Abstract:
:The severity of chronic obstructive pulmonary disease (COPD) is evaluated not only by airflow limitation but also by factors such as exercise capacity and body mass index. Recent advances in CT technology suggest that it might be a useful tool for evaluating the severity of the disease components of COPD. The aim of this study is to evaluate the correlation between the parameters measured on volumetric CT, including the extent of emphysema, air trapping, and airway thickening, and clinical parameters. CT scans were performed in 34 patients with COPD at full inspiration and expiration. We used in-house software to measure CT parameters, including volume fraction of emphysema (V(950)), mean lung density (MLD), CT air trapping index (CT ATI), segmental bronchial wall area (WA), lumen area (LA), and wall area percent (WA%). We found that the CT parameters were correlated with the pulmonary function test (PFT) results, body mass index (BMI), the modified Medical Research Council Dyspnea scale (MMRC scale), the six-minute-walk distance (6MWD), and the BODE index. V(950 insp) correlated to the BMI, FEV(1), 6MWD, and the BODE index. The CT ATI correlated with the physiologic ATI (VC-FVC) (R=0.345, p=0.045) and the MMRC scale (R=0.532, p=0.001). There was a positive correlation between the WA% and the BMI (R=0.563, p<0.001). MLD(exp) showed the strongest correlation with the BODE index (R= -0.756, p<0.001). We conclude that the severity of emphysema and air trapping measured on CT correlated with the PFT parameters 6MWD and BMI.
journal_name
Lungjournal_title
Lungauthors
Lee YK,Oh YM,Lee JH,Kim EK,Lee JH,Kim N,Seo JB,Lee SD,KOLD Study Group.doi
10.1007/s00408-008-9071-0subject
Has Abstractpub_date
2008-05-01 00:00:00pages
157-165issue
3eissn
0341-2040issn
1432-1750pii
10.1007/s00408-008-9071-0journal_volume
186pub_type
杂志文章相关文献
LUNG文献大全abstract:ABSTARCT:New anti-fibrotic agents for idiopathic pulmonary fibrosis (IPF) were approved based on the results of forced vital capacity (FVC) trends, although concerns were raised about the reliability of FVC as the only endpoint parameter. We hypothesized that IPF-specific multi-dimensional scores (Composite Physiologic...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9963-3
更新日期:2017-02-01 00:00:00
abstract::Adolescent idiopathic scoliosis may require surgical treatment for extreme curvature of the spine or loss of pulmonary function. We present a report of a 31-year-old woman with a history of scoliosis and anterolateral spinal fusion who developed chest pain and hemoptysis. Imaging revealed that a fixation rod had migra...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-018-0104-z
更新日期:2018-06-01 00:00:00
abstract:INTRODUCTION:The cardinal symptom of pulmonary hypertension (PH) is dyspnea on exertion, leading to decreased activity in daily living. The aim of this study was to analyze daily physical activity in incident patients with arterial or chronic thromboembolic PH (PAH/CTEPH) and to investigate its correlation with pulmona...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-019-00248-x
更新日期:2019-10-01 00:00:00
abstract::The aim of this study was to test the hypothesis that systemic inflammation in patients with chronic obstructive pulmonary disease (COPD) is accompanied by enhanced interleukin 18 (IL-18) expression in skeletal muscle, which may precede muscle weight loss. Twenty patients with moderate to severe COPD [12 women, 66 +/-...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-007-9000-7
更新日期:2007-05-01 00:00:00
abstract:PURPOSE:Lymphangioleiomyomatosis (LAM) is a rare, progressive, frequently lethal cystic lung disease that almost exclusively affects women. Prognostic information in LAM has been limited by small numbers and heterogeneous study methodology. Early retrospective cohorts cited 5- and 10-year mortality of 40 and 80 %, resp...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9419-3
更新日期:2013-02-01 00:00:00
abstract::Reaginic antibodies in hay fever patients belong to IgE. The immunoglobulin sensitizes basophilic granulocytes and mast cells from homologous species and mediates the release of chemical mediators which cause allergic symptoms. The sensitization is due to the binding of IgE to receptors on the target cells through the...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF02730676
更新日期:1978-01-01 00:00:00
abstract:INTRODUCTION:Chronic obstructive pulmonary disease (COPD) is a major public health problem worldwide and is proved to be the number three cause of death in globally. The objective of this study was to explore the molecular mechanism of the progression of COPD. METHODS:Using the GSE1650 affymetrix microarray data acces...
journal_title:Lung
pub_type: 杂志文章,收录出版
doi:10.1007/s00408-014-9631-4
更新日期:2014-12-01 00:00:00
abstract::Surfactant is not a homogeneous material and can be separated into subtypes. Subtype conversion is clinically important because it is thought to occur naturally and because surface activity varies depending on the subtype. Fibrinogen, a naturally occurring serum protein, is known to affect this conversion. In this stu...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/pl00007569
更新日期:1997-01-01 00:00:00
abstract:INTRODUCTION:Hypoxia has been implicated in the pathogenesis of many inflammatory and fibrotic lung diseases. The effect of hypoxia on epithelial junction protein expression is yet to be fully elucidated but evidence suggests a protective role for the hypoxia-inducible transcription factor HIF-1 in stabilising occludin...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9918-8
更新日期:2016-10-01 00:00:00
abstract:PURPOSE:Exercising or doing physical activity in polluted air could expose a person to the adverse health effects of air pollution. This study aimed to compare the cardiovascular and hematologic indices following an incremental exercise test (shuttle run) under clean versus polluted air conditions. METHODS:Nineteen ma...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-014-9679-1
更新日期:2015-04-01 00:00:00
abstract:INTRODUCTION:Living donor lobar lung transplantation (LDLLT) has been successfully used in select patient populations. MATERIALS AND METHODS:A 29-year-old male, who underwent bilateral LDLLT 12 years earlier with allografts donated by father and paternal uncle, developed bronchiolitis obliterans syndrome at distinctly...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-014-9560-2
更新日期:2014-06-01 00:00:00
abstract::Undifferentiated connective tissue disease (UCTD) is a distinct clinical entity that may be accompanied by interstitial lung disease (ILD). The natural history of UCTD-ILD is unknown. We hypothesized that patients with UCTD-ILD would be more likely to have improvement in lung function than those with idiopathic pulmon...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-009-9226-7
更新日期:2010-04-01 00:00:00
abstract::The effect of beta 2-adrenoceptor agonists on airway smooth muscle relaxation may be subject to desensitization. It could be modified by glucocorticosteroid treatment. An increase in the beta 2 agonist response by glucocorticosteroids in vitro has been described. We studied the effects of acute and chronic treatment w...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00176895
更新日期:1995-01-01 00:00:00
abstract:: ...
journal_title:Lung
pub_type: 信件
doi:10.1007/s00408-018-0187-6
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:We aimed to determine the time, dose, and volume responses in a mouse pulmonary injury model following ablative dose focal irradiation (ADFIR) in order to better understand normal lung injury. METHODS AND MATERIALS:ADFIR was administered to the left lung of mice using a small animal micro-irradiator. Histopath...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-015-9825-4
更新日期:2016-02-01 00:00:00
abstract::A 15-year-old male had a history of increasing dyspnea on exertion, cough, sputum production, fever, weakness, hemoptysis, and diarrhea. Chest radiography demonstrated bilateral alveolar consolidation. Bronchoalveolar lavage fluid analysis revealed extensive hemosiderin-laden alveolar macrophages. On the basis of iron...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-005-2596-6
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Survival implications of pre-transplant antibodies to human leukocyte antigens prior to lung transplantation (LTx) in adult cystic fibrosis (CF) patients are unknown. METHODS:Data from the United Network for Organ Sharing Registry (1987-2013) were used to compare survival differences in adult CF patients wi...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9861-8
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:Combined pulmonary fibrosis and emphysema (CPFE) is increasingly recognized, as current reports of its clinical features show. To determine CPFE's physiologic and radiologic features, we conducted quantitative assessment of computed tomography scans to compare with those of chronic obstructive pulmonary disease...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-013-9513-1
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Although lung transplantation is the only means of survival for patients with end-stage pulmonary disease, outcomes from this intervention are inferior to other solid organ transplants. The reason for the poor outcomes may be linked to an early reaction, such as primary graft dysfunction, and associated with...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-014-9588-3
更新日期:2014-08-01 00:00:00
abstract:PURPOSE:Idiopathic pulmonary fibrosis (IPF) is a restrictive fibrotic lung disease of uncertain etiology. Alveolar epithelial injury may be one of the inciting triggers in the pathogenesis of this disorder. We hypothesized that circulating antibodies to alveolar epithelial and endothelial cells may be involved in the p...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9390-z
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:Restoring the barrier integrity of the alveolar epithelium after injury is pivotal. In the current study, we evaluated the effects of surfactant, surfactant protein A (SP-A), transforming growth factor β (TGF-β), and analogues of SP-A on alveolar epithelial repair. Additionally, we assessed the influence of mic...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9424-6
更新日期:2012-12-01 00:00:00
abstract::Tracheobronchopathia osteochondroplastica (TO) is a rare disorder of the large airways characterized by the development of submucosal cartilaginous and bony nodules. The nodules involve the anterior and lateral walls and typically spare the posterior membranous wall. The clinical presentation of TO is variable and ran...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-008-9113-7
更新日期:2008-11-01 00:00:00
abstract::Bronchopleural (BPF) and alveolar-pleural (APF) fistulas are frequently encountered in clinical practice with persistent air leaks that can lead to significant morbidity, prolonged hospital stay, and potentially increased mortality. BPF and APF are commonly related to pulmonary resections. Other etiologies include min...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-009-9204-0
更新日期:2010-06-01 00:00:00
abstract:PURPOSE:The aim was to investigate whether maintenance therapy (MT) is sufficient or not to improve overall survival (OS) and progress-free survival (PFS) of advanced non-small cell lung cancer (NSCLC) patients. METHODS:Randomized controlled trials (RCTs) published between 1990 and 2013 were retrieved from PubMed, EMB...
journal_title:Lung
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00408-015-9758-y
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:In immunocompromised patients with pulmonary infiltrates, transbronchial lung biopsies (TBB) obtained by forceps has been shown to increase the diagnostic yield over simple bronchoalveolar lavage. Cryo-TBB is a novel modality for obtaining lung biopsies. We aimed to evaluate for the first time the efficacy a...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-013-9507-z
更新日期:2013-12-01 00:00:00
abstract::Lung cancer is currently one of the most common malignant diseases and is responsible for substantial mortality worldwide. Compared with never smokers, former smokers remain at relatively high risk for lung cancer, accounting for approximately half of all newly diagnosed cases in the US. Screening offers former smoker...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-013-9517-x
更新日期:2014-02-01 00:00:00
abstract::Treatment of allergic asthma with inhaled corticosteroids results in local down-regulation of proinflammatory cytokine synthesis and in marked decrease in tissue eosinophilia. Blood concentrations of inhaled corticosteroids, although significantly lower than those measured in the lung, may still have antiinflammatory ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/pl00007642
更新日期:1999-01-01 00:00:00
abstract::To determine the role of the alveolar pores in cigarette smoke-induced lung disease, we examined the alveolar pores of guinea pigs exposed to cigarette smoke for 12 months, and compared these data to those obtained from sham-smoked animals, correlating the data with airspace size and lung function. We found that the s...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s004080000048
更新日期:2001-01-01 00:00:00
abstract::Eosinophils have been shown to play a role in allergen-induced airway responses. The aim in this study was to examine the effects of TAK-661, a newly developed product as a specific inhibitory agent of eosinophil chemotaxis, on antigen-induced asthmatic responses in allergic sheep model. Seven Ascaris-sensitive, "dual...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s004080000090
更新日期:2002-01-01 00:00:00
abstract::In recent years the alveolar macrophage has been found to play a central role in interstitial lung disease. Pulmonary histiocytosis X is characterized by infiltrating fibroblasts, mononuclear cells, and CD-1-positive Langerhans cells. Bronchoalveolar lavage (BAL) fluid displays an increase of CD-1-positive cells and a...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00175659
更新日期:1995-01-01 00:00:00