Mucin gene expression (MUC1, MUC2, and MUC5/5AC) in nasal epithelial cells of cystic fibrosis, allergic rhinitis, and normal individuals.

abstract：:Chronic desquamative eosinophilic bronchitis is a characteristic pathologic feature of asthma which may even antedate the onset of symptoms. The pharmacology of asthmatic inflammation has been relatively poorly studied and most of the current data available have been inferred indirectly from studies of bronchial hyper...

journal_title：Lung

authors： Chung KF

更新日期：1990-01-01 00:00:00

abstract：:The effect of beta 2-adrenoceptor agonists on airway smooth muscle relaxation may be subject to desensitization. It could be modified by glucocorticosteroid treatment. An increase in the beta 2 agonist response by glucocorticosteroids in vitro has been described. We studied the effects of acute and chronic treatment w...

journal_title：Lung

authors： Seco AJ,Salgueiro ME,Manso G

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Tree-in-bud (TIB) is a radiologic pattern seen on high-resolution chest CT reflecting bronchiolar mucoid impaction occasionally with additional involvement of adjacent alveoli. Its microbiologic significance has not been systematically evaluated. OBJECTIVES:We aimed to establish the incidence of the TIB pat...

journal_title：Lung

authors： Shimon G,Yonit WW,Gabriel I,Naama BR,Nissim A

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:To explore the role of CARM1 in lung cancer (LC) and its relationship with TP53 and CTNNB1. METHODS:Lung cells H1299 and PC14 were randomly divided into six groups: ov-H1299, si-H1299, ov-PC14, si-PC14, Con-H1299, and Con-PC14. Transwell assay, plate clone formation assay, and flow cytometry were used to det...

journal_title：Lung

authors： Hu B,Li X,Chen L,Liu Z

更新日期：2020-04-01 00:00:00

abstract：:Reports regarding smoking differences in α-klotho expression have provided conflicting results. In the current study we focused on the influence of smoking intensity to serum levels of the aging molecule α-klotho in healthy smokers. 40 middle aged healthy smokers without airway obstruction or restriction were selected...

journal_title：Lung

authors： Verde Z,González-Moro JM,Chicharro LM,Reinoso-Barbero L,Bandrés F,Gómez-Gallego F,Santiago C

更新日期：2017-02-01 00:00:00

abstract：:The pathophysiology of cough variant asthma is poorly understood. In particular, the mechanisms that cause different symptoms in typical asthma (in which wheeze predominates) compared with cough variant asthma (in which cough predominates) have not been determined. Traditional explanations include higher wheezing thre...

journal_title：Lung

authors： Lougheed MD,Turcotte SE,Fisher T

更新日期：2012-02-01 00:00:00

abstract：:Recent research showed group B patients express higher mortality compared to group C patients when GOLD A-D grouping is used. We aimed to compare the prognostic accuracy of three GOLD classification systems, I-IV ("pre-2011"), A-D ("2011-2016") and A-D ("2017-present") in relation to mortality, exacerbation risk, qual...

journal_title：Lung

authors： Plutinsky M,Brat K,Svoboda M,Zatloukal J,Popelkova P,Koblizek V

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:Pulmonary arteriovenous malformations (PAVMs) are most commonly associated with hereditary hemorrhagic telangiectasia (HHT). Patients with PAVMs can present with serious complications including stroke, transient ischemic attack (TIA), and brain abscess. PAVMs are rare in non-HHT patients and little is known abo...

journal_title：Lung

authors： Albitar HAH,Segraves JM,Almodallal Y,Pinto CA,De Moraes AG,Iyer VN

更新日期：2020-08-01 00:00:00

abstract：INTRODUCTION:Hypoxia has been implicated in the pathogenesis of many inflammatory and fibrotic lung diseases. The effect of hypoxia on epithelial junction protein expression is yet to be fully elucidated but evidence suggests a protective role for the hypoxia-inducible transcription factor HIF-1 in stabilising occludin...

journal_title：Lung

authors： Li L,Watson CJ,Dubourd M,Bruton A,Xu M,Cooke G,Baugh JA

更新日期：2016-10-01 00:00:00

abstract：:In critically ill patients, endotracheal intubation is associated with a high risk of complications, including severe hypoxemia and hypotension. The purpose of this review is to discuss the definitions, complications, airway assessment, and patient optimization with respect to these patients. In addition, we present d...

journal_title：Lung

authors： Griesdale DE,Henderson WR,Green RS

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Prolonged exposure to crystalline silica leads to persistent pulmonary inflammation and progressive fibrosis. Connective tissue growth factor (CTGF) has emerged as a potent proinflammatory and profibrotic regulator to participate in a variety of chronic inflammatory diseases. However, the role of CTGF in sil...

journal_title：Lung

authors： Zhou T,Yu Q,Lin H,Wang Z,Fu G,Lei L,Shi Y,Zhang L,Qin L,Liu Y

更新日期：2019-12-01 00:00:00

abstract：:Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for atherosclerosis and arterial thrombosis, which are associated with high cardiovascular (CV) morbidity and mortality. In studies performed in clinical populations with elevated CV event risk profiles, the occurrence of moderate to severe OSAS was...

journal_title：Lung

authors： Toraldo DM,Peverini F,De Benedetto M,De Nuccio F

更新日期：2013-02-01 00:00:00

abstract：:This study evaluated the extracellular matrix (collagen and elastic fibers) in pleurodesis induced by intrapleural talc (TL) or silver nitrate (SN). Study subjects were 420 rabbits divided into two groups and sacrificed from 15 min to 12 months after the injection of the sclerosing agents at intervals previously defin...

journal_title：Lung

authors： Antonangelo L,Vargas FS,Teixeira LR,Acencio MM,Vaz MA,Filho MT,Marchi E

更新日期：2006-03-01 00:00:00

abstract：:Tracheobronchopathia osteochondroplastica (TO) is a rare disorder of the large airways characterized by the development of submucosal cartilaginous and bony nodules. The nodules involve the anterior and lateral walls and typically spare the posterior membranous wall. The clinical presentation of TO is variable and ran...

journal_title：Lung

authors： Abu-Hijleh M,Lee D,Braman SS

更新日期：2008-11-01 00:00:00

abstract：:Tuberculosis (TB) pleurisy is accepted to be the best model for evaluating the local protective cellular immune response to Mycobacterium tuberculosis (MTB) since it can be spontaneously self-cured. Therefore, we aimed to evaluate the involvement of cytokines and the soluble apoptosis-modulating factors sFas and sFasL...

journal_title：Lung

authors： Budak F,Uzaslan EK,Cangür S,Göral G,Oral HB

更新日期：2008-09-01 00:00:00

abstract：:Indoor air pollutants may cause inflammatory changes of the airways and adjacent pulmonary tissue. After phagocytosis of inhaled particles alveolar macrophages (AM) release chemotactic mediators capable of attracting inflammatory cells into the lung tissue. To evaluate these mechanisms further peripheral blood mononuc...

journal_title：Lung

authors： Drumm K,Schindler H,Buhl R,Küstner E,Smolarski R,Kienast K

更新日期：1999-01-01 00:00:00

abstract：:Cessation of smoking in the home is one of the most important nonpharmacologic actions to be recommended. There is a highly significant increase in wheezing, coughing, and respiratory infections in children with smoking mothers, and this increase is directly proportional to the number of cigarettes smoked. Cord blood ...

journal_title：Lung

authors： Price JA

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:The right ventricular ejection fraction (RVEF) is a surrogate marker of right ventricular function in pulmonary hypertension (PH), but its measurement is complicated and time consuming. The tricuspid annular plane systolic excursion (TAPSE) measures only the longitudinal component of RV contraction while the...

journal_title：Lung

authors： Hoette S,Creuzé N,Günther S,Montani D,Savale L,Jaïs X,Parent F,Sitbon O,Rochitte CE,Simonneau G,Humbert M,Souza R,Chemla D

更新日期：2018-04-01 00:00:00

abstract：INTRODUCTION:Living donor lobar lung transplantation (LDLLT) has been successfully used in select patient populations. MATERIALS AND METHODS:A 29-year-old male, who underwent bilateral LDLLT 12 years earlier with allografts donated by father and paternal uncle, developed bronchiolitis obliterans syndrome at distinctly...

journal_title：Lung

authors： Hayes D Jr,Baker PB

更新日期：2014-06-01 00:00:00

abstract：:Alveolar epithelial type II (AT II) cells need phosphate (Pi) for surfactant synthesis. The Na-dependent (Na(d)) Pi transporters NaPi-IIb and Pit-1 are expressed in lung, but their expression, regulation, and function in AT II cells remain unclear. We studied NaPi-IIb and Pit-1 mRNA expression in cultured AT II cells ...

journal_title：Lung

authors： Jin C,Zoidis E,Ghirlanda C,Schmid C

更新日期：2010-01-01 00:00:00

abstract：:Group B streptococcal (GBS) pneumonia, with neutrophilic granulocytes immigrating into the lungs, may occur in neonates. The incidence is particularly high among preterm infants, who often are treated with exogenous surfactant. We have previously demonstrated in vitro that neutrophils stimulated by GBS cause lipid per...

journal_title：Lung

authors： Bouhafs RK,Jarstrand C,Robertson B

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:The goal of our systematic review and meta-analysis is to examine the therapeutic effectiveness of bronchoscopic lung volume reduction (BLVR), and to compare it with medical management and lung volume reduction surgery. METHODS:Variables of interest were absolute change in FEV1, 6MWT, and SGRQ. Meta-analy...

journal_title：Lung

authors： Kumar A,Dy R,Singh K,Jeffery Mador M

更新日期：2017-02-01 00:00:00

abstract：:Recently, active remodeling may indicate a good prognosis in idiopathic interstitial pneumonias. In this study we sought to validate the importance of the collagen/elastic system in the extracellular matrix remodeling and to study the relationships between the collagen/elastic system in nonspecific interstitial idiopa...

journal_title：Lung

authors： Felício CH,Parra ER,Capelozzi VL

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Depression is an important comorbidity for patients with chronic obstructive pulmonary disease (COPD). The association between depression and acute exacerbations of COPD is unknown. This study was designed to determine the frequency of COPD exacerbations in outpatients with and without depressive symptoms. ...

journal_title：Lung

authors： Jennings JH,Digiovine B,Obeid D,Frank C

更新日期：2009-03-01 00:00:00

abstract：INTRODUCTION:Chronic obstructive pulmonary disease is a progressive lung disease characterized by abnormal cellular responses to cigarette smoke, resulting in tissue destruction and airflow limitation. Autophagy is a fundamental cellular process that eliminates long-lived proteins and damaged organelles through lysosom...

journal_title：Lung

authors： Li L,Zhang M,Zhang L,Cheng Y,Tu X,Lu Z

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:We previously demonstrated that the exposure to hyperbaric hyperoxia increased respiratory system elastance and both the "ohmic" and viscoelastic components of inspiratory resistances, probably because of increased oxygen tension toxic effects. We presently investigated the possible consequences of a single ...

journal_title：Lung

authors： Rubini A,Porzionato A,Sarasin G,Zara S,Macchi V,Camporesi E,Bosco G

更新日期：2014-08-01 00:00:00

abstract：:It is well known that exposure to hyperoxia results in lung inflammation and damage, which leads to the development of chronic lung disease. Previous studies have shown increased activities of antioxidant enzymes (AOE) in lung tissue from animals exposed to hyperoxia. We propose the hypothesis that the fetal type II p...

journal_title：Lung

authors： Bhandari V,Maulik N,Kresch M

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:Current guidelines recommend the use of low molecular weight heparin (LMWH) for most haemodynamically stable patients with pulmonary thromboembolism (PTE), however, it is not clear whether LMWH is preferable to unfractionated heparin (UFH) for the treatment of massive PTE. We aimed to compare the use of LMWH ve...

journal_title：Lung

authors： Ucar EY,Akgun M,Araz O,Tas H,Kerget B,Meral M,Kaynar H,Saglam L

更新日期：2015-02-01 00:00:00

abstract：:Endobronchial Nd:Yag laser therapy is an excellent tool to reopen the central airway(s) in patients with severe respiratory symptoms caused by endobronchial tumor growth. Rigid bronchoscopy should be the method of choice. Usually general anesthesia is necessary. Complication rate depends on the condition of the patien...

journal_title：Lung

authors： Vanderschueren RG,Westermann CJ

更新日期：1990-01-01 00:00:00

abstract：:It is well established that cotton dust inhalation can compromise lung function in textile workers. Challenges with a water-soluble extract of cotton bract (CBE) can also induce reversible airway obstruction in healthy volunteers. We have examined the effect of inhaled CBE in nonhuman primates and have attempted to in...

journal_title：Lung

authors： Witek TJ Jr,Gundel RH,Wegner CD,Schachter EN,Buck MG

更新日期：1988-01-01 00:00:00