Abstract:
:Boron Neutron Capture Therapy (BNCT) effectiveness depends on the preferential sequestration of boron in cancer cells relative to normal tissue cells. We present a novel strategy for sequestering boron using an adenovirus expressing the sodium iodide symporter (NIS). Human glioma grown subcutaneously in athymic mice and orthotopic rat brain tumors were transfected with NIS using a direct tumor injection of adenovirus. Boron bound as sodium tetrafluoroborate (NaBF(4)) was administered systemically several days after transfection. Tumors were excised hours later and assessed for boron concentration using inductively coupled plasma atomic emission spectroscopy. In the human glioma transfected with NIS, boron concentration was more than 10 fold higher with 100 mg/kg of NaBF(4), compared to tumor not transfected. In the orthotopic tumor model, the presence of NIS conferred almost 4 times the boron concentration in rat tumors transfected with human virus compared with contralateral normal brain not transfected. We conclude that adenovirus expressing NIS has the potential to be used as a novel boron delivery agent and should be explored for future clinical applications.
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Kumar S,Freytag SO,Barton KN,Burmeister J,Joiner MC,Sedghi B,Movsas B,Binns PJ,Kim JH,Brown SLdoi
10.1269/jrr.10036subject
Has Abstractpub_date
2010-01-01 00:00:00pages
621-6issue
5eissn
0449-3060issn
1349-9157pii
JST.JSTAGE/jrr/10036journal_volume
51pub_type
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