Abstract:
:Centrosomes function in proper cell division in animal cells. The centrosome consists of a pair of centrioles and the surrounding pericentriolar matrix (PCM). After cytokinesis, daughter cells each acquire one centrosome, which subsequently duplicates at the G1/S phase in a manner that is dependent upon CDK2/cyclin-E activity. Defects in the regulation of centrosome duplication lead to tumorigenesis through abnormal cell division and resulting inappropriate chromosome segregation. Therefore, maintenance of accurate centrosome number is important for cell fate. Excess number of centrosomes can be induced by several factors including ionizing radiation (IR). Recent studies have shown that several DNA repair proteins localize to the centrosome and are involved in the regulation of centrosome number possibly through cell cycle checkpoints or direct modification of centrosome proteins. Furthermore, it has been reported that the development of microcephaly is likely caused by defective expression of centrosome proteins, such as ASPM, which are also involved in the response to IR. The present review highlights centrosome duplication in association with genotoxic stresses and the regulatory mechanism mediated by DNA repair proteins.Translated and modified from Radiat. Biol. Res. Comm. Vol.43; 343-356 (2008.12, in Japanese).
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Shimada M,Komatsu Kdoi
10.1269/jrr.09039subject
Has Abstractpub_date
2009-07-01 00:00:00pages
295-301issue
4eissn
0449-3060issn
1349-9157pii
JST.JSTAGE/jrr/09039journal_volume
50pub_type
杂志文章,评审abstract::To improve treatment conformity for prostate cancer, we investigated daily applicator displacement during high-dose-rate interstitial brachytherapy (HDR-ISBT). Thirty patients treated with HDR-ISBT as monotherapy were examined. All patients received a treatment dosage of 49 Gy per 7 fractions over 4 days. For dose adm...
journal_title:Journal of radiation research
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更新日期:2019-10-23 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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journal_title:Journal of radiation research
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of radiation research
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更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1997-09-01 00:00:00
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更新日期:1994-03-01 00:00:00
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更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00