Abstract:
:Pulmonary emphysema is a major manifestation of chronic obstructive pulmonary disease (COPD), which is characterized by progressive destruction of alveolar parenchyma with persistent inflammation of the small airways. Such destruction in the distal respiratory tract is irreversible and irreparable. All-trans-retinoic acid was suggested as a novel therapy for regeneration of lost alveoli in emphysema. However, profound discrepancies were evident between studies. At present, no effective therapeutic options are available that allow for the regeneration of lost alveoli in emphysematous human lungs. Recently, some reports on rodent's models have suggested the beneficial effects of various growth factors toward alveolar maintenance and repair processes.
journal_name
Lungjournal_title
Lungauthors
Muyal JP,Muyal V,Kotnala S,Kumar D,Bhardwaj Hdoi
10.1007/s00408-012-9438-0subject
Has Abstractpub_date
2013-04-01 00:00:00pages
147-63issue
2eissn
0341-2040issn
1432-1750journal_volume
191pub_type
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