Analysis of liver damage from radon, X-ray, or alcohol treatments in mice using a self-organizing map.

abstract：:Histone H2AX undergoes phosphorylation at Ser-139 (gamma-H2AX) rapidly in response to DNA double-strand breaks (DSBs) induced by ionizing radiation. The post-translational modification of H2AX plays a central role in responses to radiation, including the repair of DSBs. Although ataxia telangiectasia mutated (ATM) kin...

journal_title：Journal of radiation research

authors： Koike M,Mashino M,Sugasawa J,Koike A

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:The aim of this study is to evaluate the cost-effectiveness of proton beam therapy with cochlear dose reduction compared with conventional X-ray radiotherapy for medulloblastoma in childhood. METHODS:We developed a Markov model to describe health states of 6-year-old children with medulloblastoma after trea...

journal_title：Journal of radiation research

authors： Hirano E,Fuji H,Onoe T,Kumar V,Shirato H,Kawabuchi K

更新日期：2014-03-01 00:00:00

abstract：:Millimeter waves are used in various fields, and the risks of this wavelength range for human health must be carefully evaluated. In this study, we investigated the effects of millimeter waves on genotoxicity and heat shock protein expression in human corneal epithelial (HCE-T) and human lens epithelial (SRA01/04) cel...

journal_title：Journal of radiation research

authors： Koyama S,Narita E,Suzuki Y,Shiina T,Taki M,Shinohara N,Miyakoshi J

更新日期：2019-07-01 00:00:00

abstract：:The purpose of this study was to analyze the clinical outcomes of simultaneous modulated accelerated radiotherapy (SMART) in patients with nasopharyngeal carcinoma (NPC). A total of 97 patients who underwent SMART for NPC between August 2005 and November 2011 were evaluated. The prescribed dose was 69.9 Gy/30 fraction...

journal_title：Journal of radiation research

authors： Tang JM,Ma XM,Hou YL,Dai LY,Cao HB,Ye M,Bai YR

更新日期：2014-07-01 00:00:00

abstract：:The expression of oncogenes was studied in 12 types of 178 mouse tumors induced by radiations and chemicals. DNA was analyzed in tumors in which the overexpression of oncogenes was noted. Amplification of the myc oncogene was found in chemically induced sarcomas, but not in sarcomas induced by radiation. Activation of...

journal_title：Journal of radiation research

authors： Niwa O,Muto M,Suzuki F,Kominami R,Yokoro K

更新日期：1991-12-01 00:00:00

abstract：:Patient A who was exposed to a critical dose of radiation developed skin lesions throughout the body surface, gastrointestinal disorder with massive diarrhea and prominent bleeding, which caused severe loss in body fluids. Gastrointestinal bleeding due to the deteriorated intestinal mucosa was considered to be one of ...

journal_title：Journal of radiation research

authors： Ishii T,Futami S,Nishida M,Suzuki T,Sakamoto T,Suzuki N,Maekawa K

更新日期：2001-09-01 00:00:00

abstract：:This study evaluated synthetic trehalose dicorynomycolate (S-TDCM), an immunomodulator, for its survival enhancing capacity and behavioral toxicity in B6D2F1 female mice. In survival experiments, mice were administered S-TDCM (25-400 micrograms/mouse i.p.) 20-24 hr before 5.6 Gy mixed-field fission-neutron irradiation...

journal_title：Journal of radiation research

authors： Landauer MR,McChesney DG,Ledney GD

更新日期：1997-03-01 00:00:00

abstract：:Neutron dose is transferred to biological materials through the recoil protons produced by elastic scattering. When a low-velocity proton collides with the atoms or molecules of a target, it changes to a hydrogen atom by electron capture; this hydrogen atom then changes to a proton by losing the electron. Because the ...

journal_title：Journal of radiation research

authors： Endo S

更新日期：2004-09-01 00:00:00

abstract：:The increasing use of mobile phones has aroused public concern regarding the potential health risks of radiofrequency (RF) fields. We investigated the effects of exposure to RF fields (2.45 GHz, continuous wave) at specific absorption rate (SAR) of 1, 5, and 10 W/kg for 1, 4, and 24 h on gene expression in a normal hu...

journal_title：Journal of radiation research

authors： Sakurai T,Kiyokawa T,Narita E,Suzuki Y,Taki M,Miyakoshi J

更新日期：2011-01-01 00:00:00

abstract：:It has previously been demonstrated that the presence of fetal bovine serum is necessary for TGF-β3 (transforming growth factor beta 3)-dependent elimination of low-dose hyper-radiosensitivity (HRS) in cells by 1 h of low-dose-rate γ-irradiation (0.2-0.3 Gy/h). The purpose of the present study was to identify the seru...

journal_title：Journal of radiation research

authors： Edin NF

更新日期：2014-11-01 00:00:00

abstract：:The purpose of the present study was to develop a hybrid magnetic resonance/computed tomography (MR/CT)-compatible phantom and tissue-equivalent materials for each MR and CT image. Therefore, the essential requirements necessary for the development of a hybrid MR/CT-compatible phantom were determined and the developme...

journal_title：Journal of radiation research

authors： Kim MJ,Lee SR,Song KH,Baek HM,Choe BY,Suh TS

更新日期：2020-03-23 00:00:00

abstract：:The aim of this study was to carry out geometric and dosimetric evaluation of the usefulness of a deformable image registration algorithm utilized for adaptive head-and-neck intensity-modulated radiotherapy. Data consisted of seven patients, each with a planning CT (pCT), a rescanning CT (ReCT) and a cone beam CT (CBC...

journal_title：Journal of radiation research

authors： Eiland RB,Maare C,Sjöström D,Samsøe E,Behrens CF

更新日期：2014-09-01 00:00:00

abstract：:Previous studies have demonstrated that X-ray irradiation affects angiogenesis in tumors. Here, we studied the effects of gamma-ray irradiation on boron-10 compound accumulation in a murine tumor model. The mouse squamous cell carcinoma was irradiated with gamma-ray before BSH ((10)B-enriched borocaptate sodium) admin...

journal_title：Journal of radiation research

authors： Liu Y,Nagata K,Masunaga S,Suzuki M,Kashino G,Kinashi Y,Tanaka H,Sakurai Y,Maruhashi A,Ono K

更新日期：2009-11-01 00:00:00

abstract：:This study was conducted in order to evaluate the cytotoxicity of high linear-energy-transfer (LET) ionizing radiation (IR) on glioblastoma cells and fibroblasts using different modes of cell inactivation assays. Two human glioblastoma cell lines with or without p53-mutation, and fibroblasts were used as materials. Ga...

journal_title：Journal of radiation research

authors： Tsuboi K,Moritake T,Tsuchida Y,Tokuuye K,Matsumura A,Ando K

更新日期：2007-07-01 00:00:00

abstract：:Radiotherapy is an integral part of overall cancer therapy. One of the most serious adverse effects of irradiation concern, for long-term survivors, the development of post-radiation sarcoma (PRS) in healthy tissues located within the irradiated area. PRS have bad prognosis and are often detected at a late stage. Ther...

journal_title：Journal of radiation research

authors： Phulpin B,Tran N,Leroux A,Poussier S,Marie PY,Pinel S,Huger S,Henrot P,Gallet P,Blaise C,Bravetti P,Graff P,Merlin JL,Dolivet G

更新日期：2012-01-01 00:00:00

abstract：:The purpose of this multi-institutional Phase II trial study was to prospectively investigate the efficacy of the herbal medicine TJ-14 for acute radiation-induced enteritis (ARE). TJ-14 was administered orally as a first-line treatment for ARE. The primary end point was efficacy at 1 week. The secondary end points we...

journal_title：Journal of radiation research

authors： Murai T,Matsuo M,Tanaka H,Manabe Y,Takaoka T,Hachiya K,Yamaguchi T,Otsuka S,Shibamoto Y

更新日期：2020-01-23 00:00:00

abstract：:The aim of this study was to evaluate the effectiveness and tolerability of definitive chemo-radiation or radiotherapy alone in patients with esophageal cancer. We retrospectively analyzed the medical records of n = 238 patients with squamous cell carcinoma or adenocarcinoma of the esophagus treated with definitive ra...

journal_title：Journal of radiation research

authors： Haefner MF,Lang K,Krug D,Koerber SA,Uhlmann L,Kieser M,Debus J,Sterzing F

更新日期：2015-07-01 00:00:00

abstract：:Boron Neutron Capture Therapy (BNCT) effectiveness depends on the preferential sequestration of boron in cancer cells relative to normal tissue cells. We present a novel strategy for sequestering boron using an adenovirus expressing the sodium iodide symporter (NIS). Human glioma grown subcutaneously in athymic mice a...

journal_title：Journal of radiation research

authors： Kumar S,Freytag SO,Barton KN,Burmeister J,Joiner MC,Sedghi B,Movsas B,Binns PJ,Kim JH,Brown SL

更新日期：2010-01-01 00:00:00

abstract：:This study evaluated the effective dose of Ga-67 for a patient undergoing Ga-67 citrate nuclear examination by applying thermoluminescent dosimeter (TLD) technique and an indigenous water phantom. The Ga-67 radionuclide remaining in the body inevitably generated a measurable internal dose even though gamma camera scan...

journal_title：Journal of radiation research

authors： Chu KH,Lin YT,Hsu CC,Chen CY,Pan LK

更新日期：2012-11-01 00:00:00

abstract：:Radiation-induced bystander effects (RIBEs) are detected in cells that are not irradiated but receive signals from treated cells. The present study explored these bystander effects in a U87MG multicellular tumour spheroid model. A medium transfer technique was employed to induce the bystander effect, and colony format...

journal_title：Journal of radiation research

authors： Faqihi F,Neshastehriz A,Soleymanifard S,Shabani R,Eivazzadeh N

更新日期：2015-09-01 00:00:00

abstract：:Radiation-induced rescue effect (RIRE) in cells refers to the phenomenon where irradiated cells (IRCs) receive help from feedback signals produced by partnered bystander unirradiated cells (UIRCs) or from the conditioned medium (CM) that has previously conditioned the UIRCs. In the present work, we explored the role o...

journal_title：Journal of radiation research

authors： Pathikonda S,Cheng SH,Yu KN

更新日期：2020-05-22 00:00:00

abstract：:An interest in the possible cancer causing ability of neutrons began soon after their discovery. Early use of neutrons from radioactive sources and from cyclotrons led to a need to define risk for such exposures. This need was soon followed by a more tangible need to define risk to the general population of high LET r...

journal_title：Journal of radiation research

authors： Hill CK,Williams-Hill D

更新日期：1999-12-01 00:00:00

abstract：:While recent advances in elucidating the enzyme/substrate relationship of phosphorylation cascades have demonstrated several distinct pathways in membrane-cytoplasm signaling, the molecular dissection of p53 and the products of other proto-oncogenes have greatly promoted the studies of nuclear signaling and expanded t...

journal_title：Journal of radiation research

authors： Wang X,Ohnishi T

更新日期：1997-09-01 00:00:00

abstract：:A number of agents are now available for use in protecting against ionizing radiation. These radiation-protective agents, however, have many adverse effects. Efforts have been made to develop new radiation-protective agents for medical application. Here, we investigated whether a compound, polyethylenimine (PEI), whic...

journal_title：Journal of radiation research

authors： Hu Z,Xing Y,Qian Y,Chen X,Tu J,Ren L,Wang K,Chen Z

更新日期：2013-03-01 00:00:00

abstract：:Low-doses of irradiation have been reported to have beneficial effects, particularly anti-tumor effects. In this paper, we show the effects of the low-dose irradiation on T cell activation induced by dendritic cells (DCs). DCs, which had been pre-irradiated at 0.02-1.0 Gy from a (137)Cs source, were cultured with allo...

journal_title：Journal of radiation research

authors： Shigematsu A,Adachi Y,Koike-Kiriyama N,Suzuki Y,Iwasaki M,Koike Y,Nakano K,Mukaide H,Imamura M,Ikehara S

更新日期：2007-01-01 00:00:00

abstract：:Reactions of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) with deoxyguanosine monophosphate (dGMP) hydroxyl radical adducts were investigated by pulse radiolysis technique. Edaravone was found to reduce the dGMP hydroxyl radical adducts through electron transfer reactions. The rate constants of the reactions were g...

journal_title：Journal of radiation research

authors： Hata K,Urushibara A,Yamashita S,Lin M,Muroya Y,Shikazono N,Yokoya A,Fu H,Katsumura Y

更新日期：2015-01-01 00:00:00

abstract：:The Rho-associated coiled-coil-containing protein kinase (ROCK) pathway is known to influence metastasis in several cancers; however, the impact of the pathway on clinical outcomes in patients undergoing radiotherapy remains unknown. In the present study, the expression of RhoA, RhoC, ROCK-1, ROCK-2 and p53 was immuno...

journal_title：Journal of radiation research

authors： Tanaka K,Matsumoto Y,Ishikawa H,Fukumitsu N,Numajiri H,Murofushi K,Oshiro Y,Okumura T,Satoh T,Sakurai H

更新日期：2020-03-23 00:00:00

abstract：:To evaluate the lifetime hazards of ionizing radiation exposure, 1680 beagles received whole-body, 60-Cobalt gamma exposures or sham-exposures during development. Eight groups of 120 dogs each received mean doses of 16 or 83 cGy at 8 (preimplantation), 28 (embryonic), or 55 (late fetal) days postcoitus (dpc), or 2 (ne...

journal_title：Journal of radiation research

authors： Benjamin SA,Saunders WJ,Angleton GM,Lee AC

更新日期：1991-12-01 00:00:00

abstract：:Chronic irradiation with low-dose-rate 137Cs-γ rays inhibits the differentiation of human neural progenitor cells and influences the expression of proteins associated with several cellular functions. We aimed to determine whether such chronic irradiation influences the expression of proteins associated with PC12 cells...

journal_title：Journal of radiation research

authors： Shinsuke K,Junya K,Tomonobu U,Yoshiko K,Izumo N,Takahiko S

更新日期：2017-11-01 00:00:00

abstract：:The brachytherapy dose calculations used in treatment planning systems (TPSs) have conventionally been performed assuming homogeneous water. Using measurements and a Monte Carlo simulation, we evaluated the dosimetric impact of an air passage on brachytherapy for bronchus cancer. To obtain the geometrical characterist...

journal_title：Journal of radiation research

authors： Okamoto H,Wakita A,Nakamura S,Nishioka S,Aikawa A,Kato T,Abe Y,Kobayashi K,Inaba K,Murakami N,Itami J

更新日期：2016-11-01 00:00:00