Preferential sensitization of tumor cells to radiation by heat shock protein 90 inhibitor geldanamycin.

abstract：:The purpose of this study is to survey the current patterns of practice, and barriers to implementation, of 3D image-guided brachytherapy (3D-IGBT) for cervical cancer in Japan. A 30-item questionnaire was sent to 171 Japanese facilities where high-dose-rate brachytherapy devices were available in 2012. In total, 135 ...

journal_title：Journal of radiation research

authors： Ohno T,Toita T,Tsujino K,Uchida N,Hatano K,Nishimura T,Ishikura S

更新日期：2015-11-01 00:00:00

abstract：:This study evaluated the effective dose of Ga-67 for a patient undergoing Ga-67 citrate nuclear examination by applying thermoluminescent dosimeter (TLD) technique and an indigenous water phantom. The Ga-67 radionuclide remaining in the body inevitably generated a measurable internal dose even though gamma camera scan...

journal_title：Journal of radiation research

authors： Chu KH,Lin YT,Hsu CC,Chen CY,Pan LK

更新日期：2012-11-01 00:00:00

abstract：:The purpose of this study was to evaluate the efficacy and toxicity of radiotherapy concurrently with weekly cisplatin, followed by adjuvant chemotherapy, for the treatment of N2-3 nasopharyngeal cancer (NPC) in Asian countries, especially regions of South and Southeast Asian countries where NPC is endemic. Between 20...

journal_title：Journal of radiation research

authors： Ohno T,Thinh DH,Kato S,Devi CR,Tung NT,Thephamongkhol K,Calaguas MJ,Zhou J,Chansilpa Y,Supriana N,Erawati D,Banu PA,Koo CC,Kobayashi K,Nakano T,Tsujii H

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:The aim of this study is to evaluate the cost-effectiveness of proton beam therapy with cochlear dose reduction compared with conventional X-ray radiotherapy for medulloblastoma in childhood. METHODS:We developed a Markov model to describe health states of 6-year-old children with medulloblastoma after trea...

journal_title：Journal of radiation research

authors： Hirano E,Fuji H,Onoe T,Kumar V,Shirato H,Kawabuchi K

更新日期：2014-03-01 00:00:00

abstract：:The increasing use of mobile phones has aroused public concern regarding the potential health risks of radiofrequency (RF) fields. We investigated the effects of exposure to RF fields (2.45 GHz, continuous wave) at specific absorption rate (SAR) of 1, 5, and 10 W/kg for 1, 4, and 24 h on gene expression in a normal hu...

journal_title：Journal of radiation research

authors： Sakurai T,Kiyokawa T,Narita E,Suzuki Y,Taki M,Miyakoshi J

更新日期：2011-01-01 00:00:00

abstract：:To determine the possible effect of hypergravity to modify the signal transduction of ionizing radiation, we analyzed the accumulation of p53 and the expression of p53-dependent genes, Waf-1 and Bax, using the western blot analysis. Hypergravity (20 x g) induced the accumulation of p53 in the human glioblastoma cell l...

journal_title：Journal of radiation research

authors： Okaichi K,Usui A,Ohnishi T,Okumura Y

更新日期：2002-12-01 00:00:00

abstract：:Resveratrol has received considerable attention as a polyphenol with anti-oxidant, anti-carcinogenic, and anti-inflammatory effects. Radiation is an important component of therapy for a wide range of malignant conditions. However, it causes damage to normal cells and, hence, can result in adverse side effects. This st...

journal_title：Journal of radiation research

authors： Jeong MH,Yang KM,Jeong DH,Lee CG,Oh SJ,Jeong SK,Lee KW,Jo YR,Jo WS

更新日期：2014-05-01 00:00:00

abstract：:The expression of oncogenes was studied in 12 types of 178 mouse tumors induced by radiations and chemicals. DNA was analyzed in tumors in which the overexpression of oncogenes was noted. Amplification of the myc oncogene was found in chemically induced sarcomas, but not in sarcomas induced by radiation. Activation of...

journal_title：Journal of radiation research

authors： Niwa O,Muto M,Suzuki F,Kominami R,Yokoro K

更新日期：1991-12-01 00:00:00

abstract：:Immediately after X-irradiation, monocytic cells can express the gene for interleukin (IL)-1beta, which enhances inflammation and contributes to radioprotection in mice. In order to analyze the mechanism(s) for the immediate-early induction of IL-1beta after X-irradiation at 20 Gy in cultured murine macrophages, we ex...

journal_title：Journal of radiation research

authors： Ishihara H,Tanaka I,Wan H,Cheeramakara C

更新日期：2003-06-01 00:00:00

abstract：:Boron Neutron Capture Therapy (BNCT) effectiveness depends on the preferential sequestration of boron in cancer cells relative to normal tissue cells. We present a novel strategy for sequestering boron using an adenovirus expressing the sodium iodide symporter (NIS). Human glioma grown subcutaneously in athymic mice a...

journal_title：Journal of radiation research

authors： Kumar S,Freytag SO,Barton KN,Burmeister J,Joiner MC,Sedghi B,Movsas B,Binns PJ,Kim JH,Brown SL

更新日期：2010-01-01 00:00:00

abstract：:We investigated the efficacy and safety of albumin-bound paclitaxel (nab-PTX) and carboplatin (CBDCA) with concurrent radiotherapy for unresectable locally advanced non-small-cell lung cancer (NSCLC). Patients with Stage III NSCLC and an Eastern Cooperative Oncology Group performance status of 0 or 1 were eligible. Co...

journal_title：Journal of radiation research

authors： Hasegawa T,Futamura Y,Horiba A,Yoshida T,Suzuki T,Kato T,Kaito D,Ohno Y,Iida T,Hayashi S,Sawa T

更新日期：2016-01-01 00:00:00

abstract：:This study investigates whether in-room computed tomography (CT)-based adaptive treatment planning (ATP) is robust against interfractional location variations, namely, interfractional organ motions and/or applicator displacements, in 3D intracavitary brachytherapy (ICBT) for uterine cervical cancer. In ATP, the radiat...

journal_title：Journal of radiation research

authors： Oku Y,Arimura H,Nguyen TT,Hiraki Y,Toyota M,Saigo Y,Yoshiura T,Hirata H

更新日期：2016-11-01 00:00:00

abstract：:New precision radiotherapy (RT) techniques reduce the uncertainties in localizing soft and moving tumors. However, there are still many uncontrollable internal organ movements. In our study, patients who underwent neoadjuvant chemoradiotherapy (NA-CRT) for rectal cancer were evaluated to determine inter-fraction mesor...

journal_title：Journal of radiation research

authors： Alickikus ZA,Kuru A,Aydin B,Akcay D,Gorken IB

更新日期：2020-03-23 00:00:00

abstract：:Ionizing radiation induces biological effects not only in irradiated cells but also in non-irradiated cells, which is called the bystander effect. Recently, in vivo and in vitro experiments have suggested that both gap junction hemichannel connexin43 (Cx43) and extracellular adenosine triphosphate (ATP) released from ...

journal_title：Journal of radiation research

authors： Ohshima Y,Tsukimoto M,Harada H,Kojima S

更新日期：2012-07-01 00:00:00

abstract：:The aims of present study were to evaluate the efficacy of combining sunitinib with ionizing radiation (IR) on endothelial cells in vitro and in vivo. Human umbilical vein endothelial cells (HUVECs) were exposed to IR with or without sunitinib pretreatment. Apoptosis assay and cell cycle distribution were analyzed by ...

journal_title：Journal of radiation research

authors： Zhang HP,Takayama K,Su B,Jiao XD,Li R,Wang JJ

更新日期：2011-01-01 00:00:00

abstract：:The aim of the study was to compare clinical outcomes and toxicity between 3D conformal radiotherapy (3DCRT) and image-guided intensity-modulated radiotherapy (IG-IMRT) administered through helical tomotherapy in locally advanced rectal cancer (LARC) patients receiving preoperative chemoradiotherapy. We reviewed 144 p...

journal_title：Journal of radiation research

authors： Huang CM,Huang MY,Tsai HL,Huang CW,Ma CJ,Lin CH,Huang CJ,Wang JY

更新日期：2017-03-01 00:00:00

abstract：:The effect of gamma-irradiation on a major nutritional function of the yolk sac (the uptake and digestion of macromolecular materials) was studied in rat visceral yolk sacs cultured in vitro being used 125I-labeled bovine serum albumin (RISA) as the tracer protein. The uptake of RISA (per g wet weight) by rat yolk sac...

journal_title：Journal of radiation research

authors： Takahashi S,Koshimoto C,Kubota Y

更新日期：1993-06-01 00:00:00

abstract：:XRCC4 is a protein associated with DNA Ligase IV, which is thought to join two DNA ends at the final step of DNA double-strand break repair through non-homologous end joining. In response to treatment with ionizing radiation or DNA damaging agents, XRCC4 undergoes DNA-PK-dependent phosphorylation. Furthermore, Ser260 ...

journal_title：Journal of radiation research

authors： Sharma MK,Imamichi S,Fukuchi M,Samarth RM,Tomita M,Matsumoto Y

更新日期：2016-03-01 00:00:00

abstract：:Female C3H strain mice, which do not spontaneously exhibit frequent bone tumors and myeloid leukemias, were injected intraperitoneally with various doses of 10 to 12,000 Bq/animal of monomeric 239Pu citrate to clarify lifetime carcinogenesis caused by alpha-particles distributed mainly in the skeleton. Survival time w...

journal_title：Journal of radiation research

authors： Oghiso Y,Yamada Y,Iida H

更新日期：1997-06-01 00:00:00

abstract：:The purpose of this study is to evaluate the dose-volume metrics under different heterogeneity corrections and the factors associated with local recurrence (LR) after stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC). Eighty-three patients who underwent SBRT for pathologically proven st...

journal_title：Journal of radiation research

authors： Ueki N,Matsuo Y,Shibuya K,Nakamura M,Narabayashi M,Sakanaka K,Norihisa Y,Mizowaki T,Hiraoka M

更新日期：2013-03-01 00:00:00

abstract：:Several models for the action of mixed irradiation with two types of radiation have been proposed in the last two decades, although the superiority or inferiority of these models is not completely elucidated. However, mixed irradiation is sometimes composed of more than two types of radiation, and for this type of mix...

journal_title：Journal of radiation research

authors： Suzuki S

更新日期：1998-09-01 00:00:00

abstract：:We evaluated the radiological response and clinical outcome in patients with femoral bone metastases after radiotherapy. 102 consecutive patients with femoral metastases without pathological fracture were treated by surgery or radiotherapy between 2002 and 2005. Twelve of them initially treated with surgery were exclu...

journal_title：Journal of radiation research

authors： Harada H,Katagiri H,Kamata M,Yoshioka Y,Asakura H,Hashimoto T,Furutani K,Takahashi M,Sakahara H,Nishimura T

更新日期：2010-01-01 00:00:00

abstract：:We compared the tumor reoxygenation patterns in three different murine tumor cell lines after X-irradiation with those after carbon-beam irradiation using a heavy-ion medical accelerator (HIMAC) system. The tumors of the cell lines SCCVII, SCCVII-variant-1 and EMT6 on the hind legs of mice received local priming irrad...

journal_title：Journal of radiation research

authors： Oya N,Sasai K,Shibata T,Takagi T,Shibuya K,Koike S,Nojima K,Furusawa Y,Ando K,Hiraoka M

更新日期：2001-06-01 00:00:00

abstract：:The aim of this study was to compare the anti-oxidative and anti-inflammatory activities of gamma-irradiated persimmon leaf extract (GPLE) with those of non-irradiated persimmon leaf extract (PLE). Ethanolic extract of persimmon leaf was exposed to gamma irradiation at a dose of 10 kGy. After gamma irradiation, the co...

journal_title：Journal of radiation research

authors： Cho BO,Nchang Che D,Yin HH,Jang SI

更新日期：2017-09-01 00:00:00

abstract：:The health effects of radiation exposure from the atomic bomb fallout remain unclear. The objective of the present study is to elucidate the association between low-dose radiation exposure from the atomic bomb fallout and cancer mortality among Nagasaki atomic bomb survivors. Of 77 884 members in the Nagasaki Universi...

journal_title：Journal of radiation research

authors： Yokota K,Mine M,Kondo H,Matsuda N,Shibata Y,Takamura N

更新日期：2018-01-01 00:00:00

abstract：:In case of an accidental overexposure to ionizing radiation where the dose received by the victim is over 5 Gy, the conventional biological indicator of dose, the dicentric assay, does not provide an accurate enough dose measurement. A more appropriate technique is to measure ring chromosomes in stimulated lymphocytes...

journal_title：Journal of radiation research

authors： Lamadrid AI,García O,Delbos M,Voisin P,Roy L

更新日期：2007-01-01 00:00:00

abstract：:When DNA is damaged by exposure to a small amount of radiation, it is repaired efficiently by innate mechanisms. However, if cellular damage is more extensive, DNA repair cannot be adequately completed. To clarify the role of the p53 gene in apoptotic tissue repair, the incidence of in-vivo radiation-induced somatic m...

journal_title：Journal of radiation research

authors： Kato F,Kakihara H,Kunugita N,Ootsuyama A,Norimura T

更新日期：2002-12-01 00:00:00

abstract：:Photon irradiation has been repeatedly suspected of increasing tumor cell motility and promoting locoregional recurrence of disease. This study was set up to analyse possible mechanisms underlying the potentially radiation-altered motility in medulloblastoma cells. Medulloblastoma cell lines D425 and Med8A were analyz...

journal_title：Journal of radiation research

authors： Rieken S,Rieber J,Brons S,Habermehl D,Rief H,Orschiedt L,Lindel K,Weber KJ,Debus J,Combs SE

更新日期：2015-05-01 00:00:00

abstract：:Spatial distributions of soil contamination by 137Cs (89 sampling points) and 239+240Pu (76 points) near and within Dolon village were analyzed. An essential exponential decrease of contamination was found in Dolon village: the distance of a half reduction in contamination is about 0.87-1.25 km (in a northwest-southea...

journal_title：Journal of radiation research

authors： Stepanenko VF,Hoshi M,Dubasov YV,Sakaguchi A,Yamamoto M,Orlov MY,Bailiff IK,Ivannikov AI,Skvortsov VG,Iaskova EK,Kryukova IG,Zhumadilov KS,Endo S,Tanaka K,Apsalikov KN,Gusev BI

更新日期：2006-02-01 00:00:00

abstract：:The hypothesis that exposure to ionizing radiation accelerates the aging process has been actively investigated at ABCC-RERF since 1958, when longitudinal cohort studies of the Adult Health Study (AHS) and the Life Span Study (LSS) were initiated. In their 1975 overall review of aging studies related to the atomic bom...

journal_title：Journal of radiation research

authors： Sasaki H,Kodama K,Yamada M

更新日期：1991-03-01 00:00:00