Fullerenol C60(OH)24 effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line.

Abstract:

:Radiotherapy-induced toxicity is a major dose-limiting factor in anti-cancer treatment. Ionizing radiation leads to the formation of reactive oxygen and nitrogen species (ROS/RNS) that are associated with radiation-induced cell death. Investigations of biological effects of fullerenol have provided evidence for its ROS/RNS scavenger properties in vitro and radioprotective efficiency in vivo. Therefore we were interested to evaluate its radioprotective properties in vitro in the human erythroleukemia cell line. Pre-treatment of irradiated cells by fullerenol exerted statistically significant effects on cell numbers and the response of antioxidative enzymes to X-ray irradiation-induced oxidative stress in cells. Our study provides evidence that the pre-treatment with fullerenol enhanced the enzymatic activity of superoxide dismutase and glutathione peroxidase in irradiated K562 cells.

journal_name

J Radiat Res

authors

Bogdanović V,Stankov K,Icević I,Zikic D,Nikolić A,Solajić S,Djordjević A,Bogdanović G

doi

10.1269/jrr.07092

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

321-7

issue

3

eissn

0449-3060

issn

1349-9157

pii

JST.JSTAGE/jrr/07092

journal_volume

49

pub_type

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