Abstract：
PURPOSE:To investigate whether lung function, especially when complicated with SDB, has an increased risk for myocardial infarction (MI) and congestive heart failure (CHF). METHODS:A prospective study was performed within the Sleep Heart Health Study (SHHS). A total of 4161 individuals were followed up for an average of 10.91 years. Forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and the predicted value of FVC and FEV1 were measured to evaluate lung function. The primary outcomes were the MI and CHF. Cox regression analysis was used to investigate the association between reduced lung function and the incidence of MI or CHF. In subgroup analysis, all the individuals were divided into Apnoea-Hypopnoea Index (AHI) < 5 subgroup and AHI ≥ 5 subgroup to explore the relationship. RESULTS:Lung function were inversely associated with the incidence of MI or CHF. The hazard ratio (HR) and 95% confidence interval (95% CI) for MI and CHF were 0.658 (0.543-0.797) and 0.792 (0.673-0.933) for every 1 L increase in FVC, 0.715 (0.567-0.902) and 0.738 (0.605-0.900) for every 1 L increase in FEV1, 0.986 (0.979-0.993) and 0.989 (0.983-0.995) for every 1% increase in FEV1/pre%, and 0.994 (0.988-0.999) and 0.991 (0.987-0.996) in FVC/pre%, respectively. In addition, the association of lung function with MI and CHF was more prominent in the subgroup with AHI ≥ 5. CONCLUSIONS:Lung function may be associated with incident MI and CHF in this large community cohort of middle-aged and older adults, especially in those with SDB.
journal_name
Lungjournal_title
Lungauthors
Li R,Zhang J,Gao Y,Li J,Yan B,Wang Gdoi
10.1007/s00408-019-00229-0subject
Has Abstractpub_date
2019-06-01 00:00:00pages
339-347issue
3eissn
0341-2040issn
1432-1750pii
10.1007/s00408-019-00229-0journal_volume
197pub_type
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