Fcγ receptor IIIb (CD16b) polymorphisms are associated with susceptibility to idiopathic pulmonary fibrosis.

Abstract:

:An excess of neutrophils in the alveoli and lung interstitium has been described in idiopathic pulmonary fibrosis (IPF). Engagement of neutrophil Fcγ receptors with IgG complexes may contribute to the pathogenesis of IPF. The neutrophil FcγRIIIb receptor occurs in two codominantly expressed allelic variants, NA1 and NA2, which exhibit different binding affinities for IgG1 and IgG3 subclasses. The aim of this study was to investigate whether FcγRIIIb genotype is associated with IPF susceptibility or disease progression. In a case-control study we compared the distribution of FcγRIIIb NA1/2 polymorphisms in 142 patients with IPF and in 218 controls using allele-specific PCR amplification. Significant skewing in the distribution of FcγRIIIb genotypes was observed between patients with IPF and control subjects. In the IPF cohort, there was higher frequency of the NA1/NA1 genotype (0.19 vs. 0.07), and lower NA2/NA2 frequency (0.31 vs. 0.50; χ(2) = 17.71, df = 2, P < 0.001). The overall frequency of the NA1 allele was increased in IPF patients compared to controls (0.44 vs. 0.29; P < 0.0001, odds ratio [OR] = 1.93, 95% confidence interval [CI] = 1.42-2.64). Heterozygotes and homozygotes of the NA1 allele were at higher risk of developing IPF (OR = 2.19, 95% CI = 1.40-3.41, P = 0.0005), whereas the NA2 allele was protective against IPF (OR = 0.34, 95% CI = 0.17-0.65, P = 0.0014). There was no association of FcγRIIIb genotype with disease progression as assessed by serial lung function measurements. FcγRIIIb NA1/2 polymorphisms are associated with IPF disease susceptibility. These results support a role for immunological mechanisms contributing to IPF pathogenesis.

journal_name

Lung

journal_title

Lung

authors

Bournazos S,Bournazou I,Murchison JT,Wallace WA,McFarlane P,Hirani N,Simpson AJ,Dransfield I,Hart SP

doi

10.1007/s00408-010-9262-3

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

475-81

issue

6

eissn

0341-2040

issn

1432-1750

journal_volume

188

pub_type

杂志文章

相关文献

LUNG文献大全
  • Physical activity in incident patients with pulmonary arterial and chronic thromboembolic hypertension.

    abstract:INTRODUCTION:The cardinal symptom of pulmonary hypertension (PH) is dyspnea on exertion, leading to decreased activity in daily living. The aim of this study was to analyze daily physical activity in incident patients with arterial or chronic thromboembolic PH (PAH/CTEPH) and to investigate its correlation with pulmona...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-019-00248-x

    authors: Saxer S,Lichtblau M,Berlier C,Hasler ED,Schwarz EI,Ulrich S

    更新日期:2019-10-01 00:00:00

  • Cystic fibrosis.

    abstract::While the care of cystic fibrosis (CF) patients has been mainly the province of pediatricians, great improvements in the therapy and life span of CF patients often results in their transition to care by adult physicians. In this review of CF, we begin with an overview of the epidemiology and genetics of the disease, w...

    journal_title:Lung

    pub_type: 杂志文章,评审

    doi:10.1007/BF00164308

    authors: Bye MR,Ewig JM,Quittell LM

    更新日期:1994-01-01 00:00:00

  • Correction to: Residual Renal Function and Obstructive Sleep Apnea in Peritoneal Dialysis: A Pilot Study.

    abstract::The original version of this article unfortunately contained a mistake in the article title. The correct article title is "Residual Renal Function and Obstructive Sleep Apnea in Peritoneal Dialysis: A Pilot Study". ...

    journal_title:Lung

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s00408-018-0135-5

    authors: Lanis A,Kerns E,Hu SL,Bublitz MH,Risica P,Martin S,Parker J,Millman R,Dworkin LD,Bourjeily G

    更新日期:2018-08-01 00:00:00

  • Characterization of surfactant subtypes of beractant and a synthetic peptide containing surfactant KL4 following surface area cycling and addition of fibrinogen.

    abstract::Surfactant is not a homogeneous material and can be separated into subtypes. Subtype conversion is clinically important because it is thought to occur naturally and because surface activity varies depending on the subtype. Fibrinogen, a naturally occurring serum protein, is known to affect this conversion. In this stu...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/pl00007569

    authors: Manalo E,Merritt TA,Amirkhanian JD,Kheiter A

    更新日期:1997-01-01 00:00:00

  • Clinical predictors of mortality and cause of death in lymphangioleiomyomatosis: a population-based registry.

    abstract:PURPOSE:Lymphangioleiomyomatosis (LAM) is a rare, progressive, frequently lethal cystic lung disease that almost exclusively affects women. Prognostic information in LAM has been limited by small numbers and heterogeneous study methodology. Early retrospective cohorts cited 5- and 10-year mortality of 40 and 80 %, resp...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-012-9419-3

    authors: Oprescu N,McCormack FX,Byrnes S,Kinder BW

    更新日期:2013-02-01 00:00:00

  • Effects of Ongoing Feedback During a 12-Month Maintenance Walking Program on Daily Physical Activity in People with COPD.

    abstract::This multi-centred, randomised controlled trial explored the effects of adding ongoing feedback to a 12-month unsupervised maintenance walking program, on daily physical activity (PA) in people with chronic obstructive pulmonary disease. Participants were randomised to either an intervention group (IG) or a usual care...

    journal_title:Lung

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00408-019-00216-5

    authors: Wootton SL,Hill K,Alison JA,Ng LWC,Jenkins S,Eastwood PR,Hillman DR,Jenkins C,Spencer LM,Cecins N,McKeough ZJ

    更新日期:2019-06-01 00:00:00

  • Idiopathic pulmonary fibrosis is associated with circulating antiepithelial antibodies.

    abstract:PURPOSE:Idiopathic pulmonary fibrosis (IPF) is a restrictive fibrotic lung disease of uncertain etiology. Alveolar epithelial injury may be one of the inciting triggers in the pathogenesis of this disorder. We hypothesized that circulating antibodies to alveolar epithelial and endothelial cells may be involved in the p...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-012-9390-z

    authors: Fahim A,Chong MC,Crooks MG,Hart SP

    更新日期:2012-08-01 00:00:00

  • Magnetic Resonance Imaging of Pulmonary Embolism: Diagnostic Accuracy of Unenhanced MR and Influence in Mortality Rates.

    abstract:OBJECTIVES:We evaluated the diagnostic value for pulmonary embolism (PE) of the True fast imaging with steady-state precession (TrueFISP) MRI, a method that allows the visualization of pulmonary vasculature without breath holding or intravenous contrast. METHODS:This is a prospective investigation including 93 patient...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-017-9975-7

    authors: Pasin L,Zanon M,Moreira J,Moreira AL,Watte G,Marchiori E,Hochhegger B

    更新日期:2017-04-01 00:00:00

  • Alpha 1-adrenergic and muscarinic receptors in adult and neonatal rat type II pneumocytes.

    abstract::Binding characteristics of the alpha 1-adrenergic radioloigand [3H]prazosin, and the muscarinic cholinergic radioligand, [3H]quinuclidinyl benzilate, were determined both in intact cell preparations of rat alveolar type II pneumocytes (TIIPs) and in membrane preparations of rat lung tissue. Binding in adult and neonat...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/BF00165701

    authors: Keeney SE,Oelberg DG

    更新日期:1993-01-01 00:00:00

  • Angiogenic factors and angiogenesis inhibitors in exudative pleural effusions.

    abstract::The angiogenesis system has been implicated in inflammatory and neoplastic processes; nevertheless, it has been little studied in relation to the pleural space. Our aim is to analyze pleural and plasma levels of the activators--vascular endothelial growth factor, basic fibroblastic growth factor, and inhibitors--endos...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-004-2533-0

    authors: Ruiz E,Alemán C,Alegre J,Monasterio J,Segura RM,Armadans L,Vázquez A,Soriano T,Fernández de Sevilla T

    更新日期:2005-05-01 00:00:00

  • RV Fractional Area Change and TAPSE as Predictors of Severe Right Ventricular Dysfunction in Pulmonary Hypertension: A CMR Study.

    abstract:BACKGROUND:The right ventricular ejection fraction (RVEF) is a surrogate marker of right ventricular function in pulmonary hypertension (PH), but its measurement is complicated and time consuming. The tricuspid annular plane systolic excursion (TAPSE) measures only the longitudinal component of RV contraction while the...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-018-0089-7

    authors: Hoette S,Creuzé N,Günther S,Montani D,Savale L,Jaïs X,Parent F,Sitbon O,Rochitte CE,Simonneau G,Humbert M,Souza R,Chemla D

    更新日期:2018-04-01 00:00:00

  • ATF3 and extracellular matrix-related genes associated with the process of chronic obstructive pulmonary.

    abstract:INTRODUCTION:Chronic obstructive pulmonary disease (COPD) is a major public health problem worldwide and is proved to be the number three cause of death in globally. The objective of this study was to explore the molecular mechanism of the progression of COPD. METHODS:Using the GSE1650 affymetrix microarray data acces...

    journal_title:Lung

    pub_type: 杂志文章,收录出版

    doi:10.1007/s00408-014-9631-4

    authors: Ye J,Wen L,Liu DL,Lai GX

    更新日期:2014-12-01 00:00:00

  • Discovery of alpha 1-antitrypsin deficiency.

    abstract::The author reviews the early history of alpha 1-antitrypsin (AAT) deficiency; the biochemical characterization of this inborn error of metabolism, its pattern of inheritance, frequency and predisposition to early, panacinar emphysema. The importance of the destructive element in emphysema and the gradual focusing on n...

    journal_title:Lung

    pub_type: 杂志文章,评审

    doi:10.1007/BF02718174

    authors: Eriksson S

    更新日期:1990-01-01 00:00:00

  • Identification of Biomarkers for Schistosoma-Associated Pulmonary Arterial Hypertension Based on RNA-Seq Data of Mouse Whole Lung Tissues.

    abstract:BACKGROUND:Pulmonary arterial hypertension (PAH) is a deadly disease, and the molecular mechanism of PAH has not been clarified clearly. The objective of this study was to identify possible biomarkers and explore the potential mechanisms of Schistosoma-induced PAH. METHODS:GSE49114 RNA-Seq data developed from mouse wh...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-017-9999-z

    authors: Sun Y,Lin X,Li L

    更新日期:2017-06-01 00:00:00

  • Preprocedural planning with prospectively triggered multidetector row CT angiography prior to bronchial artery embolization in cystic fibrosis patients with massive hemoptysis.

    abstract:STUDY OBJECTIVES:The aim of this study was to determine if electrocardiographically synchronized, prospectively triggered multidetector row computed tomography (ECG-MDR-CT) angiography of the aorta can accurately predict the location of ectopic bronchial arteries in patients with cystic fibrosis (CF) with massive hemop...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-011-9343-y

    authors: Hayes D Jr,Winkler MA,Kirkby S,Capasso P,Mansour HM,Attili AK

    更新日期:2012-04-01 00:00:00

  • The Significance of Controlling Nutritional Status (CONUT) Score as a Novel Prognostic Parameter in Small Cell Lung Cancer.

    abstract:PURPOSE:The immuno-nutritional status is closely related to the prognosis in many cancers. Controlling nutritional status (CONUT) score is a new parameter that reflects the immuno-nutritional status and is prognostic in some cancers. However, the prognostic significance of the CONUT score in small cell lung cancer (SCL...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-020-00361-2

    authors: Yılmaz A,Tekin SB,Bilici M,Yılmaz H

    更新日期:2020-08-01 00:00:00

  • Association between smoking and respiratory function before and after menopause.

    abstract::There is a lack of evidence about whether menopausal status influences the effect of smoking on lung function. This study examined the association between smoking and menopausal status and lung function independent of each other. Data were from a cohort of women attending the 21-year follow-up of the Mater University ...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-010-9269-9

    authors: Hayatbakhsh MR,Najman JM,O'Callaghan MJ,Williams GM,Paydar A,Clavarino A

    更新日期:2011-02-01 00:00:00

  • Inpatient Prevalence, Expenditures, and Comorbidities of Sarcoidosis: Nationwide Inpatient Sample 2013-2014.

    abstract:PURPOSE:To investigate inpatient prevalence, expenditures, and comorbidities of hospitalized patients with sarcoidosis in the USA. METHODS:Patients with sarcoidosis were identified within the Nationwide Inpatient Sample (NIS) database for the years 2013 and 2014 using the respective ICD-9 diagnostic code. Data on pati...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-019-00210-x

    authors: Ungprasert P,Wijarnpreecha K,Cheungpasitporn W,Thongprayoon C,Manatsathit W,Kröner PT

    更新日期:2019-04-01 00:00:00

  • Characteristics of respiratory distress syndrome in infants of different gestational ages.

    abstract:BACKGROUND:The purpose of this study was to compare the risk factors, clinical characteristics, and complications of respiratory distress syndrome (RDS) in infants delivered very preterm, late preterm, and term in order to help optimize the management of RDS in neonates. METHODS:A retrospective study was conducted on ...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-013-9475-3

    authors: Sun H,Xu F,Xiong H,Kang W,Bai Q,Zhang Y,Zhou C,Zhuang F,Wang X,Zhu C

    更新日期:2013-08-01 00:00:00

  • Factors affecting efficacy and safety of add-on combination chemotherapy for non-small-cell lung cancer: a literature-based pooled analysis of randomized controlled trials.

    abstract:BACKGROUND:Several clinical trials of chemotherapy for non-small-cell lung cancer (NSCLC) have been conducted to date. However, these studies have not been effective at identifying category 1 recommended strategies for systemic chemotherapy according to the National Comprehensive Cancer Network clinical practice guidel...

    journal_title:Lung

    pub_type: 杂志文章,评审

    doi:10.1007/s00408-012-9379-7

    authors: Inoue K,Narukawa M,Takeuchi M

    更新日期:2012-08-01 00:00:00

  • Influence of azelastine and some selected drugs on mucociliary clearance.

    abstract::The effect of azelastine and some selected compounds on ciliary beating frequency (CBF) was investigated in vitro using human mucosal samples and in vivo using anesthetized guinea pigs. Further influence of azelastine on mucus secretion was evaluated in mice and on mucociliary clearance in anesthetized rabbits. Azelas...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/BF00174117

    authors: Achterrath-Tuckermann U,Saano V,Minker E,Stroman F,Arny I,Joki S,Nuutinen J,Szelenyi I

    更新日期:1992-01-01 00:00:00

  • How the Frequency and Phenotype of Sarcoidosis is Driven by Environmental Determinants.

    abstract:BACKGROUND:Sarcoidosis is a systemic disease in which the personal environment seems to drive a differentiated disease frequency and clinical expression. The main epidemiological studies suggest a key influence of potential environmentally linked exposures related to the type of occupation, the household, life style, s...

    journal_title:Lung

    pub_type: 杂志文章,评审

    doi:10.1007/s00408-019-00243-2

    authors: Ramos-Casals M,Kostov B,Brito-Zerón P,Sisó-Almirall A,Baughman RP,Autoimmune Big Data Study Group.

    更新日期:2019-08-01 00:00:00

  • Airway eosinophilic inflammation and bronchial hyperresponsiveness after allergen inhalation challenge in asthma.

    abstract::Allergen exposure in atopic asthmatic patients is associated with recruitment and activation of eosinophils in the airways. Once activated, eosinophils release toxic products, including the eosinophil cationic protein (ECP), able to damage bronchial structures and to increase bronchial hyperresponsiveness. With this b...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/pl00007606

    authors: Oddera S,Silvestri M,Penna R,Galeazzi G,Crimi E,Rossi GA

    更新日期:1998-01-01 00:00:00

  • Postoperative Adverse Events are Associated with Oncologic Recurrence Following Curative-intent Resection for Lung Cancer.

    abstract:BACKGROUND:Up to 50% of patients suffer short-term postoperative adverse events (AEs) and metastatic recurrence in the long-term following curative-intent lung cancer resection. The association between AEs, particularly infectious in nature, and disease recurrence is controversial. We sought to evaluate the association...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-020-00395-6

    authors: Gowing S,Baker L,Tran A,Zhang Z,Ahn H,Ivanovic J,Anstee C,Grigor E,Gilbert S,Maziak DE,Shamji F,Sundaresan S,Villeneuve PJ,Seely AJE

    更新日期:2020-12-01 00:00:00

  • VIP antagonists enhance excitatory cholinergic neurotransmission in the human airway.

    abstract::It has been reported that a low concentration of exogenously applied vasoactive intestinal peptide (VIP) suppresses the release of acetylcholine (ACh) from vagus nerve terminals in the ferret and feline trachea. There has been, however, no documentation of the prejunctional action of VIP in the human airway. We observ...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/BF00175944

    authors: Aizawa H,Inoue H,Shigyo M,Takata S,Koto H,Matsumoto K,Hara N

    更新日期:1994-01-01 00:00:00

  • Early Trends in Bronchoscopic Lung Volume Reduction: A Systematic Review and Meta-analysis of Efficacy Parameters.

    abstract:INTRODUCTION:The goal of our systematic review and meta-analysis is to examine the therapeutic effectiveness of bronchoscopic lung volume reduction (BLVR), and to compare it with medical management and lung volume reduction surgery. METHODS:Variables of interest were absolute change in FEV1, 6MWT, and SGRQ. Meta-analy...

    journal_title:Lung

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00408-016-9969-x

    authors: Kumar A,Dy R,Singh K,Jeffery Mador M

    更新日期:2017-02-01 00:00:00

  • Hyperbaric air exposure at 2.5 ATA does not affect respiratory mechanics and lung histology in the rat.

    abstract:BACKGROUND:We previously demonstrated that the exposure to hyperbaric hyperoxia increased respiratory system elastance and both the "ohmic" and viscoelastic components of inspiratory resistances, probably because of increased oxygen tension toxic effects. We presently investigated the possible consequences of a single ...

    journal_title:Lung

    pub_type: 杂志文章

    doi:10.1007/s00408-014-9576-7

    authors: Rubini A,Porzionato A,Sarasin G,Zara S,Macchi V,Camporesi E,Bosco G

    更新日期:2014-08-01 00:00:00

  • Difficult weaning from mechanical ventilation.

    abstract::Difficult weaning is fortunately a rare occurrence in mechanically ventilated patients in ICU. When faced with this problem, a vast number of factors must be carefully considered simultaneously: physiological adjustment, technical problems (tubing, circuit resistances, . . .) [13]. The most promising approach to diffi...

    journal_title:Lung

    pub_type: 杂志文章,评审

    doi:10.1007/BF02718216

    authors: Chevrolet JC

    更新日期:1990-01-01 00:00:00

  • A causal relationship between cough and gastroesophageal reflux disease (GERD) has been established: a pro/con debate.

    abstract::Along with upper airway cough syndrome (formerly, postnasal drip syndrome) and eosinophilic airway inflammation (asthma, nonasthmatic eosinophilic bronchitis), gastroesophageal reflux disease (GERD) is generally considered among the most common etiologies of chronic cough. Indeed, cough management guidelines published...

    journal_title:Lung

    pub_type:

    doi:10.1007/s00408-013-9528-7

    authors: Kahrilas PJ,Smith JA,Dicpinigaitis PV

    更新日期:2014-02-01 00:00:00

  • Tracheobronchopathia osteochondroplastica: a rare large airway disorder.

    abstract::Tracheobronchopathia osteochondroplastica (TO) is a rare disorder of the large airways characterized by the development of submucosal cartilaginous and bony nodules. The nodules involve the anterior and lateral walls and typically spare the posterior membranous wall. The clinical presentation of TO is variable and ran...

    journal_title:Lung

    pub_type: 杂志文章,评审

    doi:10.1007/s00408-008-9113-7

    authors: Abu-Hijleh M,Lee D,Braman SS

    更新日期:2008-11-01 00:00:00