Abstract：
:Our aim was to compare Taxol-based chemotherapy response of non-small cell lung cancer (NSCLC) with P-glycoprotein (Pgp) or lung resistance protein expression (LRP). Immunohistochemical analyses were performed on multiple nonconsecutive sections of the biopsy specimens to detect Pgp and LPR expressions in 40 patients with advanced NSCLC before Taxol-based chemotherapy. The chemotherapy response was evaluated by clinical and radiological methods in the third month after completion of treatment. No significant differences of prognostic factors (age, sex, body weight loss, performance status, tumor size, tumor stage, and tumor cell type) were found between the 20 patients with good and the 20 patients with poor responses. The incidence difference of positive Pgp expressions between good and poor responses was significant, however, the difference of LRP expression was not. We concluded that Taxol-based chemotherapy response of patients with NSCLC was related to Pgp but not LPR expression.
journal_name
Lungjournal_title
Lungauthors
Chiou JF,Liang JA,Hsu WH,Wang JJ,Ho ST,Kao Adoi
10.1007/s00408-003-1029-7keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
267-73issue
5eissn
0341-2040issn
1432-1750journal_volume
181pub_type
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