Abstract:
:Low-doses of irradiation have been reported to have beneficial effects, particularly anti-tumor effects. In this paper, we show the effects of the low-dose irradiation on T cell activation induced by dendritic cells (DCs). DCs, which had been pre-irradiated at 0.02-1.0 Gy from a (137)Cs source, were cultured with allogeneic T cells, and the proliferation of T cells was then examined. The 0.05Gy-pre-irradiated DCs showed the highest proliferation capacity of T cells. The 0.05Gy-irradiation does not augment the expression of major histocompatibility complexes (MHCs) or costimulatory molecules on DCs, as with non-irradiated DCs or 1Gy-irradiated DCs, but does augment the production of IL-2, IL-12 and IFN-gamma DCs. These results suggest that the low-dose irradiation augments T cell-activation capacity through cytokine production by DCs, which might shift naïve helper T cells to Th1 cells.
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Shigematsu A,Adachi Y,Koike-Kiriyama N,Suzuki Y,Iwasaki M,Koike Y,Nakano K,Mukaide H,Imamura M,Ikehara Sdoi
10.1269/jrr.06048subject
Has Abstractpub_date
2007-01-01 00:00:00pages
51-5issue
1eissn
0449-3060issn
1349-9157pii
JST.JSTAGE/jrr/06048journal_volume
48pub_type
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