Abstract:
PURPOSE:Nicorandil is a hybrid between nitrates and KATP channel opener activators. The aim of this study was to evaluate the nicorandil's effects on ischemia-reperfusion (IR) lung injury and examine the mechanism of its effects. METHODS:Isolated rat lungs were divided into 6 groups. In the sham group, the lungs were perfused and ventilated for 150 min. In the IR group, after perfusion and ventilation for 30 min, they were interrupted (ischemia) for 60 min, and then resumed for 60 min. In the nicorandil (N) + IR group, nicorandil 6 mg was added before ischemia (nicorandil concentration was 75 µg ml-1). In the glibenclamide + N + IR group, the L-NAME (Nω-Nitro-L-arginine methyl ester) + N + IR group and ODQ (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one) + N + IR group, glibenclamide 3 µM, L-NAME 100 µM, and ODQ 30 µM were added 5 min before nicorandil administration, respectively. We measured the coefficient of filtration (Kfc) of the lungs, total pulmonary vascular resistance, and the wet-to-dry lung weight ratio (WW/DW ratio). RESULTS:Kfc was significantly increased after 60 min reperfusion compared with baseline in the IR group, but no change in the sham group. An increase in Kfc was inhibited in the N + IR group compared with the IR group (0.92 ± 0.28 vs. 2.82 ± 0.68 ml min-1 mmHg-1 100 g-1; P < 0.01). Also, nicorandil attenuated WW/DW ratio was compared with IR group (8.3 ± 0.41 vs. 10.9 ± 2.5; P < 0.05). Nicorandil's inhibitory effect was blocked by glibenclamide and ODQ (P < 0.01), but not by L-NAME. CONCLUSIONS:Nicorandil attenuated IR injury in isolated rat lungs. This protective effect appears to involve its activation as KATP channel opener as well as that of the sGC-cGMP pathway.
journal_name
Lungjournal_title
Lungauthors
Abe K,Horiguchi T,Enzan K,Masaki Y,Nishikawa T,Kimura Tdoi
10.1007/s00408-020-00339-0subject
Has Abstractpub_date
2020-04-01 00:00:00pages
315-321issue
2eissn
0341-2040issn
1432-1750pii
10.1007/s00408-020-00339-0journal_volume
198pub_type
杂志文章相关文献
LUNG文献大全abstract:BACKGROUND:Transbronchial lung biopsy (TBBX) is a common respiratory diagnostic procedure performed to investigate several lung diseases. There are different types of forceps used to perform this procedure. The alligator and cupped (oval) forceps are most commonly used ones. To date, there are few studies that have com...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-018-0179-6
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:In obstructive sleep apnea (OSA), hypoxia secondary to apnea and hypopnea and the resulting systemic inflammatory response are the main causes of comorbidities. The aim of this study was to investigate the relationship between OSA and vimentin, which plays an important role in the activation of cells that synth...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-020-00341-6
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Sarcoidosis is a systemic disease in which the personal environment seems to drive a differentiated disease frequency and clinical expression. The main epidemiological studies suggest a key influence of potential environmentally linked exposures related to the type of occupation, the household, life style, s...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-019-00243-2
更新日期:2019-08-01 00:00:00
abstract::Indoor air pollutants may cause inflammatory changes of the airways and adjacent pulmonary tissue. After phagocytosis of inhaled particles alveolar macrophages (AM) release chemotactic mediators capable of attracting inflammatory cells into the lung tissue. To evaluate these mechanisms further peripheral blood mononuc...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/pl00007628
更新日期:1999-01-01 00:00:00
abstract::Surfactant is not a homogeneous material and can be separated into subtypes. Subtype conversion is clinically important because it is thought to occur naturally and because surface activity varies depending on the subtype. Fibrinogen, a naturally occurring serum protein, is known to affect this conversion. In this stu...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/pl00007569
更新日期:1997-01-01 00:00:00
abstract::Genomic alterations in lung cancer tissues have been observed in various studies. To analyze the aberrations in the genome of lung cancer patients, we used array comparative genomic hybridization (array CGH) in 15 lung adenocarcinoma (AdC) tissues. Copy number gains and losses in chromosomal regions were detected and ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-006-0009-0
更新日期:2006-11-01 00:00:00
abstract::To explore further the possible etiologic role of mycobacteria in the development of sarcoidosis, we measured free, nonbound tuberculostearic acid (TSA, 10-methyloctadecanoic), a component of mycobacteria, in the sera of subjects with sarcoidosis or active untreated pulmonary tuberculosis and in healthy controls by us...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00164632
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Several clinical trials of chemotherapy for non-small-cell lung cancer (NSCLC) have been conducted to date. However, these studies have not been effective at identifying category 1 recommended strategies for systemic chemotherapy according to the National Comprehensive Cancer Network clinical practice guidel...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-012-9379-7
更新日期:2012-08-01 00:00:00
abstract::Adolescent idiopathic scoliosis may require surgical treatment for extreme curvature of the spine or loss of pulmonary function. We present a report of a 31-year-old woman with a history of scoliosis and anterolateral spinal fusion who developed chest pain and hemoptysis. Imaging revealed that a fixation rod had migra...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-018-0104-z
更新日期:2018-06-01 00:00:00
abstract:INTRODUCTION:Hypoxia has been implicated in the pathogenesis of many inflammatory and fibrotic lung diseases. The effect of hypoxia on epithelial junction protein expression is yet to be fully elucidated but evidence suggests a protective role for the hypoxia-inducible transcription factor HIF-1 in stabilising occludin...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9918-8
更新日期:2016-10-01 00:00:00
abstract::The angiogenesis system has been implicated in inflammatory and neoplastic processes; nevertheless, it has been little studied in relation to the pleural space. Our aim is to analyze pleural and plasma levels of the activators--vascular endothelial growth factor, basic fibroblastic growth factor, and inhibitors--endos...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-004-2533-0
更新日期:2005-05-01 00:00:00
abstract::Lung cancer screening (LCS) is currently advocated in a subset of current or former smokers with a thirty pack-year smoking history or higher. Studies report that few patients meeting the criteria for screening are undergoing LCS. We conducted a survey to assess if barriers to LCS (race, ethnicity, and socioeconomic s...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-019-00281-w
更新日期:2019-12-01 00:00:00
abstract::Lung cancer is currently one of the most common malignant diseases and is responsible for substantial mortality worldwide. Compared with never smokers, former smokers remain at relatively high risk for lung cancer, accounting for approximately half of all newly diagnosed cases in the US. Screening offers former smoker...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-013-9517-x
更新日期:2014-02-01 00:00:00
abstract::Clusterin is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution. It plays important roles in various pathophysiological processes, including tissue remodeling, reproduction, lipid transport, complement regulation, and apoptosis. Clusterin appears to have two main isoforms that result from alternati...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-010-9248-1
更新日期:2010-10-01 00:00:00
abstract::A nodular lesion in the medial segment of right middle lobe was discovered on a chest radiograph for chronic cough in a 42-year-old Asian woman. A chest computed tomography (CT) scan subsequently showed a right middle lobe (RML) nodular lesion, which exhibited intense fluorodeoxyglucose uptake on positron emission tom...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-009-9221-z
更新日期:2010-08-01 00:00:00
abstract:ABSTARCT:New anti-fibrotic agents for idiopathic pulmonary fibrosis (IPF) were approved based on the results of forced vital capacity (FVC) trends, although concerns were raised about the reliability of FVC as the only endpoint parameter. We hypothesized that IPF-specific multi-dimensional scores (Composite Physiologic...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9963-3
更新日期:2017-02-01 00:00:00
abstract::Simulation-based medical education has gained tremendous popularity over the past two decades. Driven by the patient safety movement, changes in the educational opportunities available to trainees and the rapidly evolving capabilities of computer technology, simulation-based medical education is now being used across ...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-010-9260-5
更新日期:2010-12-01 00:00:00
abstract::Tuberculosis (TB) pleurisy is accepted to be the best model for evaluating the local protective cellular immune response to Mycobacterium tuberculosis (MTB) since it can be spontaneously self-cured. Therefore, we aimed to evaluate the involvement of cytokines and the soluble apoptosis-modulating factors sFas and sFasL...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-008-9107-5
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:According to the National Family Health Survey, asthma is one of the leading diseases in India. In order to understand the complexity of asthma, the susceptibility genes need to be targeted for their association. Glutathione S-transferases play a major role in the detoxification of metabolites of oxidative s...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9385-9
更新日期:2012-10-01 00:00:00
abstract::Recently, active remodeling may indicate a good prognosis in idiopathic interstitial pneumonias. In this study we sought to validate the importance of the collagen/elastic system in the extracellular matrix remodeling and to study the relationships between the collagen/elastic system in nonspecific interstitial idiopa...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-006-0104-2
更新日期:2007-01-01 00:00:00
abstract::This multi-centred, randomised controlled trial explored the effects of adding ongoing feedback to a 12-month unsupervised maintenance walking program, on daily physical activity (PA) in people with chronic obstructive pulmonary disease. Participants were randomised to either an intervention group (IG) or a usual care...
journal_title:Lung
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00408-019-00216-5
更新日期:2019-06-01 00:00:00
abstract::The aim of our study was to evaluate clinical diagnoses in symptomatic persons exposed to aerosols from humidifiers or air conditioners. In addition, we tried to identify the causative antigens. Results of clinical investigations, including inhalation challenge tests, demonstrated a typical hypersensitivity pneumoniti...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF02714035
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Recent studies have shown the importance of Th17 cells in the development of allergic airway diseases. We examined Dermatophagoides pteronyssinus-induced changes in peripheral blood Th17 cells to establish the importance of these cells in late-phase allergic inflammation in patients with allergic rhinitis (A...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9411-y
更新日期:2012-10-01 00:00:00
abstract::A method has been developed for the isolation of bovine type II pneumocytes by enzymatic tissue dissociation and subsequent density gradient centrifugation. After mechanical defibrination, the crude cell suspension contains 71.9 +/- 26.6 X 10(7) cells (viability greater than 95%) with a type II cell purity of 39.4 +/-...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF02714925
更新日期:1989-01-01 00:00:00
abstract::The major goal of all diagnostic and therapeutic efforts in childhood asthma is to prevent progression of lung disease into adulthood. To improve the uncomfortable situation of underdiagnosis and undertreatment and to lower the risk of acquiring irreversible lung damage, an optimal co-working relationship between fami...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/BF02718166
更新日期:1990-01-01 00:00:00
abstract::Diffuse alveolar damage is the histopathologic hallmark of acute respiratory distress syndrome (ARDS). A significant proportion of ARDS survivors have residual pulmonary fibrosis and compromised pulmonary function. On the other hand, heat shock protein 47 (HSP47) is a collagen-binding stress protein that is assumed to...
journal_title:Lung
pub_type: 杂志文章,收录出版
doi:10.1007/s00408-006-0085-1
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:There is very little evidence of the utility of the exhaled fraction of NO (FeNO) for the diagnosis of interstitial lung disease and nearly all of it is related with connective tissue disease. Some authors have suggested that in patients with hypersensitivity pneumonitis (HP), evolution to pulmonary fibrosis...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-015-9824-5
更新日期:2016-02-01 00:00:00
abstract::The effect of beta 2-adrenoceptor agonists on airway smooth muscle relaxation may be subject to desensitization. It could be modified by glucocorticosteroid treatment. An increase in the beta 2 agonist response by glucocorticosteroids in vitro has been described. We studied the effects of acute and chronic treatment w...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/BF00176895
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:The immuno-nutritional status is closely related to the prognosis in many cancers. Controlling nutritional status (CONUT) score is a new parameter that reflects the immuno-nutritional status and is prognostic in some cancers. However, the prognostic significance of the CONUT score in small cell lung cancer (SCL...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-020-00361-2
更新日期:2020-08-01 00:00:00
abstract::High concentrations of tumor necrosis factor-a (TNF), as well as excess of polymorphonuclear leukocytes (PMNs), are present in pleural fluid of patients with complicated parapneumonic effusion (CPPE). Several studies have shown that PMNs are capable of secreting TNF. However, the correlation between levels of TNF and ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s004080000100
更新日期:2002-01-01 00:00:00