Abstract:
:Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is recognized as a preneoplastic condition by the World Health Organization. We reviewed our experience with 30 patients and performed a systematic review of the English literature to collect best evidence on the clinical features and disease course in 169 additional patients. Some patients presented with one or more carcinoid tumors associated with multiple small pulmonary nodules on imaging studies and showed DIPNECH as a somewhat unexpected pathologic finding. Others presented with multiple small pulmonary nodules that raised suspicion of metastatic disease on imaging. A third subset was presented with previously unexplained respiratory symptoms. In most patients, DIPNECH was associated with a good prognosis, with chronological progression into a subsequent carcinoid tumor noted in only one patient and death attributed directly to DIPNECH in only two patients. There is no best evidence to support the use of octreotide, steroids, or bronchodilators in DIPNECH patients.
journal_name
Lungjournal_title
Lungauthors
Wirtschafter E,Walts AE,Liu ST,Marchevsky AMdoi
10.1007/s00408-015-9755-1subject
Has Abstractpub_date
2015-10-01 00:00:00pages
659-67issue
5eissn
0341-2040issn
1432-1750pii
10.1007/s00408-015-9755-1journal_volume
193pub_type
杂志文章,评审相关文献
LUNG文献大全abstract::This study demonstrates for the first time that endothelial cells freshly isolated from small pulmonary arteries of the rat, based on their electrophysiological profile, possess two distinct populations of cells. Immunohistochemical staining revealed the presence of both anti-Kv1.5 and anti-Kir2.1 immunoreactivity in ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s004080000094
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:Acute exacerbations (AE) in patients with COPD are associated with a decline in lung function, increased risk of hospitalization, and mortality. In this cross-sectional study we tested whether the level of objectively measured daily physical activity and exercise capacity are associated with the number of COPD ...
journal_title:Lung
pub_type: 杂志文章,多中心研究
doi:10.1007/s00408-014-9673-7
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:To investigate whether lung function, especially when complicated with SDB, has an increased risk for myocardial infarction (MI) and congestive heart failure (CHF). METHODS:A prospective study was performed within the Sleep Heart Health Study (SHHS). A total of 4161 individuals were followed up for an average ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-019-00229-0
更新日期:2019-06-01 00:00:00
abstract::A method has been developed for the isolation of bovine type II pneumocytes by enzymatic tissue dissociation and subsequent density gradient centrifugation. After mechanical defibrination, the crude cell suspension contains 71.9 +/- 26.6 X 10(7) cells (viability greater than 95%) with a type II cell purity of 39.4 +/-...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF02714925
更新日期:1989-01-01 00:00:00
abstract::Long-term treatment studies with formoterol and salmeterol show that these inhaled long-acting beta 2-agonists compared to available beta 2-agonists produce better bronchodilation, decrease the need for additional doses, decrease asthma symptoms, and are strongly preferred by the patients. Development of tolerance has...
journal_title:Lung
pub_type: 临床试验,杂志文章,评审
doi:10.1007/BF02718109
更新日期:1990-01-01 00:00:00
abstract::The severity of chronic obstructive pulmonary disease (COPD) is evaluated not only by airflow limitation but also by factors such as exercise capacity and body mass index. Recent advances in CT technology suggest that it might be a useful tool for evaluating the severity of the disease components of COPD. The aim of t...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-008-9071-0
更新日期:2008-05-01 00:00:00
abstract::There is a lack of evidence about whether menopausal status influences the effect of smoking on lung function. This study examined the association between smoking and menopausal status and lung function independent of each other. Data were from a cohort of women attending the 21-year follow-up of the Mater University ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-010-9269-9
更新日期:2011-02-01 00:00:00
abstract::Antidromic stimulation of vagal sensory nerves is known to produce plasma extravasation in the rat trachea. This neurogenic inflammation is thought to be mediated by substance P or other tachykinins released from sensory nerve endings. We sought to determine whether calcitonin gene-related peptide (CGRP), which is als...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00175980
更新日期:1992-01-01 00:00:00
abstract::In previous studies, we showed that Fischer rats fed 175 mg/kg of amiodarone accumulated large amounts of drug and metabolite in the lung and developed pulmonary toxicity, whereas Wistar rats fed the same drug dose had significantly less amiodarone in the lung and did not develop pulmonary inflammation. The present st...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00167949
更新日期:1996-01-01 00:00:00
abstract::The influence of phospholipids on the ultrastructure and metabolism of reconstituted surfactants has not been well defined. The aim of this study was to determine if changes in the phospholipid composition of reconstituted surfactants altered their biophysical properties, ultrastructure, and conversion to light subtyp...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/pl00007634
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:Pulmonary arteriovenous malformations (PAVMs) are most commonly associated with hereditary hemorrhagic telangiectasia (HHT). Patients with PAVMs can present with serious complications including stroke, transient ischemic attack (TIA), and brain abscess. PAVMs are rare in non-HHT patients and little is known abo...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-020-00367-w
更新日期:2020-08-01 00:00:00
abstract::The pathophysiology of cough variant asthma is poorly understood. In particular, the mechanisms that cause different symptoms in typical asthma (in which wheeze predominates) compared with cough variant asthma (in which cough predominates) have not been determined. Traditional explanations include higher wheezing thre...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-011-9348-6
更新日期:2012-02-01 00:00:00
abstract::Surfactant is not a homogeneous material and can be separated into subtypes. Subtype conversion is clinically important because it is thought to occur naturally and because surface activity varies depending on the subtype. Fibrinogen, a naturally occurring serum protein, is known to affect this conversion. In this stu...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/pl00007569
更新日期:1997-01-01 00:00:00
abstract::Group B streptococcal (GBS) pneumonia, with neutrophilic granulocytes immigrating into the lungs, may occur in neonates. The incidence is particularly high among preterm infants, who often are treated with exogenous surfactant. We have previously demonstrated in vitro that neutrophils stimulated by GBS cause lipid per...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-003-1027-9
更新日期:2004-01-01 00:00:00
abstract:ABSTARCT:New anti-fibrotic agents for idiopathic pulmonary fibrosis (IPF) were approved based on the results of forced vital capacity (FVC) trends, although concerns were raised about the reliability of FVC as the only endpoint parameter. We hypothesized that IPF-specific multi-dimensional scores (Composite Physiologic...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9963-3
更新日期:2017-02-01 00:00:00
abstract::Recently, active remodeling may indicate a good prognosis in idiopathic interstitial pneumonias. In this study we sought to validate the importance of the collagen/elastic system in the extracellular matrix remodeling and to study the relationships between the collagen/elastic system in nonspecific interstitial idiopa...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-006-0104-2
更新日期:2007-01-01 00:00:00
abstract::Pneumocystis carinii pneumonia (PCP) is the most common presenting symptom in patients with the acquired immunodeficiency syndrome (AIDS). Clinical trials have shown that inhaled pentamidine, delivered by nebulizer, is an effective prophylaxis for PCP in high-risk patients, and can be used to treat mild to moderate ep...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF02718195
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:Sarcoidosis is a chronic granulomatous inflammatory disease of unknown etiology with heterogeneous outcomes. This study reviewed the clinical outcome status (COS) and organ involvement of Israeli sarcoidosis patients during a five-year period. Further, we compared our results to the 'World Association of Sarcoi...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-017-0015-4
更新日期:2017-08-01 00:00:00
abstract:INTRODUCTION:Driving pressure (DP) while on ECMO has been studied in acute respiratory distress syndrome (ARDS) but no studies exist in those on ECMO without ARDS. We aimed to study association of mortality with DP in all patients on ECMO and compare change in DP before and after initiation of ECMO. METHODS:Consecutiv...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-020-00381-y
更新日期:2020-10-01 00:00:00
abstract::Myofibroblasts characterized by alpha smooth muscle actin(alpha-SMA) expression play a key role in pulmonary fibrosis. Transforming growth factor-beta1 (TGF-beta1) is likely to be involved in the emergence of myofibroblasts, but the intracellular signal pathways for this process have not been well determined. The aim ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-005-2560-5
更新日期:2006-01-01 00:00:00
abstract::Accessory cardiac bronchus is a poorly recognized, usually asymptomatic, congenital abnormality of the bronchial tree. Recognition of bronchial anomalies is important since they are associated with clinical complications including recurrent episodes of infection, hemoptysis, and in some cases malignancy. ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-014-9617-2
更新日期:2014-10-01 00:00:00
abstract::Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for atherosclerosis and arterial thrombosis, which are associated with high cardiovascular (CV) morbidity and mortality. In studies performed in clinical populations with elevated CV event risk profiles, the occurrence of moderate to severe OSAS was...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-012-9427-3
更新日期:2013-02-01 00:00:00
abstract::Endobronchial Nd:Yag laser therapy is an excellent tool to reopen the central airway(s) in patients with severe respiratory symptoms caused by endobronchial tumor growth. Rigid bronchoscopy should be the method of choice. Usually general anesthesia is necessary. Complication rate depends on the condition of the patien...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF02718248
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:Exercising or doing physical activity in polluted air could expose a person to the adverse health effects of air pollution. This study aimed to compare the cardiovascular and hematologic indices following an incremental exercise test (shuttle run) under clean versus polluted air conditions. METHODS:Nineteen ma...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-014-9679-1
更新日期:2015-04-01 00:00:00
abstract::While the care of cystic fibrosis (CF) patients has been mainly the province of pediatricians, great improvements in the therapy and life span of CF patients often results in their transition to care by adult physicians. In this review of CF, we begin with an overview of the epidemiology and genetics of the disease, w...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF00164308
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Angiotensin-converting enzyme 2 (ACE2), an ACE homolog, hydrolyzes angiotensin II and opposes its actions, and plays a protective role in the pathogenesis of pulmonary arterial hypertension (PAH). However, the underlying mechanisms involved in the effect of ACE2 on PAH are still uncertain. In this study, we ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-013-9470-8
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:Improving dyspnea and exercise performance are goals of COPD therapy. We tested the hypothesis that air current applied to the face would lessen dyspnea and improve exercise performance in moderate-severe COPD patients. METHODS:We recruited 10 COPD patients (5 men, age 62 ± 6 years, FEV1 0.93 ± 0.11 L (34 ± 3%...
journal_title:Lung
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00408-015-9780-0
更新日期:2015-10-01 00:00:00
abstract::Lung cancer screening (LCS) is currently advocated in a subset of current or former smokers with a thirty pack-year smoking history or higher. Studies report that few patients meeting the criteria for screening are undergoing LCS. We conducted a survey to assess if barriers to LCS (race, ethnicity, and socioeconomic s...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-019-00281-w
更新日期:2019-12-01 00:00:00
abstract::To explore further the possible etiologic role of mycobacteria in the development of sarcoidosis, we measured free, nonbound tuberculostearic acid (TSA, 10-methyloctadecanoic), a component of mycobacteria, in the sera of subjects with sarcoidosis or active untreated pulmonary tuberculosis and in healthy controls by us...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00164632
更新日期:1996-01-01 00:00:00
abstract::This study evaluated the extracellular matrix (collagen and elastic fibers) in pleurodesis induced by intrapleural talc (TL) or silver nitrate (SN). Study subjects were 420 rabbits divided into two groups and sacrificed from 15 min to 12 months after the injection of the sclerosing agents at intervals previously defin...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-005-2569-9
更新日期:2006-03-01 00:00:00