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Vitamin E-deficiency did not exacerbate partial skin reactions in mice locally irradiated with X-rays.

Abstract：

:We previously showed that free radicals and oxidative stress are involved in radiation-induced skin reactions. Since vitamin E (VE) is a particularly important lipophilic antioxidant, VE-deficient mice were used to examine its effects on radiation-induced skin damage. The VE content of the skin was reduced to one fourth of levels of normal mice. Neither the time of onset nor the extent of the reactions quantified with a scoring system differed between normal and VE-deficient mice after local X-irradiation (50 Gy). Similarly, there was no difference in the levels of the ascorbyl radical between the groups, although they were higher in irradiated skin than non-irradiated skin. X-irradiation increased the amount of Bax protein in the skin of normal mice both in the latent and acute inflammatory stages, time- and dose-dependently. The increase was associated with an increase in cytochrome c in the cytosolic fraction, indicating that apoptosis was also promoted by the irradiation. The increase in Bax protein correlated well with the thickness of the skin. Although a deficiency in VE should lower resistance to free radicals in the mitochondrial membrane and thus enhance radiation-induced Bax expression and apoptosis, it actually attenuated the increase in Bax protein caused by irradiation.

journal_name

J Radiat Res

journal_title

Journal of radiation research

authors

Chi C,Hayashi D,Nemoto M,Nyui M,Urano S,Anzai K

doi

10.1269/jrr.10042

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

32-8

issue

1

eissn

0449-3060

issn

1349-9157

pii

JST.JSTAGE/jrr/10042

journal_volume

52

pub_type

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