Abstract：
:It has previously been demonstrated that the presence of fetal bovine serum is necessary for TGF-β3 (transforming growth factor beta 3)-dependent elimination of low-dose hyper-radiosensitivity (HRS) in cells by 1 h of low-dose-rate γ-irradiation (0.2-0.3 Gy/h). The purpose of the present study was to identify the serum constituent involved. Two human HRS-positive (T-47D, T98G) cell lines were used. The effects of different pretreatments on HRS were investigated using the colony assay. Total inducible nitric oxide synthase (iNOS) levels were measured using a cell-based ELISA assay. The serum factor was identified as interleukin-13 (IL-13). In order for low dose-rate irradiation to eliminate HRS through the TGF-β3-dependent mechanism, the cells must be exposed to IL-13 first. Inhibiting receptor IL-13Rα2 showed that this receptor is involved in the response. Adding IL-13 to serum-free medium restored the properties of full medium but not when an inhibitor of proprotein convertase activity was added together with IL-13. The presence of IL-13 resulted in upregulation of total iNOS protein levels. Thus, this study indicates that IL-13 interacts with the cells though receptor IL-13Rα2 and induces upregulation of iNOS and activation of one or more furin-like proprotein convertases.
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Edin NFdoi
10.1093/jrr/rru053subject
Has Abstractpub_date
2014-11-01 00:00:00pages
1066-74issue
6eissn
0449-3060issn
1349-9157pii
rru053journal_volume
55pub_type
杂志文章abstract：:We evaluated the interrelationship between rectal content and intrafraction motion of the prostate. Forty seven prostate cancer patients instructed to remove their rectal gas were imaged by planning CT and MRI before radiotherapy (RT) and during RT. The total scan time was comparable to our cone-beam CT scanning and t...
journal_title：Journal of radiation research
pub_type： 杂志文章
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journal_title：Journal of radiation research
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journal_title：Journal of radiation research
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journal_title：Journal of radiation research
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journal_title：Journal of radiation research
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更新日期：2014-03-01 00:00:00
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journal_title：Journal of radiation research
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更新日期：2018-09-01 00:00:00
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journal_title：Journal of radiation research
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更新日期：2016-07-01 00:00:00
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journal_title：Journal of radiation research
pub_type： 杂志文章
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更新日期：1998-12-01 00:00:00
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journal_title：Journal of radiation research
pub_type： 杂志文章
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更新日期：2013-09-01 00:00:00
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journal_title：Journal of radiation research
pub_type： 杂志文章
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更新日期：1999-06-01 00:00:00
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journal_title：Journal of radiation research
pub_type： 杂志文章
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更新日期：2009-11-01 00:00:00
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journal_title：Journal of radiation research
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更新日期：2002-12-01 00:00:00
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更新日期：2020-05-22 00:00:00
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更新日期：2017-09-01 00:00:00
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journal_title：Journal of radiation research
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doi：
更新日期：2012-01-01 00:00:00
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journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.10036
更新日期：2010-01-01 00:00:00
