Cough variant asthma: lessons learned from deep inspirations.

abstract：:Bronchopleural (BPF) and alveolar-pleural (APF) fistulas are frequently encountered in clinical practice with persistent air leaks that can lead to significant morbidity, prolonged hospital stay, and potentially increased mortality. BPF and APF are commonly related to pulmonary resections. Other etiologies include min...

journal_title：Lung

authors： Abu-Hijleh M,Blundin M

更新日期：2010-06-01 00:00:00

abstract：:Surfactant is not a homogeneous material and can be separated into subtypes. Subtype conversion is clinically important because it is thought to occur naturally and because surface activity varies depending on the subtype. Fibrinogen, a naturally occurring serum protein, is known to affect this conversion. In this stu...

journal_title：Lung

authors： Manalo E,Merritt TA,Amirkhanian JD,Kheiter A

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:Melanocortin 3 Receptor (MC3R) is one of the families of seven-transmembrane G-protein-coupled receptors, and a recent study showed that MCR3 promoter polymorphism was significantly associated with the susceptibility of tuberculosis (TB) in South African population. METHODS:We analyzed six MC3R polymorphisms t...

journal_title：Lung

authors： Park BL,Kim LH,Namgoong S,Kim JO,Kim JY,Chang HS,Park JS,Jang AS,Park SW,Kim DJ,Kim KU,Kim YG,Uh ST,Seo KH,Kim YH,Park CS,Shin HD

更新日期：2014-12-01 00:00:00

abstract：:The contribution of T-cells after lung transplant (LTx) remains controversial with no current consensus of their role concerning chronic lung allograft dysfunction. Using flow cytometry to assess T-cell subsets of bronchoalveolar lavage fluid (BALF) in 16 cystic fibrosis (CF) LTx recipients, we identified a decline in...

journal_title：Lung

authors： Hayes D Jr,Harhay MO,Nicol KK,Liyanage NPM,Keller BC,Robinson RT

更新日期：2020-02-01 00:00:00

abstract：:In severe asthma attacks beta 2-sympathomimetics lose part of their therapeutic efficiency. To elucidate this loss of efficiency in an experimental model we compared the relaxant potency of salbutamol (SAL), fenoterol (FEN), formoterol (FOR), and (-)-isoprenaline (ISO) in guinea pig tracheae partially and maximally pr...

journal_title：Lung

authors： Lemoine H,Overlack C,Köhl A,Worth H,Reinhardt D

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:The right ventricular ejection fraction (RVEF) is a surrogate marker of right ventricular function in pulmonary hypertension (PH), but its measurement is complicated and time consuming. The tricuspid annular plane systolic excursion (TAPSE) measures only the longitudinal component of RV contraction while the...

journal_title：Lung

authors： Hoette S,Creuzé N,Günther S,Montani D,Savale L,Jaïs X,Parent F,Sitbon O,Rochitte CE,Simonneau G,Humbert M,Souza R,Chemla D

更新日期：2018-04-01 00:00:00

abstract：:Tuberculosis (TB) pleurisy is accepted to be the best model for evaluating the local protective cellular immune response to Mycobacterium tuberculosis (MTB) since it can be spontaneously self-cured. Therefore, we aimed to evaluate the involvement of cytokines and the soluble apoptosis-modulating factors sFas and sFasL...

journal_title：Lung

authors： Budak F,Uzaslan EK,Cangür S,Göral G,Oral HB

更新日期：2008-09-01 00:00:00

abstract：:The effect of beta 2-adrenoceptor agonists on airway smooth muscle relaxation may be subject to desensitization. It could be modified by glucocorticosteroid treatment. An increase in the beta 2 agonist response by glucocorticosteroids in vitro has been described. We studied the effects of acute and chronic treatment w...

journal_title：Lung

authors： Seco AJ,Salgueiro ME,Manso G

更新日期：1995-01-01 00:00:00

abstract：:A 15-year-old male had a history of increasing dyspnea on exertion, cough, sputum production, fever, weakness, hemoptysis, and diarrhea. Chest radiography demonstrated bilateral alveolar consolidation. Bronchoalveolar lavage fluid analysis revealed extensive hemosiderin-laden alveolar macrophages. On the basis of iron...

journal_title：Lung

authors： Hoca NT,Dayioglu D,Ogretensoy M

更新日期：2006-09-01 00:00:00

abstract：:It is well known that chronic obstructive pulmonary disease (COPD) patients present with muscle dysfunction that may not correlate with the degree of severity of airflow obstruction. Historically, the strength deficit of the knee extensor musculature (quadriceps) has been described as an independent factor of mortalit...

journal_title：Lung

authors： Pleguezuelos E,Guirao L,Moreno E,Samitier B,Ortega P,Vila X,Garnacho-Castaño MV,Majó M,Ovejero L,Miravitlles M

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated non-inferiority of rivaroxaban when compared to warfarin for the treatment of pulmonary embolism and deep venous thrombosis. Analysis of data from the EINSTEIN trials has demonstrated that patients who received rivaroxaban had a shorter length of stay (LOS) compared to those ...

journal_title：Lung

authors： Desai A,Desai A,Calixte R,Aparnath M,Hindenburg A,Salzman S,Mathew JP

更新日期：2016-08-01 00:00:00

abstract：:In previous studies, we showed that Fischer rats fed 175 mg/kg of amiodarone accumulated large amounts of drug and metabolite in the lung and developed pulmonary toxicity, whereas Wistar rats fed the same drug dose had significantly less amiodarone in the lung and did not develop pulmonary inflammation. The present st...

journal_title：Lung

authors： Wilson BD,Lippmann ML

更新日期：1996-01-01 00:00:00

abstract：:We aimed to evaluate the utility of coagulation markers for the prediction of rapidly progressive interstitial lung disease (RP-ILD) in patients with dermatomyositis (DM). In this retrospective study, 29 patients with DM-associated ILD were analyzed. The number of patients with RP-ILD was 15 (52%). The baseline clinic...

journal_title：Lung

authors： Sagawa T,Kida T,Inaba T,Yokota I,Sagawa R,Kasahara A,Kaneshita S,Inoue T,Nagahara H,Fujioka K,Wada M,Kohno M,Kawahito Y

更新日期：2019-08-01 00:00:00

abstract：:Along with upper airway cough syndrome (formerly, postnasal drip syndrome) and eosinophilic airway inflammation (asthma, nonasthmatic eosinophilic bronchitis), gastroesophageal reflux disease (GERD) is generally considered among the most common etiologies of chronic cough. Indeed, cough management guidelines published...

journal_title：Lung

authors： Kahrilas PJ,Smith JA,Dicpinigaitis PV

更新日期：2014-02-01 00:00:00

abstract：:The effects of vitamin E deficiency on bleomycin (BLM)-induced pulmonary fibrosis have been studied by analyses of pressure volume (PV) curves and morphological examinations. Golden hamsters were divided into groups on a control diet (group C), vitamin E-deficient diet (E), control diet with BLM treatment (CB), and vi...

journal_title：Lung

authors： Nakamura H,Sato S,Takahashi K

更新日期：1988-01-01 00:00:00

abstract：:Benralizumab and mepolizumab are new therapies for severe eosinophilic asthma. They are both humanized IgG antibodies, targeting the IL-5 receptor and IL-5, respectively, suppressing the corresponding pathways. No specific biomarkers have been proposed to evaluate treatment response to benralizumab or mepolizumab. The...

journal_title：Lung

authors： Vantaggiato L,Perruzza M,Refini RM,Bergantini L,d'Alessandro M,Cameli P,Perruzza D,Bini L,Bargagli E,Landi C

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:This study was designed to review outcomes of once- (QD) versus twice-daily (BID) radiotherapy (RT) for limited stage small-cell lung cancer (L-SCLC) treated at Dana-Farber Cancer Institute/Brigham and Women's Hospital. METHODS:We reviewed records for all patients with L-SCLC treated with radical chemoradiothe...

journal_title：Lung

authors： Gazula A,Baldini EH,Chen A,Kozono D

更新日期：2014-02-01 00:00:00

abstract：:Acid glycosaminoglycans (GAG) were quantitated and partially characterized in pleural effusions in guinea pigs with experimental allergic pleurisy. Increase of GAG in the pleural effusion preceded the increase of effusion volume. Effusion was associated with the presence of cuboidal mesothelial cells on visceral pleur...

journal_title：Lung

authors： Satoh K,Arai H,Nagai H,Ito M,Sato H,Motomiya M,Konno K

更新日期：1987-01-01 00:00:00

abstract：:Air concentration of isocyanates are associated with the frequency of induced diseases. Asthma, bronchitis and rhinitis, chronic obstructive lung disease, and allergic alveolitis, respectively, were observed in exposed workers. Inhalation challenge tests with isocyanates found some 14% of symptomatic persons immunolog...

journal_title：Lung

authors： Baur X

更新日期：1990-01-01 00:00:00

abstract：:Myofibroblasts characterized by alpha smooth muscle actin(alpha-SMA) expression play a key role in pulmonary fibrosis. Transforming growth factor-beta1 (TGF-beta1) is likely to be involved in the emergence of myofibroblasts, but the intracellular signal pathways for this process have not been well determined. The aim ...

journal_title：Lung

authors： Hu Y,Peng J,Feng D,Chu L,Li X,Jin Z,Lin Z,Zeng Q

更新日期：2006-01-01 00:00:00

abstract：:The author reviews the early history of alpha 1-antitrypsin (AAT) deficiency; the biochemical characterization of this inborn error of metabolism, its pattern of inheritance, frequency and predisposition to early, panacinar emphysema. The importance of the destructive element in emphysema and the gradual focusing on n...

journal_title：Lung

authors： Eriksson S

更新日期：1990-01-01 00:00:00

abstract：:Bronchial provocation studies performed in our research center have consistently demonstrated airway hyperresponsiveness to both inhaled methacholine and histamine in subjects with chronic cervical spinal cord injury (SCI). More recently, we reported that the airways of such subjects maintained on chronic baclofen (ga...

journal_title：Lung

authors： Grimm DR,DeLuca RV,Lesser M,Bauman WA,Almenoff PL

更新日期：1997-01-01 00:00:00

abstract：INTRODUCTION:Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal fibrosing lung disease with a median survival of approximately 3 years after diagnosis. The only medical option to improve survival in IPF is lung transplantation (LTX). The purpose of this study was to evaluate trajectory data of IPF patients...

journal_title：Lung

authors： ten Klooster L,Nossent GD,Kwakkel-van Erp JM,van Kessel DA,Oudijk EJ,van de Graaf EA,Luijk B,Hoek RA,van den Blink B,van Hal PT,Verschuuren EA,van der Bij W,van Moorsel CH,Grutters JC

更新日期：2015-12-01 00:00:00

abstract：:Reaginic antibodies in hay fever patients belong to IgE. The immunoglobulin sensitizes basophilic granulocytes and mast cells from homologous species and mediates the release of chemical mediators which cause allergic symptoms. The sensitization is due to the binding of IgE to receptors on the target cells through the...

journal_title：Lung

authors： Ishizaka K,Ishizaka T

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is a deadly disease, and the molecular mechanism of PAH has not been clarified clearly. The objective of this study was to identify possible biomarkers and explore the potential mechanisms of Schistosoma-induced PAH. METHODS:GSE49114 RNA-Seq data developed from mouse wh...

journal_title：Lung

authors： Sun Y,Lin X,Li L

更新日期：2017-06-01 00:00:00

abstract：:Alveolar epithelial type II (AT II) cells need phosphate (Pi) for surfactant synthesis. The Na-dependent (Na(d)) Pi transporters NaPi-IIb and Pit-1 are expressed in lung, but their expression, regulation, and function in AT II cells remain unclear. We studied NaPi-IIb and Pit-1 mRNA expression in cultured AT II cells ...

journal_title：Lung

authors： Jin C,Zoidis E,Ghirlanda C,Schmid C

更新日期：2010-01-01 00:00:00

abstract：:Occupational exposure to oyster mushroom (Pleurotus ostreatus) has been associated with obstructive lung disease. Previously, we studied an extract of oyster mushroom (OME) and determined that it causes dose-dependent contractions of nonsensitized guinea pig trachea (GPT). We extend these studies to the investigation ...

journal_title：Lung

authors： Schachter EN,Zuskin E,Pucarin-Cvetkovic J,Chiarelli A,Goswami S

更新日期：2011-08-01 00:00:00

abstract：:Although the relative effect of racemic and (R)-albuterol on airway smooth muscle tone have been investigated in patients with airflow obstruction, the comparative effectiveness of these drugs in relaxing airway vascular smooth muscle is unknown. Therefore, we determined the actions of inhaled racemic and (R)-albutero...

journal_title：Lung

authors： Pereira A,Mendes E,Ferreira T,Wanner A

更新日期：2003-01-01 00:00:00

abstract：:Pulmonary histiocytosis X is characterized by an accumulation of CD-1-positive histiocytosis X cells in the lung, which also can be found in the bronchoalveolar lavage fluid (BALF). However, it has recently been demonstrated that CD-1-positive cells can also be detected in BALF of patients with other interstitial lung...

journal_title：Lung

authors： Auerswald U,Barth J,Magnussen H

更新日期：1991-01-01 00:00:00

abstract：INTRODUCTION:Living donor lobar lung transplantation (LDLLT) has been successfully used in select patient populations. MATERIALS AND METHODS:A 29-year-old male, who underwent bilateral LDLLT 12 years earlier with allografts donated by father and paternal uncle, developed bronchiolitis obliterans syndrome at distinctly...

journal_title：Lung

authors： Hayes D Jr,Baker PB

更新日期：2014-06-01 00:00:00