Abstract：
:Eosinophils have been shown to play a role in allergen-induced airway responses. The aim in this study was to examine the effects of TAK-661, a newly developed product as a specific inhibitory agent of eosinophil chemotaxis, on antigen-induced asthmatic responses in allergic sheep model. Seven Ascaris-sensitive, "dual-respondent" allergic sheep were provocated by an Ascaris suum antigen or phosphate-buffered saline 2 hrs after intra-stomach administration of TAK-661 or a placebo. Pulmonary resistances were measured throughout the experiment, and airway responsiveness to methacholine, bronchoalveolar lavage (BAL), and histological examination were performed 8 hrs after the antigen challenge. Antigen provocation induced dual-phase bronchoconstriction, eosinophilia in BAL and eosinophil infiltration into the airway wall, and an increase in airway responsiveness in placebo-treated sheep. The administration of TAK-661 significantly reduced the bronchoconstriction during the late phase, along with the inhibition of eosinophilia in BAL and the eosinophil infiltration into the airway wall. TAK-661 had a tendency to reduce early-phase bronchoconstriction and airway hyperresponsiveness, but there were no significant differences. These findings suggest that the eosinophil accumulation into the airway induced by antigen provocation may contribute to the development of late-phase bronchoconstriction, however, the development of airway hyperresponsiveness during late asthmatic response may not always be due to only eosinophilic inflammation in the airway.
journal_name
Lungjournal_title
Lungauthors
Fujimoto K,Tsunoda T,Koizumi T,Kubo Kdoi
10.1007/s004080000090keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
161-72issue
3eissn
0341-2040issn
1432-1750journal_volume
180pub_type
杂志文章相关文献
LUNG文献大全abstract：:A nodular lesion in the medial segment of right middle lobe was discovered on a chest radiograph for chronic cough in a 42-year-old Asian woman. A chest computed tomography (CT) scan subsequently showed a right middle lobe (RML) nodular lesion, which exhibited intense fluorodeoxyglucose uptake on positron emission tom...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-009-9221-z
更新日期：2010-08-01 00:00:00
abstract：:The author reviews the early history of alpha 1-antitrypsin (AAT) deficiency; the biochemical characterization of this inborn error of metabolism, its pattern of inheritance, frequency and predisposition to early, panacinar emphysema. The importance of the destructive element in emphysema and the gradual focusing on n...
journal_title：Lung
pub_type： 杂志文章,评审
doi：10.1007/BF02718174
更新日期：1990-01-01 00:00:00
abstract：:To explore further the possible etiologic role of mycobacteria in the development of sarcoidosis, we measured free, nonbound tuberculostearic acid (TSA, 10-methyloctadecanoic), a component of mycobacteria, in the sera of subjects with sarcoidosis or active untreated pulmonary tuberculosis and in healthy controls by us...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF00164632
更新日期：1996-01-01 00:00:00
abstract：:This study evaluated the extracellular matrix (collagen and elastic fibers) in pleurodesis induced by intrapleural talc (TL) or silver nitrate (SN). Study subjects were 420 rabbits divided into two groups and sacrificed from 15 min to 12 months after the injection of the sclerosing agents at intervals previously defin...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-005-2569-9
更新日期：2006-03-01 00:00:00
abstract：:Alveolar epithelial type II (AT II) cells need phosphate (Pi) for surfactant synthesis. The Na-dependent (Na(d)) Pi transporters NaPi-IIb and Pit-1 are expressed in lung, but their expression, regulation, and function in AT II cells remain unclear. We studied NaPi-IIb and Pit-1 mRNA expression in cultured AT II cells ...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-009-9183-1
更新日期：2010-01-01 00:00:00
abstract：PURPOSE:Improving dyspnea and exercise performance are goals of COPD therapy. We tested the hypothesis that air current applied to the face would lessen dyspnea and improve exercise performance in moderate-severe COPD patients. METHODS:We recruited 10 COPD patients (5 men, age 62 ± 6 years, FEV1 0.93 ± 0.11 L (34 ± 3%...
journal_title：Lung
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00408-015-9780-0
更新日期：2015-10-01 00:00:00
abstract：:Antidromic stimulation of vagal sensory nerves is known to produce plasma extravasation in the rat trachea. This neurogenic inflammation is thought to be mediated by substance P or other tachykinins released from sensory nerve endings. We sought to determine whether calcitonin gene-related peptide (CGRP), which is als...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF00175980
更新日期：1992-01-01 00:00:00
abstract：:Allergen exposure in atopic asthmatic patients is associated with recruitment and activation of eosinophils in the airways. Once activated, eosinophils release toxic products, including the eosinophil cationic protein (ECP), able to damage bronchial structures and to increase bronchial hyperresponsiveness. With this b...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/pl00007606
更新日期：1998-01-01 00:00:00
abstract：:Indoor air pollutants may cause inflammatory changes of the airways and adjacent pulmonary tissue. After phagocytosis of inhaled particles alveolar macrophages (AM) release chemotactic mediators capable of attracting inflammatory cells into the lung tissue. To evaluate these mechanisms further peripheral blood mononuc...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/pl00007628
更新日期：1999-01-01 00:00:00
abstract：:Gastro-oesophageal reflux disease (GORD) is generally considered one of the three main causes of chronic cough, along with asthma and nasal disease. The diagnosis of GORD is often based upon a successful trial of anti-acid treatment however GORD is a complex condition taking many forms. Only recently have studies star...
journal_title：Lung
pub_type： 杂志文章,评审
doi：10.1007/s00408-009-9210-2
更新日期：2010-01-01 00:00:00
abstract：:Recently, active remodeling may indicate a good prognosis in idiopathic interstitial pneumonias. In this study we sought to validate the importance of the collagen/elastic system in the extracellular matrix remodeling and to study the relationships between the collagen/elastic system in nonspecific interstitial idiopa...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-006-0104-2
更新日期：2007-01-01 00:00:00
abstract：:Models of pulmonary edema have been used to study the nuclear magnetic resonance (NMR) characteristics of lung water. Several investigators have measured changes in the relaxation times in the permeability type of pulmonary edema, but relatively few have measured relaxation times in the hydrostatic type of pulmonary e...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF00173138
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:According to the National Family Health Survey, asthma is one of the leading diseases in India. In order to understand the complexity of asthma, the susceptibility genes need to be targeted for their association. Glutathione S-transferases play a major role in the detoxification of metabolites of oxidative s...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-012-9385-9
更新日期：2012-10-01 00:00:00
abstract：:Tuberculosis (TB) pleurisy is accepted to be the best model for evaluating the local protective cellular immune response to Mycobacterium tuberculosis (MTB) since it can be spontaneously self-cured. Therefore, we aimed to evaluate the involvement of cytokines and the soluble apoptosis-modulating factors sFas and sFasL...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-008-9107-5
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:Depression is an important comorbidity for patients with chronic obstructive pulmonary disease (COPD). The association between depression and acute exacerbations of COPD is unknown. This study was designed to determine the frequency of COPD exacerbations in outpatients with and without depressive symptoms. ...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-009-9135-9
更新日期：2009-03-01 00:00:00
abstract：:In recent years the alveolar macrophage has been found to play a central role in interstitial lung disease. Pulmonary histiocytosis X is characterized by infiltrating fibroblasts, mononuclear cells, and CD-1-positive Langerhans cells. Bronchoalveolar lavage (BAL) fluid displays an increase of CD-1-positive cells and a...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF00175659
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:TB nanodiagnostics have witnessed considerable development. However, most of the published reports did not proceed beyond proof-of-concept. Our objectives are to evaluate the diagnostic accuracy of a novel nanogold assay in detecting patients with active pulmonary TB based on results of BACTEC MGIT (reference t...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-018-00194-0
更新日期：2019-04-01 00:00:00
abstract：:The presence and distribution of acetylcholinesterase (AChE) and cholineacetyl transferase activities (Chat) were examined in the bronchus-associated lymphoid tissue (BALT) of juvenile, adult and old rats. Histoenzymatic and immunochemical methods were used in association with quantitative analysis of images and stati...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-003-1042-x
更新日期：2004-01-01 00:00:00
abstract：PURPOSE:Idiopathic pulmonary fibrosis (IPF) is a restrictive fibrotic lung disease of uncertain etiology. Alveolar epithelial injury may be one of the inciting triggers in the pathogenesis of this disorder. We hypothesized that circulating antibodies to alveolar epithelial and endothelial cells may be involved in the p...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-012-9390-z
更新日期：2012-08-01 00:00:00
abstract：:Eosinophilic bronchitis is an essential component of bronchial asthma, and eosinophils play an important role. We studied the effect of eosinophils on cell surface plasmin generation by bronchial epithelial cells, because plasmin is thought to be involved in bronchial tissue repair/remodeling by means of fibrinolysis ...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s004080000042
更新日期：2001-01-01 00:00:00
abstract：:We aimed to evaluate the utility of coagulation markers for the prediction of rapidly progressive interstitial lung disease (RP-ILD) in patients with dermatomyositis (DM). In this retrospective study, 29 patients with DM-associated ILD were analyzed. The number of patients with RP-ILD was 15 (52%). The baseline clinic...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-019-00245-0
更新日期：2019-08-01 00:00:00
abstract：:The purpose of this study was to examine the lung pathogenesis of murine gammaherpesvirus (MHV-68) infection in mice that lack CC chemokine receptor CCR2, an important receptor for macrophage recruitment to sites of inflammation. BALB/c and CCR2(-/-) mice were inoculated intranasally (i.n.) with MHV-68 and samples wer...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-004-2535-y
更新日期：2005-07-01 00:00:00
abstract：:The aim of our study was to evaluate clinical diagnoses in symptomatic persons exposed to aerosols from humidifiers or air conditioners. In addition, we tried to identify the causative antigens. Results of clinical investigations, including inhalation challenge tests, demonstrated a typical hypersensitivity pneumoniti...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF02714035
更新日期：1988-01-01 00:00:00
abstract：:Difficult weaning is fortunately a rare occurrence in mechanically ventilated patients in ICU. When faced with this problem, a vast number of factors must be carefully considered simultaneously: physiological adjustment, technical problems (tubing, circuit resistances, . . .) [13]. The most promising approach to diffi...
journal_title：Lung
pub_type： 杂志文章,评审
doi：10.1007/BF02718216
更新日期：1990-01-01 00:00:00
abstract：:Cancer-testis antigens (CTAs) are expressed only in many cancers and limited immunoprivileged sites such as the testis and placenta. Dendritic cells (DCs) and CD8+ T lymphocytes (CTLs) play roles in the immune responses to tumor growth and may affect the prognosis of cancers. This study was designed to investigate the...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-009-9181-3
更新日期：2009-11-01 00:00:00
abstract：:A large-scale outbreak of life-threatening, inhaled synthetic cannabinoids (Spice/K2)-associated coagulopathy with bleeding complications was recently reported in Illinois. The causative agents were brodifacoum, difenacoum, and bromadiolone, potent, long-acting, 4-hydroxycoumarin anticoagulant rodenticides (LAAR) that...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-019-00227-2
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:To investigate inpatient prevalence, expenditures, and comorbidities of hospitalized patients with sarcoidosis in the USA. METHODS:Patients with sarcoidosis were identified within the Nationwide Inpatient Sample (NIS) database for the years 2013 and 2014 using the respective ICD-9 diagnostic code. Data on pati...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-019-00210-x
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Pulmonary endarterectomy is the treatment of choice in chronic thromboembolic pulmonary hypertension (CTEPH). Modern pulmonary vasoactive medication (like endothelin receptor antagonists, phosphodiesterase type 5 inhibitors, and prostacyclins) is used in patients with an inoperable disease and improved progn...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-011-9350-z
更新日期：2012-04-01 00:00:00
abstract：:Benralizumab and mepolizumab are new therapies for severe eosinophilic asthma. They are both humanized IgG antibodies, targeting the IL-5 receptor and IL-5, respectively, suppressing the corresponding pathways. No specific biomarkers have been proposed to evaluate treatment response to benralizumab or mepolizumab. The...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-020-00379-6
更新日期：2020-10-01 00:00:00
abstract：:In patients with congestive heart failure (CHF), a high prevalence of sleep-disordered breathing has been described. Cheyne-Stokes respiration (CSR) is present in up to 40% of patients with CHF. During the last decade, the medical treatment has been substantially improved. This study was designed to analyze the progno...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-009-9208-9
更新日期：2010-08-01 00:00:00
