Histone H2AX phosphorylation independent of ATM after X-irradiation in mouse liver and kidney in situ.

abstract：:Modern treatment machines have shown small inter-unit variability regarding beam data. Recently, vendor-provided average beam data, such as the Representative Beam Data (RBD) of the TrueBeam (Varian Medical Systems, Palo Alto, CA, USA), has been used for modeling of the Eclipse (Varian Medical Systems) treatment plann...

journal_title：Journal of radiation research

authors： Isono M,Akino Y,Mizuno H,Tanaka Y,Masai N,Yamamoto T

更新日期：2020-03-23 00:00:00

abstract：:In this review, we would like to introduce a unique approach for the estimation of radioadaptation. Recently, we proposed a new methodology for evaluating the repair efficiency of DNA double-strand breaks (DSB) using a model system. The model system can trace the fate of a single DSB, which is introduced within intron...

journal_title：Journal of radiation research

authors： Yatagai F,Sugasawa K,Enomoto S,Honma M

更新日期：2009-09-01 00:00:00

abstract：:Surgery is the standard modality for early-stage I-II non-small-cell lung cancer (NSCLC). Generally, patients who are >80 years old tend to have more comorbidities and inferior physical status than younger patients. Stereotactic body radiation therapy (SBRT) may provide an alternative treatment for this group of patie...

journal_title：Journal of radiation research

authors： Bei Y,Murakami N,Nakayama Y,Okuma K,Kashihara T,Raturi VP,Okamoto H,Takahashi K,Inaba K,Igaki H,Itami J

更新日期：2020-07-06 00:00:00

abstract：:The objective of the present study was to estimate cancer risk associated with the low-level radiation exposure of an average annual effective dose of 6.4 mSv (including internal exposure) in the high background-radiation areas (HBRA) in Yangjiang, China. The mortality survey consisted of two steps, i.e., the follow-u...

journal_title：Journal of radiation research

authors： Tao Z,Zha Y,Akiba S,Sun Q,Zou J,Li J,Liu Y,Kato H,Sugahara T,Wei L

更新日期：2000-10-01 00:00:00

abstract：:In this study, a mechanism in which low-dose hyper-radiosensitivity (HRS) is permanently removed, induced by low-dose-rate (LDR) (0.2-0.3 Gy/h for 1 h) but not by high-dose-rate priming (0.3 Gy at 40 Gy/h) was investigated. One HRS-negative cell line (NHIK 3025) and two HRS-positive cell lines (T-47D, T98G) were used....

journal_title：Journal of radiation research

authors： Edin NJ,Sandvik JA,Vollan HS,Reger K,Görlach A,Pettersen EO

更新日期：2013-11-01 00:00:00

abstract：:To analyze the biological effects of the space environment, we flew nine lines of rice seeds on the Chinese 20(th) recoverable satellite for a duration of 18 days. The same lines of seeds were also irradiated to low doses (2.0 mGy) of Carbon, or Neon or Iron ions (with different LET value of 13.3 keV/microm, 31 keV/mi...

journal_title：Journal of radiation research

authors： Wei LJ,Yang Q,Xia HM,Furusawa Y,Guan SH,Xin P,Sun YQ

更新日期：2006-11-01 00:00:00

abstract：:Hyper-radiosensitivity (HRS) is a well-known bioresponse under low-dose or low-dose-rate exposures. Although disorder of the DNA repair function, non-targeted effects and accumulation of cells in G2 have been experimentally observed, the mechanism for inducing HRS by long-term irradiation is still unclear. On the basi...

journal_title：Journal of radiation research

authors： Matsuya Y,Tsutsumi K,Sasaki K,Yoshii Y,Kimura T,Date H

更新日期：2017-05-01 00:00:00

abstract：:The aim of this study was to compare the dosimetric parameters of whole-pelvic radiotherapy (WPRT) for cervical cancer among plans involving 3D conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT), or spot-scanning proton therapy (SSPT). The dose distributions of 3D-CRT-, IMRT-, and SSPT-based WPRT...

journal_title：Journal of radiation research

authors： Hashimoto S,Shibamoto Y,Iwata H,Ogino H,Shibata H,Toshito T,Sugie C,Mizoe JE

更新日期：2016-09-01 00:00:00

abstract：:While recent advances in elucidating the enzyme/substrate relationship of phosphorylation cascades have demonstrated several distinct pathways in membrane-cytoplasm signaling, the molecular dissection of p53 and the products of other proto-oncogenes have greatly promoted the studies of nuclear signaling and expanded t...

journal_title：Journal of radiation research

authors： Wang X,Ohnishi T

更新日期：1997-09-01 00:00:00

abstract：:Perirectal hyaluronate gel injection (HGI) appears to be a promising technique for healthy tissue dose sparing in pelvic radiotherapy. In this analysis, we report our initial experience of HGI in gynecologic brachytherapy, focusing on its safety and effectiveness for dose reduction to the rectum. Between July 2013 and...

journal_title：Journal of radiation research

authors： Kashihara T,Murakami N,Tselis N,Kobayashi K,Tsuchida K,Shima S,Masui K,Yoshida K,Takahashi K,Inaba K,Umezawa R,Igaki H,Ito Y,Kato T,Uno T,Itami J

更新日期：2019-07-01 00:00:00

abstract：:Several models for the action of mixed irradiation with two types of radiation have been proposed in the last two decades, although the superiority or inferiority of these models is not completely elucidated. However, mixed irradiation is sometimes composed of more than two types of radiation, and for this type of mix...

journal_title：Journal of radiation research

authors： Suzuki S

更新日期：1998-09-01 00:00:00

abstract：:In Japan, the use of adjuvant radiotherapy after prostatectomy for prostate cancer has not increased compared with the use of salvage radiotherapy. We retrospectively evaluated the outcome of adjuvant radiotherapy together with prognostic factors of outcome in Japan. Between 2005 and 2007, a total of 87 patients were ...

journal_title：Journal of radiation research

authors： Aoki M,Mizowaki T,Akimoto T,Nakamura K,Ejima Y,Jingu K,Tamai Y,Nakajima N,Takemoto S,Kokubo M,Katoh H

更新日期：2014-05-01 00:00:00

abstract：:The aim of this study was to compare the anti-oxidative and anti-inflammatory activities of gamma-irradiated persimmon leaf extract (GPLE) with those of non-irradiated persimmon leaf extract (PLE). Ethanolic extract of persimmon leaf was exposed to gamma irradiation at a dose of 10 kGy. After gamma irradiation, the co...

journal_title：Journal of radiation research

authors： Cho BO,Nchang Che D,Yin HH,Jang SI

更新日期：2017-09-01 00:00:00

abstract：:X-ray induced neoplastic transformation of C3H/10T1/2 cells was suppressed equally by Lipid A and LPS. We examined the effects of several modifiers of arachidonic acid (AA) metabolism in our investigation on the suppression mechanism of LPS. Dexamethasone (DM), an inhibitor of phospholipase A2 (PLA2), abolished the ef...

journal_title：Journal of radiation research

authors： Sakiyama H,Yasukawa M,Nishijima M,Wada E,Kanegasaki S

更新日期：1993-12-01 00:00:00

abstract：:We aimed to investigate the effect of chronic radiation exposure associated with the Fukushima Daiichi Nuclear Power Plant (FNPP) accident on the testes of boar and inobuta (a hybrid of Sus scrofa and Sus scrofa domestica). This study examined the contamination levels of radioactive caesium (Cs), especially (134)Cs an...

journal_title：Journal of radiation research

authors： Yamashiro H,Abe Y,Hayashi G,Urushihara Y,Kuwahara Y,Suzuki M,Kobayashi J,Kino Y,Fukuda T,Tong B,Takino S,Sugano Y,Sugimura S,Yamada T,Isogai E,Fukumoto M

更新日期：2015-12-01 00:00:00

abstract：:We previously showed that free radicals and oxidative stress are involved in radiation-induced skin reactions. Since vitamin E (VE) is a particularly important lipophilic antioxidant, VE-deficient mice were used to examine its effects on radiation-induced skin damage. The VE content of the skin was reduced to one four...

journal_title：Journal of radiation research

authors： Chi C,Hayashi D,Nemoto M,Nyui M,Urano S,Anzai K

更新日期：2011-01-01 00:00:00

abstract：:Several studies have reported the usefulness of the field-in-field (FIF) technique in breast radiotherapy. However, the methods for the FIF technique used in these studies vary. These methods were classified into three categories. We simulated a radiotherapy plan with each method and analyzed the outcomes. In the firs...

journal_title：Journal of radiation research

authors： Tanaka H,Hayashi S,Hoshi H

更新日期：2014-07-01 00:00:00

abstract：:Clustered DNA damage is a specific type of DNA damage induced by ionizing radiation. Any type of ionizing radiation traverses the target DNA molecule as a beam, inducing damage along its track. Our previous study showed that clustered DNA damage yields decreased with increased linear energy transfer (LET), leading us ...

journal_title：Journal of radiation research

authors： Tokuyama Y,Furusawa Y,Ide H,Yasui A,Terato H

更新日期：2015-05-01 00:00:00

abstract：:To evaluate the effect of the sympathetic nervous system on radiation-induced apoptosis in jejunal crypt cells, apoptosis levels were compared in spontaneously hypertensive rats (SHR), animals which are a genetic hyperfunction model of the sympathetic nervous system, and normotensive Wistar-Kyoto rats (WKY). SHR and W...

journal_title：Journal of radiation research

authors： Matsuu M,Shichijo K,Nakamura Y,Ikeda Y,Naito S,Ito M,Okaichi K,Sekine I

更新日期：2000-03-01 00:00:00

abstract：:The NCRP has recently defined RBE values and a new quantity (Gy-Eq) for use in estimation of deterministic effects in space shielding and operations. The NCRP's RBE for neutrons is left ambiguous and not fully defined. In the present report we will suggest a complete definition of neutron RBE consistent with the NCRP ...

journal_title：Journal of radiation research

authors： Wilson JW,Kim MH,De Angelis G,Cucinotta FA,Yoshizawa N,Badavi FF

更新日期：2002-12-01 00:00:00

abstract：:This study is a subset analysis of a retrospective multicenter study performed in Japan and its purpose was to investigate the effectiveness of stereotactic body radiotherapy (SBRT) for pulmonary oligometastases from colorectal cancer. Local control (LC), freedom from further metastases, relapse-free survival and over...

journal_title：Journal of radiation research

authors： Yamamoto T,Niibe Y,Matsumoto Y,Onishi H,Aoki M,Nishikawa A,Oh RJ,Shintani T,Yahara K,Ozaki M,Manabe Y,Jingu K

更新日期：2020-11-16 00:00:00

abstract：:The radiation killing of tumor cells by ionizing radiation is best described by the linear-quadratic (LQ) model. Research into the underlying mechanisms of α- and β-inactivation has suggested that different molecular targets (DNA in different forms) and different microdosimetric energy deposits (spurs versus electron ...

journal_title：Journal of radiation research

authors： Chapman JD

更新日期：2014-01-01 00:00:00

abstract：:This project aimed to set up a Beagle dog model of radiation-induced lung injury in order to supply fresh lung tissue samples in the different injury phases for gene and protein research. Three dogs received 18 Gy X-ray irradiation in one fraction, another three dogs received 8 Gy in each of three fractions at weekly ...

journal_title：Journal of radiation research

authors： Yin Z,Deng S,Liang Z,Wang Q

更新日期：2016-09-01 00:00:00

abstract：:The rejoining efficiency of double-strand breaks (DSBs) was quantified by a DNA fragment-size analysis in tobacco protoplasts and CHO-K1 cells following gamma-ray irradiation in order to compare DNA reparability of higher plants with mammals. Results showed that the DSB rejoining efficiency of tobacco protoplasts is d...

journal_title：Journal of radiation research

authors： Yokota Y,Wada S,Hase Y,Funayama T,Kobayashi Y,Narumi I,Tanaka A

更新日期：2009-03-01 00:00:00

abstract：:Chromosome painting by fluorescence in situ hybridization (FISH) with a whole chromosome-specific DNA probe was used to detect chromosomal aberrations in lymphocytes from cancer patients given partial-body fractionated X-ray therapy. Six male patients with cancer of the stomach, prostate, lung, or hepatocellular carci...

journal_title：Journal of radiation research

authors： Matsuoka A,Yamada K,Hayashi M,Sofuni T

更新日期：1996-12-01 00:00:00

abstract：:Gated radiation therapy is a promising method for improving the dose conformality of treatments to moving targets and reducing the total volume of irradiated tissue. Target motion is of particular concern in proton beam radiotherapy, due to the finite range of proton dose deposition in tissue. Gating allows one to red...

journal_title：Journal of radiation research

authors： Sharp GC,Lu HM,Trofimov A,Tang X,Jiang SB,Turcotte J,Gierga DP,Chen GT,Hong TS

更新日期：2007-01-01 00:00:00

abstract：:The biokinetics of radon in the body has previously been studied with the assumption that its absorption through the skin is negligibly small. This assumption would be acceptable except in specific situations, such as bathing in a radon hot spring where the radon concentration in thermal water is far higher than that ...

journal_title：Journal of radiation research

authors： Sakoda A,Ishimori Y,Tschiersch J

更新日期：2016-07-01 00:00:00

abstract：:The direct biological effects of radiation, particularly accelerated heavy particle ions, on neurons are not fully known. Hence, the direct effect of carbon-ion beams on immature neurons was investigated by comparing to the effect of X-rays in vitro using primary hippocampal neurons. Primary neurons were prepared from...

journal_title：Journal of radiation research

authors： Kaminuma T,Suzuki Y,Shirai K,Mizui T,Noda SE,Yoshida Y,Funayama T,Takahashi T,Kobayashi Y,Shirao T,Nakano T

更新日期：2010-01-01 00:00:00

abstract：:In patients with various cancers, modified Glasgow prognostic score (mGPS) before treatment has predicted prognoses after antitumor therapy. This study aimed to assess whether pretreatment mGPS also has predictive value in patients with muscle-invasive bladder cancer (MIBC) after radiotherapy. A retrospective review a...

journal_title：Journal of radiation research

authors： Kikuchi K,Nakamura R,Segawa T,Oikawa H,Ariga H

更新日期：2020-07-06 00:00:00

abstract：:Radiation therapy (RT) has become particularly important recently for treatment of liver tumors, but there are few experimental investigations pertaining to radiation-induced liver injuries over long-term follow-up periods. Thus, the present study examined pathological liver features over a 10-month period using an in...

journal_title：Journal of radiation research

authors： Imaeda M,Ishikawa H,Yoshida Y,Takahashi T,Ohkubo Y,Musha A,Komachi M,Nakazato Y,Nakano T

更新日期：2014-07-01 00:00:00