ACE2 activation confers endothelial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats.

abstract：:Alveolar epithelial type II (AT II) cells need phosphate (Pi) for surfactant synthesis. The Na-dependent (Na(d)) Pi transporters NaPi-IIb and Pit-1 are expressed in lung, but their expression, regulation, and function in AT II cells remain unclear. We studied NaPi-IIb and Pit-1 mRNA expression in cultured AT II cells ...

journal_title：Lung

authors： Jin C,Zoidis E,Ghirlanda C,Schmid C

更新日期：2010-01-01 00:00:00

abstract：:This study evaluated the extracellular matrix (collagen and elastic fibers) in pleurodesis induced by intrapleural talc (TL) or silver nitrate (SN). Study subjects were 420 rabbits divided into two groups and sacrificed from 15 min to 12 months after the injection of the sclerosing agents at intervals previously defin...

journal_title：Lung

authors： Antonangelo L,Vargas FS,Teixeira LR,Acencio MM,Vaz MA,Filho MT,Marchi E

更新日期：2006-03-01 00:00:00

abstract：:Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is recognized as a preneoplastic condition by the World Health Organization. We reviewed our experience with 30 patients and performed a systematic review of the English literature to collect best evidence on the clinical features and disease cours...

journal_title：Lung

authors： Wirtschafter E,Walts AE,Liu ST,Marchevsky AM

更新日期：2015-10-01 00:00:00

abstract：:The influence of phospholipids on the ultrastructure and metabolism of reconstituted surfactants has not been well defined. The aim of this study was to determine if changes in the phospholipid composition of reconstituted surfactants altered their biophysical properties, ultrastructure, and conversion to light subtyp...

journal_title：Lung

authors： Dhand R,Young J,Krishnasamy S,Possmayer F,Gross NJ

更新日期：1999-01-01 00:00:00

abstract：:Allergen exposure in atopic asthmatic patients is associated with recruitment and activation of eosinophils in the airways. Once activated, eosinophils release toxic products, including the eosinophil cationic protein (ECP), able to damage bronchial structures and to increase bronchial hyperresponsiveness. With this b...

journal_title：Lung

authors： Oddera S,Silvestri M,Penna R,Galeazzi G,Crimi E,Rossi GA

更新日期：1998-01-01 00:00:00

abstract：:The major goal of all diagnostic and therapeutic efforts in childhood asthma is to prevent progression of lung disease into adulthood. To improve the uncomfortable situation of underdiagnosis and undertreatment and to lower the risk of acquiring irreversible lung damage, an optimal co-working relationship between fami...

journal_title：Lung

authors： Kraemer R,Speck S,Schöni MH

更新日期：1990-01-01 00:00:00

abstract：INTRODUCTION:Sarcoidosis is a systemic granulomatous disease which predominantly affects the lungs, although granulomas can also involve all other organs, including the heart. Cardiac sarcoidosis (CS) may occur at any stage of the disease and may be the cause of sudden cardiac death, even in a previously asymptomatic p...

journal_title：Lung

authors： Martusewicz-Boros MM,Boros PW,Wiatr E,Kempisty A,Piotrowska-Kownacka D,Roszkowski-Śliż K

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:Idiopathic pulmonary fibrosis (IPF) is a restrictive fibrotic lung disease of uncertain etiology. Alveolar epithelial injury may be one of the inciting triggers in the pathogenesis of this disorder. We hypothesized that circulating antibodies to alveolar epithelial and endothelial cells may be involved in the p...

journal_title：Lung

authors： Fahim A,Chong MC,Crooks MG,Hart SP

更新日期：2012-08-01 00:00:00

abstract：:In critically ill patients, endotracheal intubation is associated with a high risk of complications, including severe hypoxemia and hypotension. The purpose of this review is to discuss the definitions, complications, airway assessment, and patient optimization with respect to these patients. In addition, we present d...

journal_title：Lung

authors： Griesdale DE,Henderson WR,Green RS

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:In immunocompromised patients with pulmonary infiltrates, transbronchial lung biopsies (TBB) obtained by forceps has been shown to increase the diagnostic yield over simple bronchoalveolar lavage. Cryo-TBB is a novel modality for obtaining lung biopsies. We aimed to evaluate for the first time the efficacy a...

journal_title：Lung

authors： Fruchter O,Fridel L,Rosengarten D,Rahman NA,Kramer MR

更新日期：2013-12-01 00:00:00

abstract：ABSTARCT:New anti-fibrotic agents for idiopathic pulmonary fibrosis (IPF) were approved based on the results of forced vital capacity (FVC) trends, although concerns were raised about the reliability of FVC as the only endpoint parameter. We hypothesized that IPF-specific multi-dimensional scores (Composite Physiologic...

journal_title：Lung

authors： Hosein K,Le J,Mura M

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:Pulmonary hypertension (PH) due to COPD has dismal prognosis. We reviewed the long-term effect of PH-target therapy in severe PH-COPD. METHOD:Patients attending our PH-clinic were reviewed for PH-COPD receiving PH-target therapy. Baseline characteristics, death/transplantation until 2014, therapy, NYHA functio...

journal_title：Lung

authors： Fossati L,Müller-Mottet S,Hasler E,Speich R,Bloch KE,Huber LC,Ulrich Somaini S

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Recent studies have shown the importance of Th17 cells in the development of allergic airway diseases. We examined Dermatophagoides pteronyssinus-induced changes in peripheral blood Th17 cells to establish the importance of these cells in late-phase allergic inflammation in patients with allergic rhinitis (A...

journal_title：Lung

authors： Bajoriuniene I,Malakauskas K,Lavinskiene S,Jeroch J,Gasiuniene E,Vitkauskiene A,Sakalauskas R

更新日期：2012-10-01 00:00:00

abstract：:The role of leukotrienes in hypoxic vasoconstriction remains controversial. Our previous study using the lipoxygenase inhibitor BW 755C in dogs failed to show a substantive role for leukotrienes in hypoxic vasoconstriction. To clarify further the role of leukotrienes, we designed 3 protocols. In the first protocol, we...

journal_title：Lung

authors： Thomas HM 3rd,Sourour MS,Lopez D,Foster SH

更新日期：1989-01-01 00:00:00

abstract：:Reaginic antibodies in hay fever patients belong to IgE. The immunoglobulin sensitizes basophilic granulocytes and mast cells from homologous species and mediates the release of chemical mediators which cause allergic symptoms. The sensitization is due to the binding of IgE to receptors on the target cells through the...

journal_title：Lung

authors： Ishizaka K,Ishizaka T

更新日期：1978-01-01 00:00:00

abstract：:The pathophysiology of cough variant asthma is poorly understood. In particular, the mechanisms that cause different symptoms in typical asthma (in which wheeze predominates) compared with cough variant asthma (in which cough predominates) have not been determined. Traditional explanations include higher wheezing thre...

journal_title：Lung

authors： Lougheed MD,Turcotte SE,Fisher T

更新日期：2012-02-01 00:00:00

abstract：:Extrinsic allergic alveolitis (EAA) caused by inhaled organic environmental allergens can progress to a fibrotic end-stage lung disease. Neovascularization plays an important role in pathogenesis of pulmonary fibrosis. The aim of this study was to assess the effect of sera from EAA patients on the angiogenic capabilit...

journal_title：Lung

authors： Zielonka TM,Demkow U,Filewska M,Bialas B,Zycinska K,Radzikowska E,Wardyn AK,Skopinska-Rozewska E

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:The right ventricular ejection fraction (RVEF) is a surrogate marker of right ventricular function in pulmonary hypertension (PH), but its measurement is complicated and time consuming. The tricuspid annular plane systolic excursion (TAPSE) measures only the longitudinal component of RV contraction while the...

journal_title：Lung

authors： Hoette S,Creuzé N,Günther S,Montani D,Savale L,Jaïs X,Parent F,Sitbon O,Rochitte CE,Simonneau G,Humbert M,Souza R,Chemla D

更新日期：2018-04-01 00:00:00

abstract：:A 15-year-old male had a history of increasing dyspnea on exertion, cough, sputum production, fever, weakness, hemoptysis, and diarrhea. Chest radiography demonstrated bilateral alveolar consolidation. Bronchoalveolar lavage fluid analysis revealed extensive hemosiderin-laden alveolar macrophages. On the basis of iron...

journal_title：Lung

authors： Hoca NT,Dayioglu D,Ogretensoy M

更新日期：2006-09-01 00:00:00

abstract：:The severity of chronic obstructive pulmonary disease (COPD) is evaluated not only by airflow limitation but also by factors such as exercise capacity and body mass index. Recent advances in CT technology suggest that it might be a useful tool for evaluating the severity of the disease components of COPD. The aim of t...

journal_title：Lung

authors： Lee YK,Oh YM,Lee JH,Kim EK,Lee JH,Kim N,Seo JB,Lee SD,KOLD Study Group.

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Although lung transplantation is the only means of survival for patients with end-stage pulmonary disease, outcomes from this intervention are inferior to other solid organ transplants. The reason for the poor outcomes may be linked to an early reaction, such as primary graft dysfunction, and associated with...

journal_title：Lung

authors： Nataatmadja M,Passmore M,Russell FD,Prabowo S,Corley A,Fraser JF

更新日期：2014-08-01 00:00:00

abstract：:Adolescent idiopathic scoliosis may require surgical treatment for extreme curvature of the spine or loss of pulmonary function. We present a report of a 31-year-old woman with a history of scoliosis and anterolateral spinal fusion who developed chest pain and hemoptysis. Imaging revealed that a fixation rod had migra...

journal_title：Lung

authors： Song KJ,Colman M,Myers JA,Seder CW

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:Combined pulmonary fibrosis and emphysema (CPFE) is increasingly recognized, as current reports of its clinical features show. To determine CPFE's physiologic and radiologic features, we conducted quantitative assessment of computed tomography scans to compare with those of chronic obstructive pulmonary disease...

journal_title：Lung

authors： Ando K,Sekiya M,Tobino K,Takahashi K

更新日期：2013-12-01 00:00:00

abstract：:In patients with congestive heart failure (CHF), a high prevalence of sleep-disordered breathing has been described. Cheyne-Stokes respiration (CSR) is present in up to 40% of patients with CHF. During the last decade, the medical treatment has been substantially improved. This study was designed to analyze the progno...

journal_title：Lung

authors： Hagenah G,Zapf A,Schüttert JB

更新日期：2010-08-01 00:00:00

abstract：:High concentrations of tumor necrosis factor-a (TNF), as well as excess of polymorphonuclear leukocytes (PMNs), are present in pleural fluid of patients with complicated parapneumonic effusion (CPPE). Several studies have shown that PMNs are capable of secreting TNF. However, the correlation between levels of TNF and ...

journal_title：Lung

authors： Odeh M,Sabo E,Srugo I,Oliven A

更新日期：2002-01-01 00:00:00

abstract：:The transmission of forces from the respiratory muscles to the lung across the extremely thin pleural space has been poorly understood because of the difficulty of accurately measuring pleural liquid and pleural surface pressure (lung static recoil or transpulmonary pressure). Recent results using relatively noninvasi...

journal_title：Lung

authors： Lai-Fook SJ

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:According to the National Family Health Survey, asthma is one of the leading diseases in India. In order to understand the complexity of asthma, the susceptibility genes need to be targeted for their association. Glutathione S-transferases play a major role in the detoxification of metabolites of oxidative s...

journal_title：Lung

authors： Birbian N,Singh J,Jindal SK,Joshi A,Batra N,Singla N

更新日期：2012-10-01 00:00:00

abstract：:Myofibroblasts characterized by alpha smooth muscle actin(alpha-SMA) expression play a key role in pulmonary fibrosis. Transforming growth factor-beta1 (TGF-beta1) is likely to be involved in the emergence of myofibroblasts, but the intracellular signal pathways for this process have not been well determined. The aim ...

journal_title：Lung

authors： Hu Y,Peng J,Feng D,Chu L,Li X,Jin Z,Lin Z,Zeng Q

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Living donor lobar lung transplantation (LDLLT) has been successfully used in select patient populations. MATERIALS AND METHODS:A 29-year-old male, who underwent bilateral LDLLT 12 years earlier with allografts donated by father and paternal uncle, developed bronchiolitis obliterans syndrome at distinctly...

journal_title：Lung

authors： Hayes D Jr,Baker PB

更新日期：2014-06-01 00:00:00

abstract：:Respiratory adaptation during sleep improves with growth. The most vulnerable period for respiratory adaptation to sleep is from birth to 3 months of age. Factors that favor vulnerability are immaturity in ventilatory control and high rib cage compliance which impairs its effectiveness for ventilation. Improvement in ...

journal_title：Lung

authors： Gaultier C

更新日期：1990-01-01 00:00:00