Long-term results of high-dose-rate brachytherapy and external-beam radiotherapy in the primary treatment of endometrial cancer.


:In this report we update our long-term follow-up results of the prospective study whose aim was to evaluate the efficacy of high-dose-rate (HDR) brachytherapy in combination with external-beam radiotherapy (EBRT) in the treatment of medically inoperable endometrial cancer. Between 1995 and 1998, 29 patients with stages I-III medically inoperable carcinoma of endometrium were treated with definitive irradiation. All patients underwent combined intracavitary HDR brachytherapy and EBRT. The EBRT dose was 50 Gy with midline shield from 16 Gy. The HDR brachytherapy dose was 50 Gy, delivered in 5 fractions in a weekly schedule. Overall survival (OS) at 5 and 10 years was 48.3% and 20.7%, respectively. Disease-specific survival (DSS) at 5 and 10 years was 73.5% and 67.9%, respectively. The 10-year DSS rate was 73.5% for all stages, 85.7% for Stage I disease, 71.4% for Stage II, and 16.7% for stage III disease. Late Grade 1-2 radiation complications were observed in 4 patients (13.8%). Our long-term follow-up confirms that HDR brachytherapy with EBRT appears to be an effective and safe treatment for stage I and II medically inoperable endometrial cancer.


J Radiat Res


Inciura A,Atkocius V,Juozaityte E,Vaitkiene D




Has Abstract


2010-01-01 00:00:00














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    abstract::The 239Pu distribution in the 12.5-day-old rat conceptus was compared between in vivo and in vitro experimental systems to establish a possible mechanism of cross-placental transfer of this radionuclide. In the in vivo study, plutonium citrate solution was injected intravenously to pregnant Wistar rats. In the in vitr...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Takahashi S,Sato H,Kubota Y,Inaba J

    更新日期:1992-12-01 00:00:00

  • Analysis of inter- and intrafraction accuracy of a commercial thermoplastic mask system used for image-guided particle radiation therapy.

    abstract::The present paper reports and discusses the results concerning both the inter- and intrafraction accuracy achievable combining the immobilization system employed in patients with head-and-neck, brain and skull base tumors with image guidance at our particle therapy center. Moreover, we investigated the influence of in...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Amelio D,Winter M,Habermehl D,Jäkel O,Debus J,Combs SE

    更新日期:2013-07-01 00:00:00

  • Investigation of whether in-room CT-based adaptive intracavitary brachytherapy for uterine cervical cancer is robust against interfractional location variations of organs and/or applicators.

    abstract::This study investigates whether in-room computed tomography (CT)-based adaptive treatment planning (ATP) is robust against interfractional location variations, namely, interfractional organ motions and/or applicator displacements, in 3D intracavitary brachytherapy (ICBT) for uterine cervical cancer. In ATP, the radiat...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Oku Y,Arimura H,Nguyen TT,Hiraki Y,Toyota M,Saigo Y,Yoshiura T,Hirata H

    更新日期:2016-11-01 00:00:00

  • A questionnaire-based survey on 3D image-guided brachytherapy for cervical cancer in Japan: advances and obstacles.

    abstract::The purpose of this study is to survey the current patterns of practice, and barriers to implementation, of 3D image-guided brachytherapy (3D-IGBT) for cervical cancer in Japan. A 30-item questionnaire was sent to 171 Japanese facilities where high-dose-rate brachytherapy devices were available in 2012. In total, 135 ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Ohno T,Toita T,Tsujino K,Uchida N,Hatano K,Nishimura T,Ishikura S

    更新日期:2015-11-01 00:00:00

  • Salvage radiotherapy after radical prostatectomy: outcomes and prognostic factors especially focusing on pathological findings.

    abstract::External beam radiotherapy is a potential salvage or adjuvant therapy after radical prostatectomy (RP). The purpose of this study was to investigate the treatment outcome of salvage radiotherapy (RT) following RP for clinically localized prostate cancer and to identify factors that may predict the outcome of salvage R...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Hayashi S,Hayashi K,Yoshimura R,Masuda H,Kihara K,Shibuya H

    更新日期:2012-09-01 00:00:00

  • The role of nitric oxide radicals in removal of hyper-radiosensitivity by priming irradiation.

    abstract::In this study, a mechanism in which low-dose hyper-radiosensitivity (HRS) is permanently removed, induced by low-dose-rate (LDR) (0.2-0.3 Gy/h for 1 h) but not by high-dose-rate priming (0.3 Gy at 40 Gy/h) was investigated. One HRS-negative cell line (NHIK 3025) and two HRS-positive cell lines (T-47D, T98G) were used....

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Edin NJ,Sandvik JA,Vollan HS,Reger K,Görlach A,Pettersen EO

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  • Individuals' leukocyte DNA double-strand break repair as an indicator of radiosurgery responses for cerebral arteriovenous malformations.

    abstract::To evaluate the feasibility of using radiosensitivity of peripheral leukocytes as a predictor of clinical therapeutic responses to radiosurgery in individuals with cerebral arteriovenous malformation (AVM), we enrolled 18 patients years after they had received Gamma Knife radiosurgery for their cerebral AVM. The AVMs ...

    journal_title:Journal of radiation research

    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:2004-06-01 00:00:00

  • Dosimetric impact of an air passage on intraluminal brachytherapy for bronchus cancer.

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    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Okamoto H,Wakita A,Nakamura S,Nishioka S,Aikawa A,Kato T,Abe Y,Kobayashi K,Inaba K,Murakami N,Itami J

    更新日期:2016-11-01 00:00:00

  • Protective activity of a novel resveratrol analogue, HS-1793, against DNA damage in 137Cs-irradiated CHO-K1 cells.

    abstract::Resveratrol has received considerable attention as a polyphenol with anti-oxidant, anti-carcinogenic, and anti-inflammatory effects. Radiation is an important component of therapy for a wide range of malignant conditions. However, it causes damage to normal cells and, hence, can result in adverse side effects. This st...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Jeong MH,Yang KM,Jeong DH,Lee CG,Oh SJ,Jeong SK,Lee KW,Jo YR,Jo WS

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  • High frequency of leukemic lymphomas with osteosarcomas but no myeloid leukemias in C3H mice after 239Pu citrate injection.

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    journal_title:Journal of radiation research

    pub_type: 杂志文章


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    更新日期:1997-06-01 00:00:00

  • PU-H71, a novel Hsp90 inhibitor, as a potential cancer-specific sensitizer to carbon-ion beam therapy.

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    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Li HK,Matsumoto Y,Furusawa Y,Kamada T

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  • Disappearance of nuclear binding proteins specifically bound to the upstream region of the interleukin-1beta gene immediately after irradiation of mouse macrophages.

    abstract::Immediately after X-irradiation, monocytic cells can express the gene for interleukin (IL)-1beta, which enhances inflammation and contributes to radioprotection in mice. In order to analyze the mechanism(s) for the immediate-early induction of IL-1beta after X-irradiation at 20 Gy in cultured murine macrophages, we ex...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Ishihara H,Tanaka I,Wan H,Cheeramakara C

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  • Influence of seed extract of Syzygium Cumini (Jamun) on mice exposed to different doses of gamma-radiation.

    abstract::The radioprotective activity of the hydroalcoholic extract of jamun seeds (SCE) was studied in mice exposed to different doses of gamma radiation. The mice were injected with 0, 5, 10, 20, 40, 60, 80, 100, 120, 140 or 160 mg/kg body weight of SCE, before exposure to 10 Gy of gamma radiation, to select the optimum dose...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Jagetia GC,Baliga MS,Venkatesh P

    更新日期:2005-03-01 00:00:00

  • Anti-radiation damage effect of polyethylenimine as a toll-like receptor 5 targeted agonist.

    abstract::A number of agents are now available for use in protecting against ionizing radiation. These radiation-protective agents, however, have many adverse effects. Efforts have been made to develop new radiation-protective agents for medical application. Here, we investigated whether a compound, polyethylenimine (PEI), whic...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Hu Z,Xing Y,Qian Y,Chen X,Tu J,Ren L,Wang K,Chen Z

    更新日期:2013-03-01 00:00:00

  • Tritium concentration in unpolished rice.

    abstract::Inoue and Iwakura recently reported that the specific activity ratio of organically-bound 3H to free water 3H in polished rice samples collected in Japan and China was lower than unity. Their paper was the first to report the systematic apparent elimination of 3H for incorporation to organically-bound form in samples ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Hisamatsu S,Katsumata T,Takizawa Y

    更新日期:1991-12-01 00:00:00

  • Role of isolated and clustered DNA damage and the post-irradiating repair process in the effects of heavy ion beam irradiation.

    abstract::Clustered DNA damage is a specific type of DNA damage induced by ionizing radiation. Any type of ionizing radiation traverses the target DNA molecule as a beam, inducing damage along its track. Our previous study showed that clustered DNA damage yields decreased with increased linear energy transfer (LET), leading us ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Tokuyama Y,Furusawa Y,Ide H,Yasui A,Terato H

    更新日期:2015-05-01 00:00:00

  • Radiation chemical studies on thermosensitive N-isopropylacrylamide and its polymer in aqueous solutions.

    abstract::The pulse radiolysis technique has been employed to determine the initiation and propagation rates of different transient species involved in the polymerization of N-isopropylacrylamide (NIPA) in aqueous solutions. Polymerization by anionic mechanism has been observed to be faster than by the free-radical mechanism. T...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Acharya A,Mohan H,Sabharwal S

    更新日期:2003-12-01 00:00:00

  • Radiobiology of hypofractionated stereotactic radiotherapy: what are the optimal fractionation schedules?

    abstract::In hypofractionated stereotactic radiotherapy (SRT), high doses per fraction are usually used and the dose delivery pattern is different from that of conventional radiation. The daily dose is usually given intermittently over a longer time compared with conventional radiotherapy. During prolonged radiation delivery, s...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审


    authors: Shibamoto Y,Miyakawa A,Otsuka S,Iwata H

    更新日期:2016-08-01 00:00:00

  • Effect of N-acetylcysteine on radiation-induced genotoxicity and cytotoxicity in rat bone marrow.

    abstract::The aim of this study is to evaluate the potential radioprotective effects of N-acetylcysteine (NAC) against genotoxicity and cytotoxicity. The effect of WR-2721, as a representative of clinically used radioprotector, was compared with that of NAC, using the chromosomal aberration (CA) and micronucleus (MN) test syste...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Demirel C,Kilçiksiz S,Ay OI,Gürgül S,Ay ME,Erdal N

    更新日期:2009-01-01 00:00:00

  • Changes in normal and abnormal colony formation of thyroid cells in vivo, when transplanted at 1 day or 6 weeks after X-irradiation in situ.

    abstract::Thyroid cells were given 5.5 Gy X-rays in situ and transplanted after 1 day or after 6 weeks to form colonies in fat pads. The colony-forming efficiency unexpectedly decreased by a factor of about 2 with this increase in delay time before transplantation. In addition, there was a concomitant marked increase above the ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Watanabe H,Hendry JH

    更新日期:1994-06-01 00:00:00

  • Radon inhalation induces manganese-superoxide dismutase in mouse brain via nuclear factor-κB activation.

    abstract::Although radon inhalation increases superoxide dismutase (SOD) activities in mouse organs, the mechanisms and pathways have not yet been fully clarified. The aim of this study was to determine the details of SOD activation in mouse brain tissue following the inhalation of radon at concentrations of 500 or 2000 Bq/m3 f...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Kataoka T,Etani R,Kanzaki N,Kobashi Y,Yunoki Y,Ishida T,Sakoda A,Ishimori Y,Yamaoka K

    更新日期:2017-11-01 00:00:00

  • Monte Carlo modeling in CT-based geometries: dosimetry for biological modeling experiments with particle beam radiation.

    abstract::The space radiation environment imposes increased dangers of exposure to ionizing radiation, particularly during a solar particle event (SPE). These events consist primarily of low energy protons that produce a highly inhomogeneous dose distribution. Due to this inherent dose heterogeneity, experiments designed to inv...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Diffenderfer ES,Dolney D,Schaettler M,Sanzari JK,McDonough J,Cengel KA

    更新日期:2014-03-01 00:00:00

  • The role of interleukin-13 in the removal of hyper-radiosensitivity by priming irradiation.

    abstract::It has previously been demonstrated that the presence of fetal bovine serum is necessary for TGF-β3 (transforming growth factor beta 3)-dependent elimination of low-dose hyper-radiosensitivity (HRS) in cells by 1 h of low-dose-rate γ-irradiation (0.2-0.3 Gy/h). The purpose of the present study was to identify the seru...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Edin NF

    更新日期:2014-11-01 00:00:00

  • Occurrence and clinical features of brain metastasis after chemoradiotherapy for esophageal carcinoma.

    abstract::Brain metastasis from esophageal carcinoma has been considered rare and survival following esophageal carcinoma with distant metastasis is poor. The purpose of this report was to clarify cumulative incidence and risk factors for brain metastasis after chemoradiotherapy for esophageal carcinoma, and to consider recomme...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Kanemoto A,Hashimoto T,Harada H,Asakura H,Ogawa H,Furutani K,Boku N,Nakasu Y,Nishimura T

    更新日期:2011-01-01 00:00:00

  • 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) sensitizes mammalian cells to UV radiation by causing the S-phase arrest, not by inhibiting the repair of DNA damage as observed in Escherichia coli.

    abstract::3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) is known to be a mutagen and carcinogen isolated from the charred parts of cooked foods. We found previously that Trp-P-1 enhanced UV-induced lethality and mutation frequency in Escherichia coli by inhibiting the repair of UV-induced DNA damage. In the present stud...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Mori T,Nakagawa A,Kobayashi N,Hashimoto MW,Wakabayashi K,Shimoi K,Kinae N

    更新日期:1998-03-01 00:00:00

  • Plutonium behavior after pulmonary administration according to solubility properties, and consequences on alveolar macrophage activation.

    abstract::The physico-chemical form in which plutonium enters the body influences the lung distribution and the transfer rate from lungs to blood. In the present study, we evaluated the early lung damage and macrophage activation after pulmonary contamination of plutonium of various preparation modes which produce different sol...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Van der Meeren A,Gremy O,Renault D,Miroux A,Bruel S,Griffiths N,Tourdes F

    更新日期:2012-01-01 00:00:00

  • Radioprotective effects of Sipunculus nudus L. polysaccharide combined with WR-2721, rhIL-11 and rhG-CSF on radiation-injured mice.

    abstract::This study investigated the radioprotective effect of Sipunculus nudus L. polysaccharide (SNP) in combination with WR-2721, rhIL-11 and rhG-CSF on irradiated mice. A total of 70 Imprinting Control Region (ICR) mice were divided into seven groups: the control group, the model group and five administration groups. All g...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Jiang S,Shen X,Liu Y,He Y,Jiang D,Chen W

    更新日期:2015-05-01 00:00:00

  • Mutational effects of γ-rays and carbon ion beams on Arabidopsis seedlings.

    abstract::To assess the mutational effects of radiation on vigorously proliferating plant tissue, the mutation spectrum was analyzed with Arabidopsis seedlings using the plasmid-rescue method. Transgenic plants containing the Escherichia coli rpsL gene were irradiated with γ-rays and carbon ion beams (320-MeV (12)C(6+)), and mu...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Yoshihara R,Nozawa S,Hase Y,Narumi I,Hidema J,Sakamoto AN

    更新日期:2013-11-01 00:00:00

  • Public health activities for mitigation of radiation exposures and risk communication challenges after the Fukushima nuclear accident.

    abstract::Herein we summarize the public health actions taken to mitigate exposure of the public to radiation after the Fukushima accident that occurred on 11 March 2011 in order to record valuable lessons learned for disaster preparedness. Evacuations from the radiation-affected areas and control of the distribution of various...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审


    authors: Shimura T,Yamaguchi I,Terada H,Robert Svendsen E,Kunugita N

    更新日期:2015-05-01 00:00:00

  • Clinical outcomes for 61 cases of hypopharyngeal cancer with synchronous esophageal cancer.

    abstract::The aim of this research was to provide data from a single-center study of the treatment of synchronous hypopharyngeal cancer (HPC) and esophageal cancer (EC) with different treatment modalities. A total of 61 patients with synchronous HPC and EC were included in this study. Patients were treated with radiotherapy/che...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Yang S,Yang S,Liao W,Huang R,Li B,Lu S,Li C,Wang Z,Li C,Pei J,Wen H,Zhang S

    更新日期:2019-10-23 00:00:00