Abstract:
BACKGROUND:Patients with various chronic respiratory diseases have a higher incidence of gastroesophageal reflux disease (GERD)-related symptoms, but the mechanisms of the relationship between GERD symptoms and chronic obstructive pulmonary disease (COPD) remain unclear. The aim of the present study was to explore the association of GERD symptoms with impaired pulmonary function and other factors in patients with COPD. METHODS:Patients with clinically stable COPD were consecutively recruited, and a pulmonary function test, visual analogue scale (VAS), and Reflux Diagnostic Questionnaire (RDQ) were administered. The patients were categorized into GERD-positive and GERD-negative groups according to the RDQ. Univariate and multivariate analyses were performed to evaluate the factors associated with the incidence of GERD symptoms in COPD. RESULTS:A total of 1,486 patients with COPD were enrolled. There was no difference in age, gender proportion, body mass index, tobacco exposure, and the use of respiratory medications between the GERD-positive and GERD-negative groups. The respiratory pattern, the values of forced expiratory volume in 1 s, inspiratory capacity (IC), and residual volume, and VAS scores were significantly different between the groups (all P<0.05). Multivariate logistic regression analysis revealed that the decreased IC (odds ratio (OR) =1.56; 95% CI=1.32-2.27; P<0.001) and increased VAS scores (OR=1.38; 95% CI=1.19-1.68; P=0.011) were independent risk factors of GERD symptoms in patients with COPD. CONCLUSION:The severity of hyperinflation and dyspnea may be important associated risk factors for the incidence of GERD symptoms in patients with clinically stable COPD.
journal_name
Lungjournal_title
Lungauthors
Liang BM,Feng YLdoi
10.1007/s00408-011-9365-5subject
Has Abstractpub_date
2012-06-01 00:00:00pages
277-82issue
3eissn
0341-2040issn
1432-1750journal_volume
190pub_type
杂志文章相关文献
LUNG文献大全abstract::The original version of this article contained an error in the usage of the term "false positive rate". The intention of the authors in those instances was simply to compare the absolute percentage of false positive results in the study vs the NLST, not to make any observations about false positive rate in the strict ...
journal_title:Lung
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00408-019-00269-6
更新日期:2019-10-01 00:00:00
abstract::Electronic noses (e-noses) are based on arrays of different sensor types that respond to specific features of an odorant molecule, mostly volatile organic compounds (VOCs). Differently from gas chromatography and mass spectrometry, e-noses can distinguish VOCs spectrum by pattern recognition. E-nose technology has suc...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-017-9987-3
更新日期:2017-04-01 00:00:00
abstract::Cessation of smoking in the home is one of the most important nonpharmacologic actions to be recommended. There is a highly significant increase in wheezing, coughing, and respiratory infections in children with smoking mothers, and this increase is directly proportional to the number of cigarettes smoked. Cord blood ...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF02718144
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:The relationship between asthma and obesity is well established, although the pathophysiological mechanisms linking both diseases remain unknown. Adiponectin is a hormone secreted by adipose cells, plays a role in the modulation of inflammation and may be the key linking these two types of inflammation. METHOD...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-015-9793-8
更新日期:2015-10-01 00:00:00
abstract::The effects of vitamin E deficiency on bleomycin (BLM)-induced pulmonary fibrosis have been studied by analyses of pressure volume (PV) curves and morphological examinations. Golden hamsters were divided into groups on a control diet (group C), vitamin E-deficient diet (E), control diet with BLM treatment (CB), and vi...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF02714044
更新日期:1988-01-01 00:00:00
abstract::Methacholine challenge testing (MCT) is widely used to assess airway hyperresponsiveness (AHR). Traditionally, a 20% or greater decline in forced expiratory volume in 1 (FEV(1)) is the primary outcome measure. We examined whether the inclusion of wheeze detection as outcome measure influenced the categorical interpret...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-005-2575-y
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Sildenafil was the only phosphodiesterase-5 inhibitor available for the treatment of pulmonary arterial hypertension (PAH) until the approval and availability of once-daily tadalafil. Since no direct comparative study is likely to be performed between these agents, we sought to evaluate the feasibility of tr...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9408-6
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:This study was designed to review outcomes of once- (QD) versus twice-daily (BID) radiotherapy (RT) for limited stage small-cell lung cancer (L-SCLC) treated at Dana-Farber Cancer Institute/Brigham and Women's Hospital. METHODS:We reviewed records for all patients with L-SCLC treated with radical chemoradiothe...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-013-9518-9
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:The right ventricular ejection fraction (RVEF) is a surrogate marker of right ventricular function in pulmonary hypertension (PH), but its measurement is complicated and time consuming. The tricuspid annular plane systolic excursion (TAPSE) measures only the longitudinal component of RV contraction while the...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-018-0089-7
更新日期:2018-04-01 00:00:00
abstract::The transmission of forces from the respiratory muscles to the lung across the extremely thin pleural space has been poorly understood because of the difficulty of accurately measuring pleural liquid and pleural surface pressure (lung static recoil or transpulmonary pressure). Recent results using relatively noninvasi...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF02714442
更新日期:1987-01-01 00:00:00
abstract::Lung elastance and resistance increase in the supine posture. To evaluate the effects of change in posture on regional lung mechanics at different lung volumes, lung elastance and resistance were measured at graded volume subdivisions and three esophageal levels at seated and supine body positions, using the esophagea...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00173306
更新日期:1996-01-01 00:00:00
abstract::Recently, active remodeling may indicate a good prognosis in idiopathic interstitial pneumonias. In this study we sought to validate the importance of the collagen/elastic system in the extracellular matrix remodeling and to study the relationships between the collagen/elastic system in nonspecific interstitial idiopa...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-006-0104-2
更新日期:2007-01-01 00:00:00
abstract::Long-term treatment studies with formoterol and salmeterol show that these inhaled long-acting beta 2-agonists compared to available beta 2-agonists produce better bronchodilation, decrease the need for additional doses, decrease asthma symptoms, and are strongly preferred by the patients. Development of tolerance has...
journal_title:Lung
pub_type: 临床试验,杂志文章,评审
doi:10.1007/BF02718109
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:To explore the role of CARM1 in lung cancer (LC) and its relationship with TP53 and CTNNB1. METHODS:Lung cells H1299 and PC14 were randomly divided into six groups: ov-H1299, si-H1299, ov-PC14, si-PC14, Con-H1299, and Con-PC14. Transwell assay, plate clone formation assay, and flow cytometry were used to det...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-020-00324-7
更新日期:2020-04-01 00:00:00
abstract::The pathophysiology of cough variant asthma is poorly understood. In particular, the mechanisms that cause different symptoms in typical asthma (in which wheeze predominates) compared with cough variant asthma (in which cough predominates) have not been determined. Traditional explanations include higher wheezing thre...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-011-9348-6
更新日期:2012-02-01 00:00:00
abstract::A 41-year-old woman presented with chest pain and a cough. There was a solitary pulmonary nodule in the upper-left lobe. The patient had no history of neoplasm except a hysterectomy for uterine leiomyoma five years before. Six months after the first presentation, the tumor showed a gradual increase in size; an explora...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-008-9084-8
更新日期:2008-07-01 00:00:00
abstract::Simulation-based medical education has gained tremendous popularity over the past two decades. Driven by the patient safety movement, changes in the educational opportunities available to trainees and the rapidly evolving capabilities of computer technology, simulation-based medical education is now being used across ...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-010-9260-5
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate the clinical and radiological features of patients with fungal infection mimicking thoracic malignancy and to establish a diagnostic approach for both clinicians and radiologists to avoid misdiagnosis. METHODS:In this retrospective study, we reviewed clinical and com...
journal_title:Lung
pub_type: 杂志文章,多中心研究
doi:10.1007/s00408-013-9506-0
更新日期:2013-12-01 00:00:00
abstract::This study demonstrates for the first time that endothelial cells freshly isolated from small pulmonary arteries of the rat, based on their electrophysiological profile, possess two distinct populations of cells. Immunohistochemical staining revealed the presence of both anti-Kv1.5 and anti-Kir2.1 immunoreactivity in ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s004080000094
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:Idiopathic pulmonary fibrosis (IPF) is a restrictive fibrotic lung disease of uncertain etiology. Alveolar epithelial injury may be one of the inciting triggers in the pathogenesis of this disorder. We hypothesized that circulating antibodies to alveolar epithelial and endothelial cells may be involved in the p...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9390-z
更新日期:2012-08-01 00:00:00
abstract::The bronchus associated lymphoid tissue (BALT) and the precursor immunocompetent lymphoid cells in the nasopharynx, tonsils, and salivary glands represent the basic source of specific secretory IgA, other immunoglobulin, and T cell mediated specific immunity in the respiratory tract. The bulk of this immunologic react...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF02718155
更新日期:1990-01-01 00:00:00
abstract::Undifferentiated connective tissue disease (UCTD) is a distinct clinical entity that may be accompanied by interstitial lung disease (ILD). The natural history of UCTD-ILD is unknown. We hypothesized that patients with UCTD-ILD would be more likely to have improvement in lung function than those with idiopathic pulmon...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-009-9226-7
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:Restoring the barrier integrity of the alveolar epithelium after injury is pivotal. In the current study, we evaluated the effects of surfactant, surfactant protein A (SP-A), transforming growth factor β (TGF-β), and analogues of SP-A on alveolar epithelial repair. Additionally, we assessed the influence of mic...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9424-6
更新日期:2012-12-01 00:00:00
abstract::The author reviews the early history of alpha 1-antitrypsin (AAT) deficiency; the biochemical characterization of this inborn error of metabolism, its pattern of inheritance, frequency and predisposition to early, panacinar emphysema. The importance of the destructive element in emphysema and the gradual focusing on n...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF02718174
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Mannitol is a novel osmotic indirect bronchial challenge agent used to aid asthma diagnosis and management and is thought to reflect underlying inflammatory processes in asthma. Our objective was to evaluate relationships between mannitol airway hyperresponsiveness (AHR) and other measures of airway inflamma...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9396-6
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:According to the National Family Health Survey, asthma is one of the leading diseases in India. In order to understand the complexity of asthma, the susceptibility genes need to be targeted for their association. Glutathione S-transferases play a major role in the detoxification of metabolites of oxidative s...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9385-9
更新日期:2012-10-01 00:00:00
abstract:STUDY OBJECTIVES:The aim of this study was to determine if electrocardiographically synchronized, prospectively triggered multidetector row computed tomography (ECG-MDR-CT) angiography of the aorta can accurately predict the location of ectopic bronchial arteries in patients with cystic fibrosis (CF) with massive hemop...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-011-9343-y
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:We investigated outcomes of patients hospitalized with community-acquired pneumonia (CAP) according to the changes in red cell distribution width (RDW). METHODS:For 980 adults, clinical characteristics, outcomes during hospitalization for CAP (transfer to the intensive care unit, treatment with mechanical vent...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9942-8
更新日期:2016-12-01 00:00:00
abstract::The efficacy of the docetaxel-carboplatin combination chemotherapy was studied in various phase II studies. Based on these data we aimed to test the regimen in previously untreated patients with advanced advanced non-smoking lung cancer (NSCLC) with docetaxel 80 mg/m2 a standard dose of carboplatin at AUC = 5, in an a...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-005-2552-5
更新日期:2005-11-01 00:00:00
abstract::There is a lack of evidence about whether menopausal status influences the effect of smoking on lung function. This study examined the association between smoking and menopausal status and lung function independent of each other. Data were from a cohort of women attending the 21-year follow-up of the Mater University ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-010-9269-9
更新日期:2011-02-01 00:00:00