Mepolizumab and Benralizumab in Severe Eosinophilic Asthma: Preliminary Results of a Proteomic Study.

abstract：:The severity of chronic obstructive pulmonary disease (COPD) is evaluated not only by airflow limitation but also by factors such as exercise capacity and body mass index. Recent advances in CT technology suggest that it might be a useful tool for evaluating the severity of the disease components of COPD. The aim of t...

journal_title：Lung

authors： Lee YK,Oh YM,Lee JH,Kim EK,Lee JH,Kim N,Seo JB,Lee SD,KOLD Study Group.

更新日期：2008-05-01 00:00:00

abstract：:Tracheobronchopathia osteochondroplastica (TO) is a rare disorder of the large airways characterized by the development of submucosal cartilaginous and bony nodules. The nodules involve the anterior and lateral walls and typically spare the posterior membranous wall. The clinical presentation of TO is variable and ran...

journal_title：Lung

authors： Abu-Hijleh M,Lee D,Braman SS

更新日期：2008-11-01 00:00:00

abstract：:The pathophysiology of cough variant asthma is poorly understood. In particular, the mechanisms that cause different symptoms in typical asthma (in which wheeze predominates) compared with cough variant asthma (in which cough predominates) have not been determined. Traditional explanations include higher wheezing thre...

journal_title：Lung

authors： Lougheed MD,Turcotte SE,Fisher T

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Sarcoidosis is a systemic disease in which the personal environment seems to drive a differentiated disease frequency and clinical expression. The main epidemiological studies suggest a key influence of potential environmentally linked exposures related to the type of occupation, the household, life style, s...

journal_title：Lung

authors： Ramos-Casals M,Kostov B,Brito-Zerón P,Sisó-Almirall A,Baughman RP,Autoimmune Big Data Study Group.

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Chronic obstructive pulmonary disease is a progressive lung disease characterized by abnormal cellular responses to cigarette smoke, resulting in tissue destruction and airflow limitation. Autophagy is a fundamental cellular process that eliminates long-lived proteins and damaged organelles through lysosom...

journal_title：Lung

authors： Li L,Zhang M,Zhang L,Cheng Y,Tu X,Lu Z

更新日期：2017-06-01 00:00:00

abstract：:In recent years the alveolar macrophage has been found to play a central role in interstitial lung disease. Pulmonary histiocytosis X is characterized by infiltrating fibroblasts, mononuclear cells, and CD-1-positive Langerhans cells. Bronchoalveolar lavage (BAL) fluid displays an increase of CD-1-positive cells and a...

journal_title：Lung

authors： Uebelhoer M,Bewig B,Sternberg K,Rabe K,Nowak D,Magnussen H,Barth J

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Mannitol is a novel osmotic indirect bronchial challenge agent used to aid asthma diagnosis and management and is thought to reflect underlying inflammatory processes in asthma. Our objective was to evaluate relationships between mannitol airway hyperresponsiveness (AHR) and other measures of airway inflamma...

journal_title：Lung

authors： Anderson WJ,Lipworth BJ

更新日期：2012-10-01 00:00:00

abstract：:Overlap syndrome and represents a complex clinical condition in pulmonary medicine. We discuss in this letter factors related with mortality after long-term effects CPAP and key differences between hypercapnic versus hypoxemic overlap patients. ...

journal_title：Lung

authors： Esquinas AM,Marrero FL,Esteva JN

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:This is a meta-analysis of the safety and efficacy of indacaterol in chronic obstructive pulmonary disease (COPD) with treatment duration of ≥12 weeks. METHODS:Randomized controlled trials (RCTs) reported in English (to September 30, 2012) were identified from PubMed, the Cochrane Library, Embase, websites,...

journal_title：Lung

authors： Jiang FM,Liang ZA,Zheng QL,Wang RC,Luo J,Li CT

更新日期：2013-04-01 00:00:00

abstract：:Respiratory adaptation during sleep improves with growth. The most vulnerable period for respiratory adaptation to sleep is from birth to 3 months of age. Factors that favor vulnerability are immaturity in ventilatory control and high rib cage compliance which impairs its effectiveness for ventilation. Improvement in ...

journal_title：Lung

authors： Gaultier C

更新日期：1990-01-01 00:00:00

abstract：:Tuberculosis (TB) pleurisy is accepted to be the best model for evaluating the local protective cellular immune response to Mycobacterium tuberculosis (MTB) since it can be spontaneously self-cured. Therefore, we aimed to evaluate the involvement of cytokines and the soluble apoptosis-modulating factors sFas and sFasL...

journal_title：Lung

authors： Budak F,Uzaslan EK,Cangür S,Göral G,Oral HB

更新日期：2008-09-01 00:00:00

abstract：:We aimed to evaluate the utility of coagulation markers for the prediction of rapidly progressive interstitial lung disease (RP-ILD) in patients with dermatomyositis (DM). In this retrospective study, 29 patients with DM-associated ILD were analyzed. The number of patients with RP-ILD was 15 (52%). The baseline clinic...

journal_title：Lung

authors： Sagawa T,Kida T,Inaba T,Yokota I,Sagawa R,Kasahara A,Kaneshita S,Inoue T,Nagahara H,Fujioka K,Wada M,Kohno M,Kawahito Y

更新日期：2019-08-01 00:00:00

abstract：:Long-term treatment studies with formoterol and salmeterol show that these inhaled long-acting beta 2-agonists compared to available beta 2-agonists produce better bronchodilation, decrease the need for additional doses, decrease asthma symptoms, and are strongly preferred by the patients. Development of tolerance has...

journal_title：Lung

authors： Larsson S

更新日期：1990-01-01 00:00:00

abstract：:The lung has only a limited pattern of response to injury. Idiopathic interstitial fibrosis is a descriptive term, describing the end stage of one pattern of pulmonary fibrosis in which the inflammation lies within the structure of the alveolar walls and around vessels and bronchioli, in the interstitium. The disease ...

journal_title：Lung

authors： Lambe D

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Pulmonary endarterectomy is the treatment of choice in chronic thromboembolic pulmonary hypertension (CTEPH). Modern pulmonary vasoactive medication (like endothelin receptor antagonists, phosphodiesterase type 5 inhibitors, and prostacyclins) is used in patients with an inoperable disease and improved progn...

journal_title：Lung

authors： Scholzel BE,Post MC,Thijs Plokker HW,Snijder RJ

更新日期：2012-04-01 00:00:00

abstract：:The purpose of this study was to examine the lung pathogenesis of murine gammaherpesvirus (MHV-68) infection in mice that lack CC chemokine receptor CCR2, an important receptor for macrophage recruitment to sites of inflammation. BALB/c and CCR2(-/-) mice were inoculated intranasally (i.n.) with MHV-68 and samples wer...

journal_title：Lung

authors： Cadillac JM,Sigler RE,Weinberg JB,Lutzke ML,Rochford R

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:TB nanodiagnostics have witnessed considerable development. However, most of the published reports did not proceed beyond proof-of-concept. Our objectives are to evaluate the diagnostic accuracy of a novel nanogold assay in detecting patients with active pulmonary TB based on results of BACTEC MGIT (reference t...

journal_title：Lung

authors： El-Samadony H,Azzazy HME,Tageldin MA,Ashour ME,Deraz IM,Elmaghraby T

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:The aims of this study were to determine the incidence of tuberculosis (TB) and nontuberculous mycobacteria (NTM) lung disease in patients who were treated with tumor necrosis factor (TNF) antagonists in South Korea and to evaluate their clinical characteristics. METHODS:We surveyed all patients (N = 509) w...

journal_title：Lung

authors： Lee SK,Kim SY,Kim EY,Jung JY,Park MS,Kim YS,Kim SK,Chang J,Kang YA

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Tree-in-bud (TIB) is a radiologic pattern seen on high-resolution chest CT reflecting bronchiolar mucoid impaction occasionally with additional involvement of adjacent alveoli. Its microbiologic significance has not been systematically evaluated. OBJECTIVES:We aimed to establish the incidence of the TIB pat...

journal_title：Lung

authors： Shimon G,Yonit WW,Gabriel I,Naama BR,Nissim A

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:Sarcoidosis is a chronic granulomatous inflammatory disease of unknown etiology with heterogeneous outcomes. This study reviewed the clinical outcome status (COS) and organ involvement of Israeli sarcoidosis patients during a five-year period. Further, we compared our results to the 'World Association of Sarcoi...

journal_title：Lung

authors： Markevitz N,Epstein Shochet G,Levi Y,Israeli-Shani L,Shitrit D

更新日期：2017-08-01 00:00:00

abstract：:Pulmonary emphysema is a major manifestation of chronic obstructive pulmonary disease (COPD), which is characterized by progressive destruction of alveolar parenchyma with persistent inflammation of the small airways. Such destruction in the distal respiratory tract is irreversible and irreparable. All-trans-retinoic ...

journal_title：Lung

authors： Muyal JP,Muyal V,Kotnala S,Kumar D,Bhardwaj H

更新日期：2013-04-01 00:00:00

abstract：:Gastro-oesophageal reflux disease (GORD) is generally considered one of the three main causes of chronic cough, along with asthma and nasal disease. The diagnosis of GORD is often based upon a successful trial of anti-acid treatment however GORD is a complex condition taking many forms. Only recently have studies star...

journal_title：Lung

authors： Smith J,Woodcock A,Houghton L

更新日期：2010-01-01 00:00:00

abstract：:The original version of this article unfortunately contained a mistake in the article title. The correct article title is "Residual Renal Function and Obstructive Sleep Apnea in Peritoneal Dialysis: A Pilot Study". ...

journal_title：Lung

authors： Lanis A,Kerns E,Hu SL,Bublitz MH,Risica P,Martin S,Parker J,Millman R,Dworkin LD,Bourjeily G

更新日期：2018-08-01 00:00:00

abstract：:Diffuse alveolar damage is the histopathologic hallmark of acute respiratory distress syndrome (ARDS). A significant proportion of ARDS survivors have residual pulmonary fibrosis and compromised pulmonary function. On the other hand, heat shock protein 47 (HSP47) is a collagen-binding stress protein that is assumed to...

journal_title：Lung

authors： Hagiwara S,Iwasaka H,Matsumoto S,Noguchi T,Yoshioka H

更新日期：2007-01-01 00:00:00

abstract：:Particulate matter less than PM(10) and aromatic chemicals formed during incomplete combustion of organic matter are major environmental pollutants because of their toxic potential. The present study reports on the respiratory morbidity pattern of people exposed to auto exhaust as a result of the traffic load consisti...

journal_title：Lung

authors： Chattopadhyay BP,Mukherjee A,Mukherjee K,Roychowdhury A

更新日期：2007-09-01 00:00:00

abstract：:The effects of a pulmonary rehabilitation program on 44 patients with chronic obstructive pulmonary disease (COPD) were compared to a control group. The treated group was admitted to the program for a period of three months. The program consisted of several parts, such as physical training, health education, and psych...

journal_title：Lung

authors： Cox NJ,Hendricks JC,Binkhorst RA,van Herwaarden CL

更新日期：1993-01-01 00:00:00

abstract：:The influence of phospholipids on the ultrastructure and metabolism of reconstituted surfactants has not been well defined. The aim of this study was to determine if changes in the phospholipid composition of reconstituted surfactants altered their biophysical properties, ultrastructure, and conversion to light subtyp...

journal_title：Lung

authors： Dhand R,Young J,Krishnasamy S,Possmayer F,Gross NJ

更新日期：1999-01-01 00:00:00

abstract：:Patients with pleural effusions frequently present a diagnostic and therapeutic challenge. The diagnosis is based on the interpretation of the results of thoracentesis or pleural biopsy. When a malignant tumor metastasizes to the pleura, tumor cells can be seeded over the mesothelial surface or in the subserous layer....

journal_title：Lung

authors： Mohamed KH,Mobasher AA,Yousef AI,Salah A,Ramadan MA,Emam AK,Alhayawan HM,Light RW

更新日期：2000-11-01 00:00:00

abstract：:Models of pulmonary edema have been used to study the nuclear magnetic resonance (NMR) characteristics of lung water. Several investigators have measured changes in the relaxation times in the permeability type of pulmonary edema, but relatively few have measured relaxation times in the hydrostatic type of pulmonary e...

journal_title：Lung

authors： Shioya S,Tsuji C,Haida M,Fukuzaki M,Tanigaki T,Kurita D,Ohta Y,Yamabayashi H

更新日期：1996-01-01 00:00:00

abstract：:Adolescent idiopathic scoliosis may require surgical treatment for extreme curvature of the spine or loss of pulmonary function. We present a report of a 31-year-old woman with a history of scoliosis and anterolateral spinal fusion who developed chest pain and hemoptysis. Imaging revealed that a fixation rod had migra...

journal_title：Lung

authors： Song KJ,Colman M,Myers JA,Seder CW

更新日期：2018-06-01 00:00:00