Abstract:
:In severe asthma attacks beta 2-sympathomimetics lose part of their therapeutic efficiency. To elucidate this loss of efficiency in an experimental model we compared the relaxant potency of salbutamol (SAL), fenoterol (FEN), formoterol (FOR), and (-)-isoprenaline (ISO) in guinea pig tracheae partially and maximally precontracted by 0.1 and 60 mumol/L carbachol, respectively. In partially precontracted tracheae the beta 2-sympathomimetics exerted maximum relaxation in comparison with ISO and low EC50S (nmol/L) for relaxation (SAL, 20; FEN, 5.6; FOR, 0.28; and ISO, 2.5). In maximally precontracted tracheae, however, the beta 2-sympathomimetics were only partial agonists for relaxation with reduced intrinsic activities (%) in comparison to ISO (SAL, 59%; FEN, 61%; FOR, 76%) and significantly increased EC50S (nmol/L) for relaxation (SAL, 130; FEN, 57; FOR, 3.0; ISO, 37). To investigate if the high relaxant potency of FOR is correlated with a higher binding affinity and/or a higher intrinsic activity for adenylate cyclase stimulation than for FEN and SAL, we performed experiments in receptor membranes from guinea pig lung. Binding competition of SAL, FEN, and FOR with [3H]ICI 118,551 for lung beta 2-adrenoceptors yielded dissociation constants (KD) of 320 (SAL), 120 (FEN), and 7.6 (FOR) nmol/L, which exhibited the same ranking as EC50S for relaxation. Concentrations of SAL, FEN, and FOR equivalent to 100 KD of the respective dissociation constants stimulated beta 2-adrenoceptor-coupled adenylate cyclase with different intrinsic activities (%) incomparison to ISO (SAL, 61%; FEN, 63%; FOR, 89%) matching intrinsic activities for relaxation. From these experiments it may be concluded that FOR might improve drug therapy of severe asthma not only due to its long mode of action discovered in clinical studies but also due to its high intrinsic activity and receptor affinity.
journal_name
Lungjournal_title
Lungauthors
Lemoine H,Overlack C,Köhl A,Worth H,Reinhardt Ddoi
10.1007/BF00174319keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
163-80issue
3eissn
0341-2040issn
1432-1750journal_volume
170pub_type
杂志文章相关文献
LUNG文献大全abstract:BACKGROUND:The right ventricular ejection fraction (RVEF) is a surrogate marker of right ventricular function in pulmonary hypertension (PH), but its measurement is complicated and time consuming. The tricuspid annular plane systolic excursion (TAPSE) measures only the longitudinal component of RV contraction while the...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-018-0089-7
更新日期:2018-04-01 00:00:00
abstract::The role of leukotrienes in hypoxic vasoconstriction remains controversial. Our previous study using the lipoxygenase inhibitor BW 755C in dogs failed to show a substantive role for leukotrienes in hypoxic vasoconstriction. To clarify further the role of leukotrienes, we designed 3 protocols. In the first protocol, we...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF02714947
更新日期:1989-01-01 00:00:00
abstract::Reaginic antibodies in hay fever patients belong to IgE. The immunoglobulin sensitizes basophilic granulocytes and mast cells from homologous species and mediates the release of chemical mediators which cause allergic symptoms. The sensitization is due to the binding of IgE to receptors on the target cells through the...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF02730676
更新日期:1978-01-01 00:00:00
abstract::In recent years the alveolar macrophage has been found to play a central role in interstitial lung disease. Pulmonary histiocytosis X is characterized by infiltrating fibroblasts, mononuclear cells, and CD-1-positive Langerhans cells. Bronchoalveolar lavage (BAL) fluid displays an increase of CD-1-positive cells and a...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00175659
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Cardiopulmonary exercise testing (CPET) is a safe and clinically useful method to assess functional capacity and to follow disease progression and the response to treatment in several clinical conditions. AIM:We set out to determine the relationship between outcome measures of CPET and high-resolution compu...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-011-9316-1
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Malignant mesothelioma is an aggressive tumor of serosal surfaces that is closely associated with asbestos exposure which induces oxidative stress. Heme oxygenase (HO)-1, a rate-limiting enzyme of heme degradation, plays a protective role against oxidative stress. The HO-1 gene promoter carries (GT)n repeats...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9371-2
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Depression is an important comorbidity for patients with chronic obstructive pulmonary disease (COPD). The association between depression and acute exacerbations of COPD is unknown. This study was designed to determine the frequency of COPD exacerbations in outpatients with and without depressive symptoms. ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-009-9135-9
更新日期:2009-03-01 00:00:00
abstract:INTRODUCTION:Chronic obstructive pulmonary disease is a progressive lung disease characterized by abnormal cellular responses to cigarette smoke, resulting in tissue destruction and airflow limitation. Autophagy is a fundamental cellular process that eliminates long-lived proteins and damaged organelles through lysosom...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-017-9997-1
更新日期:2017-06-01 00:00:00
abstract::Bronchopleural (BPF) and alveolar-pleural (APF) fistulas are frequently encountered in clinical practice with persistent air leaks that can lead to significant morbidity, prolonged hospital stay, and potentially increased mortality. BPF and APF are commonly related to pulmonary resections. Other etiologies include min...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-009-9204-0
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The aims of this study were to determine the incidence of tuberculosis (TB) and nontuberculous mycobacteria (NTM) lung disease in patients who were treated with tumor necrosis factor (TNF) antagonists in South Korea and to evaluate their clinical characteristics. METHODS:We surveyed all patients (N = 509) w...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-013-9481-5
更新日期:2013-10-01 00:00:00
abstract::The early pathogenic events in cystic fibrosis (CF) include colonization of Pseudomonas in the lung, airway inflammation, and mucus hypersecretion with airway obstruction. The primary mechanisms leading to chronic infection and inflammation are not well understood. One possible explanation for this cascade of events i...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/pl00007616
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:Flexible fiberoptic bronchoscopy (FFB) plays an important role in the surveillance of cystic fibrosis (CF) patients after lung transplantation (LTx). With rapid onset and clearance, propofol provides a safe and efficient method for sedation during FFB, yet sedation requirements for CF patients are not well...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-018-0119-5
更新日期:2018-08-01 00:00:00
abstract::While the care of cystic fibrosis (CF) patients has been mainly the province of pediatricians, great improvements in the therapy and life span of CF patients often results in their transition to care by adult physicians. In this review of CF, we begin with an overview of the epidemiology and genetics of the disease, w...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF00164308
更新日期:1994-01-01 00:00:00
abstract::Pleurodesis is a useful therapeutic tool when local treatment of a recurrent malignant pleural effusion or pneumothorax is needed. We have previously demonstrated that the intrapleural injection of 0.5% silver nitrate (SN) produces a significant pleurodesis, while 0.25% SN has no sclerosing effect in a rabbit model. T...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-003-1038-6
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:Sarcoidosis is a chronic granulomatous inflammatory disease of unknown etiology with heterogeneous outcomes. This study reviewed the clinical outcome status (COS) and organ involvement of Israeli sarcoidosis patients during a five-year period. Further, we compared our results to the 'World Association of Sarcoi...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-017-0015-4
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Pulmonary hypertension (PH) is a comorbidity associated with increased mortality in chronic obstructive pulmonary disease (COPD) patients. It is not known which clinical markers are predictive of PH in COPD. The goal of this study was to develop a clinical tool to identify patients who should be sent for ini...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-011-9346-8
更新日期:2012-02-01 00:00:00
abstract::The bronchus associated lymphoid tissue (BALT) and the precursor immunocompetent lymphoid cells in the nasopharynx, tonsils, and salivary glands represent the basic source of specific secretory IgA, other immunoglobulin, and T cell mediated specific immunity in the respiratory tract. The bulk of this immunologic react...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF02718155
更新日期:1990-01-01 00:00:00
abstract::Along with upper airway cough syndrome (formerly, postnasal drip syndrome) and eosinophilic airway inflammation (asthma, nonasthmatic eosinophilic bronchitis), gastroesophageal reflux disease (GERD) is generally considered among the most common etiologies of chronic cough. Indeed, cough management guidelines published...
journal_title:Lung
pub_type:
doi:10.1007/s00408-013-9528-7
更新日期:2014-02-01 00:00:00
abstract::Methacholine challenge testing (MCT) is widely used to assess airway hyperresponsiveness (AHR). Traditionally, a 20% or greater decline in forced expiratory volume in 1 (FEV(1)) is the primary outcome measure. We examined whether the inclusion of wheeze detection as outcome measure influenced the categorical interpret...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-005-2575-y
更新日期:2006-05-01 00:00:00
abstract::The author reviews the early history of alpha 1-antitrypsin (AAT) deficiency; the biochemical characterization of this inborn error of metabolism, its pattern of inheritance, frequency and predisposition to early, panacinar emphysema. The importance of the destructive element in emphysema and the gradual focusing on n...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF02718174
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:The immuno-nutritional status is closely related to the prognosis in many cancers. Controlling nutritional status (CONUT) score is a new parameter that reflects the immuno-nutritional status and is prognostic in some cancers. However, the prognostic significance of the CONUT score in small cell lung cancer (SCL...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-020-00361-2
更新日期:2020-08-01 00:00:00
abstract::Exhaled breath condensate analysis is a developing method for investigating airway pathology. Impact of food and drink on breath condensate composition has not been systematically addressed. The aim of the study was to follow exhaled breath condensate pH after drinking an acidic and a neutral beverage. Breath condensa...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-008-9086-6
更新日期:2008-07-01 00:00:00
abstract::Impaired phagocytosis of Pseudomonas aeruginosa was found in isolated monocytes of peripheral blood of cystic fibrosis patients, but not in their neutrophils, as reported some years ago. In the present study, we analysed the phagocytic capacity of peripheral blood neutrophils and monocytes of cystic fibrosis patients ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-019-00290-9
更新日期:2020-02-01 00:00:00
abstract::Bronchiectasis is characterized by deregulated inflammatory response and recurrent bacterial infection resulting in progressive lung damage and an irreversible dilatation of bronchi and bronchioles. Generally accepted model of the development of bronchiectasis is the "vicious cycle hypothesis" that proposes compromisi...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-018-0121-y
更新日期:2018-08-01 00:00:00
abstract::It is well known that chronic obstructive pulmonary disease (COPD) patients present with muscle dysfunction that may not correlate with the degree of severity of airflow obstruction. Historically, the strength deficit of the knee extensor musculature (quadriceps) has been described as an independent factor of mortalit...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-018-0164-0
更新日期:2018-12-01 00:00:00
abstract::The lung has only a limited pattern of response to injury. Idiopathic interstitial fibrosis is a descriptive term, describing the end stage of one pattern of pulmonary fibrosis in which the inflammation lies within the structure of the alveolar walls and around vessels and bronchioli, in the interstitium. The disease ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF02718237
更新日期:1990-01-01 00:00:00
abstract:INTRODUCTION:Driving pressure (DP) while on ECMO has been studied in acute respiratory distress syndrome (ARDS) but no studies exist in those on ECMO without ARDS. We aimed to study association of mortality with DP in all patients on ECMO and compare change in DP before and after initiation of ECMO. METHODS:Consecutiv...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-020-00381-y
更新日期:2020-10-01 00:00:00
abstract:INTRODUCTION:Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal fibrosing lung disease with a median survival of approximately 3 years after diagnosis. The only medical option to improve survival in IPF is lung transplantation (LTX). The purpose of this study was to evaluate trajectory data of IPF patients...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-015-9794-7
更新日期:2015-12-01 00:00:00
abstract::Group B streptococcal (GBS) pneumonia, with neutrophilic granulocytes immigrating into the lungs, may occur in neonates. The incidence is particularly high among preterm infants, who often are treated with exogenous surfactant. We have previously demonstrated in vitro that neutrophils stimulated by GBS cause lipid per...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-003-1027-9
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Asbestos is a carcinogen linked to malignant mesothelioma (MM) and lung cancer. Some gene aberrations related to asbestos exposure are recognized, but many associated mutations remain obscure. We performed exome sequencing to determine the association of previously known mutations (driver gene mutations) wit...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-015-9814-7
更新日期:2016-02-01 00:00:00