High Expression of CARM1 Inhibits Lung Cancer Progression by Targeting TP53 by Regulating CTNNB1.

Abstract:

OBJECTIVE:To explore the role of CARM1 in lung cancer (LC) and its relationship with TP53 and CTNNB1. METHODS:Lung cells H1299 and PC14 were randomly divided into six groups: ov-H1299, si-H1299, ov-PC14, si-PC14, Con-H1299, and Con-PC14. Transwell assay, plate clone formation assay, and flow cytometry were used to determine the migration, clone formation capacity, and apoptosis situation of LC cells in the six groups, respectively. Western blot assay was used to determine the protein expression of CARM1, TP53, and CTNNB1 in the six groups. CHIP assay was applied to analyze the combined characteristics of JUN and TP53 promoter. Co-immunoprecipitation was used to analyze the interaction between TP53 and CARM1/CTNNB1. Cox proportional hazard regression model was used to analyze the relevance between the expression of CARM1 and clinicopathological information of the patient. Kaplan-Meier plot was used to determine the relevance between CARM1 and patient survival. RESULTS:High expression of CARM1 inhibits the migration and proliferation of LC cells and promoted the apoptosis of LC cell. Overexpression of CARM1 promotes the expression of CARM1 and TP53, while decreases CTNNB1 expression. CARM1 supplementation of H1299 cells induced JUN aggregation on the TP53 promoter. TP53 and CARM1 protein/TP53 and CTNNB1 protein in H1299 cells were immunoprecipitated together. High expression of CARM1was negatively correlated with the degree of tumor metastasis. The survival period of patients with high expression CARM1 was greater than that of low expression. CONCLUSION:Overexpression of CARM1 may inhibit the progression of LC by targeting TP53 via regulation CTNNB1.

journal_name

Lung

journal_title

Lung

authors

Hu B,Li X,Chen L,Liu Z

doi

10.1007/s00408-020-00324-7

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

415-422

issue

2

eissn

0341-2040

issn

1432-1750

pii

10.1007/s00408-020-00324-7

journal_volume

198

pub_type

杂志文章

相关文献

LUNG文献大全
  • Assessing the Therapeutic Response to Pirfenidone in Idiopathic Pulmonary Fibrosis: Can We Do Better than with Forced Vital Capacity Alone?

    abstract:ABSTARCT:New anti-fibrotic agents for idiopathic pulmonary fibrosis (IPF) were approved based on the results of forced vital capacity (FVC) trends, although concerns were raised about the reliability of FVC as the only endpoint parameter. We hypothesized that IPF-specific multi-dimensional scores (Composite Physiologic...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-016-9963-3

    authors: Hosein K,Le J,Mura M

    更新日期:2017-02-01 00:00:00

  • Value of CD-1-positive cells in bronchoalveolar lavage fluid for the diagnosis of pulmonary histiocytosis X.

    abstract::Pulmonary histiocytosis X is characterized by an accumulation of CD-1-positive histiocytosis X cells in the lung, which also can be found in the bronchoalveolar lavage fluid (BALF). However, it has recently been demonstrated that CD-1-positive cells can also be detected in BALF of patients with other interstitial lung...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/BF02714167

    authors: Auerswald U,Barth J,Magnussen H

    更新日期:1991-01-01 00:00:00

  • Time, Dose, and Volume Responses in a Mouse Pulmonary Injury Model Following Ablative Irradiation.

    abstract:PURPOSE:We aimed to determine the time, dose, and volume responses in a mouse pulmonary injury model following ablative dose focal irradiation (ADFIR) in order to better understand normal lung injury. METHODS AND MATERIALS:ADFIR was administered to the left lung of mice using a small animal micro-irradiator. Histopath...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-015-9825-4

    authors: Hong ZY,Lee CG,Shim HS,Lee EJ,Song KH,Choi BW,Cho J,Story MD

    更新日期:2016-02-01 00:00:00

  • Calcitonin gene-related peptide potentiates substance P-induced plasma extravasation in the rat trachea.

    abstract::Antidromic stimulation of vagal sensory nerves is known to produce plasma extravasation in the rat trachea. This neurogenic inflammation is thought to be mediated by substance P or other tachykinins released from sensory nerve endings. We sought to determine whether calcitonin gene-related peptide (CGRP), which is als...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/BF00175980

    authors: Brokaw JJ,White GW

    更新日期:1992-01-01 00:00:00

  • Coexpression of HSP47 gene and type I and type III collagen genes in LPS-induced pulmonary fibrosis in rats.

    abstract::Diffuse alveolar damage is the histopathologic hallmark of acute respiratory distress syndrome (ARDS). A significant proportion of ARDS survivors have residual pulmonary fibrosis and compromised pulmonary function. On the other hand, heat shock protein 47 (HSP47) is a collagen-binding stress protein that is assumed to...

    journal_title:Lung

    pub_type: 杂志文章,收录出版

    doi:10.1007/s00408-006-0085-1

    authors: Hagiwara S,Iwasaka H,Matsumoto S,Noguchi T,Yoshioka H

    更新日期:2007-01-01 00:00:00

  • Angiotensin receptors as sensitive markers of acute bronchiole injury after lung transplantation.

    abstract:BACKGROUND:Although lung transplantation is the only means of survival for patients with end-stage pulmonary disease, outcomes from this intervention are inferior to other solid organ transplants. The reason for the poor outcomes may be linked to an early reaction, such as primary graft dysfunction, and associated with...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-014-9588-3

    authors: Nataatmadja M,Passmore M,Russell FD,Prabowo S,Corley A,Fraser JF

    更新日期:2014-08-01 00:00:00

  • Transition of PH patients from sildenafil to tadalafil: feasibility and practical considerations.

    abstract:BACKGROUND:Sildenafil was the only phosphodiesterase-5 inhibitor available for the treatment of pulmonary arterial hypertension (PAH) until the approval and availability of once-daily tadalafil. Since no direct comparative study is likely to be performed between these agents, we sought to evaluate the feasibility of tr...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-012-9408-6

    authors: Shlobin OA,Brown AW,Weir N,Ahmad S,Lemma M,Nathan SD

    更新日期:2012-10-01 00:00:00

  • Sedation with Propofol for Bronchoscopy in Cystic Fibrosis Lung Transplant Recipients.

    abstract:INTRODUCTION:Flexible fiberoptic bronchoscopy (FFB) plays an important role in the surveillance of cystic fibrosis (CF) patients after lung transplantation (LTx). With rapid onset and clearance, propofol provides a safe and efficient method for sedation during FFB, yet sedation requirements for CF patients are not well...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-018-0119-5

    authors: Ho C,Hayes D Jr,Khosravi M,Splaingard ML,Tumin D,Lloyd EA

    更新日期:2018-08-01 00:00:00

  • Immune cell infiltration and broncovascular remodeling after nitric acid nasal instillation in a mouse bronchiolitis obliterans model.

    abstract::Immune cell airway infiltration and the bronchovascular remodeling process have shown to be promising in the understanding of bronchiolitis obliterans (BO) pathogenesis. In this study we sought to validate the importance of immune cells, whether diffusely distributed or forming lymphoid follicles, collagen density, an...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-005-2588-6

    authors: Garippo AL,Parra ER,Teodoro WR,Veloza AP,Yoshinari NH,Capelozzi VL

    更新日期:2006-07-01 00:00:00

  • Effect of hydralazine on vascular mechanics in a canine lobar preparation of pulmonary embolism.

    abstract::We studied the effect of hydralazine (H) on pulmonary vascular mechanics in an isolated, in situ, canine lobe model of normal and increased pulmonary vascular resistance (Rp) produced by Gelfoam embolization (GE). Pulmonary pressure-flow (P-Q) curves from 24 lobes were obtained at baseline and after each intervention....

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/BF00566681

    authors: Lupi-Herrera E,Furuya ME,Sandoval J,Correa E,Leal ME,Quesada A,Palomar A,Barrios R

    更新日期:1992-01-01 00:00:00

  • Safety and efficacy of 12-week or longer indacaterol treatment in moderate-to-severe COPD patients: a systematic review.

    abstract:BACKGROUND:This is a meta-analysis of the safety and efficacy of indacaterol in chronic obstructive pulmonary disease (COPD) with treatment duration of ≥12 weeks. METHODS:Randomized controlled trials (RCTs) reported in English (to September 30, 2012) were identified from PubMed, the Cochrane Library, Embase, websites,...

    journal_title:Lung

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00408-012-9444-2

    authors: Jiang FM,Liang ZA,Zheng QL,Wang RC,Luo J,Li CT

    更新日期:2013-04-01 00:00:00

  • Humidifier lung and humidifier fever.

    abstract::The aim of our study was to evaluate clinical diagnoses in symptomatic persons exposed to aerosols from humidifiers or air conditioners. In addition, we tried to identify the causative antigens. Results of clinical investigations, including inhalation challenge tests, demonstrated a typical hypersensitivity pneumoniti...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/BF02714035

    authors: Baur X,Behr J,Dewair M,Ehret W,Fruhmann G,Vogelmeier C,Weiss W,Zinkernagel V

    更新日期:1988-01-01 00:00:00

  • A causal relationship between cough and gastroesophageal reflux disease (GERD) has been established: a pro/con debate.

    abstract::Along with upper airway cough syndrome (formerly, postnasal drip syndrome) and eosinophilic airway inflammation (asthma, nonasthmatic eosinophilic bronchitis), gastroesophageal reflux disease (GERD) is generally considered among the most common etiologies of chronic cough. Indeed, cough management guidelines published...

    journal_title:Lung

    pub_type:

    doi:10.1007/s00408-013-9528-7

    authors: Kahrilas PJ,Smith JA,Dicpinigaitis PV

    更新日期:2014-02-01 00:00:00

  • Does the inclusion of wheeze detection as an outcome measure affect the interpretation of methacholine challenge tests? A study in workers at risk of occupational asthma.

    abstract::Methacholine challenge testing (MCT) is widely used to assess airway hyperresponsiveness (AHR). Traditionally, a 20% or greater decline in forced expiratory volume in 1 (FEV(1)) is the primary outcome measure. We examined whether the inclusion of wheeze detection as outcome measure influenced the categorical interpret...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-005-2575-y

    authors: Bohadana AB,Michaely JP

    更新日期:2006-05-01 00:00:00

  • Mechanisms of reaginic hypersensitivity and immunotherapy.

    abstract::Reaginic antibodies in hay fever patients belong to IgE. The immunoglobulin sensitizes basophilic granulocytes and mast cells from homologous species and mediates the release of chemical mediators which cause allergic symptoms. The sensitization is due to the binding of IgE to receptors on the target cells through the...

    journal_title:Lung

    pub_type: 杂志文章,评审

    doi:10.1007/BF02730676

    authors: Ishizaka K,Ishizaka T

    更新日期:1978-01-01 00:00:00

  • Dexamethasone and cyclic AMP regulate sodium phosphate cotransporter (NaPi-IIb and Pit-1) mRNA and phosphate uptake in rat alveolar type II epithelial cells.

    abstract::Alveolar epithelial type II (AT II) cells need phosphate (Pi) for surfactant synthesis. The Na-dependent (Na(d)) Pi transporters NaPi-IIb and Pit-1 are expressed in lung, but their expression, regulation, and function in AT II cells remain unclear. We studied NaPi-IIb and Pit-1 mRNA expression in cultured AT II cells ...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-009-9183-1

    authors: Jin C,Zoidis E,Ghirlanda C,Schmid C

    更新日期:2010-01-01 00:00:00

  • Expression of cancer-testis antigens MAGE-A3/6 and NY-ESO-1 in non-small-cell lung carcinomas and their relationship with immune cell infiltration.

    abstract::Cancer-testis antigens (CTAs) are expressed only in many cancers and limited immunoprivileged sites such as the testis and placenta. Dendritic cells (DCs) and CD8+ T lymphocytes (CTLs) play roles in the immune responses to tumor growth and may affect the prognosis of cancers. This study was designed to investigate the...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-009-9181-3

    authors: Kim SH,Lee S,Lee CH,Lee MK,Kim YD,Shin DH,Choi KU,Kim JY,Park DY,Sol MY

    更新日期:2009-11-01 00:00:00

  • Characterization of surfactant subtypes of beractant and a synthetic peptide containing surfactant KL4 following surface area cycling and addition of fibrinogen.

    abstract::Surfactant is not a homogeneous material and can be separated into subtypes. Subtype conversion is clinically important because it is thought to occur naturally and because surface activity varies depending on the subtype. Fibrinogen, a naturally occurring serum protein, is known to affect this conversion. In this stu...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/pl00007569

    authors: Manalo E,Merritt TA,Amirkhanian JD,Kheiter A

    更新日期:1997-01-01 00:00:00

  • Idiopathic and collagen vascular disease nonspecific interstitial pneumonia: clinical significance of remodeling process.

    abstract::Recently, active remodeling may indicate a good prognosis in idiopathic interstitial pneumonias. In this study we sought to validate the importance of the collagen/elastic system in the extracellular matrix remodeling and to study the relationships between the collagen/elastic system in nonspecific interstitial idiopa...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-006-0104-2

    authors: Felício CH,Parra ER,Capelozzi VL

    更新日期:2007-01-01 00:00:00

  • Effects of GABA-B agonist baclofen on bronchial hyperreactivity to inhaled histamine in subjects with cervical spinal cord injury.

    abstract::Bronchial provocation studies performed in our research center have consistently demonstrated airway hyperresponsiveness to both inhaled methacholine and histamine in subjects with chronic cervical spinal cord injury (SCI). More recently, we reported that the airways of such subjects maintained on chronic baclofen (ga...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/pl00007579

    authors: Grimm DR,DeLuca RV,Lesser M,Bauman WA,Almenoff PL

    更新日期:1997-01-01 00:00:00

  • Nanogold Assay Improves Accuracy of Conventional TB Diagnostics.

    abstract:PURPOSE:TB nanodiagnostics have witnessed considerable development. However, most of the published reports did not proceed beyond proof-of-concept. Our objectives are to evaluate the diagnostic accuracy of a novel nanogold assay in detecting patients with active pulmonary TB based on results of BACTEC MGIT (reference t...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-018-00194-0

    authors: El-Samadony H,Azzazy HME,Tageldin MA,Ashour ME,Deraz IM,Elmaghraby T

    更新日期:2019-04-01 00:00:00

  • Acute pulmonary response to cotton bract extract in monkeys: lung function and effects of mediator modifying compounds.

    abstract::It is well established that cotton dust inhalation can compromise lung function in textile workers. Challenges with a water-soluble extract of cotton bract (CBE) can also induce reversible airway obstruction in healthy volunteers. We have examined the effect of inhaled CBE in nonhuman primates and have attempted to in...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/BF02714026

    authors: Witek TJ Jr,Gundel RH,Wegner CD,Schachter EN,Buck MG

    更新日期:1988-01-01 00:00:00

  • Elevated levels of IL-18 in plasma and skeletal muscle in chronic obstructive pulmonary disease.

    abstract::The aim of this study was to test the hypothesis that systemic inflammation in patients with chronic obstructive pulmonary disease (COPD) is accompanied by enhanced interleukin 18 (IL-18) expression in skeletal muscle, which may precede muscle weight loss. Twenty patients with moderate to severe COPD [12 women, 66 +/-...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-007-9000-7

    authors: Petersen AM,Penkowa M,Iversen M,Frydelund-Larsen L,Andersen JL,Mortensen J,Lange P,Pedersen BK

    更新日期:2007-05-01 00:00:00

  • Comparison of LMWH versus UFH for hemorrhage and hospital mortality in the treatment of acute massive pulmonary thromboembolism after thrombolytic treatment : randomized controlled parallel group study.

    abstract:PURPOSE:Current guidelines recommend the use of low molecular weight heparin (LMWH) for most haemodynamically stable patients with pulmonary thromboembolism (PTE), however, it is not clear whether LMWH is preferable to unfractionated heparin (UFH) for the treatment of massive PTE. We aimed to compare the use of LMWH ve...

    journal_title:Lung

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00408-014-9660-z

    authors: Ucar EY,Akgun M,Araz O,Tas H,Kerget B,Meral M,Kaynar H,Saglam L

    更新日期:2015-02-01 00:00:00

  • Clusterin immunoexpression and its clinical significance in patients with non-small cell lung cancer.

    abstract::Clusterin is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution. It plays important roles in various pathophysiological processes, including tissue remodeling, reproduction, lipid transport, complement regulation, and apoptosis. Clusterin appears to have two main isoforms that result from alternati...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-010-9248-1

    authors: Li H,Liu S,Zhu X,Yang S,Xiang J,Chen H

    更新日期:2010-10-01 00:00:00

  • Long-term studies on long-acting sympathomimetics.

    abstract::Long-term treatment studies with formoterol and salmeterol show that these inhaled long-acting beta 2-agonists compared to available beta 2-agonists produce better bronchodilation, decrease the need for additional doses, decrease asthma symptoms, and are strongly preferred by the patients. Development of tolerance has...

    journal_title:Lung

    pub_type: 临床试验,杂志文章,评审

    doi:10.1007/BF02718109

    authors: Larsson S

    更新日期:1990-01-01 00:00:00

  • Effect of Anti-IL5, Anti-IL5R, Anti-IL13 Therapy on Asthma Exacerbations: A Network Meta-analysis.

    abstract:BACKGROUND:Several new treatments for severe asthma have become available in the last decade; yet, little data exist to guide their use in specific patient populations. OBJECTIVE:A network meta-analysis was conducted comparing the efficacy of FDA-approved monoclonal antibody therapies in preventing exacerbations in pa...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-019-00310-8

    authors: Ramonell RP,Iftikhar IH

    更新日期:2020-02-01 00:00:00

  • Pleurodesis induced by talc or silver nitrate: evaluation of collagen and elastic fibers in pleural remodeling.

    abstract::This study evaluated the extracellular matrix (collagen and elastic fibers) in pleurodesis induced by intrapleural talc (TL) or silver nitrate (SN). Study subjects were 420 rabbits divided into two groups and sacrificed from 15 min to 12 months after the injection of the sclerosing agents at intervals previously defin...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-005-2569-9

    authors: Antonangelo L,Vargas FS,Teixeira LR,Acencio MM,Vaz MA,Filho MT,Marchi E

    更新日期:2006-03-01 00:00:00

  • Postoperative Adverse Events are Associated with Oncologic Recurrence Following Curative-intent Resection for Lung Cancer.

    abstract:BACKGROUND:Up to 50% of patients suffer short-term postoperative adverse events (AEs) and metastatic recurrence in the long-term following curative-intent lung cancer resection. The association between AEs, particularly infectious in nature, and disease recurrence is controversial. We sought to evaluate the association...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-020-00395-6

    authors: Gowing S,Baker L,Tran A,Zhang Z,Ahn H,Ivanovic J,Anstee C,Grigor E,Gilbert S,Maziak DE,Shamji F,Sundaresan S,Villeneuve PJ,Seely AJE

    更新日期:2020-12-01 00:00:00

  • Mycobacterial infections in patients treated with tumor necrosis factor antagonists in South Korea.

    abstract:BACKGROUND:The aims of this study were to determine the incidence of tuberculosis (TB) and nontuberculous mycobacteria (NTM) lung disease in patients who were treated with tumor necrosis factor (TNF) antagonists in South Korea and to evaluate their clinical characteristics. METHODS:We surveyed all patients (N = 509) w...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-013-9481-5

    authors: Lee SK,Kim SY,Kim EY,Jung JY,Park MS,Kim YS,Kim SK,Chang J,Kang YA

    更新日期:2013-10-01 00:00:00