Abstract:
BACKGROUND:Although lung transplantation is the only means of survival for patients with end-stage pulmonary disease, outcomes from this intervention are inferior to other solid organ transplants. The reason for the poor outcomes may be linked to an early reaction, such as primary graft dysfunction, and associated with marked inflammatory response, bronchiole injury, and later fibrotic responses. Mediators regulating these effects include angiotensin II and matrix metalloproteinases (MMPs). METHODS:We investigated changes to these mediators over the course of cardiopulmonary bypass (CPB) and up to 72 h after lung transplantation, using immunohistochemistry, Western blot, and ELISA techniques. RESULTS:We found 4- and 16-fold increases in plasma angiotensin II and MMP-9, respectively, from pre-CPB to post-CPB. MMP-9 levels remained elevated 1 h after transplantation. MMP-2 levels were elevated 6-24 h after lung transplantation. Type 2 angiotensin II receptor (ATR2) expression was 3.5-fold higher in bronchoalveolar cells 1-6 h after transplantation than in controls. CONCLUSIONS:The study suggests that the combination of cardiopulmonary bypass and lung transplantation is associated with early changes in the angiotensin II receptor system and in MMPs, and that altered expression of these mediators may be a useful marker to examine pathological changes that occur in lungs during transplant surgery.
journal_name
Lungjournal_title
Lungauthors
Nataatmadja M,Passmore M,Russell FD,Prabowo S,Corley A,Fraser JFdoi
10.1007/s00408-014-9588-3subject
Has Abstractpub_date
2014-08-01 00:00:00pages
563-9issue
4eissn
0341-2040issn
1432-1750journal_volume
192pub_type
杂志文章相关文献
LUNG文献大全abstract:INTRODUCTION:The cardinal symptom of pulmonary hypertension (PH) is dyspnea on exertion, leading to decreased activity in daily living. The aim of this study was to analyze daily physical activity in incident patients with arterial or chronic thromboembolic PH (PAH/CTEPH) and to investigate its correlation with pulmona...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-019-00248-x
更新日期:2019-10-01 00:00:00
abstract::This multi-centred, randomised controlled trial explored the effects of adding ongoing feedback to a 12-month unsupervised maintenance walking program, on daily physical activity (PA) in people with chronic obstructive pulmonary disease. Participants were randomised to either an intervention group (IG) or a usual care...
journal_title:Lung
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00408-019-00216-5
更新日期:2019-06-01 00:00:00
abstract::It is well established that cotton dust inhalation can compromise lung function in textile workers. Challenges with a water-soluble extract of cotton bract (CBE) can also induce reversible airway obstruction in healthy volunteers. We have examined the effect of inhaled CBE in nonhuman primates and have attempted to in...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF02714026
更新日期:1988-01-01 00:00:00
abstract::Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for atherosclerosis and arterial thrombosis, which are associated with high cardiovascular (CV) morbidity and mortality. In studies performed in clinical populations with elevated CV event risk profiles, the occurrence of moderate to severe OSAS was...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-012-9427-3
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:The aim was to investigate whether maintenance therapy (MT) is sufficient or not to improve overall survival (OS) and progress-free survival (PFS) of advanced non-small cell lung cancer (NSCLC) patients. METHODS:Randomized controlled trials (RCTs) published between 1990 and 2013 were retrieved from PubMed, EMB...
journal_title:Lung
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00408-015-9758-y
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:This study was conducted to investigate the percentages of Th22 and Th17 cells in the peripheral blood of septic patients with and without acute lung injury (ALI) and their clinical significance. METHODS:A total of 479 patients were divided into non-ALI and ALI groups. The percentages of Th22 and Th17 cells an...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-020-00362-1
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:The relationship between asthma and obesity is well established, although the pathophysiological mechanisms linking both diseases remain unknown. Adiponectin is a hormone secreted by adipose cells, plays a role in the modulation of inflammation and may be the key linking these two types of inflammation. METHOD...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-015-9793-8
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To explore the role of CARM1 in lung cancer (LC) and its relationship with TP53 and CTNNB1. METHODS:Lung cells H1299 and PC14 were randomly divided into six groups: ov-H1299, si-H1299, ov-PC14, si-PC14, Con-H1299, and Con-PC14. Transwell assay, plate clone formation assay, and flow cytometry were used to det...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-020-00324-7
更新日期:2020-04-01 00:00:00
abstract::Acid glycosaminoglycans (GAG) were quantitated and partially characterized in pleural effusions in guinea pigs with experimental allergic pleurisy. Increase of GAG in the pleural effusion preceded the increase of effusion volume. Effusion was associated with the presence of cuboidal mesothelial cells on visceral pleur...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF02714437
更新日期:1987-01-01 00:00:00
abstract::The author reviews the early history of alpha 1-antitrypsin (AAT) deficiency; the biochemical characterization of this inborn error of metabolism, its pattern of inheritance, frequency and predisposition to early, panacinar emphysema. The importance of the destructive element in emphysema and the gradual focusing on n...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF02718174
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Asbestos is a carcinogen linked to malignant mesothelioma (MM) and lung cancer. Some gene aberrations related to asbestos exposure are recognized, but many associated mutations remain obscure. We performed exome sequencing to determine the association of previously known mutations (driver gene mutations) wit...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-015-9814-7
更新日期:2016-02-01 00:00:00
abstract::Eosinophils have been shown to play a role in allergen-induced airway responses. The aim in this study was to examine the effects of TAK-661, a newly developed product as a specific inhibitory agent of eosinophil chemotaxis, on antigen-induced asthmatic responses in allergic sheep model. Seven Ascaris-sensitive, "dual...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s004080000090
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Recent studies have demonstrated non-inferiority of rivaroxaban when compared to warfarin for the treatment of pulmonary embolism and deep venous thrombosis. Analysis of data from the EINSTEIN trials has demonstrated that patients who received rivaroxaban had a shorter length of stay (LOS) compared to those ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9898-8
更新日期:2016-08-01 00:00:00
abstract::The severity of chronic obstructive pulmonary disease (COPD) is evaluated not only by airflow limitation but also by factors such as exercise capacity and body mass index. Recent advances in CT technology suggest that it might be a useful tool for evaluating the severity of the disease components of COPD. The aim of t...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-008-9071-0
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Recent studies have shown the importance of Th17 cells in the development of allergic airway diseases. We examined Dermatophagoides pteronyssinus-induced changes in peripheral blood Th17 cells to establish the importance of these cells in late-phase allergic inflammation in patients with allergic rhinitis (A...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9411-y
更新日期:2012-10-01 00:00:00
abstract::Lung elastance and resistance increase in the supine posture. To evaluate the effects of change in posture on regional lung mechanics at different lung volumes, lung elastance and resistance were measured at graded volume subdivisions and three esophageal levels at seated and supine body positions, using the esophagea...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00173306
更新日期:1996-01-01 00:00:00
abstract::Antidromic stimulation of vagal sensory nerves is known to produce plasma extravasation in the rat trachea. This neurogenic inflammation is thought to be mediated by substance P or other tachykinins released from sensory nerve endings. We sought to determine whether calcitonin gene-related peptide (CGRP), which is als...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00175980
更新日期:1992-01-01 00:00:00
abstract::Patients with untreated obstructive sleep apnea hypopnea (OSAH) are predisposed to developing hypertension, and therapy with continuous positive airway pressure (CPAP) may reduce blood pressure (BP). The purpose of this study was to assess the impact of CPAP therapy on BP in patients with OSAH. We performed a comprehe...
journal_title:Lung
pub_type: 杂志文章,meta分析
doi:10.1007/s00408-006-0117-x
更新日期:2007-03-01 00:00:00
abstract::We studied the influence of age on glutathione (GSH) content in the distal lung and the lung tissue of mice. From 1 to 28 months of age, the quantity of GSH and glutathione disulfide (GSSG) in bronchoalveolar lavage (BAL) fluid and in the lung tissue were determined. The GSH content in BAL fluid, which reflects the an...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00164439
更新日期:1994-01-01 00:00:00
abstract::The influence of phospholipids on the ultrastructure and metabolism of reconstituted surfactants has not been well defined. The aim of this study was to determine if changes in the phospholipid composition of reconstituted surfactants altered their biophysical properties, ultrastructure, and conversion to light subtyp...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/pl00007634
更新日期:1999-01-01 00:00:00
abstract::Overlap syndrome and represents a complex clinical condition in pulmonary medicine. We discuss in this letter factors related with mortality after long-term effects CPAP and key differences between hypercapnic versus hypoxemic overlap patients. ...
journal_title:Lung
pub_type: 评论,信件
doi:10.1007/s00408-014-9613-6
更新日期:2014-10-01 00:00:00
abstract::This study demonstrates for the first time that endothelial cells freshly isolated from small pulmonary arteries of the rat, based on their electrophysiological profile, possess two distinct populations of cells. Immunohistochemical staining revealed the presence of both anti-Kv1.5 and anti-Kir2.1 immunoreactivity in ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s004080000094
更新日期:2002-01-01 00:00:00
abstract::We aimed to evaluate the utility of coagulation markers for the prediction of rapidly progressive interstitial lung disease (RP-ILD) in patients with dermatomyositis (DM). In this retrospective study, 29 patients with DM-associated ILD were analyzed. The number of patients with RP-ILD was 15 (52%). The baseline clinic...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-019-00245-0
更新日期:2019-08-01 00:00:00
abstract:INTRODUCTION:Lung cancer is the leading cause of cancer death in the USA, claiming more than 140,000 deaths annually. Delays in diagnosis and treatment can lead to missed opportunities for both curative and life prolonging therapies. This study aimed to evaluate duration of time to diagnosis and first treatment, as wel...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-020-00404-8
更新日期:2020-12-01 00:00:00
abstract::It has been reported that a low concentration of exogenously applied vasoactive intestinal peptide (VIP) suppresses the release of acetylcholine (ACh) from vagus nerve terminals in the ferret and feline trachea. There has been, however, no documentation of the prejunctional action of VIP in the human airway. We observ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00175944
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:This is a meta-analysis of the safety and efficacy of indacaterol in chronic obstructive pulmonary disease (COPD) with treatment duration of ≥12 weeks. METHODS:Randomized controlled trials (RCTs) reported in English (to September 30, 2012) were identified from PubMed, the Cochrane Library, Embase, websites,...
journal_title:Lung
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00408-012-9444-2
更新日期:2013-04-01 00:00:00
abstract::Reports regarding smoking differences in α-klotho expression have provided conflicting results. In the current study we focused on the influence of smoking intensity to serum levels of the aging molecule α-klotho in healthy smokers. 40 middle aged healthy smokers without airway obstruction or restriction were selected...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9944-6
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To investigate whether lung function, especially when complicated with SDB, has an increased risk for myocardial infarction (MI) and congestive heart failure (CHF). METHODS:A prospective study was performed within the Sleep Heart Health Study (SHHS). A total of 4161 individuals were followed up for an average ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-019-00229-0
更新日期:2019-06-01 00:00:00
abstract::Endobronchial Nd:Yag laser therapy is an excellent tool to reopen the central airway(s) in patients with severe respiratory symptoms caused by endobronchial tumor growth. Rigid bronchoscopy should be the method of choice. Usually general anesthesia is necessary. Complication rate depends on the condition of the patien...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF02718248
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Red cell distribution width (RDW) has been shown to be associated with adverse outcomes in left-sided heart failure, pulmonary hypertension, and in patients in the ICU. However, the role of RDW is unknown in patients with obstructive sleep apnea syndrome (OSAS), especially in OSAS patients with cardiovascula...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9376-x
更新日期:2012-06-01 00:00:00