Abstract:
:Alzheimer's disease (AD) is the most common progressive and irreversible neurodegenerative disease and it is caused by neuronal death in the brain. Recent studies have shown that non-ionizing radiofrequency (RF) radiation has some beneficial cognitive effects in animal models of AD. In this study, we examined the effect of combined RF radiation on amyloid-beta (Aβ)-induced cytotoxicity in HT22 rat hippocampal neurons. Treatment with Aβ suppressed HT22 cell proliferation in a concentration-dependent manner. RF exposure did not affect cell proliferation, and also had a marginal effect on Aβ-induced suppression of growth in HT22 cells. Cell cycle analysis showed that Aβ decreased the G1 fraction and increased the subG1 fraction, indicating increased apoptosis. Accordingly, Aβ increased the annexin V/propidium iodide (PI)-positive cell fraction and the degradation of poly (ADP ribose) polymerase and caspase-3 in HT22 cells. However, RF alone and the combination of Aβ and RF did not affect these events significantly. Aβ increased reactive oxygen species (ROS) generation, thereby suppressing cell proliferation. This was abrogated by N-acetylcysteine (NAC) treatment, indicating that Aβ-induced ROS generation is the main cause of suppression of proliferation. NAC also restored Aβ-induced annexin V/PI-positive cell populations. However, RF did not have a significant impact on these events. Finally, Aβ stimulated the ataxia telangiectasia and Rad3-related protein/checkpoint kinase 1 DNA single-strand breakage pathway, and enhanced beta-site amyloid precursor protein expression; RF had no effect on them. Taken together, our results demonstrate that RF exposure did not significantly affect the Aβ-induced decrease of cell proliferation, increase of ROS production, or induction of cell death in these cells.
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Lee JS,Kim JY,Kim HJ,Kim JC,Lee JS,Kim N,Park MJdoi
10.1093/jrr/rrw040subject
Has Abstractpub_date
2016-11-01 00:00:00pages
620-626issue
6eissn
0449-3060issn
1349-9157pii
rrw040journal_volume
57pub_type
杂志文章abstract::Although salvage external-beam radiation therapy (EBRT) is an attractive treatment option for pelvic lymph nodal recurrence (PeNR) in patients with prostate cancer (PCa), limited data are available regarding its long-term efficacy. This study examined the long-term clinical outcomes of patients who underwent salvage p...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa044
更新日期:2020-07-06 00:00:00
abstract::The aim of this study was to investigate the radiobiological effects of flattening filter (FF) and flattening filter-free (FFF) modes of linear electron accelerators and to understand whether there is any difference between the effects of these modes. We evaluated the number of chromosome aberrations following irradia...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrz073
更新日期:2020-01-23 00:00:00
abstract::Paired Fricke solutions, made up from light water or heavy water and 0.8N in H2SO4 and 1 mM in Fe(NH4)2(SO4)2 and NaCl, were calibrated with 60Co gamma rays and with mixed neutron and gamma radiation from a 252Cf source. Absorbance increases, AL and AH, in light- and heavy-water Fricke dosimeters, respectively, increa...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.37.97
更新日期:1996-06-01 00:00:00
abstract::Liquid ionization chambers (LICs) are highly sensitive to dose irradiation and have small perturbations because of their liquid-filled sensitive volume. They require a sensitive volume much smaller than conventional air-filled chambers. However, it has been reported that the collection efficiency has dependencies on t...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx088
更新日期:2018-05-01 00:00:00
abstract::The aim of this study is to evaluate the potential radioprotective effects of N-acetylcysteine (NAC) against genotoxicity and cytotoxicity. The effect of WR-2721, as a representative of clinically used radioprotector, was compared with that of NAC, using the chromosomal aberration (CA) and micronucleus (MN) test syste...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.08066
更新日期:2009-01-01 00:00:00
abstract::Boron neutron capture therapy (BNCT) is an emerging radiation treatment modality, exhibiting the potential to selectively destroy cancer cells. Currently, BNCT is conducted using a nuclear reactor. However, the future trend is to move toward an accelerator-based system for use in hospital environments. A typical BNCT ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrz101
更新日期:2020-03-23 00:00:00
abstract::Immediately after X-irradiation, monocytic cells can express the gene for interleukin (IL)-1beta, which enhances inflammation and contributes to radioprotection in mice. In order to analyze the mechanism(s) for the immediate-early induction of IL-1beta after X-irradiation at 20 Gy in cultured murine macrophages, we ex...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.44.117
更新日期:2003-06-01 00:00:00
abstract::This study investigated the radioprotective effect of Sipunculus nudus L. polysaccharide (SNP) in combination with WR-2721, rhIL-11 and rhG-CSF on irradiated mice. A total of 70 Imprinting Control Region (ICR) mice were divided into seven groups: the control group, the model group and five administration groups. All g...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv009
更新日期:2015-05-01 00:00:00
abstract::The increasing use of mobile phones has aroused public concern regarding the potential health risks of radiofrequency (RF) fields. We investigated the effects of exposure to RF fields (2.45 GHz, continuous wave) at specific absorption rate (SAR) of 1, 5, and 10 W/kg for 1, 4, and 24 h on gene expression in a normal hu...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.10116
更新日期:2011-01-01 00:00:00
abstract::The purpose of this study is to survey the current patterns of practice, and barriers to implementation, of 3D image-guided brachytherapy (3D-IGBT) for cervical cancer in Japan. A 30-item questionnaire was sent to 171 Japanese facilities where high-dose-rate brachytherapy devices were available in 2012. In total, 135 ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv047
更新日期:2015-11-01 00:00:00
abstract::This study is a subset analysis of a retrospective multicenter study performed in Japan and its purpose was to investigate the effectiveness of stereotactic body radiotherapy (SBRT) for pulmonary oligometastases from colorectal cancer. Local control (LC), freedom from further metastases, relapse-free survival and over...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa071
更新日期:2020-11-16 00:00:00
abstract::The biokinetics of radon in the body has previously been studied with the assumption that its absorption through the skin is negligibly small. This assumption would be acceptable except in specific situations, such as bathing in a radon hot spring where the radon concentration in thermal water is far higher than that ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw024
更新日期:2016-07-01 00:00:00
abstract::The effectiveness of an Electronic Personal Dosemeter (Siemens EPD) for cosmic-radiation dosimetry at aviation altitudes was examined on eight international flights between March and September, 1998. The EPD values (Hepd) of the dose equivalent from penetrating radiation, Hp(10), were assumed to be almost the same as ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.42.57
更新日期:2001-03-01 00:00:00
abstract::Inoue and Iwakura recently reported that the specific activity ratio of organically-bound 3H to free water 3H in polished rice samples collected in Japan and China was lower than unity. Their paper was the first to report the systematic apparent elimination of 3H for incorporation to organically-bound form in samples ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.32.389
更新日期:1991-12-01 00:00:00
abstract::We examined the use of the mouse Pc-3 ESTR (expanded simple tandem repeat) locus and 72 human microsatellite loci as potentially sensitive biomarkers for mutagenic exposures to germ cells in mice and humans respectively. In the mouse work, we treated male mice with TCDD (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin; a chemi...
journal_title:Journal of radiation research
pub_type: 历史文章,杂志文章
doi:10.1269/jrr.47.b31
更新日期:2006-01-01 00:00:00
abstract::Synchrotron-radiation circular-dichroism spectroscopy was used to reveal that the DNA damage response induces a decrement of α-helix and an increment of β-strand contents of histone H3-H4 extracted from X-ray-irradiated human HeLa cells. The trend of the structural alteration was qualitatively opposite to that of our ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw086
更新日期:2017-01-01 00:00:00
abstract::Fukushima residents' negative views on the safety of water and air environments have been a concern since the Fukushima Dai-ichi Nuclear power plant (FDNPP) accident. The objective of this study was to clarify the factors determining these negative views and their association with radiation risk perception using the o...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx096
更新日期:2018-04-01 00:00:00
abstract::In this paper, we compare two radiation effect models: the average surviving fraction (ASF) model and the integral biologically effective dose (IBED) model for deriving the optimal irradiation scheme and show the superiority of ASF. Minimizing the effect on an organ at risk (OAR) is important in radiotherapy. The biol...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx084
更新日期:2018-03-01 00:00:00
abstract::A synergistic interaction of hyperthermia with ionizing or UV light (254 nm) radiation was analyzed in experiments with yeast cells. For a fixed dose rate of radiation, the synergism was shown to be observed only within a definite temperature range (40-45 degrees C), inside of which there was an optimal temperature to...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.42.361
更新日期:2001-12-01 00:00:00
abstract::The aim of the study was to compare clinical outcomes and toxicity between 3D conformal radiotherapy (3DCRT) and image-guided intensity-modulated radiotherapy (IG-IMRT) administered through helical tomotherapy in locally advanced rectal cancer (LARC) patients receiving preoperative chemoradiotherapy. We reviewed 144 p...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw098
更新日期:2017-03-01 00:00:00
abstract::This project aimed to set up a Beagle dog model of radiation-induced lung injury in order to supply fresh lung tissue samples in the different injury phases for gene and protein research. Three dogs received 18 Gy X-ray irradiation in one fraction, another three dogs received 8 Gy in each of three fractions at weekly ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw053
更新日期:2016-09-01 00:00:00
abstract::Based on the accumulating evidence for equivalent results of partial-breast irradiation (PBI) and whole-breast irradiation (WBI) in breast-conserving therapy (BCT), the American Society for Radiation Oncology (ASTRO) updated the consensus statement (CS) to expand the range of potential candidates for PBI outside clini...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rry033
更新日期:2018-05-01 00:00:00
abstract::The purpose of this study was to analyze the clinical outcomes of simultaneous modulated accelerated radiotherapy (SMART) in patients with nasopharyngeal carcinoma (NPC). A total of 97 patients who underwent SMART for NPC between August 2005 and November 2011 were evaluated. The prescribed dose was 69.9 Gy/30 fraction...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru012
更新日期:2014-07-01 00:00:00
abstract::Coal, fly ash and bottom ash samples were taken from a 300-MWe coal-fired power plant with a daily coal consumption of 2400 tons. A high volume sampler coupled with several mesh testing sieves was used to separate fly ash samples into different size fractions. Determination of the concentrations of 40K, 238U, 226Ra, 2...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.33.141
更新日期:1992-06-01 00:00:00
abstract::Various kinases, such as tyrosine, protein kinase C (PKC) and MAP kinase, play important role in the cellular response to radiation, but little is known about the specific response in the whole animal. Most studies, except a few, are based on single cells. There is a paucity of data where signaling following whole bod...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.45.127
更新日期:2004-03-01 00:00:00
abstract::We examined the effect of an extremely low-frequency magnetic field (ELFMF) at 5, 50 and 400 mT on DNA strand breaks in human glioma MO54 cells. A DNA damage analysis was performed using the method of alkaline comet assay. The cells were exposed to X-rays alone (5 Gy), ELFMF alone, or X-rays followed by ELFMF at 4 deg...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.41.293
更新日期:2000-09-01 00:00:00
abstract::Preliminary results of the Polish epidemiology study on eye lens opacities among interventional cardiologists (ICs), based on the methodology proposed by ELDO (epidemiological studies of radio-induced cataracts in interventional cardiologists and radiologists: methodology implementation), are presented. The aim of the...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw019
更新日期:2016-07-01 00:00:00
abstract::Reassessment of gamma-ray doses from the atomic bombs in Hiroshima and Nagasaki has been carried out with the thermoluminescent measurements of bricks and decorative tiles which were collected from the buildings that remain as they were at the time of the explosions. The thermoluminescent measurements were performed u...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.32.supplement_40
更新日期:1991-03-01 00:00:00
abstract::Medical diagnostic X-ray workers are one occupational group that has exposure to continuous low doses of external radiation over their working lifetimes. Current ICRP recommendations [ICRP. Recommendations of the International Commission on Radiological Protection. ICRP Publication 60. Ann ICRP 1991;21 (1-3)] state th...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx073
更新日期:2018-03-01 00:00:00
abstract::Histone H2AX undergoes phosphorylation at Ser-139 (gamma-H2AX) rapidly in response to DNA double-strand breaks (DSBs) induced by ionizing radiation. The post-translational modification of H2AX plays a central role in responses to radiation, including the repair of DSBs. Although ataxia telangiectasia mutated (ATM) kin...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.08010
更新日期:2008-07-01 00:00:00