Abstract:
:This study was designed to elucidate the dose-response relationships for life-shortening and tumorigenic effect in the dose range below 1 Gy of gamma rays delivered during the infant period. Female B6C3F1 mice were irradiated with 0.10, 0.48 or 0.95 Gy at 7 days of age. All irradiated mice were allowed to live out their entire life span together with a simultaneously ongoing control group under a specific pathogen-free condition. Shortening of the mean life span was 1.58% in mice irradiated with 0.10 Gy, which was statistically significant . The coefficient of the linear dose-response relationship for life-shortening was 11.21% Gy(-1). The attributable death fraction for all causes of death in 0.10 Gy group reached 0.092. The excess relative risk for death rate from all causes was 0.102 in the group irradiated with 0.10 Gy. The coefficient of the linear dose-response relationship of the excess relative risk for death rate from all causes was 1.30 Gy(-1). The mean number of types of solid tumors at the time of death in mice irradiated with 0.10 Gy was distinctly larger than that in the control group. The excess relative risk for death rate from solid tumors was 0.45 in mice irradiated with 0.10 Gy. The coefficient of the linear dose-response relationship of excess relative risk for death rate from solid tumors was 4.52 Gy(-1). Increase in incidences of the pituitary, ovarian and adrenal tumors was observed in mice irradiated with 0.10 Gy. The results of the present study showed that infant mice are susceptible to solid tumor induction, especially of the endocrine organs.
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Sasaki S,Fukuda Ndoi
10.1269/jrr.47.135subject
Has Abstractpub_date
2006-06-01 00:00:00pages
135-45issue
2eissn
0449-3060issn
1349-9157pii
JST.JSTAGE/jrr/47.135journal_volume
47pub_type
杂志文章abstract::The objective of the present study was to estimate cancer risk associated with the low-level radiation exposure of an average annual effective dose of 6.4 mSv (including internal exposure) in the high background-radiation areas (HBRA) in Yangjiang, China. The mortality survey consisted of two steps, i.e., the follow-u...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.41.s31
更新日期:2000-10-01 00:00:00
abstract::Coal, fly ash and bottom ash samples were taken from a 300-MWe coal-fired power plant with a daily coal consumption of 2400 tons. A high volume sampler coupled with several mesh testing sieves was used to separate fly ash samples into different size fractions. Determination of the concentrations of 40K, 238U, 226Ra, 2...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.33.141
更新日期:1992-06-01 00:00:00
abstract::Liquid ionization chambers (LICs) are highly sensitive to dose irradiation and have small perturbations because of their liquid-filled sensitive volume. They require a sensitive volume much smaller than conventional air-filled chambers. However, it has been reported that the collection efficiency has dependencies on t...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx088
更新日期:2018-05-01 00:00:00
abstract::The brachytherapy dose calculations used in treatment planning systems (TPSs) have conventionally been performed assuming homogeneous water. Using measurements and a Monte Carlo simulation, we evaluated the dosimetric impact of an air passage on brachytherapy for bronchus cancer. To obtain the geometrical characterist...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw072
更新日期:2016-11-01 00:00:00
abstract::Reactive oxygen species continuously oxidize DNA bases and threaten the genetic integrity. Thymine glycol (TG), one of the representative oxidized products, is repaired mainly by base excision repair (BER). In Escherichia coli, endonuclease III (Nth) and endonuclease VIII (Nei) are known to actively remove TG from DNA...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.07100
更新日期:2008-05-01 00:00:00
abstract::Female C3H strain mice, which do not spontaneously exhibit frequent bone tumors and myeloid leukemias, were injected intraperitoneally with various doses of 10 to 12,000 Bq/animal of monomeric 239Pu citrate to clarify lifetime carcinogenesis caused by alpha-particles distributed mainly in the skeleton. Survival time w...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.38.77
更新日期:1997-06-01 00:00:00
abstract::Thermionic emission (TE)-type X-ray generators have been exclusively used in medicine, but there are many difficulties in making these X-ray sources compact. A field emission (FE)-type X-ray generator using carbon nanotubes is a newly-developed compact system that can be as small as several cm in length. Considering t...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.06071
更新日期:2007-03-01 00:00:00
abstract::In this review, we would like to introduce a unique approach for the estimation of radioadaptation. Recently, we proposed a new methodology for evaluating the repair efficiency of DNA double-strand breaks (DSB) using a model system. The model system can trace the fate of a single DSB, which is introduced within intron...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1269/jrr.09050
更新日期:2009-09-01 00:00:00
abstract::Inoue and Iwakura recently reported that the specific activity ratio of organically-bound 3H to free water 3H in polished rice samples collected in Japan and China was lower than unity. Their paper was the first to report the systematic apparent elimination of 3H for incorporation to organically-bound form in samples ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.32.389
更新日期:1991-12-01 00:00:00
abstract::The aim of this study is to demonstrate the feasibility of estimating the strength of the moving radiation source during patient implantation. The requirement for the counting time was investigated by comparing the results of the measurements for the static source with those for the source moving at 2, 5, 10 and 20 cm...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt087
更新日期:2014-01-01 00:00:00
abstract::A biological dosimetry system for measuring solar UV-B light was established using bacteriophage T1 with E. coli Bs-1 as the host cell. Also a new physical UV-B dosimeter was developed which can specifically detect the UV spectral region related to inactivation of phage T1. Phage T1 is very stable in liquid suspension...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.31.189
更新日期:1990-06-01 00:00:00
abstract::The purpose of this study was to assess the toxicity and efficacy of multimodal approaches, including three-dimensional conformal re-irradiation, for patients with recurrent or persistent esophageal cancer after radiotherapy. Thirty-one patients with esophageal cancer treated with three-dimensional conformal re-irradi...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.11066
更新日期:2011-01-01 00:00:00
abstract::We examined the use of the mouse Pc-3 ESTR (expanded simple tandem repeat) locus and 72 human microsatellite loci as potentially sensitive biomarkers for mutagenic exposures to germ cells in mice and humans respectively. In the mouse work, we treated male mice with TCDD (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin; a chemi...
journal_title:Journal of radiation research
pub_type: 历史文章,杂志文章
doi:10.1269/jrr.47.b31
更新日期:2006-01-01 00:00:00
abstract::Low-doses of irradiation have been reported to have beneficial effects, particularly anti-tumor effects. In this paper, we show the effects of the low-dose irradiation on T cell activation induced by dendritic cells (DCs). DCs, which had been pre-irradiated at 0.02-1.0 Gy from a (137)Cs source, were cultured with allo...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.06048
更新日期:2007-01-01 00:00:00
abstract::The purpose of this review was to evaluate the impact of epidermal growth factor receptor (EGFR) mutation status on disease recurrence in patients treated with chemoradiotherapy (CRT) for locally advanced non-small cell lung cancer (NSCLC). A literature search was conducted and a total of three studies were analyzed. ...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1093/jrr/rrw075
更新日期:2016-09-01 00:00:00
abstract::The prognosis and treatment of thyroid cancer depends on the type and stage of the disease. Radiosensitivity differs among cancer cells owing to their varying capacity for repair after irradiation. Radioactive iodine can be used to destroy thyroid cancer cells. However, patient prognosis and improvement after irradiat...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rry097
更新日期:2019-03-01 00:00:00
abstract::This retrospective analysis focusses on the impact of therapy on perceived long-term post-cancer treatment function. A validated questionnaire including items and components for the assessment of communicative ability, quality of voice and swallowing was sent to 129 patients. All patients were treated between 1998 and...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru093
更新日期:2015-01-01 00:00:00
abstract::This study was to investigate whether rhEGF protects radiation induced intestine injury without compromising antitumor effect of radiation in murine system. A radiation induced intestinal injury model was established in mice by whole body irradiation. Using this model, 4 groups were set; control, rhEGF (100 µg/kg intr...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.09145
更新日期:2010-01-01 00:00:00
abstract::Radiotherapy-induced toxicity is a major dose-limiting factor in anti-cancer treatment. Ionizing radiation leads to the formation of reactive oxygen and nitrogen species (ROS/RNS) that are associated with radiation-induced cell death. Investigations of biological effects of fullerenol have provided evidence for its RO...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.07092
更新日期:2008-05-01 00:00:00
abstract::An interest in the possible cancer causing ability of neutrons began soon after their discovery. Early use of neutrons from radioactive sources and from cyclotrons led to a need to define risk for such exposures. This need was soon followed by a more tangible need to define risk to the general population of high LET r...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.40.s117
更新日期:1999-12-01 00:00:00
abstract::The radioprotective effect of hawthorn (Crataegus microphylla) fruit extract against genotoxicity induced by gamma irradiation has been investigated in mouse bone marrow cells. A single intraperitoneal (ip) administration of hawthorn extract at doses of 25, 50, 100 and 200 mg/kg 1h prior to gamma irradiation (2 Gy) re...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.06032
更新日期:2007-01-01 00:00:00
abstract::In this report we update our long-term follow-up results of the prospective study whose aim was to evaluate the efficacy of high-dose-rate (HDR) brachytherapy in combination with external-beam radiotherapy (EBRT) in the treatment of medically inoperable endometrial cancer. Between 1995 and 1998, 29 patients with stage...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.10080
更新日期:2010-01-01 00:00:00
abstract::Reassessment of gamma-ray doses from the atomic bombs in Hiroshima and Nagasaki has been carried out with the thermoluminescent measurements of bricks and decorative tiles which were collected from the buildings that remain as they were at the time of the explosions. The thermoluminescent measurements were performed u...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.32.supplement_40
更新日期:1991-03-01 00:00:00
abstract::This study proposes a quality assurance (QA) method incorporating radiobiological factors based on the QUANTEC-determined tumor control probability and the normal tissue complication probability (NTCP) of head-and-neck intensity-modulated radiation therapy (HN-IMRT). Per-beam measurements were conducted for 20 cases u...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx017
更新日期:2017-09-01 00:00:00
abstract::The quality of the sublethal damage (SLD) after irradiation with high-linear energy transfer (LET) ion beams was investigated with low-LET photons. Chinese hamster V79 cells and human squamous carcinoma SAS cells were first exposed to a priming dose of different ion beams at different LETs at the Heavy Ion Medical Acc...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx030
更新日期:2017-11-01 00:00:00
abstract::Thyroid cells were given 5.5 Gy X-rays in situ and transplanted after 1 day or after 6 weeks to form colonies in fat pads. The colony-forming efficiency unexpectedly decreased by a factor of about 2 with this increase in delay time before transplantation. In addition, there was a concomitant marked increase above the ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.35.116
更新日期:1994-06-01 00:00:00
abstract::Since December 2009, after breast-conserving surgery for Stage 0-I cancer of the left breast, 21 women with relatively pendulous breasts underwent computed tomography prone and supine simulations. The adjuvant radiotherapy was 50 Gy in 25 fractions to the left breast alone. Four plans--conventional wedged tangents and...
journal_title:Journal of radiation research
pub_type: 临床试验,杂志文章
doi:10.1093/jrr/rrt019
更新日期:2013-09-01 00:00:00
abstract::Exposure to ionizing radiation leads to severe damages in radiosensitive organs and induces acute radiation syndrome, including effects on the hematopoietic system and gastrointestinal system. In this study, the radioprotective ability of KMRC011, a novel toll-like receptor 5 (TLR5) agonist, was investigated in C57BL6...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrz024
更新日期:2019-07-01 00:00:00
abstract::The effect of gamma-irradiation on a major nutritional function of the yolk sac (the uptake and digestion of macromolecular materials) was studied in rat visceral yolk sacs cultured in vitro being used 125I-labeled bovine serum albumin (RISA) as the tracer protein. The uptake of RISA (per g wet weight) by rat yolk sac...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.34.171
更新日期:1993-06-01 00:00:00
abstract::There is an urgent need to develop non-toxic radioprotectors. We tested the efficacy of a 3-drug combination (3-DC) of iloprost, misoprostol, and 3D-MPL (3-deacylated monophosphoryl lipid A) and the effects of postirradiation clinical support with high doses of antibiotics and blood transfusion. Canines were given 3-D...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.43.361
更新日期:2002-12-01 00:00:00