Abstract:
:The effect of beta 2-adrenoceptor agonists on airway smooth muscle relaxation may be subject to desensitization. It could be modified by glucocorticosteroid treatment. An increase in the beta 2 agonist response by glucocorticosteroids in vitro has been described. We studied the effects of acute and chronic treatment with dexamethasone on the relaxation response of tracheal smooth muscle to beta 2 agonists, fenoterol and salbutamol. Fenoterol showed a greater force of relaxation than salbutamol, and both drugs induced desensitization. Acute treatment with dexamethasone reduced desensitization to both beta 2 agonists. Chronic treatment (120 micrograms/kg of dexamethasone for 7 days) reduced the desensitization to fenoterol alone. Dexamethasone (200 micrograms/kg for 7 days) increased relaxation to salbutamol and reduced desensitization to both drugs. The interaction between beta 2 agonists and glucocorticosteroids could be important in the clinical use of both drugs in the treatment of asthma.
journal_name
Lungjournal_title
Lungauthors
Seco AJ,Salgueiro ME,Manso Gdoi
10.1007/BF00176895subject
Has Abstractpub_date
1995-01-01 00:00:00pages
321-8issue
5eissn
0341-2040issn
1432-1750journal_volume
173pub_type
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