Airway Vagal Neuroplasticity Associated with Respiratory Viral Infections.

Abstract:

:Respiratory virus infections leads to coughing, sneezing, and increases in reflex parasympathetic bronchoconstriction and secretions. These responses to viral infection are exclusively or largely secondary to changes in the function of the nervous system. For many with underlying airway pathologies such as asthma and COPD, this neuroplasticity can lead to disease exacerbations and hospitalization. Relatively little is understood about the cellular and molecular mechanisms that underlie the changes in neuronal control of the respiratory tract during viral infection, but the evidence supports the idea that changes occur in the physiology of both the sensory and autonomic innervation. Virus infection can lead to acute increases in the activity of sensory nerves as well as to genetic changes causing alterations in sensory nerve phenotype. In addition, respiratory viral infections are associated with changes in the control of neurotransmitter release from cholinergic nerve endings terminating at the level of the airway smooth muscle.

journal_name

Lung

journal_title

Lung

authors

Zaccone EJ,Undem BJ

doi

10.1007/s00408-015-9832-5

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

25-9

issue

1

eissn

0341-2040

issn

1432-1750

pii

10.1007/s00408-015-9832-5

journal_volume

194

pub_type

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