当前位置： SCI文献检索 > JOURNAL OF RADIATION RESEARCH期刊下所有文献 > Stereotactic body radiation therapy for early-stage non-small-cell lung cancer in octogenarians and older: an alternative treatment.

Stereotactic body radiation therapy for early-stage non-small-cell lung cancer in octogenarians and older: an alternative treatment.

Abstract：

:Surgery is the standard modality for early-stage I-II non-small-cell lung cancer (NSCLC). Generally, patients who are >80 years old tend to have more comorbidities and inferior physical status than younger patients. Stereotactic body radiation therapy (SBRT) may provide an alternative treatment for this group of patients. Here, we report our experience using SBRT to in the management of early-stage NSCLC in patients >80 years old. Patients aged ≥80 years old who were diagnosed with early-stage NSCLC and treated with definitive lung SBRT from January 2000 to January 2018 were retrospectively analysed. Local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS), cancer-specific survival (CSS), progression-free survival (PFS), overall survival (OS) and treatment-related toxicities were analysed for patients >80 years old. A total of 153 patients were included, with a median age of 85 years (range, 80-94). The median follow-up period and OS was 39.8 months (range, 10-101 months) and 76 months, respectively. The 3-year OS, PFS, CSS, RRFS and LRFS were 65.3, 58.0, 75.7, 73.9 and 85.3%, respectively. Radiation pneumonitis grade 0-1, grade 2, grade 3 and grade 4 was observed in 135 (88.2%), 13 (8.5%), 4 (2.61%) and 1 (0.6%) patient(s), respectively. On multivariate analyses, tumor size, pretreatment C-reactive protein (CRP) value, histology and pretreatment physical state were significantly associated with OS. Definitive lung SBRT appears to have high LRFS and OS without causing high-grade radiation-related toxicities in early-stage NSCLC patients who were >80 years old.

journal_name

J Radiat Res

journal_title

Journal of radiation research

authors

Bei Y,Murakami N,Nakayama Y,Okuma K,Kashihara T,Raturi VP,Okamoto H,Takahashi K,Inaba K,Igaki H,Itami J

doi

10.1093/jrr/rraa027

subject

Has Abstract

pub_date

2020-07-06 00:00:00

pages

586-593

issue

4

eissn

0449-3060

issn

1349-9157

pii

5834370

journal_volume

61

pub_type

杂志文章

相关文献

JOURNAL OF RADIATION RESEARCH文献大全
  • Exposure rate as a determinant of the synergistic interaction of heat combined with ionizing or ultraviolet radiation in cell killing.

    abstract：:A synergistic interaction of hyperthermia with ionizing or UV light (254 nm) radiation was analyzed in experiments with yeast cells. For a fixed dose rate of radiation, the synergism was shown to be observed only within a definite temperature range (40-45 degrees C), inside of which there was an optimal temperature to...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.42.361

    authors： Kim JK,Petin VG,Zhurakovskaya GP

    更新日期：2001-12-01 00:00:00

  • PCC-ring induction in human lymphocytes exposed to gamma and neutron irradiation.

    abstract：:In case of an accidental overexposure to ionizing radiation where the dose received by the victim is over 5 Gy, the conventional biological indicator of dose, the dicentric assay, does not provide an accurate enough dose measurement. A more appropriate technique is to measure ring chromosomes in stimulated lymphocytes...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.0625

    authors： Lamadrid AI,García O,Delbos M,Voisin P,Roy L

    更新日期：2007-01-01 00:00:00

  • Evaluation of effective dose for a patient under Ga-67 nuclear examination using TLD, water phantom and a simplified model.

    abstract：:This study evaluated the effective dose of Ga-67 for a patient undergoing Ga-67 citrate nuclear examination by applying thermoluminescent dosimeter (TLD) technique and an indigenous water phantom. The Ga-67 radionuclide remaining in the body inevitably generated a measurable internal dose even though gamma camera scan...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrs050

    authors： Chu KH,Lin YT,Hsu CC,Chen CY,Pan LK

    更新日期：2012-11-01 00:00:00

  • Cancer mortality in residents of the terrain-shielded area exposed to fallout from the Nagasaki atomic bombing.

    abstract：:The health effects of radiation exposure from the atomic bomb fallout remain unclear. The objective of the present study is to elucidate the association between low-dose radiation exposure from the atomic bomb fallout and cancer mortality among Nagasaki atomic bomb survivors. Of 77 884 members in the Nagasaki Universi...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrx047

    authors： Yokota K,Mine M,Kondo H,Matsuda N,Shibata Y,Takamura N

    更新日期：2018-01-01 00:00:00

  • Long-term results of high-dose-rate brachytherapy and external-beam radiotherapy in the primary treatment of endometrial cancer.

    abstract：:In this report we update our long-term follow-up results of the prospective study whose aim was to evaluate the efficacy of high-dose-rate (HDR) brachytherapy in combination with external-beam radiotherapy (EBRT) in the treatment of medically inoperable endometrial cancer. Between 1995 and 1998, 29 patients with stage...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.10080

    authors： Inciura A,Atkocius V,Juozaityte E,Vaitkiene D

    更新日期：2010-01-01 00:00:00

  • Analysis of liver damage from radon, X-ray, or alcohol treatments in mice using a self-organizing map.

    abstract：:In our previous studies, we found that low-dose radiation inhibits oxidative stress-induced diseases due to increased antioxidants. Although these effects of low-dose radiation were demonstrated, further research was needed to clarify the effects. However, the analysis of oxidative stress is challenging, especially th...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrw083

    authors： Kanzaki N,Kataoka T,Etani R,Sasaoka K,Kanagawa A,Yamaoka K

    更新日期：2017-01-01 00:00:00

  • Effect of a hypoxic cell sensitizer doranidazole on the radiation-induced apoptosis of mouse L5178Y lymphoma cells.

    abstract：:We investigated the sensitizing effect of the 2-nitroimidazole analogue doranidazole, a new hypoxic radiosensitizer, on radiation-induced apoptosis in L5178Y cells. Apoptosis was assessed by checking DNA ladder formation, the presence of sub-G1 peaks in flow cytometry, and chromatin condensation. A radiosensitizing ef...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.43.161

    authors： Aoki M,Furusawa Y,Shibamoto Y,Kobayashi A,Tsujitani M

    更新日期：2002-06-01 00:00:00

  • Radiation-induced bystander effect in non-irradiated glioblastoma spheroid cells.

    abstract：:Radiation-induced bystander effects (RIBEs) are detected in cells that are not irradiated but receive signals from treated cells. The present study explored these bystander effects in a U87MG multicellular tumour spheroid model. A medium transfer technique was employed to induce the bystander effect, and colony format...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrv039

    authors： Faqihi F,Neshastehriz A,Soleymanifard S,Shabani R,Eivazzadeh N

    更新日期：2015-09-01 00:00:00

  • Preliminary survey of 3D image-guided brachytherapy for cervical cancer at representative hospitals in Asian countries.

    abstract：:3D image-guided brachytherapy (3D-IGBT) has become a standard therapy for cervical cancer. However, the use of 3D-IGBT is limited in East and Southeast Asia. This study aimed to clarify the current usage patterns of 3D-IGBT for cervical cancer in East and Southeast Asia. A questionnaire-based survey was performed in 1...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rraa025

    authors： Okonogi N,Wakatsuki M,Mizuno H,Fukuda S,Cao J,Kodrat H,Lau FN,Calaguas MJ,de Los Reyes RH,Chansilpa Y,Uddin AFMK,Adylkhanov T,Cho CK,Tsegmed U,Hoang NC,Ohno T,Nakano T,Kato S,Forum for Nuclear Cooperation in Asia.

    更新日期：2020-07-06 00:00:00

  • Cost-effectiveness analysis of cochlear dose reduction by proton beam therapy for medulloblastoma in childhood.

    abstract：BACKGROUND:The aim of this study is to evaluate the cost-effectiveness of proton beam therapy with cochlear dose reduction compared with conventional X-ray radiotherapy for medulloblastoma in childhood. METHODS:We developed a Markov model to describe health states of 6-year-old children with medulloblastoma after trea...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrt112

    authors： Hirano E,Fuji H,Onoe T,Kumar V,Shirato H,Kawabuchi K

    更新日期：2014-03-01 00:00:00

  • Radon inhalation induces manganese-superoxide dismutase in mouse brain via nuclear factor-κB activation.

    abstract：:Although radon inhalation increases superoxide dismutase (SOD) activities in mouse organs, the mechanisms and pathways have not yet been fully clarified. The aim of this study was to determine the details of SOD activation in mouse brain tissue following the inhalation of radon at concentrations of 500 or 2000 Bq/m3 f...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrx048

    authors： Kataoka T,Etani R,Kanzaki N,Kobashi Y,Yunoki Y,Ishida T,Sakoda A,Ishimori Y,Yamaoka K

    更新日期：2017-11-01 00:00:00

  • Neutron carcinogenesis: past, present, and future.

    abstract：:An interest in the possible cancer causing ability of neutrons began soon after their discovery. Early use of neutrons from radioactive sources and from cyclotrons led to a need to define risk for such exposures. This need was soon followed by a more tangible need to define risk to the general population of high LET r...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.40.s117

    authors： Hill CK,Williams-Hill D

    更新日期：1999-12-01 00:00:00

  • Radiobiology of hypofractionated stereotactic radiotherapy: what are the optimal fractionation schedules?

    abstract：:In hypofractionated stereotactic radiotherapy (SRT), high doses per fraction are usually used and the dose delivery pattern is different from that of conventional radiation. The daily dose is usually given intermittently over a longer time compared with conventional radiotherapy. During prolonged radiation delivery, s...

    journal_title：Journal of radiation research

    pub_type： 杂志文章,评审

    doi：10.1093/jrr/rrw015

    authors： Shibamoto Y,Miyakawa A,Otsuka S,Iwata H

    更新日期：2016-08-01 00:00:00

  • Effects of low-dose irradiation on enhancement of immunity by dendritic cells.

    abstract：:Low-doses of irradiation have been reported to have beneficial effects, particularly anti-tumor effects. In this paper, we show the effects of the low-dose irradiation on T cell activation induced by dendritic cells (DCs). DCs, which had been pre-irradiated at 0.02-1.0 Gy from a (137)Cs source, were cultured with allo...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.06048

    authors： Shigematsu A,Adachi Y,Koike-Kiriyama N,Suzuki Y,Iwasaki M,Koike Y,Nakano K,Mukaide H,Imamura M,Ikehara S

    更新日期：2007-01-01 00:00:00

  • Acquired radioresistance after low dose X-irradiation in mice.

    abstract：:Low doses (2.5-15 cGy) of X-irradiation two months prior to a second exposure to a sublethal dose enhanced the survival rate in mice. Optimal and significant increase was observed with 5-10 cGy. Endogenous spleen colony counts (endo-CFUs) after 7 Gy increased by a factor of about 1.7 in mice pre-irradiated with 5-10 c...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.31.256

    authors： Yonezawa M,Takeda A,Misonoh J

    更新日期：1990-09-01 00:00:00

  • Application of a newly developed photoluminescence glass dosimeter for measuring the absorbed dose in individual mice exposed to low-dose rate 137Cs gamma-rays.

    abstract：:A photoluminescence glass dosimeter, GD-301, was applied to the measurement of low absorbed doses in mice exposed to low-dose rate 137Cs gamma-rays. The dosimeter system consists of small rod-shaped glass chip detectors capable of embedded in the body of a mouse and an automatic readout device equipped with a standard...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.41.129

    authors： Hoshi Y,Nomura T,Oda T,Iwasaki T,Fujita K,Ishikawa T,Kato A,Ikegami T,Sakai K,Tanooka H,Yamada T

    更新日期：2000-06-01 00:00:00

  • A novel combination treatment of armed oncolytic adenovirus expressing IL-12 and GM-CSF with radiotherapy in murine hepatocarcinoma.

    abstract：:In this study, a novel combination treatment of armed oncolytic adenovirus expressing interleukin 12 (IL-12) and granulocyte-macrophage colony-stimulating factor (GM-CSF) with radiation was investigated for antitumor and antimetastatic effect in a murine hepatic cancer (HCa-I) model. Tumor bearing syngeneic mice were ...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.10185

    authors： Kim W,Seong J,Oh HJ,Koom WS,Choi KJ,Yun CO

    更新日期：2011-01-01 00:00:00

  • Fullerenol C60(OH)24 effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line.

    abstract：:Radiotherapy-induced toxicity is a major dose-limiting factor in anti-cancer treatment. Ionizing radiation leads to the formation of reactive oxygen and nitrogen species (ROS/RNS) that are associated with radiation-induced cell death. Investigations of biological effects of fullerenol have provided evidence for its RO...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.07092

    authors： Bogdanović V,Stankov K,Icević I,Zikic D,Nikolić A,Solajić S,Djordjević A,Bogdanović G

    更新日期：2008-05-01 00:00:00

  • Role of PARP1 regulation in radiation-induced rescue effect.

    abstract：:Radiation-induced rescue effect (RIRE) in cells refers to the phenomenon where irradiated cells (IRCs) receive help from feedback signals produced by partnered bystander unirradiated cells (UIRCs) or from the conditioned medium (CM) that has previously conditioned the UIRCs. In the present work, we explored the role o...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rraa023

    authors： Pathikonda S,Cheng SH,Yu KN

    更新日期：2020-05-22 00:00:00

  • Dosimetric and geometric evaluation of the use of deformable image registration in adaptive intensity-modulated radiotherapy for head-and-neck cancer.

    abstract：:The aim of this study was to carry out geometric and dosimetric evaluation of the usefulness of a deformable image registration algorithm utilized for adaptive head-and-neck intensity-modulated radiotherapy. Data consisted of seven patients, each with a planning CT (pCT), a rescanning CT (ReCT) and a cone beam CT (CBC...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rru044

    authors： Eiland RB,Maare C,Sjöström D,Samsøe E,Behrens CF

    更新日期：2014-09-01 00:00:00

  • Differential activation of kinases in ex vivo and in vivo irradiated mice lymphocytes.

    abstract：:Various kinases, such as tyrosine, protein kinase C (PKC) and MAP kinase, play important role in the cellular response to radiation, but little is known about the specific response in the whole animal. Most studies, except a few, are based on single cells. There is a paucity of data where signaling following whole bod...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.45.127

    authors： Varadkar PA,Krishna M

    更新日期：2004-03-01 00:00:00

  • Influence of seed extract of Syzygium Cumini (Jamun) on mice exposed to different doses of gamma-radiation.

    abstract：:The radioprotective activity of the hydroalcoholic extract of jamun seeds (SCE) was studied in mice exposed to different doses of gamma radiation. The mice were injected with 0, 5, 10, 20, 40, 60, 80, 100, 120, 140 or 160 mg/kg body weight of SCE, before exposure to 10 Gy of gamma radiation, to select the optimum dose...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.46.59

    authors： Jagetia GC,Baliga MS,Venkatesh P

    更新日期：2005-03-01 00:00:00

  • Monte Carlo simulation of water radiolysis for low-energy charged particles.

    abstract：:The paper describes the development of chemical modules simulating the prechemical and chemical stages of charged particle tracks in pure liquid water. These calculations are based on our physical track structure codes for electrons and ions (KURBUC, LEPHIST and LEAHIST) which provide the initial spatial distribution ...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.47.69

    authors： Uehara S,Nikjoo H

    更新日期：2006-03-01 00:00:00

  • Tritium precipitation in European cities and in Osaka, Japan owing to the Chernobyl nuclear accident.

    abstract：:Tritium precipitations in European cities and in Osaka, Japan were analyzed before and after the Chernobyl nuclear plant accident by the time series analysis code Census IIX11 developed by US Department of Commerce Bureau of the Census. Results of this analysis showed no significant tritium precipitation was produced ...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.32.267

    authors： Koga T,Morishima H,Niwa T,Kawai H

    更新日期：1991-09-01 00:00:00

  • Interfractional change of high-risk CTV D90 during image-guided brachytherapy for uterine cervical cancer.

    abstract：:The purpose of this study was to evaluate interfractional changes of the minimum dose delivered to 90% of the high-risk clinical target volume (HR-CTV D90) and D2cc of the bladder and rectum during brachytherapy for uterine cervical cancer patients. A total of 52 patients received external beam radiotherapy and high-d...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrt073

    authors： Ohkubo Y,Ohno T,Noda SE,Kubo N,Nakagawa A,Kawahara M,Abe T,Kiyohara H,Wakatsuki M,Nakano T

    更新日期：2013-11-01 00:00:00

  • Analysis of inter- and intrafraction accuracy of a commercial thermoplastic mask system used for image-guided particle radiation therapy.

    abstract：:The present paper reports and discusses the results concerning both the inter- and intrafraction accuracy achievable combining the immobilization system employed in patients with head-and-neck, brain and skull base tumors with image guidance at our particle therapy center. Moreover, we investigated the influence of in...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrt038

    authors： Amelio D,Winter M,Habermehl D,Jäkel O,Debus J,Combs SE

    更新日期：2013-07-01 00:00:00

  • Tritium concentration in unpolished rice.

    abstract：:Inoue and Iwakura recently reported that the specific activity ratio of organically-bound 3H to free water 3H in polished rice samples collected in Japan and China was lower than unity. Their paper was the first to report the systematic apparent elimination of 3H for incorporation to organically-bound form in samples ...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.32.389

    authors： Hisamatsu S,Katsumata T,Takizawa Y

    更新日期：1991-12-01 00:00:00

  • Microdosimetric quantities of an accelerator-based neutron source used for boron neutron capture therapy measured using a gas-filled proportional counter.

    abstract：:Boron neutron capture therapy (BNCT) is an emerging radiation treatment modality, exhibiting the potential to selectively destroy cancer cells. Currently, BNCT is conducted using a nuclear reactor. However, the future trend is to move toward an accelerator-based system for use in hospital environments. A typical BNCT ...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrz101

    authors： Hu N,Tanaka H,Takata T,Okazaki K,Uchida R,Sakurai Y

    更新日期：2020-03-23 00:00:00

  • Radiation protection by disulfiram: protection of membrane and DNA in vitro and in vivo against gamma-radiation.

    abstract：:Disufiram (a drug used for the treatment of alcoholism) protected microsomal membranes and plasmid DNA against damages induced by gamma-radiation. The peroxidation of membrane lipids increased linearly with the radiation dose up to 600 Gy, and the presence of disulfiram inhibited membrane lipid peroxidation as assayed...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.44.255

    authors： Gandhi NM,Gopalaswamy UV,Nair Cr

    更新日期：2003-09-01 00:00:00

  • Hypergravity modifies the signal transduction of ionizing radiation through p53.

    abstract：:To determine the possible effect of hypergravity to modify the signal transduction of ionizing radiation, we analyzed the accumulation of p53 and the expression of p53-dependent genes, Waf-1 and Bax, using the western blot analysis. Hypergravity (20 x g) induced the accumulation of p53 in the human glioblastoma cell l...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.43.s261

    authors： Okaichi K,Usui A,Ohnishi T,Okumura Y

    更新日期：2002-12-01 00:00:00