Abstract:
INTRODUCTION:Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal fibrosing lung disease with a median survival of approximately 3 years after diagnosis. The only medical option to improve survival in IPF is lung transplantation (LTX). The purpose of this study was to evaluate trajectory data of IPF patients listed for LTX and to investigate the survival after LTX. METHODS AND RESULTS:Data were retrospectively collected from September 1989 until July 2011 of all IPF patients registered for LTX in the Netherlands. Patients were included after revision of the diagnosis based on the criteria set by the ATS/ERS/JRS/ALAT. Trajectory data, clinical data at time of screening, and donor data were collected. In total, 98 IPF patients were listed for LTX. During the waiting list period, 30 % of the patients died. Mean pulmonary artery pressure, 6-min walking distance, and the use of supplemental oxygen were significant predictors of mortality on the waiting list. Fifty-two patients received LTX with a median overall survival after transplantation of 10 years. CONCLUSIONS:This study demonstrated a 10-year survival time after LTX in IPF. Furthermore, our study demonstrated a significantly better survival after bilateral LTX in IPF compared to single LTX although bilateral LTX patients were significantly younger.
journal_name
Lungjournal_title
Lungauthors
ten Klooster L,Nossent GD,Kwakkel-van Erp JM,van Kessel DA,Oudijk EJ,van de Graaf EA,Luijk B,Hoek RA,van den Blink B,van Hal PT,Verschuuren EA,van der Bij W,van Moorsel CH,Grutters JCdoi
10.1007/s00408-015-9794-7subject
Has Abstractpub_date
2015-12-01 00:00:00pages
919-26issue
6eissn
0341-2040issn
1432-1750pii
10.1007/s00408-015-9794-7journal_volume
193pub_type
杂志文章相关文献
LUNG文献大全abstract:INTRODUCTION:Prophylactic continuous positive airway pressure (CPAP) can prevent pulmonary adverse events following upper abdominal surgeries. The present meta-regression evaluates and quantifies the effect of degree/duration of (CPAP) on the incidence of postoperative pulmonary events. METHODS:Medical databases were ...
journal_title:Lung
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00408-016-9855-6
更新日期:2016-04-01 00:00:00
abstract::The pathophysiology of cough variant asthma is poorly understood. In particular, the mechanisms that cause different symptoms in typical asthma (in which wheeze predominates) compared with cough variant asthma (in which cough predominates) have not been determined. Traditional explanations include higher wheezing thre...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-011-9348-6
更新日期:2012-02-01 00:00:00
abstract:PURPOSE:We aimed to determine the time, dose, and volume responses in a mouse pulmonary injury model following ablative dose focal irradiation (ADFIR) in order to better understand normal lung injury. METHODS AND MATERIALS:ADFIR was administered to the left lung of mice using a small animal micro-irradiator. Histopath...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-015-9825-4
更新日期:2016-02-01 00:00:00
abstract::The original version of this article unfortunately contained a mistake in the article title. The correct article title is "Residual Renal Function and Obstructive Sleep Apnea in Peritoneal Dialysis: A Pilot Study". ...
journal_title:Lung
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00408-018-0135-5
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Depression is an important comorbidity for patients with chronic obstructive pulmonary disease (COPD). The association between depression and acute exacerbations of COPD is unknown. This study was designed to determine the frequency of COPD exacerbations in outpatients with and without depressive symptoms. ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-009-9135-9
更新日期:2009-03-01 00:00:00
abstract::In previous studies, we showed that Fischer rats fed 175 mg/kg of amiodarone accumulated large amounts of drug and metabolite in the lung and developed pulmonary toxicity, whereas Wistar rats fed the same drug dose had significantly less amiodarone in the lung and did not develop pulmonary inflammation. The present st...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00167949
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Cardiopulmonary exercise testing (CPET) is a safe and clinically useful method to assess functional capacity and to follow disease progression and the response to treatment in several clinical conditions. AIM:We set out to determine the relationship between outcome measures of CPET and high-resolution compu...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-011-9316-1
更新日期:2011-10-01 00:00:00
abstract::Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for atherosclerosis and arterial thrombosis, which are associated with high cardiovascular (CV) morbidity and mortality. In studies performed in clinical populations with elevated CV event risk profiles, the occurrence of moderate to severe OSAS was...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-012-9427-3
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Up to 50% of patients suffer short-term postoperative adverse events (AEs) and metastatic recurrence in the long-term following curative-intent lung cancer resection. The association between AEs, particularly infectious in nature, and disease recurrence is controversial. We sought to evaluate the association...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-020-00395-6
更新日期:2020-12-01 00:00:00
abstract::The role of leukotrienes in hypoxic vasoconstriction remains controversial. Our previous study using the lipoxygenase inhibitor BW 755C in dogs failed to show a substantive role for leukotrienes in hypoxic vasoconstriction. To clarify further the role of leukotrienes, we designed 3 protocols. In the first protocol, we...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF02714947
更新日期:1989-01-01 00:00:00
abstract::Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is recognized as a preneoplastic condition by the World Health Organization. We reviewed our experience with 30 patients and performed a systematic review of the English literature to collect best evidence on the clinical features and disease cours...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-015-9755-1
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:We evaluated the diagnostic value for pulmonary embolism (PE) of the True fast imaging with steady-state precession (TrueFISP) MRI, a method that allows the visualization of pulmonary vasculature without breath holding or intravenous contrast. METHODS:This is a prospective investigation including 93 patient...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-017-9975-7
更新日期:2017-04-01 00:00:00
abstract::Particulate matter less than PM(10) and aromatic chemicals formed during incomplete combustion of organic matter are major environmental pollutants because of their toxic potential. The present study reports on the respiratory morbidity pattern of people exposed to auto exhaust as a result of the traffic load consisti...
journal_title:Lung
pub_type: 杂志文章,多中心研究
doi:10.1007/s00408-007-9015-0
更新日期:2007-09-01 00:00:00
abstract:PURPOSE:This study was designed to review outcomes of once- (QD) versus twice-daily (BID) radiotherapy (RT) for limited stage small-cell lung cancer (L-SCLC) treated at Dana-Farber Cancer Institute/Brigham and Women's Hospital. METHODS:We reviewed records for all patients with L-SCLC treated with radical chemoradiothe...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-013-9518-9
更新日期:2014-02-01 00:00:00
abstract::During acute asthma reversible increase in lung compliance and total lung capacity (TLC) have been observed. The magnitude of the increase in TLC, however, was found to be relatively small when TLC was measured radiographically. We wondered if structural distortion of the respiratory bellows develops during acute asth...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00177642
更新日期:1993-01-01 00:00:00
abstract::Bronchopleural (BPF) and alveolar-pleural (APF) fistulas are frequently encountered in clinical practice with persistent air leaks that can lead to significant morbidity, prolonged hospital stay, and potentially increased mortality. BPF and APF are commonly related to pulmonary resections. Other etiologies include min...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-009-9204-0
更新日期:2010-06-01 00:00:00
abstract::The practice of sedation dosing strategy in mechanically ventilated patient has a profound effect on cognitive function. We conducted a comprehensive review of outcome of sedation on mental health function in critically ill patients on mechanical ventilation in the intensive care unit (ICU). We specifically evaluated ...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-015-9820-9
更新日期:2016-02-01 00:00:00
abstract::Reports regarding smoking differences in α-klotho expression have provided conflicting results. In the current study we focused on the influence of smoking intensity to serum levels of the aging molecule α-klotho in healthy smokers. 40 middle aged healthy smokers without airway obstruction or restriction were selected...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9944-6
更新日期:2017-02-01 00:00:00
abstract::Undifferentiated connective tissue disease (UCTD) is a distinct clinical entity that may be accompanied by interstitial lung disease (ILD). The natural history of UCTD-ILD is unknown. We hypothesized that patients with UCTD-ILD would be more likely to have improvement in lung function than those with idiopathic pulmon...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-009-9226-7
更新日期:2010-04-01 00:00:00
abstract::In patients with congestive heart failure (CHF), a high prevalence of sleep-disordered breathing has been described. Cheyne-Stokes respiration (CSR) is present in up to 40% of patients with CHF. During the last decade, the medical treatment has been substantially improved. This study was designed to analyze the progno...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-009-9208-9
更新日期:2010-08-01 00:00:00
abstract::Benralizumab and mepolizumab are new therapies for severe eosinophilic asthma. They are both humanized IgG antibodies, targeting the IL-5 receptor and IL-5, respectively, suppressing the corresponding pathways. No specific biomarkers have been proposed to evaluate treatment response to benralizumab or mepolizumab. The...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-020-00379-6
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Histological subdivision into typical (TC) and atypical (AC) is crucial for treatment and prognosis of lung carcinoids but can be also very challenging, even for experts. In this study, we aimed to strengthen or reduce the prognostic value of several pathological, clinical, or per-operative factors some of w...
journal_title:Lung
pub_type: 杂志文章,多中心研究
doi:10.1007/s00408-017-0056-8
更新日期:2017-12-01 00:00:00
abstract::Eosinophils have been shown to play a role in allergen-induced airway responses. The aim in this study was to examine the effects of TAK-661, a newly developed product as a specific inhibitory agent of eosinophil chemotaxis, on antigen-induced asthmatic responses in allergic sheep model. Seven Ascaris-sensitive, "dual...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s004080000090
更新日期:2002-01-01 00:00:00
abstract::Patients with untreated obstructive sleep apnea hypopnea (OSAH) are predisposed to developing hypertension, and therapy with continuous positive airway pressure (CPAP) may reduce blood pressure (BP). The purpose of this study was to assess the impact of CPAP therapy on BP in patients with OSAH. We performed a comprehe...
journal_title:Lung
pub_type: 杂志文章,meta分析
doi:10.1007/s00408-006-0117-x
更新日期:2007-03-01 00:00:00
abstract::Our aim was to compare Taxol-based chemotherapy response of non-small cell lung cancer (NSCLC) with P-glycoprotein (Pgp) or lung resistance protein expression (LRP). Immunohistochemical analyses were performed on multiple nonconsecutive sections of the biopsy specimens to detect Pgp and LPR expressions in 40 patients ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-003-1029-7
更新日期:2003-01-01 00:00:00
abstract::To determine whether changes in breathing pattern alone affect respiratory heat loss (RHL) and the constrictor response to cold dry gas hyperpnea in asthmatic subjects, we performed the following 2 part study: first we measured RHL in 8 asthmatic and 8 normal subjects during controlled eucapnic hyperpnea while they br...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF02719670
更新日期:1990-01-01 00:00:00
abstract::Reaginic antibodies in hay fever patients belong to IgE. The immunoglobulin sensitizes basophilic granulocytes and mast cells from homologous species and mediates the release of chemical mediators which cause allergic symptoms. The sensitization is due to the binding of IgE to receptors on the target cells through the...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF02730676
更新日期:1978-01-01 00:00:00
abstract::Pleurodesis is a useful therapeutic tool when local treatment of a recurrent malignant pleural effusion or pneumothorax is needed. We have previously demonstrated that the intrapleural injection of 0.5% silver nitrate (SN) produces a significant pleurodesis, while 0.25% SN has no sclerosing effect in a rabbit model. T...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-003-1038-6
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:Exercising or doing physical activity in polluted air could expose a person to the adverse health effects of air pollution. This study aimed to compare the cardiovascular and hematologic indices following an incremental exercise test (shuttle run) under clean versus polluted air conditions. METHODS:Nineteen ma...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-014-9679-1
更新日期:2015-04-01 00:00:00
abstract::There is a lack of evidence about whether menopausal status influences the effect of smoking on lung function. This study examined the association between smoking and menopausal status and lung function independent of each other. Data were from a cohort of women attending the 21-year follow-up of the Mater University ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-010-9269-9
更新日期:2011-02-01 00:00:00