Biological effects of intermittent radiation in cultured tumor cells: influence of fraction number and dose per fraction.

abstract：:This study proposes a quality assurance (QA) method incorporating radiobiological factors based on the QUANTEC-determined tumor control probability and the normal tissue complication probability (NTCP) of head-and-neck intensity-modulated radiation therapy (HN-IMRT). Per-beam measurements were conducted for 20 cases u...

journal_title：Journal of radiation research

authors： Hamatani N,Sumida I,Takahashi Y,Oda M,Seo Y,Isohashi F,Tamari K,Ogawa K

更新日期：2017-09-01 00:00:00

abstract：:We aimed to investigate the effect of chronic radiation exposure associated with the Fukushima Daiichi Nuclear Power Plant (FNPP) accident on the testes of boar and inobuta (a hybrid of Sus scrofa and Sus scrofa domestica). This study examined the contamination levels of radioactive caesium (Cs), especially (134)Cs an...

journal_title：Journal of radiation research

authors： Yamashiro H,Abe Y,Hayashi G,Urushihara Y,Kuwahara Y,Suzuki M,Kobayashi J,Kino Y,Fukuda T,Tong B,Takino S,Sugano Y,Sugimura S,Yamada T,Isogai E,Fukumoto M

更新日期：2015-12-01 00:00:00

abstract：:An interest in the possible cancer causing ability of neutrons began soon after their discovery. Early use of neutrons from radioactive sources and from cyclotrons led to a need to define risk for such exposures. This need was soon followed by a more tangible need to define risk to the general population of high LET r...

journal_title：Journal of radiation research

authors： Hill CK,Williams-Hill D

更新日期：1999-12-01 00:00:00

abstract：:Thyroid cells were given 5.5 Gy X-rays in situ and transplanted after 1 day or after 6 weeks to form colonies in fat pads. The colony-forming efficiency unexpectedly decreased by a factor of about 2 with this increase in delay time before transplantation. In addition, there was a concomitant marked increase above the ...

journal_title：Journal of radiation research

authors： Watanabe H,Hendry JH

更新日期：1994-06-01 00:00:00

abstract：:Radiotherapy-induced toxicity is a major dose-limiting factor in anti-cancer treatment. Ionizing radiation leads to the formation of reactive oxygen and nitrogen species (ROS/RNS) that are associated with radiation-induced cell death. Investigations of biological effects of fullerenol have provided evidence for its RO...

journal_title：Journal of radiation research

authors： Bogdanović V,Stankov K,Icević I,Zikic D,Nikolić A,Solajić S,Djordjević A,Bogdanović G

更新日期：2008-05-01 00:00:00

abstract：:This study investigates whether in-room computed tomography (CT)-based adaptive treatment planning (ATP) is robust against interfractional location variations, namely, interfractional organ motions and/or applicator displacements, in 3D intracavitary brachytherapy (ICBT) for uterine cervical cancer. In ATP, the radiat...

journal_title：Journal of radiation research

authors： Oku Y,Arimura H,Nguyen TT,Hiraki Y,Toyota M,Saigo Y,Yoshiura T,Hirata H

更新日期：2016-11-01 00:00:00

abstract：:This study aimed to evaluate the relationship between cardiac toxicity after definitive chemoradiotherapy (CRT) for esophageal cancer and the dose-volume histogram (DVH) of organs at risk (OARs) [using biological effective dose (BED)]. We analyzed the data of 83 patients with esophageal cancer treated using definitive...

journal_title：Journal of radiation research

authors： Takeuchi Y,Murakami Y,Kameoka T,Ochi M,Imano N,Takahashi I,Nishibuchi I,Kimura T,Kawahara D,Saito A,Nagata Y

更新日期：2020-03-23 00:00:00

abstract：:The aim of this study was to determine the outcomes and adverse events for 300 men with prostate cancer treated with 125iodine (125I) brachytherapy with and without external-beam radiation therapy (EBRT) at a single institution in Japan. Between February 2005 and November 2011, 300 consecutive patients with clinically...

journal_title：Journal of radiation research

authors： Maki S,Itoh Y,Kubota S,Okada T,Nakahara R,Ito J,Kawamura M,Naganawa S,Yoshino Y,Fujita T,Kato M,Gotoh M,Ikeda M

更新日期：2017-11-01 00:00:00

abstract：:The aims of present study were to evaluate the efficacy of combining sunitinib with ionizing radiation (IR) on endothelial cells in vitro and in vivo. Human umbilical vein endothelial cells (HUVECs) were exposed to IR with or without sunitinib pretreatment. Apoptosis assay and cell cycle distribution were analyzed by ...

journal_title：Journal of radiation research

authors： Zhang HP,Takayama K,Su B,Jiao XD,Li R,Wang JJ

更新日期：2011-01-01 00:00:00

abstract：:Several models for the action of mixed irradiation with two types of radiation have been proposed in the last two decades, although the superiority or inferiority of these models is not completely elucidated. However, mixed irradiation is sometimes composed of more than two types of radiation, and for this type of mix...

journal_title：Journal of radiation research

authors： Suzuki S

更新日期：1998-09-01 00:00:00

abstract：:The purpose of this review was to evaluate the impact of epidermal growth factor receptor (EGFR) mutation status on disease recurrence in patients treated with chemoradiotherapy (CRT) for locally advanced non-small cell lung cancer (NSCLC). A literature search was conducted and a total of three studies were analyzed. ...

journal_title：Journal of radiation research

authors： Ochiai S,Nomoto Y,Watanabe Y,Yamashita Y,Toyomasu Y,Kawamura T,Takada A,Noriko,Sakuma H

更新日期：2016-09-01 00:00:00

abstract：:In Japan, the use of adjuvant radiotherapy after prostatectomy for prostate cancer has not increased compared with the use of salvage radiotherapy. We retrospectively evaluated the outcome of adjuvant radiotherapy together with prognostic factors of outcome in Japan. Between 2005 and 2007, a total of 87 patients were ...

journal_title：Journal of radiation research

authors： Aoki M,Mizowaki T,Akimoto T,Nakamura K,Ejima Y,Jingu K,Tamai Y,Nakajima N,Takemoto S,Kokubo M,Katoh H

更新日期：2014-05-01 00:00:00

abstract：:Direct irradiation may cause malfunctioning of cardiac implantable electronic devices (CIEDs). Therefore, a treatment plan that does not involve direct irradiation of CIEDs should be formulated. However, CIEDs may be directly exposed to radiation because of the sudden intrafractional movement of the patient. The proba...

journal_title：Journal of radiation research

authors： Nakamura K,Aoyama T,Kaneda N,Otsuji M,Minami Y,Sakuragi A,Nakamura M

更新日期：2020-05-22 00:00:00

abstract：:In vivo laboratory experiments on tritium gas (HT) fixation in pine trees were conducted using one-way circuit inhalation apparatus and dwarf pine trees. After 2 hours of exposure to HT, tritium distribution in pine needles, branches, trunk, roots and soil was measured. The specific activity of tritium in pine needles...

journal_title：Journal of radiation research

authors： Ichimasa M,Ichimasa Y,Akita Y

更新日期：1989-12-01 00:00:00

abstract：:We evaluated the radiological response and clinical outcome in patients with femoral bone metastases after radiotherapy. 102 consecutive patients with femoral metastases without pathological fracture were treated by surgery or radiotherapy between 2002 and 2005. Twelve of them initially treated with surgery were exclu...

journal_title：Journal of radiation research

authors： Harada H,Katagiri H,Kamata M,Yoshioka Y,Asakura H,Hashimoto T,Furutani K,Takahashi M,Sakahara H,Nishimura T

更新日期：2010-01-01 00:00:00

abstract：:Photon irradiation has been repeatedly suspected of increasing tumor cell motility and promoting locoregional recurrence of disease. This study was set up to analyse possible mechanisms underlying the potentially radiation-altered motility in medulloblastoma cells. Medulloblastoma cell lines D425 and Med8A were analyz...

journal_title：Journal of radiation research

authors： Rieken S,Rieber J,Brons S,Habermehl D,Rief H,Orschiedt L,Lindel K,Weber KJ,Debus J,Combs SE

更新日期：2015-05-01 00:00:00

abstract：:The purpose of this study is to evaluate the dose-volume metrics under different heterogeneity corrections and the factors associated with local recurrence (LR) after stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC). Eighty-three patients who underwent SBRT for pathologically proven st...

journal_title：Journal of radiation research

authors： Ueki N,Matsuo Y,Shibuya K,Nakamura M,Narabayashi M,Sakanaka K,Norihisa Y,Mizowaki T,Hiraoka M

更新日期：2013-03-01 00:00:00

abstract：:The Radiation Effects Research Foundation (RERF) continues to conduct a follow-up study initiated some years ago of cancer mortality and incidence among the survivors of the atomic bombing of Hiroshima and Nagasaki exposed in utero. Although only 18 incident cases of cancer were identified in the years 1950-1984 (of w...

journal_title：Journal of radiation research

authors： Yoshimoto Y,Kato H,Schull WJ

更新日期：1991-03-01 00:00:00

abstract：:Immediately after X-irradiation, monocytic cells can express the gene for interleukin (IL)-1beta, which enhances inflammation and contributes to radioprotection in mice. In order to analyze the mechanism(s) for the immediate-early induction of IL-1beta after X-irradiation at 20 Gy in cultured murine macrophages, we ex...

journal_title：Journal of radiation research

authors： Ishihara H,Tanaka I,Wan H,Cheeramakara C

更新日期：2003-06-01 00:00:00

abstract：:We investigated the effects of proton irradiation on the function and structure of the Pseudomonas aeruginosa peroxiredoxin (PaPrx). Polyacrylamide gel demonstrated that PaPrx proteins exposed to proton irradiation at several doses exhibited simultaneous formation of high molecular weight (HMW) complexes and fragmenta...

journal_title：Journal of radiation research

authors： Park CH,Lee SS,Kim KR,Jung MH,Lee SY,Cho EJ,Singh S,Chung BY

更新日期：2014-01-01 00:00:00

abstract：:The purpose of this study was to analyze the clinical outcomes of simultaneous modulated accelerated radiotherapy (SMART) in patients with nasopharyngeal carcinoma (NPC). A total of 97 patients who underwent SMART for NPC between August 2005 and November 2011 were evaluated. The prescribed dose was 69.9 Gy/30 fraction...

journal_title：Journal of radiation research

authors： Tang JM,Ma XM,Hou YL,Dai LY,Cao HB,Ye M,Bai YR

更新日期：2014-07-01 00:00:00

abstract：:The objective of the present study was to estimate cancer risk associated with the low-level radiation exposure of an average annual effective dose of 6.4 mSv (including internal exposure) in the high background-radiation areas (HBRA) in Yangjiang, China. The mortality survey consisted of two steps, i.e., the follow-u...

journal_title：Journal of radiation research

authors： Tao Z,Zha Y,Akiba S,Sun Q,Zou J,Li J,Liu Y,Kato H,Sugahara T,Wei L

更新日期：2000-10-01 00:00:00

abstract：:We have examined the neutron energy dependency of cell killing and mutation induction at the hprt locus in Chinese hamster V79 cells. Monoenergetic neutrons at 0.32, 0.57, and 1.2 MeV were generated at the Hiroshima University Radiobiological Research Accelerator (HIRRAC) Facility, and were used to irradiate cells. Th...

journal_title：Journal of radiation research

authors： Kubota N,Okada S,Nagatomo S,Ozawa F,Inada T,Hill CK,Endo S,Komatsu K

更新日期：1999-12-01 00:00:00

abstract：:The paper describes the development of chemical modules simulating the prechemical and chemical stages of charged particle tracks in pure liquid water. These calculations are based on our physical track structure codes for electrons and ions (KURBUC, LEPHIST and LEAHIST) which provide the initial spatial distribution ...

journal_title：Journal of radiation research

authors： Uehara S,Nikjoo H

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:To elucidate the mechanism underlying the in vivo radioprotection activity by Zn-containing, heat-treated Saccharomyces cerevisiae yeast (Zn-yeast). MATERIALS AND METHODS:Zn-yeast suspension was administered into C3H/He mice immediately after whole body irradiation (WBI) at 7.5 Gy. Bone marrow was extracted fr...

journal_title：Journal of radiation research

authors： Ueno M,Imadome K,Iwakawa M,Anzai K,Ikota N,Imai T

更新日期：2010-01-01 00:00:00

abstract：:Radiation-induced bystander effects (RIBEs) are detected in cells that are not irradiated but receive signals from treated cells. The present study explored these bystander effects in a U87MG multicellular tumour spheroid model. A medium transfer technique was employed to induce the bystander effect, and colony format...

journal_title：Journal of radiation research

authors： Faqihi F,Neshastehriz A,Soleymanifard S,Shabani R,Eivazzadeh N

更新日期：2015-09-01 00:00:00

abstract：:An overview is given of the dose-response relationship for stable chromosome aberrations (i.e., translocations and inversions) in the peripheral blood lymphocytes of A-bomb survivors in Hiroshima. Special emphasis is placed on (i) the overdispersion of survivor cases with either unexpectedly high or low aberration fre...

journal_title：Journal of radiation research

authors： Awa AA,Nakano M,Ohtaki K,Kodama Y,Lucas J,Gray J

更新日期：1992-03-01 00:00:00

abstract：:Several studies have reported the usefulness of the field-in-field (FIF) technique in breast radiotherapy. However, the methods for the FIF technique used in these studies vary. These methods were classified into three categories. We simulated a radiotherapy plan with each method and analyzed the outcomes. In the firs...

journal_title：Journal of radiation research

authors： Tanaka H,Hayashi S,Hoshi H

更新日期：2014-07-01 00:00:00

abstract：:Tumor hypoxia and angiogenesis have been studied extensively. However, the relation between normal tissue injury and hypoxia is still unclear. In this study, we investigated the effect of hypoxia on radiation-induced late rectal injury in mice. The rectum of C57BL/6N mice was irradiated locally with a single dose of 2...

journal_title：Journal of radiation research

authors： Liu Y,Kudo K,Abe Y,Aoki M,Hu DL,Kijima H,Nakane A

更新日期：2008-05-01 00:00:00

abstract：:It has previously been demonstrated that the presence of fetal bovine serum is necessary for TGF-β3 (transforming growth factor beta 3)-dependent elimination of low-dose hyper-radiosensitivity (HRS) in cells by 1 h of low-dose-rate γ-irradiation (0.2-0.3 Gy/h). The purpose of the present study was to identify the seru...

journal_title：Journal of radiation research

authors： Edin NF

更新日期：2014-11-01 00:00:00