Pre-transplant Panel Reactive Antibody and Survival in Adult Cystic Fibrosis Patients After Lung Transplantation.

Abstract:

BACKGROUND:Survival implications of pre-transplant antibodies to human leukocyte antigens prior to lung transplantation (LTx) in adult cystic fibrosis (CF) patients are unknown. METHODS:Data from the United Network for Organ Sharing Registry (1987-2013) were used to compare survival differences in adult CF patients with pre-transplant class I and II panel reactive antibody (PRA) levels ≤10 versus >10 %. RESULTS:Of 3149 CF LTx recipients, 1526 and 1399 were included in univariate survival analyses of class I and II PRA, respectively, while 1106 and 1001 were included in multivariate Cox analyses for class I and class II, respectively. Kaplan-Meier survival functions failed to demonstrate significant differences in survival with PRA >10 % for class I (Log-rank test: χ (2) (df = 1): 1.11, p = 0.293) or class II (Log-rank test: χ (2) (df = 1): 0.99, p = 0.320). Adjusting for covariates, multivariate Cox models demonstrated that class II PRA >10 % was associated with a significant increase in mortality hazard (HR 1.918; 95 % CI 1.128, 3.261; p = 0.016), whereas class I PRA >10 % was uncorrelated with this outcome. CONCLUSIONS:Pre-transplant PRA class II >10 % in adult CF patients is associated with elevated mortality hazard after LTx.

journal_name

Lung

journal_title

Lung

authors

Hayes D Jr,Tumin D,Tobias JD

doi

10.1007/s00408-016-9861-8

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

429-35

issue

3

eissn

0341-2040

issn

1432-1750

pii

10.1007/s00408-016-9861-8

journal_volume

194

pub_type

杂志文章

相关文献

LUNG文献大全
  • Elevated levels of IL-18 in plasma and skeletal muscle in chronic obstructive pulmonary disease.

    abstract::The aim of this study was to test the hypothesis that systemic inflammation in patients with chronic obstructive pulmonary disease (COPD) is accompanied by enhanced interleukin 18 (IL-18) expression in skeletal muscle, which may precede muscle weight loss. Twenty patients with moderate to severe COPD [12 women, 66 +/-...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-007-9000-7

    authors: Petersen AM,Penkowa M,Iversen M,Frydelund-Larsen L,Andersen JL,Mortensen J,Lange P,Pedersen BK

    更新日期:2007-05-01 00:00:00

  • Fcγ receptor IIIb (CD16b) polymorphisms are associated with susceptibility to idiopathic pulmonary fibrosis.

    abstract::An excess of neutrophils in the alveoli and lung interstitium has been described in idiopathic pulmonary fibrosis (IPF). Engagement of neutrophil Fcγ receptors with IgG complexes may contribute to the pathogenesis of IPF. The neutrophil FcγRIIIb receptor occurs in two codominantly expressed allelic variants, NA1 and N...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-010-9262-3

    authors: Bournazos S,Bournazou I,Murchison JT,Wallace WA,McFarlane P,Hirani N,Simpson AJ,Dransfield I,Hart SP

    更新日期:2010-12-01 00:00:00

  • Incidence and Management of Post-Lobectomy and Pneumonectomy Bronchopleural Fistula.

    abstract:INTRODUCTION:Bronchopleural fistula is a rare but potentially fatal complication of pulmonary resections and proper management is essential for its resolution. In this study, we analyzed the incidence of fistula after pulmonary resection and reported data about endoscopic and conservative treatments of this complicatio...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-016-9841-z

    authors: Fuso L,Varone F,Nachira D,Leli I,Salimbene I,Congedo MT,Margaritora S,Granone P

    更新日期:2016-04-01 00:00:00

  • ACE2 activation confers endothelial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats.

    abstract:BACKGROUND:Angiotensin-converting enzyme 2 (ACE2), an ACE homolog, hydrolyzes angiotensin II and opposes its actions, and plays a protective role in the pathogenesis of pulmonary arterial hypertension (PAH). However, the underlying mechanisms involved in the effect of ACE2 on PAH are still uncertain. In this study, we ...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-013-9470-8

    authors: Li G,Liu Y,Zhu Y,Liu A,Xu Y,Li X,Li Z,Su J,Sun L

    更新日期:2013-08-01 00:00:00

  • Effect of Anti-IL5, Anti-IL5R, Anti-IL13 Therapy on Asthma Exacerbations: A Network Meta-analysis.

    abstract:BACKGROUND:Several new treatments for severe asthma have become available in the last decade; yet, little data exist to guide their use in specific patient populations. OBJECTIVE:A network meta-analysis was conducted comparing the efficacy of FDA-approved monoclonal antibody therapies in preventing exacerbations in pa...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-019-00310-8

    authors: Ramonell RP,Iftikhar IH

    更新日期:2020-02-01 00:00:00

  • Treatment of atopic cough caused by Basidiomycetes antigen with low-dose itraconazol.

    abstract::We report two patients with atopic cough due to Basidiomycetes antigen. One patient was a 27 year-old woman and the other was a 17 year-old boy. Both patients visited our hospital because of severe nonproductive cough. They did not have bronchial hyperresponsiveness to methacholine or heightened bronchomotor tone. Bro...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-004-2509-0

    authors: Ogawa H,Fujimura M,Tofuku Y

    更新日期:2004-01-01 00:00:00

  • Nicorandil, a KATP Channel Opener, Attenuates Ischemia-Reperfusion Injury in Isolated Rat Lungs.

    abstract:PURPOSE:Nicorandil is a hybrid between nitrates and KATP channel opener activators. The aim of this study was to evaluate the nicorandil's effects on ischemia-reperfusion (IR) lung injury and examine the mechanism of its effects. METHODS:Isolated rat lungs were divided into 6 groups. In the sham group, the lungs were ...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-020-00339-0

    authors: Abe K,Horiguchi T,Enzan K,Masaki Y,Nishikawa T,Kimura T

    更新日期:2020-04-01 00:00:00

  • Cholinergic innervation of BALT (bronchus associated lymphoid tissue) in rat.

    abstract::The presence and distribution of acetylcholinesterase (AChE) and cholineacetyl transferase activities (Chat) were examined in the bronchus-associated lymphoid tissue (BALT) of juvenile, adult and old rats. Histoenzymatic and immunochemical methods were used in association with quantitative analysis of images and stati...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-003-1042-x

    authors: Cavallotti C,Tonnarini GF,Tranquilli Leali FM

    更新日期:2004-01-01 00:00:00

  • Angiogenic activity of sera from extrinsic allergic alveolitis patients in relation to clinical, radiological, and functional pulmonary changes.

    abstract::Extrinsic allergic alveolitis (EAA) caused by inhaled organic environmental allergens can progress to a fibrotic end-stage lung disease. Neovascularization plays an important role in pathogenesis of pulmonary fibrosis. The aim of this study was to assess the effect of sera from EAA patients on the angiogenic capabilit...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-010-9228-5

    authors: Zielonka TM,Demkow U,Filewska M,Bialas B,Zycinska K,Radzikowska E,Wardyn AK,Skopinska-Rozewska E

    更新日期:2010-10-01 00:00:00

  • The Significance of Controlling Nutritional Status (CONUT) Score as a Novel Prognostic Parameter in Small Cell Lung Cancer.

    abstract:PURPOSE:The immuno-nutritional status is closely related to the prognosis in many cancers. Controlling nutritional status (CONUT) score is a new parameter that reflects the immuno-nutritional status and is prognostic in some cancers. However, the prognostic significance of the CONUT score in small cell lung cancer (SCL...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-020-00361-2

    authors: Yılmaz A,Tekin SB,Bilici M,Yılmaz H

    更新日期:2020-08-01 00:00:00

  • Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function.

    abstract::Undifferentiated connective tissue disease (UCTD) is a distinct clinical entity that may be accompanied by interstitial lung disease (ILD). The natural history of UCTD-ILD is unknown. We hypothesized that patients with UCTD-ILD would be more likely to have improvement in lung function than those with idiopathic pulmon...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-009-9226-7

    authors: Kinder BW,Shariat C,Collard HR,Koth LL,Wolters PJ,Golden JA,Panos RJ,King TE Jr

    更新日期:2010-04-01 00:00:00

  • Fungal infection mimicking pulmonary malignancy: clinical and radiological characteristics.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the clinical and radiological features of patients with fungal infection mimicking thoracic malignancy and to establish a diagnostic approach for both clinicians and radiologists to avoid misdiagnosis. METHODS:In this retrospective study, we reviewed clinical and com...

    journal_title:Lung

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00408-013-9506-0

    authors: Guimarães MD,Marchiori E,Meirelles GS,Hochhegger B,Santana PR,Gross JL,Bitencourt AG,Boonsirikamchai P,Godoy MC

    更新日期:2013-12-01 00:00:00

  • Laboratory Cross-Contamination of Mycobacterium tuberculosis: A Systematic Review and Meta-analysis.

    abstract:BACKGROUND:Microbiological cultures are the mainstay of the diagnosis of tuberculosis (TB). False-positive TB results lead to significant unnecessary therapeutic and economic burden and are frequently caused by laboratory cross-contamination. The aim of this meta-analysis was to quantify the prevalence of laboratory cr...

    journal_title:Lung

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00408-019-00241-4

    authors: Barac A,Karimzadeh-Esfahani H,Pourostadi M,Rahimi MT,Ahmadpour E,Rashedi J,Mahdavipoor B,Kafil HS,Spotin A,Abate KH,Mathioudakis AG,Asgharzadeh M

    更新日期:2019-10-01 00:00:00

  • Preprocedural planning with prospectively triggered multidetector row CT angiography prior to bronchial artery embolization in cystic fibrosis patients with massive hemoptysis.

    abstract:STUDY OBJECTIVES:The aim of this study was to determine if electrocardiographically synchronized, prospectively triggered multidetector row computed tomography (ECG-MDR-CT) angiography of the aorta can accurately predict the location of ectopic bronchial arteries in patients with cystic fibrosis (CF) with massive hemop...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-011-9343-y

    authors: Hayes D Jr,Winkler MA,Kirkby S,Capasso P,Mansour HM,Attili AK

    更新日期:2012-04-01 00:00:00

  • A Multidisciplinary Lung Cancer Program: Does It Reduce Delay Between Diagnosis and Treatment?

    abstract:INTRODUCTION:Lung cancer is the leading cause of cancer death in the USA, claiming more than 140,000 deaths annually. Delays in diagnosis and treatment can lead to missed opportunities for both curative and life prolonging therapies. This study aimed to evaluate duration of time to diagnosis and first treatment, as wel...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-020-00404-8

    authors: Albano D,Bilfinger T,Feraca M,Kuperberg S,Nemesure B

    更新日期:2020-12-01 00:00:00

  • Value of CD-1-positive cells in bronchoalveolar lavage fluid for the diagnosis of pulmonary histiocytosis X.

    abstract::Pulmonary histiocytosis X is characterized by an accumulation of CD-1-positive histiocytosis X cells in the lung, which also can be found in the bronchoalveolar lavage fluid (BALF). However, it has recently been demonstrated that CD-1-positive cells can also be detected in BALF of patients with other interstitial lung...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/BF02714167

    authors: Auerswald U,Barth J,Magnussen H

    更新日期:1991-01-01 00:00:00

  • Airway eosinophilic inflammation and bronchial hyperresponsiveness after allergen inhalation challenge in asthma.

    abstract::Allergen exposure in atopic asthmatic patients is associated with recruitment and activation of eosinophils in the airways. Once activated, eosinophils release toxic products, including the eosinophil cationic protein (ECP), able to damage bronchial structures and to increase bronchial hyperresponsiveness. With this b...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/pl00007606

    authors: Oddera S,Silvestri M,Penna R,Galeazzi G,Crimi E,Rossi GA

    更新日期:1998-01-01 00:00:00

  • Response to oyster mushroom (Pleurotus ostreatus) extract by sensitized and nonsensitized guinea pig trachea.

    abstract::Occupational exposure to oyster mushroom (Pleurotus ostreatus) has been associated with obstructive lung disease. Previously, we studied an extract of oyster mushroom (OME) and determined that it causes dose-dependent contractions of nonsensitized guinea pig trachea (GPT). We extend these studies to the investigation ...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-011-9302-7

    authors: Schachter EN,Zuskin E,Pucarin-Cvetkovic J,Chiarelli A,Goswami S

    更新日期:2011-08-01 00:00:00

  • Effect of inhaled racemic and (R)-albuterol on airway vascular smooth muscle tone in healthy and asthmatic subjects.

    abstract::Although the relative effect of racemic and (R)-albuterol on airway smooth muscle tone have been investigated in patients with airflow obstruction, the comparative effectiveness of these drugs in relaxing airway vascular smooth muscle is unknown. Therefore, we determined the actions of inhaled racemic and (R)-albutero...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-003-1022-1

    authors: Pereira A,Mendes E,Ferreira T,Wanner A

    更新日期:2003-01-01 00:00:00

  • Clusterin immunoexpression and its clinical significance in patients with non-small cell lung cancer.

    abstract::Clusterin is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution. It plays important roles in various pathophysiological processes, including tissue remodeling, reproduction, lipid transport, complement regulation, and apoptosis. Clusterin appears to have two main isoforms that result from alternati...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-010-9248-1

    authors: Li H,Liu S,Zhu X,Yang S,Xiang J,Chen H

    更新日期:2010-10-01 00:00:00

  • Expression of cancer-testis antigens MAGE-A3/6 and NY-ESO-1 in non-small-cell lung carcinomas and their relationship with immune cell infiltration.

    abstract::Cancer-testis antigens (CTAs) are expressed only in many cancers and limited immunoprivileged sites such as the testis and placenta. Dendritic cells (DCs) and CD8+ T lymphocytes (CTLs) play roles in the immune responses to tumor growth and may affect the prognosis of cancers. This study was designed to investigate the...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-009-9181-3

    authors: Kim SH,Lee S,Lee CH,Lee MK,Kim YD,Shin DH,Choi KU,Kim JY,Park DY,Sol MY

    更新日期:2009-11-01 00:00:00

  • Low concentration silver nitrate pleurodesis in rabbits: optimal concentration for rapid and complete sclerosing effect.

    abstract::Pleurodesis is a useful therapeutic tool when local treatment of a recurrent malignant pleural effusion or pneumothorax is needed. We have previously demonstrated that the intrapleural injection of 0.5% silver nitrate (SN) produces a significant pleurodesis, while 0.25% SN has no sclerosing effect in a rabbit model. T...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-003-1038-6

    authors: Teixeira LR,Vargas FS,Antonangelo L,Mattos VC,Vaz MA,Acencio MM,Marchi E

    更新日期:2003-11-01 00:00:00

  • Tracheobronchopathia osteochondroplastica: a rare large airway disorder.

    abstract::Tracheobronchopathia osteochondroplastica (TO) is a rare disorder of the large airways characterized by the development of submucosal cartilaginous and bony nodules. The nodules involve the anterior and lateral walls and typically spare the posterior membranous wall. The clinical presentation of TO is variable and ran...

    journal_title:Lung

    pub_type: 杂志文章,评审

    doi:10.1007/s00408-008-9113-7

    authors: Abu-Hijleh M,Lee D,Braman SS

    更新日期:2008-11-01 00:00:00

  • Relationship between quantitative CT metrics and pulmonary function in combined pulmonary fibrosis and emphysema.

    abstract:PURPOSE:Combined pulmonary fibrosis and emphysema (CPFE) is increasingly recognized, as current reports of its clinical features show. To determine CPFE's physiologic and radiologic features, we conducted quantitative assessment of computed tomography scans to compare with those of chronic obstructive pulmonary disease...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-013-9513-1

    authors: Ando K,Sekiya M,Tobino K,Takahashi K

    更新日期:2013-12-01 00:00:00

  • Acute and chronic treatment with glucocorticosteroids, modifying the beta 2-adrenergic response of the guinea pig trachea.

    abstract::The effect of beta 2-adrenoceptor agonists on airway smooth muscle relaxation may be subject to desensitization. It could be modified by glucocorticosteroid treatment. An increase in the beta 2 agonist response by glucocorticosteroids in vitro has been described. We studied the effects of acute and chronic treatment w...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/BF00176895

    authors: Seco AJ,Salgueiro ME,Manso G

    更新日期:1995-01-01 00:00:00

  • Effects of vitamin E deficiency on bleomycin-induced pulmonary fibrosis in the hamster.

    abstract::The effects of vitamin E deficiency on bleomycin (BLM)-induced pulmonary fibrosis have been studied by analyses of pressure volume (PV) curves and morphological examinations. Golden hamsters were divided into groups on a control diet (group C), vitamin E-deficient diet (E), control diet with BLM treatment (CB), and vi...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/BF02714044

    authors: Nakamura H,Sato S,Takahashi K

    更新日期:1988-01-01 00:00:00

  • Respiratory adaptation during sleep in infants.

    abstract::Respiratory adaptation during sleep improves with growth. The most vulnerable period for respiratory adaptation to sleep is from birth to 3 months of age. Factors that favor vulnerability are immaturity in ventilatory control and high rib cage compliance which impairs its effectiveness for ventilation. Improvement in ...

    journal_title:Lung

    pub_type: 杂志文章,评审

    doi:10.1007/BF02718226

    authors: Gaultier C

    更新日期:1990-01-01 00:00:00

  • Comparison of LMWH versus UFH for hemorrhage and hospital mortality in the treatment of acute massive pulmonary thromboembolism after thrombolytic treatment : randomized controlled parallel group study.

    abstract:PURPOSE:Current guidelines recommend the use of low molecular weight heparin (LMWH) for most haemodynamically stable patients with pulmonary thromboembolism (PTE), however, it is not clear whether LMWH is preferable to unfractionated heparin (UFH) for the treatment of massive PTE. We aimed to compare the use of LMWH ve...

    journal_title:Lung

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00408-014-9660-z

    authors: Ucar EY,Akgun M,Araz O,Tas H,Kerget B,Meral M,Kaynar H,Saglam L

    更新日期:2015-02-01 00:00:00

  • New developments in reflux-associated cough.

    abstract::Gastro-oesophageal reflux disease (GORD) is generally considered one of the three main causes of chronic cough, along with asthma and nasal disease. The diagnosis of GORD is often based upon a successful trial of anti-acid treatment however GORD is a complex condition taking many forms. Only recently have studies star...

    journal_title:Lung

    pub_type: 杂志文章,评审

    doi:10.1007/s00408-009-9210-2

    authors: Smith J,Woodcock A,Houghton L

    更新日期:2010-01-01 00:00:00

  • Airway Vagal Neuroplasticity Associated with Respiratory Viral Infections.

    abstract::Respiratory virus infections leads to coughing, sneezing, and increases in reflex parasympathetic bronchoconstriction and secretions. These responses to viral infection are exclusively or largely secondary to changes in the function of the nervous system. For many with underlying airway pathologies such as asthma and ...

    journal_title:Lung

    pub_type: 杂志文章,评审

    doi:10.1007/s00408-015-9832-5

    authors: Zaccone EJ,Undem BJ

    更新日期:2016-02-01 00:00:00