Abstract：
:Lung cancer is currently one of the most common malignant diseases and is responsible for substantial mortality worldwide. Compared with never smokers, former smokers remain at relatively high risk for lung cancer, accounting for approximately half of all newly diagnosed cases in the US. Screening offers former smokers the best opportunity to reduce their risk of advanced stage lung cancer and there is now evidence that annual screening using low-dose computed tomography (LDCT) is effective in preventing mortality. Studies are being conducted to evaluate whether the benefits of LDCT screening outweigh its costs and potential harms and to determine the most appropriate workup for patients with screen-detected lung nodules. Program efficiency would be optimized by targeting high-risk current smokers, but low uptake among this group is a concern. Former smokers may be invited for screening; however, if fewer long-term current smokers and more former smokers with long quit duration elect to attend, this could have very adverse effects on cost and screening test parameters. To illustrate this point, we present three possible screening scenarios with lung cancer prevalence ranging from between 0.62 and 5.0 %. In summary, cost-effectiveness of lung cancer screening may be improved if linked to successful smoking cessation programs and if better approaches are developed to reach very high-risk patients, e.g., long-term current smokers or others based on more accurate risk prediction models.
journal_name
Lungjournal_title
Lungauthors
Tota JE,Ramanakumar AV,Franco ELdoi
10.1007/s00408-013-9517-xsubject
Has Abstractpub_date
2014-02-01 00:00:00pages
55-63issue
1eissn
0341-2040issn
1432-1750journal_volume
192pub_type
杂志文章,评审相关文献
LUNG文献大全abstract：:Cessation of smoking in the home is one of the most important nonpharmacologic actions to be recommended. There is a highly significant increase in wheezing, coughing, and respiratory infections in children with smoking mothers, and this increase is directly proportional to the number of cigarettes smoked. Cord blood ...
journal_title：Lung
pub_type： 杂志文章,评审
doi：10.1007/BF02718144
更新日期：1990-01-01 00:00:00
abstract：:Genomic alterations in lung cancer tissues have been observed in various studies. To analyze the aberrations in the genome of lung cancer patients, we used array comparative genomic hybridization (array CGH) in 15 lung adenocarcinoma (AdC) tissues. Copy number gains and losses in chromosomal regions were detected and ...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-006-0009-0
更新日期：2006-11-01 00:00:00
abstract：:A multiuser system for whole body plethysmographic measurements and interpretation which has been developed under clinical conditions is described. The following measurements can be carried out in a rapid way and in one session with the patient: specific airway resistance during spontaneous breathing, determination of...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF02718260
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to evaluate the clinical and radiological features of patients with fungal infection mimicking thoracic malignancy and to establish a diagnostic approach for both clinicians and radiologists to avoid misdiagnosis. METHODS:In this retrospective study, we reviewed clinical and com...
journal_title：Lung
pub_type： 杂志文章,多中心研究
doi：10.1007/s00408-013-9506-0
更新日期：2013-12-01 00:00:00
abstract：PURPOSE:Long Acting Beta2 Agonists (LABA) prevent COPD exacerbations in strictly standardized clinical trials. Our aim was to evaluate the relationship between the amount of LABA provided by the government and the trend in COPD hospital admission (HA) rate in Brazil. METHODS:This is a longitudinal large-scale real-lif...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-018-0158-y
更新日期：2018-12-01 00:00:00
abstract：:In recent years the alveolar macrophage has been found to play a central role in interstitial lung disease. Pulmonary histiocytosis X is characterized by infiltrating fibroblasts, mononuclear cells, and CD-1-positive Langerhans cells. Bronchoalveolar lavage (BAL) fluid displays an increase of CD-1-positive cells and a...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF00175659
更新日期：1995-01-01 00:00:00
abstract：:Tracheobronchopathia osteochondroplastica (TO) is a rare disorder of the large airways characterized by the development of submucosal cartilaginous and bony nodules. The nodules involve the anterior and lateral walls and typically spare the posterior membranous wall. The clinical presentation of TO is variable and ran...
journal_title：Lung
pub_type： 杂志文章,评审
doi：10.1007/s00408-008-9113-7
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND:We previously demonstrated that the exposure to hyperbaric hyperoxia increased respiratory system elastance and both the "ohmic" and viscoelastic components of inspiratory resistances, probably because of increased oxygen tension toxic effects. We presently investigated the possible consequences of a single ...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-014-9576-7
更新日期：2014-08-01 00:00:00
abstract：:The lung has only a limited pattern of response to injury. Idiopathic interstitial fibrosis is a descriptive term, describing the end stage of one pattern of pulmonary fibrosis in which the inflammation lies within the structure of the alveolar walls and around vessels and bronchioli, in the interstitium. The disease ...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF02718237
更新日期：1990-01-01 00:00:00
abstract：PURPOSE:To investigate whether lung function, especially when complicated with SDB, has an increased risk for myocardial infarction (MI) and congestive heart failure (CHF). METHODS:A prospective study was performed within the Sleep Heart Health Study (SHHS). A total of 4161 individuals were followed up for an average ...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-019-00229-0
更新日期：2019-06-01 00:00:00
abstract：:Undifferentiated connective tissue disease (UCTD) is a distinct clinical entity that may be accompanied by interstitial lung disease (ILD). The natural history of UCTD-ILD is unknown. We hypothesized that patients with UCTD-ILD would be more likely to have improvement in lung function than those with idiopathic pulmon...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-009-9226-7
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:The aims of this study were to determine the incidence of tuberculosis (TB) and nontuberculous mycobacteria (NTM) lung disease in patients who were treated with tumor necrosis factor (TNF) antagonists in South Korea and to evaluate their clinical characteristics. METHODS:We surveyed all patients (N = 509) w...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-013-9481-5
更新日期：2013-10-01 00:00:00
abstract：:Allergen exposure in atopic asthmatic patients is associated with recruitment and activation of eosinophils in the airways. Once activated, eosinophils release toxic products, including the eosinophil cationic protein (ECP), able to damage bronchial structures and to increase bronchial hyperresponsiveness. With this b...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/pl00007606
更新日期：1998-01-01 00:00:00
abstract：:Six European treatment centers contributed to a controlled trial to study nocturnal hypoxemia in COPD patients having daytime PaO2 of 60-70 mmHg. The trial is composed of two parts: first, patients inclusion, taking men aged under 70 years, excluding sleep apnea syndrome and all other concomitant pathologies leading t...
journal_title：Lung
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF02718206
更新日期：1990-01-01 00:00:00
abstract：:The effect of beta 2-adrenoceptor agonists on airway smooth muscle relaxation may be subject to desensitization. It could be modified by glucocorticosteroid treatment. An increase in the beta 2 agonist response by glucocorticosteroids in vitro has been described. We studied the effects of acute and chronic treatment w...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF00176895
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:Pulmonary endarterectomy is the treatment of choice in chronic thromboembolic pulmonary hypertension (CTEPH). Modern pulmonary vasoactive medication (like endothelin receptor antagonists, phosphodiesterase type 5 inhibitors, and prostacyclins) is used in patients with an inoperable disease and improved progn...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-011-9350-z
更新日期：2012-04-01 00:00:00
abstract：:To explore further the possible etiologic role of mycobacteria in the development of sarcoidosis, we measured free, nonbound tuberculostearic acid (TSA, 10-methyloctadecanoic), a component of mycobacteria, in the sera of subjects with sarcoidosis or active untreated pulmonary tuberculosis and in healthy controls by us...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF00164632
更新日期：1996-01-01 00:00:00
abstract：:Binding characteristics of the alpha 1-adrenergic radioloigand [3H]prazosin, and the muscarinic cholinergic radioligand, [3H]quinuclidinyl benzilate, were determined both in intact cell preparations of rat alveolar type II pneumocytes (TIIPs) and in membrane preparations of rat lung tissue. Binding in adult and neonat...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF00165701
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:Cardiopulmonary exercise testing (CPET) is a safe and clinically useful method to assess functional capacity and to follow disease progression and the response to treatment in several clinical conditions. AIM:We set out to determine the relationship between outcome measures of CPET and high-resolution compu...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-011-9316-1
更新日期：2011-10-01 00:00:00
abstract：:Immune cell airway infiltration and the bronchovascular remodeling process have shown to be promising in the understanding of bronchiolitis obliterans (BO) pathogenesis. In this study we sought to validate the importance of immune cells, whether diffusely distributed or forming lymphoid follicles, collagen density, an...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-005-2588-6
更新日期：2006-07-01 00:00:00
abstract：:Bronchial provocation studies performed in our research center have consistently demonstrated airway hyperresponsiveness to both inhaled methacholine and histamine in subjects with chronic cervical spinal cord injury (SCI). More recently, we reported that the airways of such subjects maintained on chronic baclofen (ga...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/pl00007579
更新日期：1997-01-01 00:00:00
abstract：PURPOSE:The change in vital capacity from the seated to supine position (∆VC-supine) is used to screen for diaphragm dysfunction (DD), but some individuals are unable to tolerate the supine position. Since expiratory muscle function is often preserved in patients with isolated DD and inspiratory strength is reduced, th...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-016-9959-z
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Malignant mesothelioma is an aggressive tumor of serosal surfaces that is closely associated with asbestos exposure which induces oxidative stress. Heme oxygenase (HO)-1, a rate-limiting enzyme of heme degradation, plays a protective role against oxidative stress. The HO-1 gene promoter carries (GT)n repeats...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-012-9371-2
更新日期：2012-06-01 00:00:00
abstract：:A large-scale outbreak of life-threatening, inhaled synthetic cannabinoids (Spice/K2)-associated coagulopathy with bleeding complications was recently reported in Illinois. The causative agents were brodifacoum, difenacoum, and bromadiolone, potent, long-acting, 4-hydroxycoumarin anticoagulant rodenticides (LAAR) that...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-019-00227-2
更新日期：2019-06-01 00:00:00
abstract：:Isoniazid (INH) is one of the most important first line drugs in the treatment of tuberculosis. We utilized high performance liquid chromatography with a hydrazone extraction technique to measure INH in bronchoalveolar lavage (BAL) fluid specimens from six patients with active pulmonary tuberculosis. We found BAL flui...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/pl00007603
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to compare the risk factors, clinical characteristics, and complications of respiratory distress syndrome (RDS) in infants delivered very preterm, late preterm, and term in order to help optimize the management of RDS in neonates. METHODS:A retrospective study was conducted on ...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-013-9475-3
更新日期：2013-08-01 00:00:00
abstract：:The aim of our study was to evaluate clinical diagnoses in symptomatic persons exposed to aerosols from humidifiers or air conditioners. In addition, we tried to identify the causative antigens. Results of clinical investigations, including inhalation challenge tests, demonstrated a typical hypersensitivity pneumoniti...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF02714035
更新日期：1988-01-01 00:00:00
abstract：PURPOSE:Pulmonary arteriovenous malformations (PAVMs) are most commonly associated with hereditary hemorrhagic telangiectasia (HHT). Patients with PAVMs can present with serious complications including stroke, transient ischemic attack (TIA), and brain abscess. PAVMs are rare in non-HHT patients and little is known abo...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-020-00367-w
更新日期：2020-08-01 00:00:00
abstract：:Chronic desquamative eosinophilic bronchitis is a characteristic pathologic feature of asthma which may even antedate the onset of symptoms. The pharmacology of asthmatic inflammation has been relatively poorly studied and most of the current data available have been inferred indirectly from studies of bronchial hyper...
journal_title：Lung
pub_type： 杂志文章,评审
doi：10.1007/BF02718126
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Red cell distribution width (RDW) has been shown to be associated with adverse outcomes in left-sided heart failure, pulmonary hypertension, and in patients in the ICU. However, the role of RDW is unknown in patients with obstructive sleep apnea syndrome (OSAS), especially in OSAS patients with cardiovascula...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-012-9376-x
更新日期：2012-06-01 00:00:00
