Abstract：
PURPOSE:Combined pulmonary fibrosis and emphysema (CPFE) is increasingly recognized, as current reports of its clinical features show. To determine CPFE's physiologic and radiologic features, we conducted quantitative assessment of computed tomography scans to compare with those of chronic obstructive pulmonary disease (COPD). METHODS:In 23 patients with CPFE and 42 patients with COPD, we measured the extent of emphysema (LAA %), parenchymal density, and total cross-sectional areas of pulmonary vessels smaller than 5 mm(2) (%CSA <5) and 5-10 mm(2) (%CSA 5-10). RESULTS:For CPFE, airflow was better, but diffusing capacity for carbon monoxide (DLCO) was worse than for COPD, whereas LAA % was similar for both groups. The %CSA <5 was greater but %CSA5-10 was less in CPFE than COPD. COPD involved a negative correlation between DLCO and LAA % at all lung sites; those factors correlated for CPFE only in the upper lobe (r = -0.535). In contrast, CPFE had a negative correlation between DLCO and parenchymal density in lower lobes (r = -0.453), but COPD showed no correlation in any such sections. In CPFE, no correlation was apparent between LAA in upper lobes and parenchymal density in lower lobes. The annual rate of FVC decline (-169.26 ml/year) in CPFE patients correlated with parenchymal density (r = -0.714). CONCLUSIONS:In CPFE, fibrosis and emphysema apparently existed independently, but both correlate with and likely contribute to the disproportionate reduction in gas exchange. Our study also suggested that pulmonary fibrotic changes may be more important contributors than emphysema for disease progression.
journal_name
Lungjournal_title
Lungauthors
Ando K,Sekiya M,Tobino K,Takahashi Kdoi
10.1007/s00408-013-9513-1subject
Has Abstractpub_date
2013-12-01 00:00:00pages
585-91issue
6eissn
0341-2040issn
1432-1750journal_volume
191pub_type
杂志文章相关文献
LUNG文献大全abstract：:Air concentration of isocyanates are associated with the frequency of induced diseases. Asthma, bronchitis and rhinitis, chronic obstructive lung disease, and allergic alveolitis, respectively, were observed in exposed workers. Inhalation challenge tests with isocyanates found some 14% of symptomatic persons immunolog...
journal_title：Lung
pub_type： 杂志文章,评审
doi：10.1007/BF02718184
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Asbestos is a carcinogen linked to malignant mesothelioma (MM) and lung cancer. Some gene aberrations related to asbestos exposure are recognized, but many associated mutations remain obscure. We performed exome sequencing to determine the association of previously known mutations (driver gene mutations) wit...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-015-9814-7
更新日期：2016-02-01 00:00:00
abstract：PURPOSE:Lymphangioleiomyomatosis (LAM) is a rare, progressive, frequently lethal cystic lung disease that almost exclusively affects women. Prognostic information in LAM has been limited by small numbers and heterogeneous study methodology. Early retrospective cohorts cited 5- and 10-year mortality of 40 and 80 %, resp...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-012-9419-3
更新日期：2013-02-01 00:00:00
abstract：:We report two patients with atopic cough due to Basidiomycetes antigen. One patient was a 27 year-old woman and the other was a 17 year-old boy. Both patients visited our hospital because of severe nonproductive cough. They did not have bronchial hyperresponsiveness to methacholine or heightened bronchomotor tone. Bro...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-004-2509-0
更新日期：2004-01-01 00:00:00
abstract：:Tracheobronchopathia osteochondroplastica (TO) is a rare disorder of the large airways characterized by the development of submucosal cartilaginous and bony nodules. The nodules involve the anterior and lateral walls and typically spare the posterior membranous wall. The clinical presentation of TO is variable and ran...
journal_title：Lung
pub_type： 杂志文章,评审
doi：10.1007/s00408-008-9113-7
更新日期：2008-11-01 00:00:00
abstract：INTRODUCTION:Driving pressure (DP) while on ECMO has been studied in acute respiratory distress syndrome (ARDS) but no studies exist in those on ECMO without ARDS. We aimed to study association of mortality with DP in all patients on ECMO and compare change in DP before and after initiation of ECMO. METHODS:Consecutiv...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-020-00381-y
更新日期：2020-10-01 00:00:00
abstract：:The effects of vitamin E deficiency on bleomycin (BLM)-induced pulmonary fibrosis have been studied by analyses of pressure volume (PV) curves and morphological examinations. Golden hamsters were divided into groups on a control diet (group C), vitamin E-deficient diet (E), control diet with BLM treatment (CB), and vi...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF02714044
更新日期：1988-01-01 00:00:00
abstract：:Immune cell airway infiltration and the bronchovascular remodeling process have shown to be promising in the understanding of bronchiolitis obliterans (BO) pathogenesis. In this study we sought to validate the importance of immune cells, whether diffusely distributed or forming lymphoid follicles, collagen density, an...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-005-2588-6
更新日期：2006-07-01 00:00:00
abstract：:This study was designed to determine the effects of thromboxane A2 (TxA2) on the distribution of vascular resistance, lung weight, and microvascular permeability in isolated dog lungs perfused at a constant pressure with autologous blood. The stable TxA2 analogue (STA2; 30 micrograms, n = 5) caused an increase in pulm...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF00181873
更新日期：1995-01-01 00:00:00
abstract：:We aimed to evaluate the utility of coagulation markers for the prediction of rapidly progressive interstitial lung disease (RP-ILD) in patients with dermatomyositis (DM). In this retrospective study, 29 patients with DM-associated ILD were analyzed. The number of patients with RP-ILD was 15 (52%). The baseline clinic...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-019-00245-0
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Depression is an important comorbidity for patients with chronic obstructive pulmonary disease (COPD). The association between depression and acute exacerbations of COPD is unknown. This study was designed to determine the frequency of COPD exacerbations in outpatients with and without depressive symptoms. ...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-009-9135-9
更新日期：2009-03-01 00:00:00
abstract：:Cardiothoracic surgery posits an arrangement of large, significant hemodynamic, and physiologic alterations upon the human body, which predisposes a patient to develop pathology. The care of these patients in the postoperative realm requires an astute physician with deep understanding of the cardiopulmonary system, wh...
journal_title：Lung
pub_type： 杂志文章,评审
doi：10.1007/s00408-020-00405-7
更新日期：2020-12-01 00:00:00
abstract：:The effect of azelastine and some selected compounds on ciliary beating frequency (CBF) was investigated in vitro using human mucosal samples and in vivo using anesthetized guinea pigs. Further influence of azelastine on mucus secretion was evaluated in mice and on mucociliary clearance in anesthetized rabbits. Azelas...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF00174117
更新日期：1992-01-01 00:00:00
abstract：:Our aim was to compare Taxol-based chemotherapy response of non-small cell lung cancer (NSCLC) with P-glycoprotein (Pgp) or lung resistance protein expression (LRP). Immunohistochemical analyses were performed on multiple nonconsecutive sections of the biopsy specimens to detect Pgp and LPR expressions in 40 patients ...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-003-1029-7
更新日期：2003-01-01 00:00:00
abstract：:Particulate matter less than PM(10) and aromatic chemicals formed during incomplete combustion of organic matter are major environmental pollutants because of their toxic potential. The present study reports on the respiratory morbidity pattern of people exposed to auto exhaust as a result of the traffic load consisti...
journal_title：Lung
pub_type： 杂志文章,多中心研究
doi：10.1007/s00408-007-9015-0
更新日期：2007-09-01 00:00:00
abstract：PURPOSE:Improving dyspnea and exercise performance are goals of COPD therapy. We tested the hypothesis that air current applied to the face would lessen dyspnea and improve exercise performance in moderate-severe COPD patients. METHODS:We recruited 10 COPD patients (5 men, age 62 ± 6 years, FEV1 0.93 ± 0.11 L (34 ± 3%...
journal_title：Lung
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00408-015-9780-0
更新日期：2015-10-01 00:00:00
abstract：PURPOSE:Nicorandil is a hybrid between nitrates and KATP channel opener activators. The aim of this study was to evaluate the nicorandil's effects on ischemia-reperfusion (IR) lung injury and examine the mechanism of its effects. METHODS:Isolated rat lungs were divided into 6 groups. In the sham group, the lungs were ...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-020-00339-0
更新日期：2020-04-01 00:00:00
abstract：:Lung cancer is currently one of the most common malignant diseases and is responsible for substantial mortality worldwide. Compared with never smokers, former smokers remain at relatively high risk for lung cancer, accounting for approximately half of all newly diagnosed cases in the US. Screening offers former smoker...
journal_title：Lung
pub_type： 杂志文章,评审
doi：10.1007/s00408-013-9517-x
更新日期：2014-02-01 00:00:00
abstract：:Methacholine challenge testing (MCT) is widely used to assess airway hyperresponsiveness (AHR). Traditionally, a 20% or greater decline in forced expiratory volume in 1 (FEV(1)) is the primary outcome measure. We examined whether the inclusion of wheeze detection as outcome measure influenced the categorical interpret...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-005-2575-y
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND:Transbronchial lung biopsy (TBBX) is a common respiratory diagnostic procedure performed to investigate several lung diseases. There are different types of forceps used to perform this procedure. The alligator and cupped (oval) forceps are most commonly used ones. To date, there are few studies that have com...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-018-0179-6
更新日期：2019-02-01 00:00:00
abstract：:Diffuse alveolar damage is the histopathologic hallmark of acute respiratory distress syndrome (ARDS). A significant proportion of ARDS survivors have residual pulmonary fibrosis and compromised pulmonary function. On the other hand, heat shock protein 47 (HSP47) is a collagen-binding stress protein that is assumed to...
journal_title：Lung
pub_type： 杂志文章,收录出版
doi：10.1007/s00408-006-0085-1
更新日期：2007-01-01 00:00:00
abstract：:Indoor air pollutants may cause inflammatory changes of the airways and adjacent pulmonary tissue. After phagocytosis of inhaled particles alveolar macrophages (AM) release chemotactic mediators capable of attracting inflammatory cells into the lung tissue. To evaluate these mechanisms further peripheral blood mononuc...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/pl00007628
更新日期：1999-01-01 00:00:00
abstract：: ...
journal_title：Lung
pub_type： 信件
doi：10.1007/s00408-018-0187-6
更新日期：2019-02-01 00:00:00
abstract：:Reports regarding smoking differences in α-klotho expression have provided conflicting results. In the current study we focused on the influence of smoking intensity to serum levels of the aging molecule α-klotho in healthy smokers. 40 middle aged healthy smokers without airway obstruction or restriction were selected...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-016-9944-6
更新日期：2017-02-01 00:00:00
abstract：INTRODUCTION:Chronic obstructive pulmonary disease is a progressive lung disease characterized by abnormal cellular responses to cigarette smoke, resulting in tissue destruction and airflow limitation. Autophagy is a fundamental cellular process that eliminates long-lived proteins and damaged organelles through lysosom...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-017-9997-1
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:According to the National Family Health Survey, asthma is one of the leading diseases in India. In order to understand the complexity of asthma, the susceptibility genes need to be targeted for their association. Glutathione S-transferases play a major role in the detoxification of metabolites of oxidative s...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-012-9385-9
更新日期：2012-10-01 00:00:00
abstract：STUDY OBJECTIVES:The aim of this study was to determine if electrocardiographically synchronized, prospectively triggered multidetector row computed tomography (ECG-MDR-CT) angiography of the aorta can accurately predict the location of ectopic bronchial arteries in patients with cystic fibrosis (CF) with massive hemop...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-011-9343-y
更新日期：2012-04-01 00:00:00
abstract：:The major goal of all diagnostic and therapeutic efforts in childhood asthma is to prevent progression of lung disease into adulthood. To improve the uncomfortable situation of underdiagnosis and undertreatment and to lower the risk of acquiring irreversible lung damage, an optimal co-working relationship between fami...
journal_title：Lung
pub_type： 杂志文章,评审
doi：10.1007/BF02718166
更新日期：1990-01-01 00:00:00
abstract：:It is well known that chronic obstructive pulmonary disease (COPD) patients present with muscle dysfunction that may not correlate with the degree of severity of airflow obstruction. Historically, the strength deficit of the knee extensor musculature (quadriceps) has been described as an independent factor of mortalit...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-018-0164-0
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Recent studies have shown the importance of Th17 cells in the development of allergic airway diseases. We examined Dermatophagoides pteronyssinus-induced changes in peripheral blood Th17 cells to establish the importance of these cells in late-phase allergic inflammation in patients with allergic rhinitis (A...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-012-9411-y
更新日期：2012-10-01 00:00:00
