Abstract:
:Pneumocystis carinii pneumonia (PCP) is the most common presenting symptom in patients with the acquired immunodeficiency syndrome (AIDS). Clinical trials have shown that inhaled pentamidine, delivered by nebulizer, is an effective prophylaxis for PCP in high-risk patients, and can be used to treat mild to moderate episodes. Side effects are minor, in marked contrast to the parenteral route of administration. The choice of nebulizer system will determine both alveolar delivery of pentamidine and the incidence of cough related to deposition of droplets on large conducting airways. Radioaerosol studies have suggested that optimum nebulizer systems for inhaled pentamidine deliver the majority of the aerosol mass in droplets smaller than 2 microns diameter, ideal for alveolar penetration.
journal_name
Lungjournal_title
Lungauthors
Newman SP,Simonds AKdoi
10.1007/BF02718195subject
Has Abstractpub_date
1990-01-01 00:00:00pages
685-91eissn
0341-2040issn
1432-1750journal_volume
168 Supplpub_type
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