Abstract:
:The purpose of this study was to describe the results of definitive radiotherapy (RT) with concurrent chemotherapy for maxillary sinus carcinomas (MSCs) with neck lymph node metastasis to clarify its limitation. Local control (LC), progression-free survival (PFS) and overall survival (OS) rates were calculated using the Kaplan-Meier method and were compared between subgroups using the log rank test. Toxicity was classified using common terminology criteria of adverse events version 5.0. Eighteen patients with inoperable MSC with neck lymph node metastasis including 12 men and 6 women with a median age of 67 years were analyzed. The histologic diagnoses were as follows: 16 patients had squamous cell carcinomas and 2 had other histology. Four patients had stage T3 MSC, 6 had T4a and 8 had T4b. Among 18 patients, 7 received concurrent systemic chemotherapy and 11 received selective arterial chemo-infusion. The median follow-up period was 17 months. The 2-year LC, PFS and OS rates for the entire cohort were 34, 31 and 46%, respectively. No significant differences were observed for LC, PFS and OS rates between systemic chemotherapy and selective arterial chemo-infusion cohorts. Grade 3 or higher acute toxicity, including both non-hematological and hematological, was observed in nine patients (50%), while no grade 3 or higher late toxicity was observed. In conclusion, we described the results of definitive RT for MSCs with neck lymph node metastasis. Local recurrence of primary tumor was a frequent pattern of failure and it should be addressed in future study.
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Abe T,Saito S,Iino M,Aoshika T,Ryuno Y,Ohta T,Igari M,Hirai R,Kumazaki Y,Ebihara Y,Nakahira M,Sugasawa M,Noda SE,Kato Sdoi
10.1093/jrr/rraa120subject
Has Abstractpub_date
2021-01-01 00:00:00pages
104-109issue
1eissn
0449-3060issn
1349-9157pii
6024750journal_volume
62pub_type
杂志文章abstract::Direct irradiation may cause malfunctioning of cardiac implantable electronic devices (CIEDs). Therefore, a treatment plan that does not involve direct irradiation of CIEDs should be formulated. However, CIEDs may be directly exposed to radiation because of the sudden intrafractional movement of the patient. The proba...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa016
更新日期:2020-05-22 00:00:00
abstract::We previously showed that free radicals and oxidative stress are involved in radiation-induced skin reactions. Since vitamin E (VE) is a particularly important lipophilic antioxidant, VE-deficient mice were used to examine its effects on radiation-induced skin damage. The VE content of the skin was reduced to one four...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.10042
更新日期:2011-01-01 00:00:00
abstract::Irregular breathing can influence the outcome of 4D computed tomography imaging and cause artifacts. Visual biofeedback systems associated with a patient-specific guiding waveform are known to reduce respiratory irregularities. In Japan, abdomen and chest motion self-control devices (Abches) (representing simpler visu...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv106
更新日期:2016-07-01 00:00:00
abstract::Disufiram (a drug used for the treatment of alcoholism) protected microsomal membranes and plasmid DNA against damages induced by gamma-radiation. The peroxidation of membrane lipids increased linearly with the radiation dose up to 600 Gy, and the presence of disulfiram inhibited membrane lipid peroxidation as assayed...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.44.255
更新日期:2003-09-01 00:00:00
abstract::Modern treatment machines have shown small inter-unit variability regarding beam data. Recently, vendor-provided average beam data, such as the Representative Beam Data (RBD) of the TrueBeam (Varian Medical Systems, Palo Alto, CA, USA), has been used for modeling of the Eclipse (Varian Medical Systems) treatment plann...
journal_title:Journal of radiation research
pub_type: 杂志文章,多中心研究
doi:10.1093/jrr/rrz082
更新日期:2020-03-23 00:00:00
abstract::The aim of this study is to demonstrate the feasibility of estimating the strength of the moving radiation source during patient implantation. The requirement for the counting time was investigated by comparing the results of the measurements for the static source with those for the source moving at 2, 5, 10 and 20 cm...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt087
更新日期:2014-01-01 00:00:00
abstract::To evaluate the feasibility of using radiosensitivity of peripheral leukocytes as a predictor of clinical therapeutic responses to radiosurgery in individuals with cerebral arteriovenous malformation (AVM), we enrolled 18 patients years after they had received Gamma Knife radiosurgery for their cerebral AVM. The AVMs ...
journal_title:Journal of radiation research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1269/jrr.45.269
更新日期:2004-06-01 00:00:00
abstract::A synergistic interaction of hyperthermia with ionizing or UV light (254 nm) radiation was analyzed in experiments with yeast cells. For a fixed dose rate of radiation, the synergism was shown to be observed only within a definite temperature range (40-45 degrees C), inside of which there was an optimal temperature to...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.42.361
更新日期:2001-12-01 00:00:00
abstract::In this study, a mechanism in which low-dose hyper-radiosensitivity (HRS) is permanently removed, induced by low-dose-rate (LDR) (0.2-0.3 Gy/h for 1 h) but not by high-dose-rate priming (0.3 Gy at 40 Gy/h) was investigated. One HRS-negative cell line (NHIK 3025) and two HRS-positive cell lines (T-47D, T98G) were used....
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt061
更新日期:2013-11-01 00:00:00
abstract::Ionizing radiation induces biological effects not only in irradiated cells but also in non-irradiated cells, which is called the bystander effect. Recently, in vivo and in vitro experiments have suggested that both gap junction hemichannel connexin43 (Cx43) and extracellular adenosine triphosphate (ATP) released from ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs014
更新日期:2012-07-01 00:00:00
abstract::XRCC4 is a protein associated with DNA Ligase IV, which is thought to join two DNA ends at the final step of DNA double-strand break repair through non-homologous end joining. In response to treatment with ionizing radiation or DNA damaging agents, XRCC4 undergoes DNA-PK-dependent phosphorylation. Furthermore, Ser260 ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv086
更新日期:2016-03-01 00:00:00
abstract::The aim of this research was to provide data from a single-center study of the treatment of synchronous hypopharyngeal cancer (HPC) and esophageal cancer (EC) with different treatment modalities. A total of 61 patients with synchronous HPC and EC were included in this study. Patients were treated with radiotherapy/che...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrz042
更新日期:2019-10-23 00:00:00
abstract::To investigate the importance of gender and aging on the individual radiosensitivity of lineage-committed myeloid hematopoietic stem/progenitor cells (HSPCs) detected in mononuclear cells (MNCs) of steady-state human peripheral blood (PB), the clonogenic survival of HPCs, including colony-forming unit-granulocyte macr...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.10142
更新日期:2011-01-01 00:00:00
abstract::Herein we summarize the public health actions taken to mitigate exposure of the public to radiation after the Fukushima accident that occurred on 11 March 2011 in order to record valuable lessons learned for disaster preparedness. Evacuations from the radiation-affected areas and control of the distribution of various...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1093/jrr/rrv013
更新日期:2015-05-01 00:00:00
abstract::The quality of the sublethal damage (SLD) after irradiation with high-linear energy transfer (LET) ion beams was investigated with low-LET photons. Chinese hamster V79 cells and human squamous carcinoma SAS cells were first exposed to a priming dose of different ion beams at different LETs at the Heavy Ion Medical Acc...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx030
更新日期:2017-11-01 00:00:00
abstract::We have proposed four dimensional (4D) digitally reconstructed radiography (DRR) for verifying a lung tumor position during volumetric modulated arc therapy (VMAT). An internal target volume (ITV) was defined based on two clinical target volumes (CTVs) delineated on maximum exhalation and maximum inhalation images acq...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs013
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:The aim of this study is to evaluate the cost-effectiveness of proton beam therapy with cochlear dose reduction compared with conventional X-ray radiotherapy for medulloblastoma in childhood. METHODS:We developed a Markov model to describe health states of 6-year-old children with medulloblastoma after trea...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt112
更新日期:2014-03-01 00:00:00
abstract::Neutron dose is transferred to biological materials through the recoil protons produced by elastic scattering. When a low-velocity proton collides with the atoms or molecules of a target, it changes to a hydrogen atom by electron capture; this hydrogen atom then changes to a proton by losing the electron. Because the ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.45.351
更新日期:2004-09-01 00:00:00
abstract::Spatial distributions of soil contamination by 137Cs (89 sampling points) and 239+240Pu (76 points) near and within Dolon village were analyzed. An essential exponential decrease of contamination was found in Dolon village: the distance of a half reduction in contamination is about 0.87-1.25 km (in a northwest-southea...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.47.a149
更新日期:2006-02-01 00:00:00
abstract::Tumor hypoxia and angiogenesis have been studied extensively. However, the relation between normal tissue injury and hypoxia is still unclear. In this study, we investigated the effect of hypoxia on radiation-induced late rectal injury in mice. The rectum of C57BL/6N mice was irradiated locally with a single dose of 2...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.07099
更新日期:2008-05-01 00:00:00
abstract::The pulse radiolysis technique has been employed to determine the initiation and propagation rates of different transient species involved in the polymerization of N-isopropylacrylamide (NIPA) in aqueous solutions. Polymerization by anionic mechanism has been observed to be faster than by the free-radical mechanism. T...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.44.335
更新日期:2003-12-01 00:00:00
abstract::We examined the effect of whole body low-dose gamma-irradiation on the status of the antioxidant defense system in the rodent kidneys at different time intervals. Young male Balb/c mice were exposed to whole body radiation from a (60)Co source at doses of 10, 25 and 50 cGy (48.78 cGy/min). Antioxidant status and lipid...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.06063
更新日期:2007-03-01 00:00:00
abstract::Immediately after X-irradiation, monocytic cells can express the gene for interleukin (IL)-1beta, which enhances inflammation and contributes to radioprotection in mice. In order to analyze the mechanism(s) for the immediate-early induction of IL-1beta after X-irradiation at 20 Gy in cultured murine macrophages, we ex...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.44.117
更新日期:2003-06-01 00:00:00
abstract::Liquid ionization chambers (LICs) are highly sensitive to dose irradiation and have small perturbations because of their liquid-filled sensitive volume. They require a sensitive volume much smaller than conventional air-filled chambers. However, it has been reported that the collection efficiency has dependencies on t...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx088
更新日期:2018-05-01 00:00:00
abstract::To evaluate the lifetime hazards of ionizing radiation exposure, 1680 beagles received whole-body, 60-Cobalt gamma exposures or sham-exposures during development. Eight groups of 120 dogs each received mean doses of 16 or 83 cGy at 8 (preimplantation), 28 (embryonic), or 55 (late fetal) days postcoitus (dpc), or 2 (ne...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.32.supplement2_86
更新日期:1991-12-01 00:00:00
abstract::Thyroid cells were given 5.5 Gy X-rays in situ and transplanted after 1 day or after 6 weeks to form colonies in fat pads. The colony-forming efficiency unexpectedly decreased by a factor of about 2 with this increase in delay time before transplantation. In addition, there was a concomitant marked increase above the ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.35.116
更新日期:1994-06-01 00:00:00
abstract::Reassessment of gamma-ray doses from the atomic bombs in Hiroshima and Nagasaki has been carried out with the thermoluminescent measurements of bricks and decorative tiles which were collected from the buildings that remain as they were at the time of the explosions. The thermoluminescent measurements were performed u...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.32.supplement_40
更新日期:1991-03-01 00:00:00
abstract::The aim of this study was to describe our initial experience with a gold flexible linear fiducial marker and to evaluate the safety and technical and clinical efficacy of stereotactic body radiotherapy using this marker for malignant liver tumors. Between July 2012 and February 2015, 18 patients underwent percutaneous...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv099
更新日期:2016-03-01 00:00:00
abstract::This study is a subset analysis of a retrospective multicenter study performed in Japan and its purpose was to investigate the effectiveness of stereotactic body radiotherapy (SBRT) for pulmonary oligometastases from colorectal cancer. Local control (LC), freedom from further metastases, relapse-free survival and over...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa071
更新日期:2020-11-16 00:00:00
abstract::X-ray induced neoplastic transformation of C3H/10T1/2 cells was suppressed equally by Lipid A and LPS. We examined the effects of several modifiers of arachidonic acid (AA) metabolism in our investigation on the suppression mechanism of LPS. Dexamethasone (DM), an inhibitor of phospholipase A2 (PLA2), abolished the ef...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.34.285
更新日期:1993-12-01 00:00:00