Individuals' leukocyte DNA double-strand break repair as an indicator of radiosurgery responses for cerebral arteriovenous malformations.

abstract：:Herein we summarize the public health actions taken to mitigate exposure of the public to radiation after the Fukushima accident that occurred on 11 March 2011 in order to record valuable lessons learned for disaster preparedness. Evacuations from the radiation-affected areas and control of the distribution of various...

journal_title：Journal of radiation research

authors： Shimura T,Yamaguchi I,Terada H,Robert Svendsen E,Kunugita N

更新日期：2015-05-01 00:00:00

abstract：:Radiation-induced rescue effect (RIRE) in cells refers to the phenomenon where irradiated cells (IRCs) receive help from feedback signals produced by partnered bystander unirradiated cells (UIRCs) or from the conditioned medium (CM) that has previously conditioned the UIRCs. In the present work, we explored the role o...

journal_title：Journal of radiation research

authors： Pathikonda S,Cheng SH,Yu KN

更新日期：2020-05-22 00:00:00

abstract：:An interest in the possible cancer causing ability of neutrons began soon after their discovery. Early use of neutrons from radioactive sources and from cyclotrons led to a need to define risk for such exposures. This need was soon followed by a more tangible need to define risk to the general population of high LET r...

journal_title：Journal of radiation research

authors： Hill CK,Williams-Hill D

更新日期：1999-12-01 00:00:00

abstract：:We examined the effect of whole body low-dose gamma-irradiation on the status of the antioxidant defense system in the rodent kidneys at different time intervals. Young male Balb/c mice were exposed to whole body radiation from a (60)Co source at doses of 10, 25 and 50 cGy (48.78 cGy/min). Antioxidant status and lipid...

journal_title：Journal of radiation research

authors： Pathak CM,Avti PK,Kumar S,Khanduja KL,Sharma SC

更新日期：2007-03-01 00:00:00

abstract：:Ionizing radiation induces biological effects not only in irradiated cells but also in non-irradiated cells, which is called the bystander effect. Recently, in vivo and in vitro experiments have suggested that both gap junction hemichannel connexin43 (Cx43) and extracellular adenosine triphosphate (ATP) released from ...

journal_title：Journal of radiation research

authors： Ohshima Y,Tsukimoto M,Harada H,Kojima S

更新日期：2012-07-01 00:00:00

abstract：:We examined dose-dependent or dose rate-dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m(3) for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2...

journal_title：Journal of radiation research

authors： Kataoka T,Sakoda A,Ishimori Y,Toyota T,Nishiyama Y,Tanaka H,Mitsunobu F,Yamaoka K

更新日期：2011-01-01 00:00:00

abstract：:The purpose of this study was to describe the results of definitive radiotherapy (RT) with concurrent chemotherapy for maxillary sinus carcinomas (MSCs) with neck lymph node metastasis to clarify its limitation. Local control (LC), progression-free survival (PFS) and overall survival (OS) rates were calculated using t...

journal_title：Journal of radiation research

authors： Abe T,Saito S,Iino M,Aoshika T,Ryuno Y,Ohta T,Igari M,Hirai R,Kumazaki Y,Ebihara Y,Nakahira M,Sugasawa M,Noda SE,Kato S

更新日期：2021-01-01 00:00:00

abstract：:Chronic irradiation with low-dose-rate 137Cs-γ rays inhibits the differentiation of human neural progenitor cells and influences the expression of proteins associated with several cellular functions. We aimed to determine whether such chronic irradiation influences the expression of proteins associated with PC12 cells...

journal_title：Journal of radiation research

authors： Shinsuke K,Junya K,Tomonobu U,Yoshiko K,Izumo N,Takahiko S

更新日期：2017-11-01 00:00:00

abstract：:A number of agents are now available for use in protecting against ionizing radiation. These radiation-protective agents, however, have many adverse effects. Efforts have been made to develop new radiation-protective agents for medical application. Here, we investigated whether a compound, polyethylenimine (PEI), whic...

journal_title：Journal of radiation research

authors： Hu Z,Xing Y,Qian Y,Chen X,Tu J,Ren L,Wang K,Chen Z

更新日期：2013-03-01 00:00:00

abstract：:X-ray induced formation of micronuclei is generally thought to result from DNA double-strand breaks (DSBs). However, DNA DSBs inhibit the cell cycle progression that is required for micronucleus formation. In order to reconcile this apparent discrepancy, we investigated whether DNA DSBs induced during the G1 phase cou...

journal_title：Journal of radiation research

authors： Okada T,Kashino G,Nishiura H,Tano K,Watanabe M

更新日期：2012-01-01 00:00:00

abstract：:Clustered DNA damage is a specific type of DNA damage induced by ionizing radiation. Any type of ionizing radiation traverses the target DNA molecule as a beam, inducing damage along its track. Our previous study showed that clustered DNA damage yields decreased with increased linear energy transfer (LET), leading us ...

journal_title：Journal of radiation research

authors： Tokuyama Y,Furusawa Y,Ide H,Yasui A,Terato H

更新日期：2015-05-01 00:00:00

abstract：:To identify the repair dynamics involved in high linear energy transfer (LET) radiation-induced DNA damage, phospho-H2AX (gammaH2AX) foci formation was analyzed after cellular exposure to iron ions (Fe-ions, 500 MeV u(-1), 200 KeV microm(-1)). The foci located at DNA damage sites were visualized using immunocytochemic...

journal_title：Journal of radiation research

authors： Takahashi A,Yamakawa N,Kirita T,Omori K,Ishioka N,Furusawa Y,Mori E,Ohnishi K,Ohnishi T

更新日期：2008-11-01 00:00:00

abstract：:We have examined the neutron energy dependency of cell killing and mutation induction at the hprt locus in Chinese hamster V79 cells. Monoenergetic neutrons at 0.32, 0.57, and 1.2 MeV were generated at the Hiroshima University Radiobiological Research Accelerator (HIRRAC) Facility, and were used to irradiate cells. Th...

journal_title：Journal of radiation research

authors： Kubota N,Okada S,Nagatomo S,Ozawa F,Inada T,Hill CK,Endo S,Komatsu K

更新日期：1999-12-01 00:00:00

abstract：:An overview is given of the dose-response relationship for stable chromosome aberrations (i.e., translocations and inversions) in the peripheral blood lymphocytes of A-bomb survivors in Hiroshima. Special emphasis is placed on (i) the overdispersion of survivor cases with either unexpectedly high or low aberration fre...

journal_title：Journal of radiation research

authors： Awa AA,Nakano M,Ohtaki K,Kodama Y,Lucas J,Gray J

更新日期：1992-03-01 00:00:00

abstract：:Carbon-ion therapy by layer-stacking irradiation for static targets has been practised in clinical treatments. In order to apply this technique to a moving target, disturbances of carbon-ion dose distributions due to respiratory motion have been studied based on the measurement using a respiratory motion phantom, and ...

journal_title：Journal of radiation research

authors： Tajiri S,Tashiro M,Mizukami T,Tsukishima C,Torikoshi M,Kanai T

更新日期：2017-11-01 00:00:00

abstract：:The purpose of this study was to investigate the radiosensitizing effect of geldanamycin (GA), an inhibitor of heat shock protein 90, on tumour cells and normal cells. We tested the effect of a combination of GA and radiation on cell survival, PI3K/Akt-related proteins and apoptosis induction. GA sensitized tumour cel...

journal_title：Journal of radiation research

authors： Matsumoto Y,Machida H,Kubota N

更新日期：2005-06-01 00:00:00

abstract：:This study evaluated cytogenetic damage by measuring the frequency of micronucleated cells (MNC) in peripheral blood and buccal mucosa of head-and-neck cancer patients undergoing radiotherapy. MNC frequencies were assessed in 31 patients before, during, and after radiotherapy, and in 17 healthy controls matched for ge...

journal_title：Journal of radiation research

authors： Minicucci EM,Kowalski LP,Maia MA,Pereira A,Ribeiro LR,de Camargo JL,Salvadori DM

更新日期：2005-06-01 00:00:00

abstract：:The Rho-associated coiled-coil-containing protein kinase (ROCK) pathway is known to influence metastasis in several cancers; however, the impact of the pathway on clinical outcomes in patients undergoing radiotherapy remains unknown. In the present study, the expression of RhoA, RhoC, ROCK-1, ROCK-2 and p53 was immuno...

journal_title：Journal of radiation research

authors： Tanaka K,Matsumoto Y,Ishikawa H,Fukumitsu N,Numajiri H,Murofushi K,Oshiro Y,Okumura T,Satoh T,Sakurai H

更新日期：2020-03-23 00:00:00

abstract：:This study is a subset analysis of a retrospective multicenter study performed in Japan and its purpose was to investigate the effectiveness of stereotactic body radiotherapy (SBRT) for pulmonary oligometastases from colorectal cancer. Local control (LC), freedom from further metastases, relapse-free survival and over...

journal_title：Journal of radiation research

authors： Yamamoto T,Niibe Y,Matsumoto Y,Onishi H,Aoki M,Nishikawa A,Oh RJ,Shintani T,Yahara K,Ozaki M,Manabe Y,Jingu K

更新日期：2020-11-16 00:00:00

abstract：:Investigating the biological effects of high-LET heavy-ion irradiation at low fluence is important to evaluate the risk of radiation in space. It is especially necessary to detect radiation damage induced by a precise number of heavy ions in individual cells. We thus compared the number of ions traversing a cell and t...

journal_title：Journal of radiation research

authors： Wada S,Kobayashi Y,Funayama T,Natsuhori M,Ito N,Yamamoto K

更新日期：2002-12-01 00:00:00

abstract：:Our purpose was to develop recommendations for contouring the computed tomography (CT)-based high-risk clinical target volume (CTVHR) for 3D image-guided brachytherapy (3D-IGBT) for cervical cancer. A 15-member Japanese Radiation Oncology Study Group (JROSG) committee with expertise in gynecological radiation oncology...

journal_title：Journal of radiation research

authors： Ohno T,Wakatsuki M,Toita T,Kaneyasu Y,Yoshida K,Kato S,Ii N,Tokumaru S,Ikushima H,Uno T,Noda SE,Kazumoto T,Harima Y,The Working Group of the Gynecological Tumor Committee of the Japanese Radiation Oncology Study Group (JROSG).

更新日期：2017-05-01 00:00:00

abstract：:Low doses (2.5-15 cGy) of X-irradiation two months prior to a second exposure to a sublethal dose enhanced the survival rate in mice. Optimal and significant increase was observed with 5-10 cGy. Endogenous spleen colony counts (endo-CFUs) after 7 Gy increased by a factor of about 1.7 in mice pre-irradiated with 5-10 c...

journal_title：Journal of radiation research

authors： Yonezawa M,Takeda A,Misonoh J

更新日期：1990-09-01 00:00:00

abstract：:The aim of the study was to evaluate inter-fractional dosimetric variations for high-dose rate breast brachytherapy using a strut-adjusted volume implant (SAVI). For the nine patients included, dosimetric constraints for treatment were as follows: for the planning target volume for evaluation (PTV_Eval), the volume re...

journal_title：Journal of radiation research

authors： Iijima K,Okamoto H,Takahashi K,Aikawa A,Wakita A,Nakamura S,Nishioka S,Harada K,Notake R,Sugawara A,Yoshimura R,Kunieda E,Itami J

更新日期：2020-01-23 00:00:00

abstract：:Centrosomes function in proper cell division in animal cells. The centrosome consists of a pair of centrioles and the surrounding pericentriolar matrix (PCM). After cytokinesis, daughter cells each acquire one centrosome, which subsequently duplicates at the G1/S phase in a manner that is dependent upon CDK2/cyclin-E ...

journal_title：Journal of radiation research

authors： Shimada M,Komatsu K

更新日期：2009-07-01 00:00:00

abstract：:The present paper is part of an attempt at finally reconstructing the realities of nuclear tests and their human effects near Semipalatinsk, Kazakhstan. As a first step, it tries to reconstruct the overall image of nuclear tests and their human effects. Our data are 199 written testimonies of those affected by radiati...

journal_title：Journal of radiation research

authors： Matsuo M,Kawano N,Satoh K,Apsalikov KN,Moldagaliev T

更新日期：2006-02-01 00:00:00

abstract：:This study aimed to clarify the motivations and timing of the decision to become radiation oncologists. MATERIALS AND METHODS:We conducted an online survey for new members of the Japanese Society for Radiation Oncology (JASTRO). RESULTS:The response rate was 43.3%. Data of the 79 respondents who wanted to obtain a b...

journal_title：Journal of radiation research

authors： Murakami Y,Noda SE,Hatayama Y,Maebayashi T,Jingu K,Nagata Y,Mizowaki T

更新日期：2020-09-08 00:00:00

abstract：:The aim of this study was to carry out geometric and dosimetric evaluation of the usefulness of a deformable image registration algorithm utilized for adaptive head-and-neck intensity-modulated radiotherapy. Data consisted of seven patients, each with a planning CT (pCT), a rescanning CT (ReCT) and a cone beam CT (CBC...

journal_title：Journal of radiation research

authors： Eiland RB,Maare C,Sjöström D,Samsøe E,Behrens CF

更新日期：2014-09-01 00:00:00

abstract：:The yield of OH radical induced by ionizing radiation was estimated by an empirical model; a prescribed diffusion model for a spur of single size applying to neutral water. Two representative spur distances were introduced, one for an incident primary charged particle and one for a representative secondary electron, t...

journal_title：Journal of radiation research

authors： Yamaguchi H,Uchihori Y,Yasuda N,Takada M,Kitamura H

更新日期：2005-09-01 00:00:00

abstract：:Tritium precipitations in European cities and in Osaka, Japan were analyzed before and after the Chernobyl nuclear plant accident by the time series analysis code Census IIX11 developed by US Department of Commerce Bureau of the Census. Results of this analysis showed no significant tritium precipitation was produced ...

journal_title：Journal of radiation research

authors： Koga T,Morishima H,Niwa T,Kawai H

更新日期：1991-09-01 00:00:00

abstract：:In the last few years, hospital-based facilities for carbon-ion radiotherapy are being constructed and proposed in Europe and Asia. During the next few years, several new facilities will be opened for carbon-ion radiotherapy in the world. These facilities in operation or under construction are categorized in two types...

journal_title：Journal of radiation research

authors： Minohara S,Fukuda S,Kanematsu N,Takei Y,Furukawa T,Inaniwa T,Matsufuji N,Mori S,Noda K

更新日期：2010-01-01 00:00:00