Kashihara T,Murakami N,Tselis N,Kobayashi K,Tsuchida K,Shima S,Masui K,Yoshida K,Takahashi K,Inaba K,Umezawa R,Igaki H,Ito Y,Kato T,Uno T,Itami J

更新日期：2019-07-01 00:00:00

abstract：:The aim of this study was to investigate the radiobiological effects of flattening filter (FF) and flattening filter-free (FFF) modes of linear electron accelerators and to understand whether there is any difference between the effects of these modes. We evaluated the number of chromosome aberrations following irradia...

journal_title：Journal of radiation research

authors： Farkas G,Kocsis ZS,Székely G,Mihály D,Pesznyák C,Pócza T,Major T,Polgár C,Jurányi Z

更新日期：2020-01-23 00:00:00

abstract：:We have examined the neutron energy dependency of cell killing and mutation induction at the hprt locus in Chinese hamster V79 cells. Monoenergetic neutrons at 0.32, 0.57, and 1.2 MeV were generated at the Hiroshima University Radiobiological Research Accelerator (HIRRAC) Facility, and were used to irradiate cells. Th...

journal_title：Journal of radiation research

authors： Kubota N,Okada S,Nagatomo S,Ozawa F,Inada T,Hill CK,Endo S,Komatsu K

更新日期：1999-12-01 00:00:00

abstract：:In this paper, we compare two radiation effect models: the average surviving fraction (ASF) model and the integral biologically effective dose (IBED) model for deriving the optimal irradiation scheme and show the superiority of ASF. Minimizing the effect on an organ at risk (OAR) is important in radiotherapy. The biol...

journal_title：Journal of radiation research

authors： Takagi R,Komiya Y,Sutherland KL,Shirato H,Date H,Mizuta M

更新日期：2018-03-01 00:00:00

abstract：:The aim of this study was to carry out geometric and dosimetric evaluation of the usefulness of a deformable image registration algorithm utilized for adaptive head-and-neck intensity-modulated radiotherapy. Data consisted of seven patients, each with a planning CT (pCT), a rescanning CT (ReCT) and a cone beam CT (CBC...

journal_title：Journal of radiation research

authors： Eiland RB,Maare C,Sjöström D,Samsøe E,Behrens CF

更新日期：2014-09-01 00:00:00

abstract：:The effectiveness of an Electronic Personal Dosemeter (Siemens EPD) for cosmic-radiation dosimetry at aviation altitudes was examined on eight international flights between March and September, 1998. The EPD values (Hepd) of the dose equivalent from penetrating radiation, Hp(10), were assumed to be almost the same as ...

journal_title：Journal of radiation research

authors： Yasuda H,Fujitaka K

更新日期：2001-03-01 00:00:00

abstract：:Centrosomes function in proper cell division in animal cells. The centrosome consists of a pair of centrioles and the surrounding pericentriolar matrix (PCM). After cytokinesis, daughter cells each acquire one centrosome, which subsequently duplicates at the G1/S phase in a manner that is dependent upon CDK2/cyclin-E ...

journal_title：Journal of radiation research

authors： Shimada M,Komatsu K

更新日期：2009-07-01 00:00:00

abstract：:The aim of this study was to compare the dosimetric parameters of whole-pelvic radiotherapy (WPRT) for cervical cancer among plans involving 3D conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT), or spot-scanning proton therapy (SSPT). The dose distributions of 3D-CRT-, IMRT-, and SSPT-based WPRT...

journal_title：Journal of radiation research

authors： Hashimoto S,Shibamoto Y,Iwata H,Ogino H,Shibata H,Toshito T,Sugie C,Mizoe JE

更新日期：2016-09-01 00:00:00

abstract：:The quality of the sublethal damage (SLD) after irradiation with high-linear energy transfer (LET) ion beams was investigated with low-LET photons. Chinese hamster V79 cells and human squamous carcinoma SAS cells were first exposed to a priming dose of different ion beams at different LETs at the Heavy Ion Medical Acc...

journal_title：Journal of radiation research

authors： Furusawa Y,Nakano-Aoki M,Matsumoto Y,Hirayama R,Kobayashi A,Konishi T

更新日期：2017-11-01 00:00:00

abstract：:The purpose of this study is to evaluate the dose-volume metrics under different heterogeneity corrections and the factors associated with local recurrence (LR) after stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC). Eighty-three patients who underwent SBRT for pathologically proven st...

journal_title：Journal of radiation research

authors： Ueki N,Matsuo Y,Shibuya K,Nakamura M,Narabayashi M,Sakanaka K,Norihisa Y,Mizowaki T,Hiraoka M

更新日期：2013-03-01 00:00:00

abstract：:The aim of the study was to compare clinical outcomes and toxicity between 3D conformal radiotherapy (3DCRT) and image-guided intensity-modulated radiotherapy (IG-IMRT) administered through helical tomotherapy in locally advanced rectal cancer (LARC) patients receiving preoperative chemoradiotherapy. We reviewed 144 p...

journal_title：Journal of radiation research

authors： Huang CM,Huang MY,Tsai HL,Huang CW,Ma CJ,Lin CH,Huang CJ,Wang JY

更新日期：2017-03-01 00:00:00

abstract：:The expression of oncogenes was studied in 12 types of 178 mouse tumors induced by radiations and chemicals. DNA was analyzed in tumors in which the overexpression of oncogenes was noted. Amplification of the myc oncogene was found in chemically induced sarcomas, but not in sarcomas induced by radiation. Activation of...

journal_title：Journal of radiation research

authors： Niwa O,Muto M,Suzuki F,Kominami R,Yokoro K

更新日期：1991-12-01 00:00:00

abstract：:Herein we summarize the public health actions taken to mitigate exposure of the public to radiation after the Fukushima accident that occurred on 11 March 2011 in order to record valuable lessons learned for disaster preparedness. Evacuations from the radiation-affected areas and control of the distribution of various...

journal_title：Journal of radiation research

authors： Shimura T,Yamaguchi I,Terada H,Robert Svendsen E,Kunugita N

更新日期：2015-05-01 00:00:00

abstract：:Disufiram (a drug used for the treatment of alcoholism) protected microsomal membranes and plasmid DNA against damages induced by gamma-radiation. The peroxidation of membrane lipids increased linearly with the radiation dose up to 600 Gy, and the presence of disulfiram inhibited membrane lipid peroxidation as assayed...

journal_title：Journal of radiation research

authors： Gandhi NM,Gopalaswamy UV,Nair Cr

更新日期：2003-09-01 00:00:00

abstract：:The health effects of radiation exposure from the atomic bomb fallout remain unclear. The objective of the present study is to elucidate the association between low-dose radiation exposure from the atomic bomb fallout and cancer mortality among Nagasaki atomic bomb survivors. Of 77 884 members in the Nagasaki Universi...

journal_title：Journal of radiation research

authors： Yokota K,Mine M,Kondo H,Matsuda N,Shibata Y,Takamura N

更新日期：2018-01-01 00:00:00

abstract：:Medical diagnostic X-ray workers are one occupational group that has exposure to continuous low doses of external radiation over their working lifetimes. Current ICRP recommendations [ICRP. Recommendations of the International Commission on Radiological Protection. ICRP Publication 60. Ann ICRP 1991;21 (1-3)] state th...

journal_title：Journal of radiation research

authors： Xu XS,Zhang LA,Sun QF,Qin YC,Yu NL

更新日期：2018-03-01 00:00:00

abstract：:When DNA is damaged by exposure to a small amount of radiation, it is repaired efficiently by innate mechanisms. However, if cellular damage is more extensive, DNA repair cannot be adequately completed. To clarify the role of the p53 gene in apoptotic tissue repair, the incidence of in-vivo radiation-induced somatic m...

journal_title：Journal of radiation research

authors： Kato F,Kakihara H,Kunugita N,Ootsuyama A,Norimura T

更新日期：2002-12-01 00:00:00

abstract：:To determine the patterns of gene expression responsible for the radiosensitivity of glioblastoma cells, we analyzed transcriptional changes after ionizing radiation in different cell lines. After completing clonogenic survival assays, we selected two glioblastoma cell lines with different radiosensitivities. Subseque...

journal_title：Journal of radiation research

authors： Otomo T,Hishii M,Arai H,Sato K,Sasai K

更新日期：2004-03-01 00:00:00

abstract：:PU-H71, a heat shock protein 90 (Hsp90) inhibitor, has yielded therapeutic efficacy in many preclinical models and is currently in clinical trials. Carbon-ion radiotherapy (CIRT) has provided successful tumor control; however, there is still room for improvement, particularly in terms of tumor-specific radiosensitizat...

journal_title：Journal of radiation research

authors： Li HK,Matsumoto Y,Furusawa Y,Kamada T

更新日期：2016-09-01 00:00:00

abstract：:This study aimed to identify factors that predict prognosis after radiotherapy for brain metastases (BMs) from small-cell lung cancer (SCLC). This study retrospectively evaluated 48 consecutive patients who underwent whole-brain radiotherapy (WBRT) for BMs from SCLC between February 2008 and December 2017. WBRT was de...

journal_title：Journal of radiation research

authors： Anami S,Doi H,Nakamatsu K,Uehara T,Wada Y,Fukuda K,Inada M,Ishikawa K,Kanamori S,Nishimura Y

更新日期：2019-03-01 00:00:00

abstract：:We evaluated the radiological response and clinical outcome in patients with femoral bone metastases after radiotherapy. 102 consecutive patients with femoral metastases without pathological fracture were treated by surgery or radiotherapy between 2002 and 2005. Twelve of them initially treated with surgery were exclu...

journal_title：Journal of radiation research

authors： Harada H,Katagiri H,Kamata M,Yoshioka Y,Asakura H,Hashimoto T,Furutani K,Takahashi M,Sakahara H,Nishimura T

更新日期：2010-01-01 00:00:00

abstract：:While recent advances in elucidating the enzyme/substrate relationship of phosphorylation cascades have demonstrated several distinct pathways in membrane-cytoplasm signaling, the molecular dissection of p53 and the products of other proto-oncogenes have greatly promoted the studies of nuclear signaling and expanded t...

journal_title：Journal of radiation research

authors： Wang X,Ohnishi T

更新日期：1997-09-01 00:00:00

abstract：:A conceptual design of a mobile isocenter carbon ion gantry was carried out in the framework of the Particle Training Network for European Radiotherapy (PARTNER) and Union of Light Ion Centres in Europe (ULICE) projects. To validate the magnets used in this gantry, Finite Element Method (FEM) simulations were performe...

journal_title：Journal of radiation research

authors： Moreno JO,Pullia MG,Priano C,Lante V,Necchi MM,Savazzi S

更新日期：2013-07-01 00:00:00

abstract：:In our previous studies, we found that low-dose radiation inhibits oxidative stress-induced diseases due to increased antioxidants. Although these effects of low-dose radiation were demonstrated, further research was needed to clarify the effects. However, the analysis of oxidative stress is challenging, especially th...

journal_title：Journal of radiation research

authors： Kanzaki N,Kataoka T,Etani R,Sasaoka K,Kanagawa A,Yamaoka K

更新日期：2017-01-01 00:00:00

abstract：:The study aimed to detect features of human serum proteome that were associated with exposure to ionizing radiation. The analyzed group consisted of 46 patients treated with radical radiotherapy for larynx cancer; patients were irradiated with total doses in a range from 51 to 72 Gy. Three consecutive blood samples we...

journal_title：Journal of radiation research

authors： Widłak P,Pietrowska M,Wojtkiewicz K,Rutkowski T,Wygoda A,Marczak L,Marczyk M,Polańska J,Walaszczyk A,Domińczyk I,Składowski K,Stobiecki M,Polański A

更新日期：2011-01-01 00:00:00

abstract：:The aim of this study was to compare the anti-oxidative and anti-inflammatory activities of gamma-irradiated persimmon leaf extract (GPLE) with those of non-irradiated persimmon leaf extract (PLE). Ethanolic extract of persimmon leaf was exposed to gamma irradiation at a dose of 10 kGy. After gamma irradiation, the co...

journal_title：Journal of radiation research

authors： Cho BO,Nchang Che D,Yin HH,Jang SI

更新日期：2017-09-01 00:00:00

abstract：:The Rho-associated coiled-coil-containing protein kinase (ROCK) pathway is known to influence metastasis in several cancers; however, the impact of the pathway on clinical outcomes in patients undergoing radiotherapy remains unknown. In the present study, the expression of RhoA, RhoC, ROCK-1, ROCK-2 and p53 was immuno...

journal_title：Journal of radiation research

authors： Tanaka K,Matsumoto Y,Ishikawa H,Fukumitsu N,Numajiri H,Murofushi K,Oshiro Y,Okumura T,Satoh T,Sakurai H

更新日期：2020-03-23 00:00:00

abstract：:Immediately after X-irradiation, monocytic cells can express the gene for interleukin (IL)-1beta, which enhances inflammation and contributes to radioprotection in mice. In order to analyze the mechanism(s) for the immediate-early induction of IL-1beta after X-irradiation at 20 Gy in cultured murine macrophages, we ex...

journal_title：Journal of radiation research

authors： Ishihara H,Tanaka I,Wan H,Cheeramakara C

更新日期：2003-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common progressive and irreversible neurodegenerative disease and it is caused by neuronal death in the brain. Recent studies have shown that non-ionizing radiofrequency (RF) radiation has some beneficial cognitive effects in animal models of AD. In this study, we examined the effe...

journal_title：Journal of radiation research

authors： Lee JS,Kim JY,Kim HJ,Kim JC,Lee JS,Kim N,Park MJ

更新日期：2016-11-01 00:00:00