Abstract:
:The measurement and potential technological significance of in vivo missense errors are briefly reviewed. A recently developed approach is described in which reporter enzyme activity is generated by mistranslation of a gene coding for an inactive mutant form of the enzyme. Initial results obtained using the alpha subunit of E coli tryptophan synthetase and bacterial luciferase are discussed, as well as the prospects for further development of this method.
journal_name
Biochimiejournal_title
Biochimieauthors
Cornut B,Willson RCdoi
10.1016/0300-9084(91)90192-4subject
Has Abstractpub_date
1991-12-01 00:00:00pages
1567-72issue
12eissn
0300-9084issn
1638-6183pii
0300-9084(91)90192-4journal_volume
73pub_type
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