Influence of seed extract of Syzygium Cumini (Jamun) on mice exposed to different doses of gamma-radiation.

Abstract:

:The radioprotective activity of the hydroalcoholic extract of jamun seeds (SCE) was studied in mice exposed to different doses of gamma radiation. The mice were injected with 0, 5, 10, 20, 40, 60, 80, 100, 120, 140 or 160 mg/kg body weight of SCE, before exposure to 10 Gy of gamma radiation, to select the optimum dose of radiation protection. The 80 mg/kg SCE was found to offer highest protection, therefore, further studies were carried out using this dose. The drug was more effective when administered through the intraperitoneal route at equimolar doses than the oral route. Since higher survival was observed for the i.p. route (50%), than the oral route (29.2%), all other studies were carried out by injecting SCE intraperitoneally. The mice treated with 80 mg/kg body weight SCE intraperitoneally before exposure to 6, 7, 8, 9, 10 and 11 Gy of gamma radiation showed reduction in the symptoms of radiation sickness and mortality at all exposure doses and caused a significant increase in the animal survival when compared with the concurrent double distilled water (DDW) + irradiation group. The SCE treatment protected mice against the gastrointestinal as well as bone marrow deaths and the DRF was found to be 1.24.

journal_name

J Radiat Res

authors

Jagetia GC,Baliga MS,Venkatesh P

doi

10.1269/jrr.46.59

keywords:

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

59-65

issue

1

eissn

0449-3060

issn

1349-9157

pii

JST.JSTAGE/jrr/46.59

journal_volume

46

pub_type

杂志文章
  • A validated proton beam therapy patch-field protocol for effective treatment of large hepatocellular carcinoma.

    abstract::Development of a curative local treatment for large hepatocellular carcinoma (HCC) is an important issue. Here, we investigated the dose homogeneity, safety and antitumor effectiveness of proton beam therapy (PBT) using a patch-field technique for large HCC. Data from nine patients (aged 52-79 years) with large HCC tr...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rry056

    authors: Nakamura M,Fukumitsu N,Kamizawa S,Numajiri H,Nemoto Murofushi K,Ohnishi K,Aihara T,Ishikawa H,Okumura T,Tsuboi K,Sakurai H

    更新日期:2018-09-01 00:00:00

  • Development of a markerless tumor-tracking algorithm using prior four-dimensional cone-beam computed tomography.

    abstract::Respiratory motion management is a huge challenge in radiation therapy. Respiratory motion induces temporal anatomic changes that distort the tumor volume and its position. In this study, a markerless tumor-tracking algorithm was investigated by performing phase recognition during stereotactic body radiation therapy (...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rry085

    authors: Bhusal Chhatkuli R,Demachi K,Uesaka M,Nakagawa K,Haga A

    更新日期:2019-01-01 00:00:00

  • A comparison of the dose from natural radionuclides and artificial radionuclides after the Fukushima nuclear accident.

    abstract::Due to the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident, the evacuees from Namie Town still cannot reside in the town, and some continue to live in temporary housing units. In this study, the radon activity concentrations were measured at temporary housing facilities, apartments and detached houses in Fukush...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrv102

    authors: Hosoda M,Tokonami S,Omori Y,Ishikawa T,Iwaoka K

    更新日期:2016-07-01 00:00:00

  • Cell cycle checkpoint and apoptosis induction in glioblastoma cells and fibroblasts irradiated with carbon beam.

    abstract::This study was conducted in order to evaluate the cytotoxicity of high linear-energy-transfer (LET) ionizing radiation (IR) on glioblastoma cells and fibroblasts using different modes of cell inactivation assays. Two human glioblastoma cell lines with or without p53-mutation, and fibroblasts were used as materials. Ga...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.06081

    authors: Tsuboi K,Moritake T,Tsuchida Y,Tokuuye K,Matsumura A,Ando K

    更新日期:2007-07-01 00:00:00

  • Whole-pelvic radiotherapy with spot-scanning proton beams for uterine cervical cancer: a planning study.

    abstract::The aim of this study was to compare the dosimetric parameters of whole-pelvic radiotherapy (WPRT) for cervical cancer among plans involving 3D conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT), or spot-scanning proton therapy (SSPT). The dose distributions of 3D-CRT-, IMRT-, and SSPT-based WPRT...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrw052

    authors: Hashimoto S,Shibamoto Y,Iwata H,Ogino H,Shibata H,Toshito T,Sugie C,Mizoe JE

    更新日期:2016-09-01 00:00:00

  • Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines.

    abstract::The prognosis and treatment of thyroid cancer depends on the type and stage of the disease. Radiosensitivity differs among cancer cells owing to their varying capacity for repair after irradiation. Radioactive iodine can be used to destroy thyroid cancer cells. However, patient prognosis and improvement after irradiat...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rry097

    authors: Ihara M,Ashizawa K,Shichijo K,Kudo T

    更新日期:2019-03-01 00:00:00

  • Disappearance of nuclear binding proteins specifically bound to the upstream region of the interleukin-1beta gene immediately after irradiation of mouse macrophages.

    abstract::Immediately after X-irradiation, monocytic cells can express the gene for interleukin (IL)-1beta, which enhances inflammation and contributes to radioprotection in mice. In order to analyze the mechanism(s) for the immediate-early induction of IL-1beta after X-irradiation at 20 Gy in cultured murine macrophages, we ex...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.44.117

    authors: Ishihara H,Tanaka I,Wan H,Cheeramakara C

    更新日期:2003-06-01 00:00:00

  • Cosmic radiation protection dosimetry using an Electronic personal Dosemeter (Siemens EPD) on selected international flights.

    abstract::The effectiveness of an Electronic Personal Dosemeter (Siemens EPD) for cosmic-radiation dosimetry at aviation altitudes was examined on eight international flights between March and September, 1998. The EPD values (Hepd) of the dose equivalent from penetrating radiation, Hp(10), were assumed to be almost the same as ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.42.57

    authors: Yasuda H,Fujitaka K

    更新日期:2001-03-01 00:00:00

  • Activities of the Japanese space weather forecast center at Communications Research Laboratory.

    abstract::The International Space Environment Service (ISES) is an international organization for space weather forecasts and belongs to the International Union of Radio Science (URSI). There are eleven ISES forecast centers in the world, and Communications Research Laboratory (CRL) runs the Japanese one. We make forecasts on t...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.43.s53

    authors: Watari S,Tomita F

    更新日期:2002-12-01 00:00:00

  • Radiation carcinogenesis in dogs irradiated during prenatal and postnatal development.

    abstract::To evaluate the lifetime hazards of ionizing radiation exposure, 1680 beagles received whole-body, 60-Cobalt gamma exposures or sham-exposures during development. Eight groups of 120 dogs each received mean doses of 16 or 83 cGy at 8 (preimplantation), 28 (embryonic), or 55 (late fetal) days postcoitus (dpc), or 2 (ne...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.32.supplement2_86

    authors: Benjamin SA,Saunders WJ,Angleton GM,Lee AC

    更新日期:1991-12-01 00:00:00

  • Biological effects of intermittent radiation in cultured tumor cells: influence of fraction number and dose per fraction.

    abstract::In intensity-modulated radiation therapy (IMRT) and stereotactic irradiation using a linear accelerator, radiation is administered intermittently and one treatment session often requires 30 min or a longer time. The purpose of the present study was to investigate the effect of fractionation and dose per fraction on ce...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.46.401

    authors: Ogino H,Shibamoto Y,Sugie C,Ito M

    更新日期:2005-12-01 00:00:00

  • Analysis of liver damage from radon, X-ray, or alcohol treatments in mice using a self-organizing map.

    abstract::In our previous studies, we found that low-dose radiation inhibits oxidative stress-induced diseases due to increased antioxidants. Although these effects of low-dose radiation were demonstrated, further research was needed to clarify the effects. However, the analysis of oxidative stress is challenging, especially th...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrw083

    authors: Kanzaki N,Kataoka T,Etani R,Sasaoka K,Kanagawa A,Yamaoka K

    更新日期:2017-01-01 00:00:00

  • Preliminary study on radiosensitivity to carbon ions in human breast cancer.

    abstract::The aim of the study was to investigate the various effects of high linear energy transfer (LET) carbon ion (12C6+) and low LET X-ray radiation on MDA-MB-231 and MCF-7 human breast cancer cells and to explore the underlying mechanisms of radiation sensitivity. Cell proliferation, cell colony formation, cell cycle dist...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rraa017

    authors: Zhang Q,Kong Y,Yang Z,Liu Y,Liu R,Geng Y,Luo H,Zhang H,Li H,Feng S,Wang X

    更新日期:2020-05-22 00:00:00

  • Monte Carlo modeling in CT-based geometries: dosimetry for biological modeling experiments with particle beam radiation.

    abstract::The space radiation environment imposes increased dangers of exposure to ionizing radiation, particularly during a solar particle event (SPE). These events consist primarily of low energy protons that produce a highly inhomogeneous dose distribution. Due to this inherent dose heterogeneity, experiments designed to inv...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrt118

    authors: Diffenderfer ES,Dolney D,Schaettler M,Sanzari JK,McDonough J,Cengel KA

    更新日期:2014-03-01 00:00:00

  • Three-dimensional dose prediction and validation with the radiobiological gamma index based on a relative seriality model for head-and-neck IMRT.

    abstract::This study proposes a quality assurance (QA) method incorporating radiobiological factors based on the QUANTEC-determined tumor control probability and the normal tissue complication probability (NTCP) of head-and-neck intensity-modulated radiation therapy (HN-IMRT). Per-beam measurements were conducted for 20 cases u...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrx017

    authors: Hamatani N,Sumida I,Takahashi Y,Oda M,Seo Y,Isohashi F,Tamari K,Ogawa K

    更新日期:2017-09-01 00:00:00

  • Gamma-ray irradiation enhanced boron-10 compound accumulation in murine tumors.

    abstract::Previous studies have demonstrated that X-ray irradiation affects angiogenesis in tumors. Here, we studied the effects of gamma-ray irradiation on boron-10 compound accumulation in a murine tumor model. The mouse squamous cell carcinoma was irradiated with gamma-ray before BSH ((10)B-enriched borocaptate sodium) admin...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.09071

    authors: Liu Y,Nagata K,Masunaga S,Suzuki M,Kashino G,Kinashi Y,Tanaka H,Sakurai Y,Maruhashi A,Ono K

    更新日期:2009-11-01 00:00:00

  • Radiotherapy for localized sebaceous carcinoma of the eyelid: a retrospective analysis of 83 patients.

    abstract::The current study retrospectively analyzed the results of radiotherapy for clinically localized sebaceous carcinoma of the eyelid.We reviewed records of 83 patients with histologically confirmed sebaceous carcinoma who were treated radiotherapeutically between 1983 and 2015. Sixty-five patients (78%) were initially tr...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrz046

    authors: Takagawa Y,Tamaki W,Suzuki S,Inaba K,Murakami N,Takahashi K,Igaki H,Nakayama Y,Shigematsu N,Itami J

    更新日期:2019-10-23 00:00:00

  • A questionnaire-based survey on 3D image-guided brachytherapy for cervical cancer in Japan: advances and obstacles.

    abstract::The purpose of this study is to survey the current patterns of practice, and barriers to implementation, of 3D image-guided brachytherapy (3D-IGBT) for cervical cancer in Japan. A 30-item questionnaire was sent to 171 Japanese facilities where high-dose-rate brachytherapy devices were available in 2012. In total, 135 ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrv047

    authors: Ohno T,Toita T,Tsujino K,Uchida N,Hatano K,Nishimura T,Ishikura S

    更新日期:2015-11-01 00:00:00

  • Treatment outcomes of patients with FIGO Stage I/II uterine cervical cancer treated with definitive radiotherapy: a multi-institutional retrospective research study.

    abstract::The purpose of this study was to analyze the patterns of care and outcomes of patients with FIGO Stage I/II cervical cancer who underwent definitive radiotherapy (RT) at multiple Japanese institutions. The Japanese Radiation Oncology Study Group (JROSG) performed a questionnaire-based survey of their cervical cancer p...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jrr/rrv036

    authors: Ariga T,Toita T,Kato S,Kazumoto T,Kubozono M,Tokumaru S,Eto H,Nishimura T,Niibe Y,Nakata K,Kaneyasu Y,Nonoshita T,Uno T,Ohno T,Iwata H,Harima Y,Wada H,Yoshida K,Gomi H,Numasaki H,Teshima T,Yamada S,Nakano T

    更新日期:2015-09-01 00:00:00

  • Megakaryocytic differentiation in human chronic myelogenous leukemia K562 cells induced by ionizing radiation in combination with phorbol 12-myristate 13-acetate.

    abstract::Differentiation-induction therapy is an attractive approach in leukemia treatment. It has been suggested that the accumulation of intracellular reactive oxygen species (ROS) is involved in megakaryocytic differentiation induced by phorbol 12-myristate 13-acetate (PMA) in the K562 leukemia cell line. Therefore, a ROS-i...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrs125

    authors: Hirose K,Monzen S,Sato H,Sato M,Aoki M,Hatayama Y,Kawaguchi H,Narita Y,Takai Y,Kashiwakura I

    更新日期:2013-05-01 00:00:00

  • Analysis of simultaneous modulated accelerated radiotherapy (SMART) for nasopharyngeal carcinomas.

    abstract::The purpose of this study was to analyze the clinical outcomes of simultaneous modulated accelerated radiotherapy (SMART) in patients with nasopharyngeal carcinoma (NPC). A total of 97 patients who underwent SMART for NPC between August 2005 and November 2011 were evaluated. The prescribed dose was 69.9 Gy/30 fraction...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rru012

    authors: Tang JM,Ma XM,Hou YL,Dai LY,Cao HB,Ye M,Bai YR

    更新日期:2014-07-01 00:00:00

  • Histone H2AX phosphorylation independent of ATM after X-irradiation in mouse liver and kidney in situ.

    abstract::Histone H2AX undergoes phosphorylation at Ser-139 (gamma-H2AX) rapidly in response to DNA double-strand breaks (DSBs) induced by ionizing radiation. The post-translational modification of H2AX plays a central role in responses to radiation, including the repair of DSBs. Although ataxia telangiectasia mutated (ATM) kin...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.08010

    authors: Koike M,Mashino M,Sugasawa J,Koike A

    更新日期:2008-07-01 00:00:00

  • Serum lactate dehydrogenase predicts survival in small-cell lung cancer patients with brain metastases that were treated with whole-brain radiotherapy.

    abstract::This study aimed to identify factors that predict prognosis after radiotherapy for brain metastases (BMs) from small-cell lung cancer (SCLC). This study retrospectively evaluated 48 consecutive patients who underwent whole-brain radiotherapy (WBRT) for BMs from SCLC between February 2008 and December 2017. WBRT was de...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rry107

    authors: Anami S,Doi H,Nakamatsu K,Uehara T,Wada Y,Fukuda K,Inada M,Ishikawa K,Kanamori S,Nishimura Y

    更新日期:2019-03-01 00:00:00

  • Chromatin-regulating proteins as targets for cancer therapy.

    abstract::Chromatin-regulating proteins represent a large class of novel targets for cancer therapy. In the context of radiotherapy, acetylation and deacetylation of histones by histone acetyltransferases (HATs) and histone deacetylases (HDACs) play important roles in the repair of DNA double-strand breaks generated by ionizing...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审

    doi:10.1093/jrr/rrt227

    authors: Oike T,Ogiwara H,Amornwichet N,Nakano T,Kohno T

    更新日期:2014-07-01 00:00:00

  • Carcinogenic effects of tritiated water (HTO) in mice: in comparison to those of neutrons and gamma-rays.

    abstract::A series of experiments was carried out using female (C57BL/6N x C3H/He)F1 mice (BCF1) to assess the carcinogenic effect of tritiated water (HTO) following a preliminary experiment in which the acute effect of HTO was studied in young female mice of C57BL/6L strain in an attempt to gain basic information on the long-t...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.32.supplement2_132

    authors: Seyama T,Yamamoto O,Kinomura A,Yokoro K

    更新日期:1991-12-01 00:00:00

  • Chemical repair activity of free radical scavenger edaravone: reduction reactions with dGMP hydroxyl radical adducts and suppression of base lesions and AP sites on irradiated plasmid DNA.

    abstract::Reactions of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) with deoxyguanosine monophosphate (dGMP) hydroxyl radical adducts were investigated by pulse radiolysis technique. Edaravone was found to reduce the dGMP hydroxyl radical adducts through electron transfer reactions. The rate constants of the reactions were g...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rru079

    authors: Hata K,Urushibara A,Yamashita S,Lin M,Muroya Y,Shikazono N,Yokoya A,Fu H,Katsumura Y

    更新日期:2015-01-01 00:00:00

  • Effect of gamma-irradiation on the uptake and digestion of 125I-labeled bovine serum albumin by rat visceral yolk sac cultured in vitro.

    abstract::The effect of gamma-irradiation on a major nutritional function of the yolk sac (the uptake and digestion of macromolecular materials) was studied in rat visceral yolk sacs cultured in vitro being used 125I-labeled bovine serum albumin (RISA) as the tracer protein. The uptake of RISA (per g wet weight) by rat yolk sac...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.34.171

    authors: Takahashi S,Koshimoto C,Kubota Y

    更新日期:1993-06-01 00:00:00

  • Reassessment of gamma-ray doses in Hiroshima and Nagasaki.

    abstract::Reassessment of gamma-ray doses from the atomic bombs in Hiroshima and Nagasaki has been carried out with the thermoluminescent measurements of bricks and decorative tiles which were collected from the buildings that remain as they were at the time of the explosions. The thermoluminescent measurements were performed u...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.32.supplement_40

    authors: Maruyama T,Kumamoto Y,Noda Y

    更新日期:1991-03-01 00:00:00

  • Cytogenetic damage in circulating lymphocytes and buccal mucosa cells of head-and-neck cancer patients undergoing radiotherapy.

    abstract::This study evaluated cytogenetic damage by measuring the frequency of micronucleated cells (MNC) in peripheral blood and buccal mucosa of head-and-neck cancer patients undergoing radiotherapy. MNC frequencies were assessed in 31 patients before, during, and after radiotherapy, and in 17 healthy controls matched for ge...

    journal_title:Journal of radiation research

    pub_type: 临床试验,杂志文章

    doi:10.1269/jrr.46.135

    authors: Minicucci EM,Kowalski LP,Maia MA,Pereira A,Ribeiro LR,de Camargo JL,Salvadori DM

    更新日期:2005-06-01 00:00:00

  • Kinetic analysis of double-strand break rejoining reveals the DNA reparability of gamma-irradiated tobacco cultured cells.

    abstract::The rejoining efficiency of double-strand breaks (DSBs) was quantified by a DNA fragment-size analysis in tobacco protoplasts and CHO-K1 cells following gamma-ray irradiation in order to compare DNA reparability of higher plants with mammals. Results showed that the DSB rejoining efficiency of tobacco protoplasts is d...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.08064

    authors: Yokota Y,Wada S,Hase Y,Funayama T,Kobayashi Y,Narumi I,Tanaka A

    更新日期:2009-03-01 00:00:00