Management of Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia: Review and a Single Center Experience.

Abstract:

BACKGROUND:Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare pulmonary condition, characterized by diffuse proliferation of neuroendocrine cells in the respiratory epithelium. DIPNECH lesions are less than 5 mm in size and are limited to the basement membrane with no invasion. There is limited information regarding epidemiology, natural history of disease progression, or the management of this rare entity. We present the experience of a center with extensive expertise in neuroendocrine disease. METHODS:A cohort of patients (N = 13) with DIPNECH treated and followed at our institution was identified. We describe the our approach to their care, our disease management and also provide a review of DIPNECH pathophysiology. RESULTS:Our patient cohort consisted of twelve females and one male with a mean age of 63 years at the time of diagnosis. Dyspnea on exertion and dry cough were the most common presenting symptoms. Two patients were under surveillance without treatment; three patients were treated with a short-acting somatostatin analog; three patients were treated with azithromycin alone; four were treated with a combination of long-acting monthly somatostatin analogs and azithromycin; one patient received a combination of long-acting somatostatin analog and everolimus. Five patients had concomitant bronchial carcinoids. CONCLUSIONS:DIPNECH is a rare pathology that can profoundly affect a patient's quality of life. Paroxysmal coughing episodes can be difficult to treat. Our limited single center experience shows encouraging response to use of somatostatin analogs, azithromycin, and everolimus in the management of debilitating DIPNECH associated symptoms.

journal_name

Lung

journal_title

Lung

authors

Myint ZW,McCormick J,Chauhan A,Behrens E,Anthony LB

doi

10.1007/s00408-018-0149-z

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

577-581

issue

5

eissn

0341-2040

issn

1432-1750

pii

10.1007/s00408-018-0149-z

journal_volume

196

pub_type

杂志文章,评审

相关文献

LUNG文献大全
  • Response of peripheral blood Th17 cells to inhaled Dermatophagoides pteronyssinus in patients with allergic rhinitis and asthma.

    abstract:BACKGROUND:Recent studies have shown the importance of Th17 cells in the development of allergic airway diseases. We examined Dermatophagoides pteronyssinus-induced changes in peripheral blood Th17 cells to establish the importance of these cells in late-phase allergic inflammation in patients with allergic rhinitis (A...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-012-9411-y

    authors: Bajoriuniene I,Malakauskas K,Lavinskiene S,Jeroch J,Gasiuniene E,Vitkauskiene A,Sakalauskas R

    更新日期:2012-10-01 00:00:00

  • Pleurodesis induced by talc or silver nitrate: evaluation of collagen and elastic fibers in pleural remodeling.

    abstract::This study evaluated the extracellular matrix (collagen and elastic fibers) in pleurodesis induced by intrapleural talc (TL) or silver nitrate (SN). Study subjects were 420 rabbits divided into two groups and sacrificed from 15 min to 12 months after the injection of the sclerosing agents at intervals previously defin...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-005-2569-9

    authors: Antonangelo L,Vargas FS,Teixeira LR,Acencio MM,Vaz MA,Filho MT,Marchi E

    更新日期:2006-03-01 00:00:00

  • Effects of GABA-B agonist baclofen on bronchial hyperreactivity to inhaled histamine in subjects with cervical spinal cord injury.

    abstract::Bronchial provocation studies performed in our research center have consistently demonstrated airway hyperresponsiveness to both inhaled methacholine and histamine in subjects with chronic cervical spinal cord injury (SCI). More recently, we reported that the airways of such subjects maintained on chronic baclofen (ga...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/pl00007579

    authors: Grimm DR,DeLuca RV,Lesser M,Bauman WA,Almenoff PL

    更新日期:1997-01-01 00:00:00

  • Electromechanical effects of tetraethylammonium and K+ on histamine-induced contraction in pig isolated tracheal smooth muscle.

    abstract::The effect of tetraethylammonium (TEA) and K+ on contractions to histamine and acetylcholine have been compared in the pig isolated trachea using organ bath and sucrose-gap techniques. Histamine elicited weak contractions, compared with acetylcholine; however, these contractions were markedly potentiated by pretreatme...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/BF02714429

    authors: Mitchell HW

    更新日期:1987-01-01 00:00:00

  • ACE2 activation confers endothelial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats.

    abstract:BACKGROUND:Angiotensin-converting enzyme 2 (ACE2), an ACE homolog, hydrolyzes angiotensin II and opposes its actions, and plays a protective role in the pathogenesis of pulmonary arterial hypertension (PAH). However, the underlying mechanisms involved in the effect of ACE2 on PAH are still uncertain. In this study, we ...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-013-9470-8

    authors: Li G,Liu Y,Zhu Y,Liu A,Xu Y,Li X,Li Z,Su J,Sun L

    更新日期:2013-08-01 00:00:00

  • Comparison of LMWH versus UFH for hemorrhage and hospital mortality in the treatment of acute massive pulmonary thromboembolism after thrombolytic treatment : randomized controlled parallel group study.

    abstract:PURPOSE:Current guidelines recommend the use of low molecular weight heparin (LMWH) for most haemodynamically stable patients with pulmonary thromboembolism (PTE), however, it is not clear whether LMWH is preferable to unfractionated heparin (UFH) for the treatment of massive PTE. We aimed to compare the use of LMWH ve...

    journal_title:Lung

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00408-014-9660-z

    authors: Ucar EY,Akgun M,Araz O,Tas H,Kerget B,Meral M,Kaynar H,Saglam L

    更新日期:2015-02-01 00:00:00

  • Treatment of atopic cough caused by Basidiomycetes antigen with low-dose itraconazol.

    abstract::We report two patients with atopic cough due to Basidiomycetes antigen. One patient was a 27 year-old woman and the other was a 17 year-old boy. Both patients visited our hospital because of severe nonproductive cough. They did not have bronchial hyperresponsiveness to methacholine or heightened bronchomotor tone. Bro...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-004-2509-0

    authors: Ogawa H,Fujimura M,Tofuku Y

    更新日期:2004-01-01 00:00:00

  • Optimizing Prophylactic CPAP in Patients Without Obstructive Sleep Apnoea for High-Risk Abdominal Surgeries: A Meta-regression Analysis.

    abstract:INTRODUCTION:Prophylactic continuous positive airway pressure (CPAP) can prevent pulmonary adverse events following upper abdominal surgeries. The present meta-regression evaluates and quantifies the effect of degree/duration of (CPAP) on the incidence of postoperative pulmonary events. METHODS:Medical databases were ...

    journal_title:Lung

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00408-016-9855-6

    authors: Singh PM,Borle A,Shah D,Sinha A,Makkar JK,Trikha A,Goudra BG

    更新日期:2016-04-01 00:00:00

  • Effects of vitamin E deficiency on bleomycin-induced pulmonary fibrosis in the hamster.

    abstract::The effects of vitamin E deficiency on bleomycin (BLM)-induced pulmonary fibrosis have been studied by analyses of pressure volume (PV) curves and morphological examinations. Golden hamsters were divided into groups on a control diet (group C), vitamin E-deficient diet (E), control diet with BLM treatment (CB), and vi...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/BF02714044

    authors: Nakamura H,Sato S,Takahashi K

    更新日期:1988-01-01 00:00:00

  • How the Frequency and Phenotype of Sarcoidosis is Driven by Environmental Determinants.

    abstract:BACKGROUND:Sarcoidosis is a systemic disease in which the personal environment seems to drive a differentiated disease frequency and clinical expression. The main epidemiological studies suggest a key influence of potential environmentally linked exposures related to the type of occupation, the household, life style, s...

    journal_title:Lung

    pub_type: 杂志文章,评审

    doi:10.1007/s00408-019-00243-2

    authors: Ramos-Casals M,Kostov B,Brito-Zerón P,Sisó-Almirall A,Baughman RP,Autoimmune Big Data Study Group.

    更新日期:2019-08-01 00:00:00

  • Cough variant asthma: lessons learned from deep inspirations.

    abstract::The pathophysiology of cough variant asthma is poorly understood. In particular, the mechanisms that cause different symptoms in typical asthma (in which wheeze predominates) compared with cough variant asthma (in which cough predominates) have not been determined. Traditional explanations include higher wheezing thre...

    journal_title:Lung

    pub_type: 杂志文章,评审

    doi:10.1007/s00408-011-9348-6

    authors: Lougheed MD,Turcotte SE,Fisher T

    更新日期:2012-02-01 00:00:00

  • Aerosol therapy in AIDS.

    abstract::Pneumocystis carinii pneumonia (PCP) is the most common presenting symptom in patients with the acquired immunodeficiency syndrome (AIDS). Clinical trials have shown that inhaled pentamidine, delivered by nebulizer, is an effective prophylaxis for PCP in high-risk patients, and can be used to treat mild to moderate ep...

    journal_title:Lung

    pub_type: 杂志文章,评审

    doi:10.1007/BF02718195

    authors: Newman SP,Simonds AK

    更新日期:1990-01-01 00:00:00

  • Red cell distribution width in patients with obstructive sleep apnea syndrome.

    abstract:BACKGROUND:Red cell distribution width (RDW) has been shown to be associated with adverse outcomes in left-sided heart failure, pulmonary hypertension, and in patients in the ICU. However, the role of RDW is unknown in patients with obstructive sleep apnea syndrome (OSAS), especially in OSAS patients with cardiovascula...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-012-9376-x

    authors: Ozsu S,Abul Y,Gulsoy A,Bulbul Y,Yaman S,Ozlu T

    更新日期:2012-06-01 00:00:00

  • Greater Access to Long Acting Beta2 Agonists Is Associated with Less Hospital Admissions Due to COPD: A Longitudinal Nation-Wide Study.

    abstract:PURPOSE:Long Acting Beta2 Agonists (LABA) prevent COPD exacerbations in strictly standardized clinical trials. Our aim was to evaluate the relationship between the amount of LABA provided by the government and the trend in COPD hospital admission (HA) rate in Brazil. METHODS:This is a longitudinal large-scale real-lif...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-018-0158-y

    authors: Ponte EV,Cruz ÁA,Lima VB,Stelmach R,Viegi G

    更新日期:2018-12-01 00:00:00

  • Impact of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea hypopnea: a meta-analysis of randomized controlled trials.

    abstract::Patients with untreated obstructive sleep apnea hypopnea (OSAH) are predisposed to developing hypertension, and therapy with continuous positive airway pressure (CPAP) may reduce blood pressure (BP). The purpose of this study was to assess the impact of CPAP therapy on BP in patients with OSAH. We performed a comprehe...

    journal_title:Lung

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00408-006-0117-x

    authors: Alajmi M,Mulgrew AT,Fox J,Davidson W,Schulzer M,Mak E,Ryan CF,Fleetham J,Choi P,Ayas NT

    更新日期:2007-03-01 00:00:00

  • Benign metastasizing leiomyoma.

    abstract::A 41-year-old woman presented with chest pain and a cough. There was a solitary pulmonary nodule in the upper-left lobe. The patient had no history of neoplasm except a hysterectomy for uterine leiomyoma five years before. Six months after the first presentation, the tumor showed a gradual increase in size; an explora...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-008-9084-8

    authors: Sapmaz F,Ergin M,Katrancioglu O,Gonlugur T,Gonlugur U,Elagoz S

    更新日期:2008-07-01 00:00:00

  • Comparing the relationship of Taxol-based chemotherapy response with P-glycoprotein and lung resistance-related protein expression in non-small cell lung cancer.

    abstract::Our aim was to compare Taxol-based chemotherapy response of non-small cell lung cancer (NSCLC) with P-glycoprotein (Pgp) or lung resistance protein expression (LRP). Immunohistochemical analyses were performed on multiple nonconsecutive sections of the biopsy specimens to detect Pgp and LPR expressions in 40 patients ...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-003-1029-7

    authors: Chiou JF,Liang JA,Hsu WH,Wang JJ,Ho ST,Kao A

    更新日期:2003-01-01 00:00:00

  • Difficult weaning from mechanical ventilation.

    abstract::Difficult weaning is fortunately a rare occurrence in mechanically ventilated patients in ICU. When faced with this problem, a vast number of factors must be carefully considered simultaneously: physiological adjustment, technical problems (tubing, circuit resistances, . . .) [13]. The most promising approach to diffi...

    journal_title:Lung

    pub_type: 杂志文章,评审

    doi:10.1007/BF02718216

    authors: Chevrolet JC

    更新日期:1990-01-01 00:00:00

  • A Paradox: α-Klotho Levels and Smoking Intensity.

    abstract::Reports regarding smoking differences in α-klotho expression have provided conflicting results. In the current study we focused on the influence of smoking intensity to serum levels of the aging molecule α-klotho in healthy smokers. 40 middle aged healthy smokers without airway obstruction or restriction were selected...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-016-9944-6

    authors: Verde Z,González-Moro JM,Chicharro LM,Reinoso-Barbero L,Bandrés F,Gómez-Gallego F,Santiago C

    更新日期:2017-02-01 00:00:00

  • A pulmonary rehabilitation program for patients with asthma and mild chronic obstructive pulmonary diseases (COPD).

    abstract::The effects of a pulmonary rehabilitation program on 44 patients with chronic obstructive pulmonary disease (COPD) were compared to a control group. The treated group was admitted to the program for a period of three months. The program consisted of several parts, such as physical training, health education, and psych...

    journal_title:Lung

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF00203723

    authors: Cox NJ,Hendricks JC,Binkhorst RA,van Herwaarden CL

    更新日期:1993-01-01 00:00:00

  • ATF3 and extracellular matrix-related genes associated with the process of chronic obstructive pulmonary.

    abstract:INTRODUCTION:Chronic obstructive pulmonary disease (COPD) is a major public health problem worldwide and is proved to be the number three cause of death in globally. The objective of this study was to explore the molecular mechanism of the progression of COPD. METHODS:Using the GSE1650 affymetrix microarray data acces...

    journal_title:Lung

    pub_type: 杂志文章,收录出版

    doi:10.1007/s00408-014-9631-4

    authors: Ye J,Wen L,Liu DL,Lai GX

    更新日期:2014-12-01 00:00:00

  • Airway Vagal Neuroplasticity Associated with Respiratory Viral Infections.

    abstract::Respiratory virus infections leads to coughing, sneezing, and increases in reflex parasympathetic bronchoconstriction and secretions. These responses to viral infection are exclusively or largely secondary to changes in the function of the nervous system. For many with underlying airway pathologies such as asthma and ...

    journal_title:Lung

    pub_type: 杂志文章,评审

    doi:10.1007/s00408-015-9832-5

    authors: Zaccone EJ,Undem BJ

    更新日期:2016-02-01 00:00:00

  • Serum sRAGE as a potential biomarker for pediatric bronchiolitis: a pilot study.

    abstract:PURPOSE:Traditional inflammatory biomarkers are insufficient for the evaluation of bronchiolitis severity. Recent investigations have shown that the receptor for advanced glycation end product (RAGE) and its soluble isoforms (sRAGE) play a critical role in the pathogenesis of lung injury. Main objective was to assess t...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-014-9663-9

    authors: García-Salido A,Oñoro G,Melen GJ,Gómez-Piña V,Serrano-González A,Ramírez-Orellana M,Casado-Flores J

    更新日期:2015-02-01 00:00:00

  • Living donor lobar lung transplantation: a longstanding concept being revisited with the same old NEMESIS.

    abstract:INTRODUCTION:Living donor lobar lung transplantation (LDLLT) has been successfully used in select patient populations. MATERIALS AND METHODS:A 29-year-old male, who underwent bilateral LDLLT 12 years earlier with allografts donated by father and paternal uncle, developed bronchiolitis obliterans syndrome at distinctly...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-014-9560-2

    authors: Hayes D Jr,Baker PB

    更新日期:2014-06-01 00:00:00

  • Formoterol, fenoterol, and salbutamol as partial agonists for relaxation of maximally contracted guinea pig tracheae: comparison of relaxation with receptor binding.

    abstract::In severe asthma attacks beta 2-sympathomimetics lose part of their therapeutic efficiency. To elucidate this loss of efficiency in an experimental model we compared the relaxant potency of salbutamol (SAL), fenoterol (FEN), formoterol (FOR), and (-)-isoprenaline (ISO) in guinea pig tracheae partially and maximally pr...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/BF00174319

    authors: Lemoine H,Overlack C,Köhl A,Worth H,Reinhardt D

    更新日期:1992-01-01 00:00:00

  • Mechanics of the pleural space: fundamental concepts.

    abstract::The transmission of forces from the respiratory muscles to the lung across the extremely thin pleural space has been poorly understood because of the difficulty of accurately measuring pleural liquid and pleural surface pressure (lung static recoil or transpulmonary pressure). Recent results using relatively noninvasi...

    journal_title:Lung

    pub_type: 杂志文章,评审

    doi:10.1007/BF02714442

    authors: Lai-Fook SJ

    更新日期:1987-01-01 00:00:00

  • Volumetric capnography for the evaluation of pulmonary disease in adult patients with cystic fibrosis and noncystic fibrosis bronchiectasis.

    abstract::This study was designed to use volumetric capnography to evaluate the breathing pattern and ventilation inhomogeneities in patients with chronic sputum production and bronchiectasis and to correlate the phase 3 slope of the capnographic curve to spirometric measurements. Twenty-four patients with cystic fibrosis (CF) ...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-009-9213-z

    authors: Veronez L,Moreira MM,Soares ST,Pereira MC,Ribeiro MA,Ribeiro JD,Terzi RG,Martins LC,Paschoal IA

    更新日期:2010-06-01 00:00:00

  • Pulmonary Complications of Cardiac Surgery.

    abstract::Cardiothoracic surgery posits an arrangement of large, significant hemodynamic, and physiologic alterations upon the human body, which predisposes a patient to develop pathology. The care of these patients in the postoperative realm requires an astute physician with deep understanding of the cardiopulmonary system, wh...

    journal_title:Lung

    pub_type: 杂志文章,评审

    doi:10.1007/s00408-020-00405-7

    authors: Tanner TG,Colvin MO

    更新日期:2020-12-01 00:00:00

  • Impact of environmental air pollutants on disease control in asmathic patients.

    abstract:PURPOSE:Asthmatics are adversely affected by the presence of air pollutants, the concentrations of which can nowadays be measured. However, the utility of this information in clinical practice has not been defined in a group of asthmatics in stable condition. Our objective was to determine what impact the level of air ...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-015-9695-9

    authors: Fernandez R,Ariza M,Iscar M,Martinez C,Rubinos G,Gagatek S,Montoliu MA,Casan P

    更新日期:2015-04-01 00:00:00

  • Association between smoking and respiratory function before and after menopause.

    abstract::There is a lack of evidence about whether menopausal status influences the effect of smoking on lung function. This study examined the association between smoking and menopausal status and lung function independent of each other. Data were from a cohort of women attending the 21-year follow-up of the Mater University ...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-010-9269-9

    authors: Hayatbakhsh MR,Najman JM,O'Callaghan MJ,Williams GM,Paydar A,Clavarino A

    更新日期:2011-02-01 00:00:00