Driver Gene and Novel Mutations in Asbestos-Exposed Lung Adenocarcinoma and Malignant Mesothelioma Detected by Exome Sequencing.

abstract：:The transmission of forces from the respiratory muscles to the lung across the extremely thin pleural space has been poorly understood because of the difficulty of accurately measuring pleural liquid and pleural surface pressure (lung static recoil or transpulmonary pressure). Recent results using relatively noninvasi...

journal_title：Lung

authors： Lai-Fook SJ

更新日期：1987-01-01 00:00:00

abstract：:High concentrations of tumor necrosis factor-a (TNF), as well as excess of polymorphonuclear leukocytes (PMNs), are present in pleural fluid of patients with complicated parapneumonic effusion (CPPE). Several studies have shown that PMNs are capable of secreting TNF. However, the correlation between levels of TNF and ...

journal_title：Lung

authors： Odeh M,Sabo E,Srugo I,Oliven A

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare pulmonary condition, characterized by diffuse proliferation of neuroendocrine cells in the respiratory epithelium. DIPNECH lesions are less than 5 mm in size and are limited to the basement membrane with no invasion. There is li...

journal_title：Lung

authors： Myint ZW,McCormick J,Chauhan A,Behrens E,Anthony LB

更新日期：2018-10-01 00:00:00

abstract：:Exhaled breath condensate analysis is a developing method for investigating airway pathology. Impact of food and drink on breath condensate composition has not been systematically addressed. The aim of the study was to follow exhaled breath condensate pH after drinking an acidic and a neutral beverage. Breath condensa...

journal_title：Lung

authors： Kullmann T,Barta I,Antus B,Horváth I

更新日期：2008-07-01 00:00:00

abstract：:Overlap syndrome and represents a complex clinical condition in pulmonary medicine. We discuss in this letter factors related with mortality after long-term effects CPAP and key differences between hypercapnic versus hypoxemic overlap patients. ...

journal_title：Lung

authors： Esquinas AM,Marrero FL,Esteva JN

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Patients with various chronic respiratory diseases have a higher incidence of gastroesophageal reflux disease (GERD)-related symptoms, but the mechanisms of the relationship between GERD symptoms and chronic obstructive pulmonary disease (COPD) remain unclear. The aim of the present study was to explore the ...

journal_title：Lung

authors： Liang BM,Feng YL

更新日期：2012-06-01 00:00:00

abstract：:Binding characteristics of the alpha 1-adrenergic radioloigand [3H]prazosin, and the muscarinic cholinergic radioligand, [3H]quinuclidinyl benzilate, were determined both in intact cell preparations of rat alveolar type II pneumocytes (TIIPs) and in membrane preparations of rat lung tissue. Binding in adult and neonat...

journal_title：Lung

authors： Keeney SE,Oelberg DG

更新日期：1993-01-01 00:00:00

abstract：:The lung has only a limited pattern of response to injury. Idiopathic interstitial fibrosis is a descriptive term, describing the end stage of one pattern of pulmonary fibrosis in which the inflammation lies within the structure of the alveolar walls and around vessels and bronchioli, in the interstitium. The disease ...

journal_title：Lung

authors： Lambe D

更新日期：1990-01-01 00:00:00

abstract：:Lung cancer is currently one of the most common malignant diseases and is responsible for substantial mortality worldwide. Compared with never smokers, former smokers remain at relatively high risk for lung cancer, accounting for approximately half of all newly diagnosed cases in the US. Screening offers former smoker...

journal_title：Lung

authors： Tota JE,Ramanakumar AV,Franco EL

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Exhaled nitric oxide (NO) levels have been reported to be lower in patients with cystic fibrosis (CF) than in controls; however the mechanism(s) responsible and the effect on pathogenesis are unclear. The objective of these studies was to determine if the low levels of gas phase NO (gNO) could be reproduced ...

journal_title：Lung

authors： Ostrowski LE,Stewart D,Hazucha M

更新日期：2012-10-01 00:00:00

abstract：ABSTARCT:New anti-fibrotic agents for idiopathic pulmonary fibrosis (IPF) were approved based on the results of forced vital capacity (FVC) trends, although concerns were raised about the reliability of FVC as the only endpoint parameter. We hypothesized that IPF-specific multi-dimensional scores (Composite Physiologic...

journal_title：Lung

authors： Hosein K,Le J,Mura M

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Tree-in-bud (TIB) is a radiologic pattern seen on high-resolution chest CT reflecting bronchiolar mucoid impaction occasionally with additional involvement of adjacent alveoli. Its microbiologic significance has not been systematically evaluated. OBJECTIVES:We aimed to establish the incidence of the TIB pat...

journal_title：Lung

authors： Shimon G,Yonit WW,Gabriel I,Naama BR,Nissim A

更新日期：2015-10-01 00:00:00

abstract：:Bronchiectasis is characterized by deregulated inflammatory response and recurrent bacterial infection resulting in progressive lung damage and an irreversible dilatation of bronchi and bronchioles. Generally accepted model of the development of bronchiectasis is the "vicious cycle hypothesis" that proposes compromisi...

journal_title：Lung

authors： Nikolic A

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:We investigated outcomes of patients hospitalized with community-acquired pneumonia (CAP) according to the changes in red cell distribution width (RDW). METHODS:For 980 adults, clinical characteristics, outcomes during hospitalization for CAP (transfer to the intensive care unit, treatment with mechanical vent...

journal_title：Lung

authors： Gorelik O,Izhakian S,Barchel D,Almoznino-Sarafian D,Tzur I,Swarka M,Beberashvili I,Feldman L,Cohen N,Shteinshnaider M

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:The relationship between asthma and obesity is well established, although the pathophysiological mechanisms linking both diseases remain unknown. Adiponectin is a hormone secreted by adipose cells, plays a role in the modulation of inflammation and may be the key linking these two types of inflammation. METHOD...

journal_title：Lung

authors： de Lima Azambuja R,da Costa Santos Azambuja LS,Costa C,Rufino R

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:Chronic obstructive pulmonary disease is a progressive lung disease characterized by abnormal cellular responses to cigarette smoke, resulting in tissue destruction and airflow limitation. Autophagy is a fundamental cellular process that eliminates long-lived proteins and damaged organelles through lysosom...

journal_title：Lung

authors： Li L,Zhang M,Zhang L,Cheng Y,Tu X,Lu Z

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:Pulmonary hypertension (PH) due to COPD has dismal prognosis. We reviewed the long-term effect of PH-target therapy in severe PH-COPD. METHOD:Patients attending our PH-clinic were reviewed for PH-COPD receiving PH-target therapy. Baseline characteristics, death/transplantation until 2014, therapy, NYHA functio...

journal_title：Lung

authors： Fossati L,Müller-Mottet S,Hasler E,Speich R,Bloch KE,Huber LC,Ulrich Somaini S

更新日期：2014-12-01 00:00:00

abstract：:The author reviews the early history of alpha 1-antitrypsin (AAT) deficiency; the biochemical characterization of this inborn error of metabolism, its pattern of inheritance, frequency and predisposition to early, panacinar emphysema. The importance of the destructive element in emphysema and the gradual focusing on n...

journal_title：Lung

authors： Eriksson S

更新日期：1990-01-01 00:00:00

abstract：:Acid glycosaminoglycans (GAG) were quantitated and partially characterized in pleural effusions in guinea pigs with experimental allergic pleurisy. Increase of GAG in the pleural effusion preceded the increase of effusion volume. Effusion was associated with the presence of cuboidal mesothelial cells on visceral pleur...

journal_title：Lung

authors： Satoh K,Arai H,Nagai H,Ito M,Sato H,Motomiya M,Konno K

更新日期：1987-01-01 00:00:00

abstract：:The efficacy of the docetaxel-carboplatin combination chemotherapy was studied in various phase II studies. Based on these data we aimed to test the regimen in previously untreated patients with advanced advanced non-smoking lung cancer (NSCLC) with docetaxel 80 mg/m2 a standard dose of carboplatin at AUC = 5, in an a...

journal_title：Lung

authors： Tsavaris N,Kosmas C,Skopelitis E,Gennatas K,Zorbala A,Papas P,Gouveris P,Antypas G,Rokana S,Tzelepis G

更新日期：2005-11-01 00:00:00

abstract：:Our aim was to compare Taxol-based chemotherapy response of non-small cell lung cancer (NSCLC) with P-glycoprotein (Pgp) or lung resistance protein expression (LRP). Immunohistochemical analyses were performed on multiple nonconsecutive sections of the biopsy specimens to detect Pgp and LPR expressions in 40 patients ...

journal_title：Lung

authors： Chiou JF,Liang JA,Hsu WH,Wang JJ,Ho ST,Kao A

更新日期：2003-01-01 00:00:00

abstract：:In severe asthma attacks beta 2-sympathomimetics lose part of their therapeutic efficiency. To elucidate this loss of efficiency in an experimental model we compared the relaxant potency of salbutamol (SAL), fenoterol (FEN), formoterol (FOR), and (-)-isoprenaline (ISO) in guinea pig tracheae partially and maximally pr...

journal_title：Lung

authors： Lemoine H,Overlack C,Köhl A,Worth H,Reinhardt D

更新日期：1992-01-01 00:00:00

abstract：:Pneumocystis carinii pneumonia (PCP) is the most common presenting symptom in patients with the acquired immunodeficiency syndrome (AIDS). Clinical trials have shown that inhaled pentamidine, delivered by nebulizer, is an effective prophylaxis for PCP in high-risk patients, and can be used to treat mild to moderate ep...

journal_title：Lung

authors： Newman SP,Simonds AK

更新日期：1990-01-01 00:00:00

abstract：:Particulate matter less than PM(10) and aromatic chemicals formed during incomplete combustion of organic matter are major environmental pollutants because of their toxic potential. The present study reports on the respiratory morbidity pattern of people exposed to auto exhaust as a result of the traffic load consisti...

journal_title：Lung

authors： Chattopadhyay BP,Mukherjee A,Mukherjee K,Roychowdhury A

更新日期：2007-09-01 00:00:00

abstract：:The effects of vitamin E deficiency on bleomycin (BLM)-induced pulmonary fibrosis have been studied by analyses of pressure volume (PV) curves and morphological examinations. Golden hamsters were divided into groups on a control diet (group C), vitamin E-deficient diet (E), control diet with BLM treatment (CB), and vi...

journal_title：Lung

authors： Nakamura H,Sato S,Takahashi K

更新日期：1988-01-01 00:00:00

abstract：:This study was designed to use volumetric capnography to evaluate the breathing pattern and ventilation inhomogeneities in patients with chronic sputum production and bronchiectasis and to correlate the phase 3 slope of the capnographic curve to spirometric measurements. Twenty-four patients with cystic fibrosis (CF) ...

journal_title：Lung

authors： Veronez L,Moreira MM,Soares ST,Pereira MC,Ribeiro MA,Ribeiro JD,Terzi RG,Martins LC,Paschoal IA

更新日期：2010-06-01 00:00:00

abstract：:Tuberculosis (TB) pleurisy is accepted to be the best model for evaluating the local protective cellular immune response to Mycobacterium tuberculosis (MTB) since it can be spontaneously self-cured. Therefore, we aimed to evaluate the involvement of cytokines and the soluble apoptosis-modulating factors sFas and sFasL...

journal_title：Lung

authors： Budak F,Uzaslan EK,Cangür S,Göral G,Oral HB

更新日期：2008-09-01 00:00:00

abstract：:It is well known that chronic obstructive pulmonary disease (COPD) patients present with muscle dysfunction that may not correlate with the degree of severity of airflow obstruction. Historically, the strength deficit of the knee extensor musculature (quadriceps) has been described as an independent factor of mortalit...

journal_title：Lung

authors： Pleguezuelos E,Guirao L,Moreno E,Samitier B,Ortega P,Vila X,Garnacho-Castaño MV,Majó M,Ovejero L,Miravitlles M

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Sildenafil was the only phosphodiesterase-5 inhibitor available for the treatment of pulmonary arterial hypertension (PAH) until the approval and availability of once-daily tadalafil. Since no direct comparative study is likely to be performed between these agents, we sought to evaluate the feasibility of tr...

journal_title：Lung

authors： Shlobin OA,Brown AW,Weir N,Ahmad S,Lemma M,Nathan SD

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Malignant mesothelioma is an aggressive tumor of serosal surfaces that is closely associated with asbestos exposure which induces oxidative stress. Heme oxygenase (HO)-1, a rate-limiting enzyme of heme degradation, plays a protective role against oxidative stress. The HO-1 gene promoter carries (GT)n repeats...

journal_title：Lung

authors： Murakami A,Fujimori Y,Yoshikawa Y,Yamada S,Tamura K,Hirayama N,Terada T,Kuribayashi K,Tabata C,Fukuoka K,Tamaoki T,Nakano T

更新日期：2012-06-01 00:00:00