Abstract:
:Reaginic antibodies in hay fever patients belong to IgE. The immunoglobulin sensitizes basophilic granulocytes and mast cells from homologous species and mediates the release of chemical mediators which cause allergic symptoms. The sensitization is due to the binding of IgE to receptors on the target cells through the Fc portion of the molecules. High affinity of the molecules for the receptor is responsible for the biologic activity of IgE antibodies and for the persistence of sensitization with the antibodies. The initial step of the reaginic hypersensitivity reactions is bridging of cell-bound IgE antibody molecules by a multivalent antigen. Since IgE is firmly bound with receptors, cross-linkage of IgE molecules will cause a disturbance of membrane structure and/or interaction between receptor molecules at the cell membrane, which will activate membrane-associated enzymes. It appears that the activation of sequences of enzymes will lead to the release of chemical mediators from the cells. In view of the role of IgE antibodies in allergic diseases such as hay fever, attempts were made to depress the IgE antibody response to allergen. A experimental model in the mouse indicated that the generation of antigen-specific suppressor T cells is involved in the depression of IgE antibody formation by immunotherapy.
journal_name
Lungjournal_title
Lungauthors
Ishizaka K,Ishizaka Tdoi
10.1007/BF02730676subject
Has Abstractpub_date
1978-01-01 00:00:00pages
3-22issue
1eissn
0341-2040issn
1432-1750journal_volume
155pub_type
杂志文章,评审相关文献
LUNG文献大全abstract::It is well known that exposure to hyperoxia results in lung inflammation and damage, which leads to the development of chronic lung disease. Previous studies have shown increased activities of antioxidant enzymes (AOE) in lung tissue from animals exposed to hyperoxia. We propose the hypothesis that the fetal type II p...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s004080000006
更新日期:2000-01-01 00:00:00
abstract::Models of pulmonary edema have been used to study the nuclear magnetic resonance (NMR) characteristics of lung water. Several investigators have measured changes in the relaxation times in the permeability type of pulmonary edema, but relatively few have measured relaxation times in the hydrostatic type of pulmonary e...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00173138
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:In immunocompromised patients with pulmonary infiltrates, transbronchial lung biopsies (TBB) obtained by forceps has been shown to increase the diagnostic yield over simple bronchoalveolar lavage. Cryo-TBB is a novel modality for obtaining lung biopsies. We aimed to evaluate for the first time the efficacy a...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-013-9507-z
更新日期:2013-12-01 00:00:00
abstract::This study was designed to determine the effects of thromboxane A2 (TxA2) on the distribution of vascular resistance, lung weight, and microvascular permeability in isolated dog lungs perfused at a constant pressure with autologous blood. The stable TxA2 analogue (STA2; 30 micrograms, n = 5) caused an increase in pulm...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00181873
更新日期:1995-01-01 00:00:00
abstract::In patients with congestive heart failure (CHF), a high prevalence of sleep-disordered breathing has been described. Cheyne-Stokes respiration (CSR) is present in up to 40% of patients with CHF. During the last decade, the medical treatment has been substantially improved. This study was designed to analyze the progno...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-009-9208-9
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The right ventricular ejection fraction (RVEF) is a surrogate marker of right ventricular function in pulmonary hypertension (PH), but its measurement is complicated and time consuming. The tricuspid annular plane systolic excursion (TAPSE) measures only the longitudinal component of RV contraction while the...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-018-0089-7
更新日期:2018-04-01 00:00:00
abstract::The effects of vitamin E deficiency on bleomycin (BLM)-induced pulmonary fibrosis have been studied by analyses of pressure volume (PV) curves and morphological examinations. Golden hamsters were divided into groups on a control diet (group C), vitamin E-deficient diet (E), control diet with BLM treatment (CB), and vi...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF02714044
更新日期:1988-01-01 00:00:00
abstract::Cryoextraction is a procedure for recanalization of obstructed airways caused by exophytic growing tumors. Biopsy samples obtained with this method can be used for histological diagnosis. The objective of this study was to evaluate the parameters influencing the size of cryobiopsies in an in vitro animal model. New fl...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-009-9156-4
更新日期:2009-08-01 00:00:00
abstract::The effect of tetraethylammonium (TEA) and K+ on contractions to histamine and acetylcholine have been compared in the pig isolated trachea using organ bath and sucrose-gap techniques. Histamine elicited weak contractions, compared with acetylcholine; however, these contractions were markedly potentiated by pretreatme...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF02714429
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:Melanocortin 3 Receptor (MC3R) is one of the families of seven-transmembrane G-protein-coupled receptors, and a recent study showed that MCR3 promoter polymorphism was significantly associated with the susceptibility of tuberculosis (TB) in South African population. METHODS:We analyzed six MC3R polymorphisms t...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-014-9625-2
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:Pulmonary hypertension (PH) due to COPD has dismal prognosis. We reviewed the long-term effect of PH-target therapy in severe PH-COPD. METHOD:Patients attending our PH-clinic were reviewed for PH-COPD receiving PH-target therapy. Baseline characteristics, death/transplantation until 2014, therapy, NYHA functio...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-014-9650-1
更新日期:2014-12-01 00:00:00
abstract::Bronchopleural (BPF) and alveolar-pleural (APF) fistulas are frequently encountered in clinical practice with persistent air leaks that can lead to significant morbidity, prolonged hospital stay, and potentially increased mortality. BPF and APF are commonly related to pulmonary resections. Other etiologies include min...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-009-9204-0
更新日期:2010-06-01 00:00:00
abstract::The original version of this article contained an error in the usage of the term "false positive rate". The intention of the authors in those instances was simply to compare the absolute percentage of false positive results in the study vs the NLST, not to make any observations about false positive rate in the strict ...
journal_title:Lung
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00408-019-00269-6
更新日期:2019-10-01 00:00:00
abstract::We aimed to evaluate the utility of coagulation markers for the prediction of rapidly progressive interstitial lung disease (RP-ILD) in patients with dermatomyositis (DM). In this retrospective study, 29 patients with DM-associated ILD were analyzed. The number of patients with RP-ILD was 15 (52%). The baseline clinic...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-019-00245-0
更新日期:2019-08-01 00:00:00
abstract::Indoor air pollutants may cause inflammatory changes of the airways and adjacent pulmonary tissue. After phagocytosis of inhaled particles alveolar macrophages (AM) release chemotactic mediators capable of attracting inflammatory cells into the lung tissue. To evaluate these mechanisms further peripheral blood mononuc...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/pl00007628
更新日期:1999-01-01 00:00:00
abstract::A large-scale outbreak of life-threatening, inhaled synthetic cannabinoids (Spice/K2)-associated coagulopathy with bleeding complications was recently reported in Illinois. The causative agents were brodifacoum, difenacoum, and bromadiolone, potent, long-acting, 4-hydroxycoumarin anticoagulant rodenticides (LAAR) that...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-019-00227-2
更新日期:2019-06-01 00:00:00
abstract::Benralizumab and mepolizumab are new therapies for severe eosinophilic asthma. They are both humanized IgG antibodies, targeting the IL-5 receptor and IL-5, respectively, suppressing the corresponding pathways. No specific biomarkers have been proposed to evaluate treatment response to benralizumab or mepolizumab. The...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-020-00379-6
更新日期:2020-10-01 00:00:00
abstract::The effects of a pulmonary rehabilitation program on 44 patients with chronic obstructive pulmonary disease (COPD) were compared to a control group. The treated group was admitted to the program for a period of three months. The program consisted of several parts, such as physical training, health education, and psych...
journal_title:Lung
pub_type: 临床试验,杂志文章
doi:10.1007/BF00203723
更新日期:1993-01-01 00:00:00
abstract::In critically ill patients, endotracheal intubation is associated with a high risk of complications, including severe hypoxemia and hypotension. The purpose of this review is to discuss the definitions, complications, airway assessment, and patient optimization with respect to these patients. In addition, we present d...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-011-9278-3
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:To explore the role of CARM1 in lung cancer (LC) and its relationship with TP53 and CTNNB1. METHODS:Lung cells H1299 and PC14 were randomly divided into six groups: ov-H1299, si-H1299, ov-PC14, si-PC14, Con-H1299, and Con-PC14. Transwell assay, plate clone formation assay, and flow cytometry were used to det...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-020-00324-7
更新日期:2020-04-01 00:00:00
abstract::Occupational exposure to oyster mushroom (Pleurotus ostreatus) has been associated with obstructive lung disease. Previously, we studied an extract of oyster mushroom (OME) and determined that it causes dose-dependent contractions of nonsensitized guinea pig trachea (GPT). We extend these studies to the investigation ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-011-9302-7
更新日期:2011-08-01 00:00:00
abstract::The transmission of forces from the respiratory muscles to the lung across the extremely thin pleural space has been poorly understood because of the difficulty of accurately measuring pleural liquid and pleural surface pressure (lung static recoil or transpulmonary pressure). Recent results using relatively noninvasi...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF02714442
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:Idiopathic pulmonary fibrosis (IPF) is a restrictive fibrotic lung disease of uncertain etiology. Alveolar epithelial injury may be one of the inciting triggers in the pathogenesis of this disorder. We hypothesized that circulating antibodies to alveolar epithelial and endothelial cells may be involved in the p...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9390-z
更新日期:2012-08-01 00:00:00
abstract::Electronic noses (e-noses) are based on arrays of different sensor types that respond to specific features of an odorant molecule, mostly volatile organic compounds (VOCs). Differently from gas chromatography and mass spectrometry, e-noses can distinguish VOCs spectrum by pattern recognition. E-nose technology has suc...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-017-9987-3
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:Lymphangioleiomyomatosis (LAM) is a rare, progressive, frequently lethal cystic lung disease that almost exclusively affects women. Prognostic information in LAM has been limited by small numbers and heterogeneous study methodology. Early retrospective cohorts cited 5- and 10-year mortality of 40 and 80 %, resp...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9419-3
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:This study was conducted to investigate the percentages of Th22 and Th17 cells in the peripheral blood of septic patients with and without acute lung injury (ALI) and their clinical significance. METHODS:A total of 479 patients were divided into non-ALI and ALI groups. The percentages of Th22 and Th17 cells an...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-020-00362-1
更新日期:2020-08-01 00:00:00
abstract::In previous studies, we showed that Fischer rats fed 175 mg/kg of amiodarone accumulated large amounts of drug and metabolite in the lung and developed pulmonary toxicity, whereas Wistar rats fed the same drug dose had significantly less amiodarone in the lung and did not develop pulmonary inflammation. The present st...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00167949
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION:Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal fibrosing lung disease with a median survival of approximately 3 years after diagnosis. The only medical option to improve survival in IPF is lung transplantation (LTX). The purpose of this study was to evaluate trajectory data of IPF patients...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-015-9794-7
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:This is a meta-analysis of the safety and efficacy of indacaterol in chronic obstructive pulmonary disease (COPD) with treatment duration of ≥12 weeks. METHODS:Randomized controlled trials (RCTs) reported in English (to September 30, 2012) were identified from PubMed, the Cochrane Library, Embase, websites,...
journal_title:Lung
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00408-012-9444-2
更新日期:2013-04-01 00:00:00
abstract::The purpose of this study was to examine the lung pathogenesis of murine gammaherpesvirus (MHV-68) infection in mice that lack CC chemokine receptor CCR2, an important receptor for macrophage recruitment to sites of inflammation. BALB/c and CCR2(-/-) mice were inoculated intranasally (i.n.) with MHV-68 and samples wer...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-004-2535-y
更新日期:2005-07-01 00:00:00