Abstract：
:Alkylcarbonates of gamma-cyclodextrins were produced and their inclusion complexes with four poorly water-soluble drugs of different structures and solubilities were prepared. The alkylcarbonates and the alkylcarbonate drug complexes were characterized by DSC and XRPD; the physical mixtures were used as control. Solubility capacities were evaluated by phase solubility studies. The effect of alkyl chain length on the complexation and release behaviour was investigated as well. The XRPD patterns of alkylcarbonates showed that the derivatives lose the original crystallinity of gamma-cyclodextrins. The series of alkylcarbonates formed inclusion complexes with the drugs considered. Both XRPD and DSC analyses did not show neither the reflections of the crystalline structures nor the melting peaks of the drugs, respectively. These gamma-cyclodextrin derivatives can improve drug solubility and influence the drug release rates while the alkyl chain length may affect these properties.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Cavalli R,Trotta F,Trotta M,Pastero L,Aquilano Ddoi
10.1016/j.ijpharm.2007.03.001subject
Has Abstractpub_date
2007-07-18 00:00:00pages
197-204issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(07)00231-1journal_volume
339pub_type
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