Can the two mechanisms of tumor cell killing by radiation be exploited for therapeutic gain?

abstract：:We evaluated the interrelationship between rectal content and intrafraction motion of the prostate. Forty seven prostate cancer patients instructed to remove their rectal gas were imaged by planning CT and MRI before radiotherapy (RT) and during RT. The total scan time was comparable to our cone-beam CT scanning and t...

journal_title：Journal of radiation research

authors： Ogino I,Kaneko T,Suzuki R,Matsui T,Takebayashi S,Inoue T,Morita S

更新日期：2011-01-01 00:00:00

abstract：:The effectiveness of an Electronic Personal Dosemeter (Siemens EPD) for cosmic-radiation dosimetry at aviation altitudes was examined on eight international flights between March and September, 1998. The EPD values (Hepd) of the dose equivalent from penetrating radiation, Hp(10), were assumed to be almost the same as ...

journal_title：Journal of radiation research

authors： Yasuda H,Fujitaka K

更新日期：2001-03-01 00:00:00

abstract：:The purpose of this study is to investigate the normal tissue damage caused by carbon-ion therapy. We measured chromosomal aberrations in peripheral blood lymphocytes before, during, and after radiotherapy, using the techniques of fluorescence in situ hybridization (FISH) and chemically induced premature chromosome co...

journal_title：Journal of radiation research

authors： Lee R,Yamada S,Yamamoto N,Miyamoto T,Ando K,Durante M,Tsujii H

更新日期：2004-06-01 00:00:00

abstract：:Low doses (2.5-15 cGy) of X-irradiation two months prior to a second exposure to a sublethal dose enhanced the survival rate in mice. Optimal and significant increase was observed with 5-10 cGy. Endogenous spleen colony counts (endo-CFUs) after 7 Gy increased by a factor of about 1.7 in mice pre-irradiated with 5-10 c...

journal_title：Journal of radiation research

authors： Yonezawa M,Takeda A,Misonoh J

更新日期：1990-09-01 00:00:00

abstract：:Chromatin-regulating proteins represent a large class of novel targets for cancer therapy. In the context of radiotherapy, acetylation and deacetylation of histones by histone acetyltransferases (HATs) and histone deacetylases (HDACs) play important roles in the repair of DNA double-strand breaks generated by ionizing...

journal_title：Journal of radiation research

authors： Oike T,Ogiwara H,Amornwichet N,Nakano T,Kohno T

更新日期：2014-07-01 00:00:00

abstract：:Reactive oxygen species continuously oxidize DNA bases and threaten the genetic integrity. Thymine glycol (TG), one of the representative oxidized products, is repaired mainly by base excision repair (BER). In Escherichia coli, endonuclease III (Nth) and endonuclease VIII (Nei) are known to actively remove TG from DNA...

journal_title：Journal of radiation research

authors： Yamamoto R,Akiyama M,Ide H,Yamamoto K,Matsuyama S,Kubo K

更新日期：2008-05-01 00:00:00

abstract：:Medical diagnostic X-ray workers are one occupational group that has exposure to continuous low doses of external radiation over their working lifetimes. Current ICRP recommendations [ICRP. Recommendations of the International Commission on Radiological Protection. ICRP Publication 60. Ann ICRP 1991;21 (1-3)] state th...

journal_title：Journal of radiation research

authors： Xu XS,Zhang LA,Sun QF,Qin YC,Yu NL

更新日期：2018-03-01 00:00:00

abstract：:The radioprotective effect of hawthorn (Crataegus microphylla) fruit extract against genotoxicity induced by gamma irradiation has been investigated in mouse bone marrow cells. A single intraperitoneal (ip) administration of hawthorn extract at doses of 25, 50, 100 and 200 mg/kg 1h prior to gamma irradiation (2 Gy) re...

journal_title：Journal of radiation research

authors： Hosseinimehr SJ,Azadbakht M,Mousavi SM,Mahmoudzadeh A,Akhlaghpoor S

更新日期：2007-01-01 00:00:00

abstract：:Wistar rats inhaled 239PuO2 particles prepared by the calcination of 239Pu hydroxide at 1150 and 400 degrees C. Lung retention, fecal and urinary excretion, and translocation of 239Pu were compared between the two calcination temperatures. The clearance of 239Pu from the lungs was significantly faster in the rats expo...

journal_title：Journal of radiation research

authors： Sato H,Yamada Y,Ishigure N,Nakano T,Enomoto H,Takahashi S,Kubota Y,Inaba J

更新日期：1999-06-01 00:00:00

abstract：:We generated low-flux X-ray micro-planar beams (MPBs) using a laboratory-scale industrial X-ray generator (60 kV/20 mA) with custom-made collimators with three different peak/pitch widths (50/200 μm, 100/400 μm, 50/400 μm). To evaluate normal skin reactions, the thighs of C3H/HeN mice were exposed to 100 and 200 Gy MP...

journal_title：Journal of radiation research

authors： Hong Z,Zenkoh J,Le B,Gerelchuluun A,Suzuki K,Moritake T,Washio M,Urakawa J,Tsuboi K

更新日期：2015-09-01 00:00:00

abstract：:Radiation-induced bystander effects (RIBEs) are detected in cells that are not irradiated but receive signals from treated cells. The present study explored these bystander effects in a U87MG multicellular tumour spheroid model. A medium transfer technique was employed to induce the bystander effect, and colony format...

journal_title：Journal of radiation research

authors： Faqihi F,Neshastehriz A,Soleymanifard S,Shabani R,Eivazzadeh N

更新日期：2015-09-01 00:00:00

abstract：:Chronic irradiation with low-dose-rate 137Cs-γ rays inhibits the differentiation of human neural progenitor cells and influences the expression of proteins associated with several cellular functions. We aimed to determine whether such chronic irradiation influences the expression of proteins associated with PC12 cells...

journal_title：Journal of radiation research

authors： Shinsuke K,Junya K,Tomonobu U,Yoshiko K,Izumo N,Takahiko S

更新日期：2017-11-01 00:00:00

abstract：:Several studies have reported the usefulness of the field-in-field (FIF) technique in breast radiotherapy. However, the methods for the FIF technique used in these studies vary. These methods were classified into three categories. We simulated a radiotherapy plan with each method and analyzed the outcomes. In the firs...

journal_title：Journal of radiation research

authors： Tanaka H,Hayashi S,Hoshi H

更新日期：2014-07-01 00:00:00

abstract：:The aims of present study were to evaluate the efficacy of combining sunitinib with ionizing radiation (IR) on endothelial cells in vitro and in vivo. Human umbilical vein endothelial cells (HUVECs) were exposed to IR with or without sunitinib pretreatment. Apoptosis assay and cell cycle distribution were analyzed by ...

journal_title：Journal of radiation research

authors： Zhang HP,Takayama K,Su B,Jiao XD,Li R,Wang JJ

更新日期：2011-01-01 00:00:00

abstract：:The present paper is part of an attempt at finally reconstructing the realities of nuclear tests and their human effects near Semipalatinsk, Kazakhstan. As a first step, it tries to reconstruct the overall image of nuclear tests and their human effects. Our data are 199 written testimonies of those affected by radiati...

journal_title：Journal of radiation research

authors： Matsuo M,Kawano N,Satoh K,Apsalikov KN,Moldagaliev T

更新日期：2006-02-01 00:00:00

abstract：:This study was designed to elucidate the dose-response relationships for life-shortening and tumorigenic effect in the dose range below 1 Gy of gamma rays delivered during the infant period. Female B6C3F1 mice were irradiated with 0.10, 0.48 or 0.95 Gy at 7 days of age. All irradiated mice were allowed to live out the...

journal_title：Journal of radiation research

authors： Sasaki S,Fukuda N

更新日期：2006-06-01 00:00:00

abstract：:The purpose of this study was to describe the results of definitive radiotherapy (RT) with concurrent chemotherapy for maxillary sinus carcinomas (MSCs) with neck lymph node metastasis to clarify its limitation. Local control (LC), progression-free survival (PFS) and overall survival (OS) rates were calculated using t...

journal_title：Journal of radiation research

authors： Abe T,Saito S,Iino M,Aoshika T,Ryuno Y,Ohta T,Igari M,Hirai R,Kumazaki Y,Ebihara Y,Nakahira M,Sugasawa M,Noda SE,Kato S

更新日期：2021-01-01 00:00:00

abstract：:The aim of this study was to compare the anti-oxidative and anti-inflammatory activities of gamma-irradiated persimmon leaf extract (GPLE) with those of non-irradiated persimmon leaf extract (PLE). Ethanolic extract of persimmon leaf was exposed to gamma irradiation at a dose of 10 kGy. After gamma irradiation, the co...

journal_title：Journal of radiation research

authors： Cho BO,Nchang Che D,Yin HH,Jang SI

更新日期：2017-09-01 00:00:00

abstract：:The purpose of the study was to quantify local setup errors and evaluate the planning target volume (PTV) margins for sub-regions in cone-beam computed tomography (CBCT)-guided post-mastectomy radiation therapy (PMRT). The local setup errors of 20 patients undergoing CBCT-guided PMRT were analysed retrospectively. Ima...

journal_title：Journal of radiation research

authors： Zhou J,Li S,Ye C,Shen K,Li A,Chen G,Li X,Bai S,Wang W,Zhong R

更新日期：2020-05-22 00:00:00

abstract：:Exposure to ionizing radiation leads to severe damages in radiosensitive organs and induces acute radiation syndrome, including effects on the hematopoietic system and gastrointestinal system. In this study, the radioprotective ability of KMRC011, a novel toll-like receptor 5 (TLR5) agonist, was investigated in C57BL6...

journal_title：Journal of radiation research

authors： Kim JY,Park JH,Seo SM,Park JI,Jeon HY,Lee HK,Yoo RJ,Lee YJ,Woo SK,Lee WJ,Choi CM,Choi YK

更新日期：2019-07-01 00:00:00

abstract：:This study was to investigate whether rhEGF protects radiation induced intestine injury without compromising antitumor effect of radiation in murine system. A radiation induced intestinal injury model was established in mice by whole body irradiation. Using this model, 4 groups were set; control, rhEGF (100 µg/kg intr...

journal_title：Journal of radiation research

authors： Oh H,Seong J,Kim W,Park S,Koom WS,Cho NH,Song M

更新日期：2010-01-01 00:00:00

abstract：:This study was conducted in order to evaluate the cytotoxicity of high linear-energy-transfer (LET) ionizing radiation (IR) on glioblastoma cells and fibroblasts using different modes of cell inactivation assays. Two human glioblastoma cell lines with or without p53-mutation, and fibroblasts were used as materials. Ga...

journal_title：Journal of radiation research

authors： Tsuboi K,Moritake T,Tsuchida Y,Tokuuye K,Matsumura A,Ando K

更新日期：2007-07-01 00:00:00

abstract：:Investigating the biological effects of high-LET heavy-ion irradiation at low fluence is important to evaluate the risk of radiation in space. It is especially necessary to detect radiation damage induced by a precise number of heavy ions in individual cells. We thus compared the number of ions traversing a cell and t...

journal_title：Journal of radiation research

authors： Wada S,Kobayashi Y,Funayama T,Natsuhori M,Ito N,Yamamoto K

更新日期：2002-12-01 00:00:00

abstract：:To improve treatment conformity for prostate cancer, we investigated daily applicator displacement during high-dose-rate interstitial brachytherapy (HDR-ISBT). Thirty patients treated with HDR-ISBT as monotherapy were examined. All patients received a treatment dosage of 49 Gy per 7 fractions over 4 days. For dose adm...

journal_title：Journal of radiation research

authors： Takenaka T,Yoshida K,Ueda M,Yamazaki H,Miyake S,Tanaka E,Yoshida M,Yoshimura Y,Oka T,Honda K

更新日期：2012-01-01 00:00:00

abstract：:Brain metastasis from esophageal carcinoma has been considered rare and survival following esophageal carcinoma with distant metastasis is poor. The purpose of this report was to clarify cumulative incidence and risk factors for brain metastasis after chemoradiotherapy for esophageal carcinoma, and to consider recomme...

journal_title：Journal of radiation research

authors： Kanemoto A,Hashimoto T,Harada H,Asakura H,Ogawa H,Furutani K,Boku N,Nakasu Y,Nishimura T

更新日期：2011-01-01 00:00:00

abstract：:Disufiram (a drug used for the treatment of alcoholism) protected microsomal membranes and plasmid DNA against damages induced by gamma-radiation. The peroxidation of membrane lipids increased linearly with the radiation dose up to 600 Gy, and the presence of disulfiram inhibited membrane lipid peroxidation as assayed...

journal_title：Journal of radiation research

authors： Gandhi NM,Gopalaswamy UV,Nair Cr

更新日期：2003-09-01 00:00:00

abstract：:The space radiation environment imposes increased dangers of exposure to ionizing radiation, particularly during a solar particle event (SPE). These events consist primarily of low energy protons that produce a highly inhomogeneous dose distribution. Due to this inherent dose heterogeneity, experiments designed to inv...

journal_title：Journal of radiation research

authors： Diffenderfer ES,Dolney D,Schaettler M,Sanzari JK,McDonough J,Cengel KA

更新日期：2014-03-01 00:00:00

abstract：:The purpose of this study was to investigate the radiosensitizing effect of geldanamycin (GA), an inhibitor of heat shock protein 90, on tumour cells and normal cells. We tested the effect of a combination of GA and radiation on cell survival, PI3K/Akt-related proteins and apoptosis induction. GA sensitized tumour cel...

journal_title：Journal of radiation research

authors： Matsumoto Y,Machida H,Kubota N

更新日期：2005-06-01 00:00:00

abstract：:Hyper-radiosensitivity (HRS) is a well-known bioresponse under low-dose or low-dose-rate exposures. Although disorder of the DNA repair function, non-targeted effects and accumulation of cells in G2 have been experimentally observed, the mechanism for inducing HRS by long-term irradiation is still unclear. On the basi...

journal_title：Journal of radiation research

authors： Matsuya Y,Tsutsumi K,Sasaki K,Yoshii Y,Kimura T,Date H

更新日期：2017-05-01 00:00:00

abstract：:Respiratory motion management is a huge challenge in radiation therapy. Respiratory motion induces temporal anatomic changes that distort the tumor volume and its position. In this study, a markerless tumor-tracking algorithm was investigated by performing phase recognition during stereotactic body radiation therapy (...

journal_title：Journal of radiation research

authors： Bhusal Chhatkuli R,Demachi K,Uesaka M,Nakagawa K,Haga A

更新日期：2019-01-01 00:00:00