Abstract:
:The practice of sedation dosing strategy in mechanically ventilated patient has a profound effect on cognitive function. We conducted a comprehensive review of outcome of sedation on mental health function in critically ill patients on mechanical ventilation in the intensive care unit (ICU). We specifically evaluated current sedative dosing strategy and the development of delirium, post-traumatic stress disorders (PTSDs) and agitation. Based on this review, heavy dosing sedation strategy with benzodiazepines contributes to cognitive dysfunction. However, outcome for mental health dysfunction is mixed in regard to newer sedatives agents such as dexmedetomidine and propofol. Moreover, studies that examine the impact of sedatives for persistence of PTSD/delirium and its long-term cognitive and functional outcomes for post-ICU patients are frequently underpowered. Most studies suffer from low sample sizes and methodological variations. Therefore, larger randomized controlled trials are needed to properly assess the impact of sedation dosing strategy on cognitive function.
journal_name
Lungjournal_title
Lungauthors
Porhomayon J,El-Solh AA,Adlparvar G,Jaoude P,Nader NDdoi
10.1007/s00408-015-9820-9subject
Has Abstractpub_date
2016-02-01 00:00:00pages
43-52issue
1eissn
0341-2040issn
1432-1750pii
10.1007/s00408-015-9820-9journal_volume
194pub_type
杂志文章,评审相关文献
LUNG文献大全abstract:BACKGROUND:Depression is an important comorbidity for patients with chronic obstructive pulmonary disease (COPD). The association between depression and acute exacerbations of COPD is unknown. This study was designed to determine the frequency of COPD exacerbations in outpatients with and without depressive symptoms. ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-009-9135-9
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Exhaled nitric oxide (NO) levels have been reported to be lower in patients with cystic fibrosis (CF) than in controls; however the mechanism(s) responsible and the effect on pathogenesis are unclear. The objective of these studies was to determine if the low levels of gas phase NO (gNO) could be reproduced ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9395-7
更新日期:2012-10-01 00:00:00
abstract::We studied the influence of age on glutathione (GSH) content in the distal lung and the lung tissue of mice. From 1 to 28 months of age, the quantity of GSH and glutathione disulfide (GSSG) in bronchoalveolar lavage (BAL) fluid and in the lung tissue were determined. The GSH content in BAL fluid, which reflects the an...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00164439
更新日期:1994-01-01 00:00:00
abstract::In severe asthma attacks beta 2-sympathomimetics lose part of their therapeutic efficiency. To elucidate this loss of efficiency in an experimental model we compared the relaxant potency of salbutamol (SAL), fenoterol (FEN), formoterol (FOR), and (-)-isoprenaline (ISO) in guinea pig tracheae partially and maximally pr...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00174319
更新日期:1992-01-01 00:00:00
abstract::Pulmonary histiocytosis X is characterized by an accumulation of CD-1-positive histiocytosis X cells in the lung, which also can be found in the bronchoalveolar lavage fluid (BALF). However, it has recently been demonstrated that CD-1-positive cells can also be detected in BALF of patients with other interstitial lung...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF02714167
更新日期:1991-01-01 00:00:00
abstract::Group B streptococcal (GBS) pneumonia, with neutrophilic granulocytes immigrating into the lungs, may occur in neonates. The incidence is particularly high among preterm infants, who often are treated with exogenous surfactant. We have previously demonstrated in vitro that neutrophils stimulated by GBS cause lipid per...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-003-1027-9
更新日期:2004-01-01 00:00:00
abstract::A 15-year-old male had a history of increasing dyspnea on exertion, cough, sputum production, fever, weakness, hemoptysis, and diarrhea. Chest radiography demonstrated bilateral alveolar consolidation. Bronchoalveolar lavage fluid analysis revealed extensive hemosiderin-laden alveolar macrophages. On the basis of iron...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-005-2596-6
更新日期:2006-09-01 00:00:00
abstract::A multiuser system for whole body plethysmographic measurements and interpretation which has been developed under clinical conditions is described. The following measurements can be carried out in a rapid way and in one session with the patient: specific airway resistance during spontaneous breathing, determination of...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF02718260
更新日期:1990-01-01 00:00:00
abstract::Allergen exposure in atopic asthmatic patients is associated with recruitment and activation of eosinophils in the airways. Once activated, eosinophils release toxic products, including the eosinophil cationic protein (ECP), able to damage bronchial structures and to increase bronchial hyperresponsiveness. With this b...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/pl00007606
更新日期:1998-01-01 00:00:00
abstract::Endobronchial Nd:Yag laser therapy is an excellent tool to reopen the central airway(s) in patients with severe respiratory symptoms caused by endobronchial tumor growth. Rigid bronchoscopy should be the method of choice. Usually general anesthesia is necessary. Complication rate depends on the condition of the patien...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF02718248
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:We investigated outcomes of patients hospitalized with community-acquired pneumonia (CAP) according to the changes in red cell distribution width (RDW). METHODS:For 980 adults, clinical characteristics, outcomes during hospitalization for CAP (transfer to the intensive care unit, treatment with mechanical vent...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9942-8
更新日期:2016-12-01 00:00:00
abstract:INTRODUCTION:To evaluate the cardio-pulmonary hemodynamics changes before and after valve treatment, and their correlation with lobe volume reduction. METHODS:This retrospective multicentre study included consecutive patients undergoing bronchoscopic valve treatment for heterogeneous emphysema. In addition to standard...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-020-00351-4
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:Acute exacerbations (AE) in patients with COPD are associated with a decline in lung function, increased risk of hospitalization, and mortality. In this cross-sectional study we tested whether the level of objectively measured daily physical activity and exercise capacity are associated with the number of COPD ...
journal_title:Lung
pub_type: 杂志文章,多中心研究
doi:10.1007/s00408-014-9673-7
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:Improving dyspnea and exercise performance are goals of COPD therapy. We tested the hypothesis that air current applied to the face would lessen dyspnea and improve exercise performance in moderate-severe COPD patients. METHODS:We recruited 10 COPD patients (5 men, age 62 ± 6 years, FEV1 0.93 ± 0.11 L (34 ± 3%...
journal_title:Lung
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00408-015-9780-0
更新日期:2015-10-01 00:00:00
abstract::Recently, active remodeling may indicate a good prognosis in idiopathic interstitial pneumonias. In this study we sought to validate the importance of the collagen/elastic system in the extracellular matrix remodeling and to study the relationships between the collagen/elastic system in nonspecific interstitial idiopa...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-006-0104-2
更新日期:2007-01-01 00:00:00
abstract::Cessation of smoking in the home is one of the most important nonpharmacologic actions to be recommended. There is a highly significant increase in wheezing, coughing, and respiratory infections in children with smoking mothers, and this increase is directly proportional to the number of cigarettes smoked. Cord blood ...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF02718144
更新日期:1990-01-01 00:00:00
abstract::Patients with untreated obstructive sleep apnea hypopnea (OSAH) are predisposed to developing hypertension, and therapy with continuous positive airway pressure (CPAP) may reduce blood pressure (BP). The purpose of this study was to assess the impact of CPAP therapy on BP in patients with OSAH. We performed a comprehe...
journal_title:Lung
pub_type: 杂志文章,meta分析
doi:10.1007/s00408-006-0117-x
更新日期:2007-03-01 00:00:00
abstract:PURPOSE:The aim was to investigate whether maintenance therapy (MT) is sufficient or not to improve overall survival (OS) and progress-free survival (PFS) of advanced non-small cell lung cancer (NSCLC) patients. METHODS:Randomized controlled trials (RCTs) published between 1990 and 2013 were retrieved from PubMed, EMB...
journal_title:Lung
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00408-015-9758-y
更新日期:2015-10-01 00:00:00
abstract::Antidromic stimulation of vagal sensory nerves is known to produce plasma extravasation in the rat trachea. This neurogenic inflammation is thought to be mediated by substance P or other tachykinins released from sensory nerve endings. We sought to determine whether calcitonin gene-related peptide (CGRP), which is als...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00175980
更新日期:1992-01-01 00:00:00
abstract::The major goal of all diagnostic and therapeutic efforts in childhood asthma is to prevent progression of lung disease into adulthood. To improve the uncomfortable situation of underdiagnosis and undertreatment and to lower the risk of acquiring irreversible lung damage, an optimal co-working relationship between fami...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF02718166
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:Traditional inflammatory biomarkers are insufficient for the evaluation of bronchiolitis severity. Recent investigations have shown that the receptor for advanced glycation end product (RAGE) and its soluble isoforms (sRAGE) play a critical role in the pathogenesis of lung injury. Main objective was to assess t...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-014-9663-9
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Up to 50% of patients suffer short-term postoperative adverse events (AEs) and metastatic recurrence in the long-term following curative-intent lung cancer resection. The association between AEs, particularly infectious in nature, and disease recurrence is controversial. We sought to evaluate the association...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-020-00395-6
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:We previously demonstrated that the exposure to hyperbaric hyperoxia increased respiratory system elastance and both the "ohmic" and viscoelastic components of inspiratory resistances, probably because of increased oxygen tension toxic effects. We presently investigated the possible consequences of a single ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-014-9576-7
更新日期:2014-08-01 00:00:00
abstract::Undifferentiated connective tissue disease (UCTD) is a distinct clinical entity that may be accompanied by interstitial lung disease (ILD). The natural history of UCTD-ILD is unknown. We hypothesized that patients with UCTD-ILD would be more likely to have improvement in lung function than those with idiopathic pulmon...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-009-9226-7
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:We aimed to determine the time, dose, and volume responses in a mouse pulmonary injury model following ablative dose focal irradiation (ADFIR) in order to better understand normal lung injury. METHODS AND MATERIALS:ADFIR was administered to the left lung of mice using a small animal micro-irradiator. Histopath...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-015-9825-4
更新日期:2016-02-01 00:00:00
abstract::Binding characteristics of the alpha 1-adrenergic radioloigand [3H]prazosin, and the muscarinic cholinergic radioligand, [3H]quinuclidinyl benzilate, were determined both in intact cell preparations of rat alveolar type II pneumocytes (TIIPs) and in membrane preparations of rat lung tissue. Binding in adult and neonat...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00165701
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Patients with various chronic respiratory diseases have a higher incidence of gastroesophageal reflux disease (GERD)-related symptoms, but the mechanisms of the relationship between GERD symptoms and chronic obstructive pulmonary disease (COPD) remain unclear. The aim of the present study was to explore the ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-011-9365-5
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare pulmonary condition, characterized by diffuse proliferation of neuroendocrine cells in the respiratory epithelium. DIPNECH lesions are less than 5 mm in size and are limited to the basement membrane with no invasion. There is li...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-018-0149-z
更新日期:2018-10-01 00:00:00
abstract::Respiratory virus infections leads to coughing, sneezing, and increases in reflex parasympathetic bronchoconstriction and secretions. These responses to viral infection are exclusively or largely secondary to changes in the function of the nervous system. For many with underlying airway pathologies such as asthma and ...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-015-9832-5
更新日期:2016-02-01 00:00:00
abstract::In previous studies, we showed that Fischer rats fed 175 mg/kg of amiodarone accumulated large amounts of drug and metabolite in the lung and developed pulmonary toxicity, whereas Wistar rats fed the same drug dose had significantly less amiodarone in the lung and did not develop pulmonary inflammation. The present st...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00167949
更新日期:1996-01-01 00:00:00